Real DOCTOR reacts to CELLS AT WORK! // Episode 6 // "Erythroblasts and Myelocytes"

Where do the cells in your blood come from? We find out by watching episode 6 of Cells at Work (Hataraku Saibou) from a real doctor's perspective! I'll be breaking down what's on screen, reacting to the scenes and explaining a little more about the medicine and how the cells work.
We learn about how erythroblasts become erythrocytes, why pseudomonas infections are so bad, what are NK cells, how your cells recognise viruses and cancer cells, and much, much more!
As with all these reviews I skim over a lot of medical terms, please leave a comment if you want any clarifications!
If you like this you can check out my look at the first episode here:
• Real DOCTOR reacts to ...
Or the second one here:
• Real DOCTOR reacts to ...
Or even the third one here:
• Real DOCTOR reacts to ...
Or even the fourth one here:
• Real DOCTOR reacts to ...
Or EVEN the fifth one!
• Real DOCTOR reacts to ...
You can watch Cells at Work! here:
crunchyroll.com...
Be warned this video is again very medical / lots of talk about cell biology, so it's not just a straight up reaction, I try and bring something different to each video, so if you enjoyed this please check out my other reviews of Medical TV dramas; House MD, Scrubs, The Good Doctor, Grey’s Anatomy, The Resident and ER!
Instagram: / drhopesicknotes
Twitter: / drhopesicknotes
FB: / drhopesicknotes
Clips used under fair use (education and review):
THANK YOU FOR NOT COPY STRIKING THIS VIDEO SO I CAN CONTINUE TO USE THESE GREAT SHOWS FOR EDUCATION AND REVIEW.
ALL Cells At Work! Clips owned by Kodansha / Kodansha USA and distributor Sony Music Entertainment (Japan) Inc.
Clip of Oddjob:
• Goldfinger at Stoke Pa...
Dash of Raspberry Beret by Prince:
• Prince & The Revolutio...
Thank you to all the artists that make their music available for these videos:
Song 'Escapists' by The AutoDisko
Song 'First Day' by Huma-Huma
Song ‘Finding Me’ by Eveningland
#doctorreacts #doctorwatches #cellsatwork

[@darkness4311]

Why does our red blood cell have red hair? Well let me tell you she has a verry serious mutation that causes a verry dangerous sickness we call: main-character syndrome. It causes a person to have verry notable features so any random person will recognise her as a main-character.

[@ToastyMozart]

Other symptoms include being assigned a window seat near the back of your classroom, befriending transfer students, and absentee parents.

[@Luzbel2912]

The DRs at the foundation still haven't find a cure

[@ThePigKnight]

She also has a bad case of bestgirlitis. It's usually marked by having a lot of fan art.

[@majorblitz3846]

In additional, there is possibility of getting another symptom during the second stage. -Imouto complex _Causing the incestuous stimulation in your brain, giving you the feeling that your own sister looks attractive, In worse case this mogyt lead you into literally getting the "Haruka White sickness" that causing you to have the massive urge of having sex with your blood related sister, however the odd is more likely that you'll grt the contagious effect from your sister more._

[@TheNymanator]

Dang, I was going to make that joke

[@painnful]

RBC: will I ever see you again? *YES in every single episode. 100% ALL OF THE TIME*

[@reeeec]

I don't even get that logic. WBC don't last that long in the body

[@berylscorner6321]

Like what are the odddsssss

[@crazyadri5079]

@@reeeec shh power of love. (And main character plot armor)

[@ZenoDLC]

@@berylscorner6321 Just listen to the OP, the odds are mentioned there. Then again, what are the odds of getting all these sickness and injuries in the span of one Neutrophil's life?

[@kazemizu]

From our perspective, it seems to be a long time. But really, this all might be happening within a few hours.

[@--Paws--]

17:06 So NK Cells can feel the disturbance in the force...

[@Razorcarl]

Lo

[@Razorcarl]

Lol

[@DreamyDiamond]

I mean. From what I took from that yeah

[@zeeee3530]

Natural Killer Cells can eliminate any cell, ally cells or foreign cells once they detected it posses any harm ... so basically something like that

[@exocakes4587]

When an Immune cell kills innocent cells (also diabetes): "YOU HAVE BECOME WHAT YOU SWORE TO DESTROY!"

[@OnAHeroicMission]

To be perfectly honest, human anatomy and bio really freaked me out in school? Still kinda does, but you're making this a lot easier to understand, and it isn't freaking me out nearly as much. Thanks for doing this- it's super cool!

[@NarinsCreativeCorner]

10:57 I love seeing that White Blood Cell was protecting Red before we knew them. So cute.☺️

[@questocanale]

1:08 Mate, you deserve a like just for that Ahoge !

[@nujumkey]

Step 1: like the video Step 2: watch the video

[@surrealcereal3688]

Step 3: like this comment Step 4: like this reply

[@HateshWarkio]

This "arc" in Cells at Work is absolutely amazing. Looking forward to your reaction/review!

[@iii7139]

I think you can make a new video of 5 things may have missed after ep.7 . I already had a few: 1, The cell that sends reports of nausea and emesis is a Nerve Cell according to the author 2, The Memory T Cell in ep 5 is actually a Memory B Cell, since the memory t is in ep 3 with the pink notebook 3, The gun of B Cell is made from the structure of different types of antibodies. For example his gun in ep.5 is the real shape of IgE antibody 4, natural killer cells have chances to attack Cytotoxic t cells since NK is one of the major factor that causes autoimmune diseases and just a note, the chapter 27 of the manga is a specific chapter that describes the differentiation of granulocytes and the Left Shift of band cells.

[@destymoonshine7553]

I love your bus n police car analogy. Your video explain NK cell n other cell in a very easy way and interesting to understand. I really like this anime. But. I need to watch like all of your videos before i can idependeltly watch the season 2. Great video Ed Hope.

[@spectraphantom98]

You HAVE to get to episode 7!!!

[@fjgenso2]

I can’t wait for your review about cancer on next episode :D.

[@masterofmoe2154]

I showed Cells at Work to my Health teacher, and she was amazed by its accuracy

[@shiroXmanju]

Episode 7 please, Dr. Hope! :)

[@Soulcrushers666]

Macrophage to Red Blood Cell: "It's time for phagocytosis!" Red Blood Cell: "Was I a good red blood cell?" Macrophage: "No, I was told you were the best!"

[@DragonNicho98]

awesome ! still waiting cancer episode and don't forget there is a christmas episode released about 2 weeks ago :D

[@danielavargas4956]

Please, please continue this series

[@Fate025]

Wow i revisited and now i find Japanese subtitles!!!! Real Doctor reacts must be popular with japanese anime fans as well!!!

[@EmmaAppleBerry]

When they stop the cells from seeing their proteins on the surface its like they put a balaclava or other disguise so they dont get recognised and captured lol

[@JOE-bq9yc]

待ってました～♪(ｏ・ω・)ノ))

[@sexyscales]

I personally find it extraordinary that the anime is able to relate to both sides of Dr. Hope through itself. A. the technical jargon that we expect him to react to and lecture about, and b. the artistic license the show takes that isn't anatomically accurate, BUT Dr. Hope seems to relate to it from his own experiences becoming a doctor.

[@ibelieveinwoozisupremacy8681]

now you're my official teacher

[@AmatMN]

i think the red blood cells hair is just a case of main character syndrome

[@jacobblitshtein419]

Can wait for him to get to episode 10 i really want to see how he reacts

[@hips_gaming7643]

You're so inspirational

[@luckywithpaint7773]

Dr. Hope is to smart for this show. He is the natural killer T cell of the show.

[@DellOsso]

Still waiting for episode 7.

[@tangerian319]

Hope you are hyped for cells at work code black this year. Though they might put it off given covid and all. Or maybe not.

[@alexalyncake4256]

"a purple criminal" me:purple guy? william afton? why is he in this? hahahaahahah

[@motherhoodsbeauty9279]

Just imagine your teacher(macrophage) will eat and destroy you after you(red blood cell) turn 120 days old. That sound brutal and sad😱🤯.

[@yurineri2227]

Amazing video

[@gof666]

Wait.. it just clicked for me... You are Dr. Ed Hope... Dred Hope... Dread Hope *^_^*

[@pigeontato272]

Dr Hope: why is the main character’s hair different? Me: you must be new

[@jaynator495]

Right!? Lol

[@branddransnothing]

*your first time?*

[@berylscorner6321]

Ikr😂😂😂

[@koatam]

Newbie: Why is your hair like that? Veteran : I see, you must be the main character.

[@legobionicle2795]

*New round here? Let me show ya round.*

[@Robert-ke5lb]

1:08 "Ahoge". Slowly, but surely, Dr. Hope is becoming a weeb like us.

[@milky5432]

I was like Ahoge not expecting some weebyness lol I was like ohhhh

[@maucaw]

At first I read ahegao and was really confused

[@18grape]

I'm lovin' it!

[@abyssaljoey7695]

@@maucaw I feel you

[@DaveAp7]

"Mite mite!! Kawaii 😆✌️" - Dr. Hope, pointing to his ahoge.

[@TheSleepysleep]

This series is 50% "this is just like in your body" and 50% "this is just like in med school" 😂😂

[@ArlanKels]

The med school comment threw me. Didn't expect that a white blood cell was using handpuppets at med school to terrorize children.

[@GabrielaPerez-tj9sb]

@@ArlanKels medicine teachers enjoy to terrorize students sometimes XD

[@user-pr6ed3ri2k]

990thliket

[@Electroblade360]

​@@GabrielaPerez-tj9sb such as the whole clotting cascade for example lol

[@merwinbagano2525]

NO ONE SPOIL HIM FOR EP 7 LOVE YOUR REACTS DOC HOPE

[@DrHopeSickNotes]

oooooo I look forward to the next one

[@rapa624]

iknow

[@finikksu]

I'm exited for him to watch that one and 11.

[@Ikbob11]

You know he reads the titles of the episodes, right? lol

[@GreyFox23]

To be fair, the Title of Ep 7 is a bit of a spoiler already.

[@EsWandervogel]

6:07 those zombies are like “You get a hat and you get a HAT!!!”

[@michadylawerski2939]

You get a hat and you get hit by T cells

[@flyingspacebrainedidiot]

@@michadylawerski2939 You get a hat unless you already have one

[@SonTran-vb8xt]

Imagine Covid being like, "LET'S AIM FOR THE HUMaNS. THEY NEED BETTER HATS"

[@amymenear7382]

I always wanted to be toad from mario

[@kitariauthor5943]

eVERYBODY GETS A HAAAAAAT

[@Trainfan1055Janathan]

As a school bus driver, your bus analogy really made me laugh. It gave me the image of a bus driver being pulled over for a roadside inspection. Cop: - *inspects* *bus* - *finds* *a* *flat* *tire* - *nukes* *the* *bus*

[@SleepyNerve]

100th like (:

[@CeCactus13]

Police: _sees tinted window_ Police: "Seems kinda sus. Better nuke _just_ to be sure."

[@jacthing1]

@@CeCactus13 Policeman: *pulls fat man out of pocket*

[@vyxnx7384]

@@jacthing1 Me and my friends on the bus: Oh Hell No-

[@dartfield4655]

the roads will be safer for everybody else tho :)

[@thomasderosso5625]

Moral of the story: if your bus gets a flat tire or has dark windows, the cops will come kill everyone aboard.

[@genghiskhan5701]

Sounds like Murican cops

[@jack_copperz]

XD. So dark yet so funny.

[@ZenoDLC]

If it has any criminals, the whole bus die

[@laartje24]

Nah not only everyone aboard, they will kill the whole bus including everyone aboard.

[@deaddead698]

Bus: *gets tiny scratch on window* Cop: you weren’t supposed to do that

[@kizarose5083]

Patiently waits for the 7th episode 😀

[@silverheart7091]

*Insert patient pun here*

[@erinacchiiii]

Me too! 💓💓💓💓

[@shkhrvarshney]

It's a great episode. Hope he reviews it soon.!

[@komocakeps527]

we can only patiently wait for the next episode.

[@spoonerooneyy_]

@Silver Heart lol PATIENTLY

[@grandmask]

:o another episode of doctery boi doing doctory stuff on anime

[@DrHopeSickNotes]

I think I may change the title of my videos to this

[@gwaynebrouwn844]

@@DrHopeSickNotes that would be amazing😂

[@horaciohernandez2850]

Here comes dat doctery boi!

[@Archgeek0]

@@horaciohernandez2850 Oh sick, wat up!

[@alexandermayro7145]

@@DrHopeSickNotes You should put this in the description of the playlist XD

[@sweaves]

The main character red blood cell probably just has red hair to differentiate her as the main character among a crowd of similar characters. Sort of like a bright red shirt in a crowd of grey shirts.

[@undefined0_]

@@blankblank1661 no, watch the i card episode.

[@christopheryoung935]

Yup. It's a trope in anime that a main character will have some sort of bright red/pink/ whatever hair so that they stand out.

[@vanessawhite2084]

There are other red blood cells with red hair everywhere though.

[@starwatcher09]

Like Catriona Gray and the final 4? 😂

[@ShadowDaPk]

@@blankblank1661 that's not canon.

[@gtf234]

AE-3803's red hair has only been called out during this storyline- they decided to make her an erythrocyte simply because she had red hair, but nobody bats an eye at it being significant. Her number is a play on this though because AE3803 is the hexcode for the color of her hair. Her senior is named AA5100, that also being a hexcode that produces a color that matches said character's hair. I explain this in reference to how they are colored in the manga's colored illustrations. Meanwhile the name code for the protagonist neutrophil was eventually cracked (and by cracked I mean the official fan anthology book explained it)- his name is a verbal pun: 1146 is said "i-i-shi-ro" verbally sounding similar to the words good/nice and white, Ī and Shiro

[@linwoodvalentine7693]

Thank you!

[@nailasalsabila3342]

Thank you! I've been expecting that there might be something behind their numbers... And the name "Iishiro" just sounds so fitting for him :3

[@alexandermayro7145]

Isn't AE-3803's number also a verbal pun of some kind? I could be wrong, but I feel like I remember reading that somewhere... Also, the number for White Blood Cell 4989 (a minor character usually in the background, in episode 2 he was the one who almost fell into the abrasion) is also a verbal pun, sounding similar to "having a hard time."

[@gtf234]

Correct, U-4989 is the Neutrophil that has the wide eyes out of U-1146's regular squadmates; he's typically shown doing something goofy in the background or improvising a weapon in nearly every fight ranging from using a box of manju to tying his knife to a pipe and using pots and pans as armor plating. His number is said as Shi-Ku-Ha-Ku, which sounds like shikuhakku, as you said: "having a difficult time" The heroine of BLACK is U-1196, the 9 and 6 being Ku and Ro when read number by number as they do, changing the pun in U-1146's White to Black. I am not aware of the Erythrocytes having such puns beyond the hexcode gimmick, though my memory could be off.

[@FishOniDeviantArt]

wow I never even thought about that, thanks!!

[@ayyylmao101]

" _Blimey,_ what the hell kinda cell is that?" I CAN'T BREATHE 😂

[@furorteutonicus9045]

I love this content! Nice Ahoge by the way! :3

[@DrHopeSickNotes]

I know, every time I watch the video back the idiot hair is there

[@ThePigKnight]

NOT to be confused with ahegao.

[@estebanf9282]

@@ThePigKnight oh man, oh no

[@ToastyMozart]

@@ThePigKnight What a legend that thread was.

[@sleepingkirby]

@@DrHopeSickNotes If it makes you feel any better, I have straight hair and I get ahoges all the time. My wife always points it out. Ahoge havers unite!

[@BaileyL018]

I really like the police analogy. The killer t cells are like cops because they have to be informed of the situation, there has to be someone on the radio telling them what the suspect looks like. The nk cells are like detectives, they look at the evidence and crime scene first to follow it back to the perp, relying on their ability to sniff out suspicious activity

[@daisuke910]

Do you know that cancer cells can recruit our immune system to be on their side (cancer-associated immune cells). They become a bad police! Instead of killing the cancer cells, the help them sustain, grow and spread to other parts of the body. It seems the world in our body is not far-off from the real world.

[@genghiskhan5701]

The NK cells are like Stalinist Secret Police tbh, purging things that are 'out of place'

[@oofmaroomph4913]

I'd say that the nk cells are more like a secret agent department that suddenly launches an operation against a terrorist, something like the cia

[@briannalawson3478]

1:09 what an adorable dork 😂❤️ He pointed out his little ahoge

[@painnful]

Of course theyll skip over the phagocyting... Because who wants to see Macrophage-sama eat our main character

[@vaughnalexander31]

I kinda want to

[@RandoSando.]

*fanfiction intensifies *

[@taillessboo9599]

Its actually shown in the spin-off manga Code Black where the body is dealing with much more serious issues such as smoking and drinking. One of the RBCs that the main Red Blood Cell we follow dies and is phagocytosed (not sure how to type it out ^^;) in the liver by a type of Macrophage and is made into a very emotional moment.

[@redblackroses23]

Rule 34 including but not limited to lesbian, mother-daughter, and vore Now please excuse me while I drown my sorrows in vodka

[@tommyliu7020]

Tailless Boo, it was a Kupffer cell wasn’t it?

[@MinZilla]

CytoToxic cells CT cells Counter Terrorist cell

[@simonlow0210]

Mind = Blown

[@Regular_Citizen_Studio]

Counter Terrorists Win

[@ferretzim8694]

* Loud Inception sound*

[@CodeNameTC]

So .. "B" cell need to be RUSH?

[@salmanmahyuddin8384]

*ENEMY SPOTTED*

[@BladedDragonia]

Blue and purple markers were hard to differentiate between. Great episode once again..., I love these videos. Pump them out sooner will you! :P

[@DrHopeSickNotes]

Yeh - I only saw this in the edit, sorry! My over head camera is just a webcam, so might need to upgrade it. Thanks for the support! Next one is already planned in...

[@BladedDragonia]

@@DrHopeSickNotes it's fine for the most part, since it was easy to infer what was what. Maybe just use complimentary colors and the webcam would be fine. And you are most welcome. I love your passion for this..., I watched this anime and completely loved it (my pick for best anime fall 2018) and these videos are like the perfect little 'epilogues' to each episodes. Excited to see more of these episodes and what you take on in the next project.

[@SherrifOfNottingham]

To be fair the analogy still kind of worked, cause like the killer cell we couldn't really tell the difference at first.

[@michael22000]

I think this makes the analogy makes more sense. Not only that the Cytotoxic T didn't has the antigen, but even the appearance is also the same as the other normal cell. :d

[@mballew32]

@@DrHopeSickNotes Was a bit hard to follow for me too. I have a bit of color blindness. I was able to follow along, but only since you used cutouts. Great videos so far!

[@ohhoworiginal]

14:21 This is exactly why your series fills a neat little niche for fans of this show, as when I was watching this episode, I was sort of losing track of individual distinctions among immune cells. They could only fit so much in the introductory blurbs, after all. Your bus-and-police-car analogy was perfect to explain NK from T cells! Thank you so much for taking the time and enhancing my Cells at Work experience (and general biological education!).

[@Ryo39]

Never knew Hemoglobin had a British English spelling

[@DrHopeSickNotes]

"you learn something every day"

[@ajoajoajoaj]

British English often preserves the Latin æ which was reduced to e in Romance languages. Thus American encyclopedia is more French in spelling while British encyclopaedia is more Latinate in spelling.

[@IamesChosen]

And then you get words like honor/honour, where the pattern is reversed - British English inheriting a French u via the Norman conquest, while American English has reverted to the more Latin spelling.

[@madpinoy5683]

@@IamesChosen Ah...English.

[@Pagokeraunos]

@@ajoajoajoaj It's not a latin word though.

[@melikajahedpari1902]

I think this show has made me go insane, every time I get a scratch and it starts to bleed I say "sorry cells" when It dries up I say "thank you platelets". I think Im mad...

[@yutas8509]

same 😂

[@Technotoadnotafrog]

Remember to not pick at the scab. Wouldn't want to destroy their hard work!

[@seiya-chon]

Same here!

[@EarlyOwOwl]

3:33 that reminds me of the time I was anemic. My blood tests showed that although I had lower haemoglobin levels, I actually had higher levels of younger, less developed red blood cells. It seems my body was trying to make up for the lack of haemoglobin. (P.S. I'm taking iron supplements now so my blood is back to normal, in case anyone was wondering ;)

[@Darksky1001able]

Praise be to Allah and midern science. Glad youre okay.

[@harryfreeman1157]

Holy cow you really do have an ahoge

[@DrHopeSickNotes]

Yep

[@kennhern]

Better to have an ahoge than ahegao

[@JJtoob]

@@kennhern LMAO

[@YANI922]

@@kennhern Oh my god, I really hope Doctor Hope dont go and google that XD he might lose his innocent

[@svenjaloher]

Kenneth Hernandez why did I google that (o_o)

[@dianacuteako]

Don't give Doc spoiler for the next episode... 😉😉😉😉

[@battlecast9202]

@The Meme Reaper Lol

[@luckandlogic900]

Canc- ce-

[@stephaniest.5336]

I think he already knows.

[@thejamplan]

Dammit I can only see those as raspberry berets now

[@tanyanguyen3704]

Right? And that song.... dang you dr!

[@C_Bat]

I kind of want to give raspberries berets, it would look cute.

[@madpinoy5683]

Complete with accompanying Prince song.

[@IceMetalPunk]

For those of you who, like me, wanted to understand how NK cells work without the analogy, I looked it up :) The way cells bring pieces of their insides onto the surface is by using a molecule called MHC-I. These molecules actually take those pieces out to the surface. As we know, when an MHC-I molecule takes a pathogen's antigen onto the cell surface, then T-cells can recognize them and destroy them. So some pathogens have evolved a defense, where they stop the cell from producing MHC-I, thereby stopping their antigens from coming to the surface where T-cells can see them. In response, we've evolved NK cells: the NK cells will basically try to kill any cell, but are inhibited / stopped by MHC-I molecules. So when an NK cell finds a healthy cell, the natural MHC-I on its surface will stop it from attacking; but a cell that's had its MHC-I reduced from an infection or other abnormality won't inhibit the NK cell, allowing it to destroy the abnormal cell. Cellular and molecular biology are cool :D

[@Dedelove5095]

Nice

[@travisstoll3582]

I appreciated the explanation. Thanks.

[@kurtlangberg6143]

You know, I wondered why the NK cell, as a character in the anime, was a jerk to other cells. But given your explanation, it actually makes sense. They’re always on the prowl looking to destroy other cells, they’re just inhibited from doing so because of the regular expression of MHC-1. Otherwise NK is just looking for an excuse to attack.

[@strawhatleon]

I know this is old, but I'm just discovering this series now, and I'm wondering, is it possible for NK cells to malfunction and ignore MHC-I and kill the healthy cell anyway?

[@twilight_lupinesilva4691]

@@strawhatleon I haven't seen code black yet, but I imagine that might happen in auto-immune disorders. If Cytotoxic t-cells can overreact and kill healthy cells, I'm sure Natural Killer cells can do the same. Maybe it could be represented by the NK cell being "blind" and thus unable to see or sense the MHC-I on healthy cells, thus killing them.

[@artturikalimo9101]

I think the fact that the red blood cell is constantly lost is a reference to the fact (which you mentioned) that they do not actually have control over where they go.

[@RainAngel111]

Except that is the very reason why red blood cells could never get lost...

[@scottflickinger6303]

In most anime it's a trope to give the main character a bright color to distinguish them from the rest

A bright color. And then you have Yugi oh lmao.

[@totallypotat5911]

Gerardo Mejías If I remember right Yugi Oh has thunder bolts jolting out of his head and red dyed tips combined with the most gravity defying hair in anime history 🤣

[@bobrobrules]

@@totallypotat5911 did you just call Yugi Moto "Yugi Oh"? Hahahahaha

[@thataverageguy826]

This anime change how i see myself especially my body, back then when i catch a cold i just ignores it, sooner or later I'll be healthy again, last month i catch a cold n think to myself inside me by white blood cells fight virus to save me, i must do anything that i can to help them, I also try to eat more healthy food for my cell lol

[@alexandermayro7145]

I feel the same. After watching most episodes, I hug myself to let my cells know they are appreciated. ^_^

[@steve00alt70]

all us anime people love this

[@whatdoyoumeanyouforgotthec382]

Food for my cell this is so wholesome

[@WhiteKoneko]

Same, I have been even talking with a nutrionalist.

[@Mernom]

Don't take it as an invitation to overdue medicine though. Those things can be VERY dangerous if not handled correctly.

[@richardlsp7670]

I think the macrophages are maids because unlike the neutrophils, they mainly act as cleaners inside our body, macrophages are not the first fighters to deal with invaders. Additionally, as you have seen in this episode, the macrophage enucleates erythroblasts, so they are nurturing cells that make the red blood cells mature, so an analogy would be being a teacher to take care children (erythroblasts). I would consider the macrophage is very versatile, so that’s why the author gave her this character. There will be another episode talks more about the macrophages, so you will know why such strong cells are characterized as maids.

[@himankgupta9949]

True. Macrophages kill/clean the old cells, platelets and microbes in spleen. That enucleation thing is something I hvnt read as well. Its more like that a nucleated rbc is not normal and killed by macophage

[@bruhhbrahh]

That one hair poking out from Ed's head. This is a prove he slowly turning into red blood cell

[@Jygerthe2nd]

16:15 So basically, the cop sees the crook on the bus and goes "Okay, there's a criminal on the bus! Get the bazooka!" 🤣

[@martinvaclavik3393]

PLEASE PLEASE DO EPISODE 7 ASAP since it is basically a double-episode with the 6th ♥♥

[@kattyt23]

I haven't clicked on a video this fast in a long time

[@theprocess90]

I am Japanese.I am looking forward to this video please keep on positing videos in the future.

[@memegumin]

Soo NK cells are like "hey that looks wierd? Kill it!" Edit: One year later and I saw my misspelling, my bad

[@medjov1061]

Pretty much. What happens specifically is that NK cells communicate by sending message to any nucleated cell kinda saying "Hey show me your ID." If the ID is tampered, unmatched, misleading, stolen, or can't show any, the cell will be killed.

[@memegumin]

@@medjov1061 NK:hey your hair is different by one inch, did you cut your hair? Nucleus: y-yes... Nk: *stab*

[@arrayenamardie9641]

@@memegumin YOU ARE NOT PAID TO CUT YOUR HAIR! REEEE!!!!

[@RedHairdo]

@@medjov1061 What about cells without a nucleus, like the red blood cells?

[@medjov1061]

@@RedHairdo Cells that are enucleated like RBC shouldn't be a target for NK cells as RBCs don't have a way to replicate which is the problem with cancer cells. If you're also wondering "What about defective RBCs?(if there's any)" Once the defective RBCs reach the liver and spleen they are recycled; eaten by macrophages then reused as nourishment. So to simplify NK cells only target virus-infected or malignant (nucleated) cells.

[@niantica1869]

Our doctor has really contracted the illness. THIS IS THE SECOND TIME HE'S HAD AN AHOGE AND THE FIRST TERM HE USED FOR IT WAS A 'COWLICK'!!!

[@aloknight3656]

Top 10 professional doctors who love anime

[@theenviousfox7589]

Lol ikr

[@f1nger605]

This is where the show starts to get... dystopian. So far, the "human body as a giant company/factory" analogy has been fun and relatively light-hearted, but the cancer episodes turn it into some kind of Orwellian nightmare. When you're a cell, thinking and living for yourself is the greatest crime imaginable, for which the penalty is immediate death. Orwell himself used the analogy of "cells in an organism" to describe what a totalitarian regime does to people, reducing individuals to the mere sum of their usefulness to the system. It's all well and good when we're just talking about regular, dumb, cells, but these cells are literally humanized. They're given character, wants, needs, emotions, and even interpersonal relationships. Seeing a person just like them, who's only crime was being born "wrong", hunted like an animal for just being who they are, then being expected to root against them in favor of an uncaring state/company/system, is wholely unsettling to me. Still, I love that they didn't ignore or try to sugar coat this rather bleak implication of their world. This show is a damn masterpiece.

[@zjzr08]

Of course, it's also the truth that him existing in this world physically destroys it, too. It's tragic that his fate is to destory the world he wants to live in, and it's tragic that they had to be stopped before it happens, even though in their world it is the right thing to do.

[@DaDualityofMan]

Holy spoilers, Batman!

[@linwoodvalentine7693]

Like the manga cells at work black,cells that don't work & bacteria at work and the story of cells.

[@lyssaearland618]

No spoilers for the people who haven't seen it yet, please. I watched it when it was airing on Crunchyroll Premium weekly, but I want everyone to have the same initial "Wtf is going on" reaction without future spoilers. Maybe you should just take out the part about the future tone of the anime. Your analysis of the body in general is spot on, so definitely keep that. Just take out the spoilers to the future tone and atmosphere of the anime.

[@seanallard9335]

I want to feel bad, for this cancer cell. I want to feel bad for what they're going through. I know that our own bodies are the embodiment of the dystopias we wish to never happen upon us. I lost an uncle to leukaemia. I want this cancer cell to die.

[@rensu7802]

FINALLY! BEEN WAITING FOR THIS EPISODE. You should watch the Next Episode, Doc!

[@StenThaBear]

And the episode 10, and the special, those will be fun, i think.

[@rensu7802]

@@StenThaBear I have already watched the Special Episode. It was very funny episode I should say. Doc should react to it. I hope David Productions make an Season 2 for this, because the Vol 6 of this manga are out or they just pre-order on amazon.

[@ilose21]

After this series you should look into cells at work Black... I personally think that Cells at Work Black should be reading material for smoking/drinking patients in hospitals

[@squidmaster6752]

"I wonder if her red hair has any symbolic meaning?" Uh yes. She is the protagonist. Welcome to anime.

[@UltraMarineBlue]

NK cell: ".. that's kinda sus"

[@sakurachan288]

Oh so Cancer Cells can really disguise themselves as regular-looking cells? I thought that was a creative license on the author's part but since you whipped out the analogy with the bus and police cars, it actually happens! NK Cell is really amazing! Thank you Dr. Hope. I knew I would get the answer once I watch your reaction video of this episode!

[@Hanmacx]

Yeah look at the shirt of Cancer It just shows "cell" like normal ones Also Cancer cells can get themselves a protein that works like "don't kill me" sign so that normal cells ignore it. I read that in a study

[@NKG_Grimm]

This can explain how cancer cells manage to become a real cancer, they basically disguise themselves so they can spread more easily.

[@zjzr08]

NK is practically a vigilante, T Cell a SWAT. Sometimes NK may be rash, but can do the job. Big guy T Cell is intimidated by this gung ho behavior and tried to tease NK. But NK knows what's up, and is just doing her job to protect, not only other cells, but T Cell too.

[@sergiosarmiento4371]

Nk is a renegade cop who doesn't play by the rules. It can be a little racist at times but damn it, it gets results.

[@fragrantwinter8233]

I think their butting heads was mostly to display their natural aggression as characters, used in turn as an allusion to their actual roles as cells: Killing other cells, foreign or otherwise infected. It’s a way of saying “Piss me off and I won’t hesitate to make you next on my list.” Again, because they’re known to kill cells produced by the body as well as foreign cells. (Unlike Neutrophils, who only ever display aggression towards foreign cells.) Not that they’d ever kill a normal cell for no reason... But it works as a character trait for those cell types.

[@velvetbluez9823]

@@sergiosarmiento4371 so it's Mel Gibson?

[@hstsvstyve]

@@fragrantwinter8233 Natural killer (NK) cells promote dendritic cell (DC) maturation and influence T cell differentiation in vitro. To better understand the nature of the ..................intravital microscopy revealed that NK cells in the superficial regions of LNs were slowly motile and maintained their interactions with DCs over extended times in the presence or absence of immune-activating signals.Therefore, NK cells form a reactive but low mobile network in a strategic area of the LN where they can receive inflammatory signals, interact with DCs, and regulate colocalized T cell responses. taken from: www.researchgate.net/publication/7272814_Natural_killer_cell_behavior_in_lymph_nodes_revealed_by_static_and_real-time_imaging

[@KazumaTheKloud]

I see someone had fun with the editing button. This show is always a fun way to review some medical lessons. I still remember being in middle school and the teacher showed us a video of a 3D interpretation of an NK cell being placed in a pool of sheep blood cells and the NK cells basically just nuked the entire pool. I still remember thinking how cool that was. It's what started me studying medicine. I didn't end up in a field that would have me studying NK cells. But I do thank them for being the catalyst that caused me to get into medicine.

[@Bananas1000]

3:44 You should read Cells at Work Black then :D

[@DrHopeSickNotes]

Yeh I'll try and get hold of it

[@CryingZombie666]

@Dr Hope's Sick Notes In case you can't acquire the physical copy, this will solve the problem :) mangakakalot.com/manga/hataraku_saibou_black

[@renayu2326]

the Cells at Work Black is good too.. b-but it is not for kids. xD

[@HopeforAllKind]

There’s also bacteria at work that focuses on the good bacteria in the body

[@renayu2326]

@@YoBoyNeptune yah, its way more darker than fifty shades... xD

[@wills.junks7]

I have been waiting for this video for a long time...

[@merchant69420]

That's how mafia works.

[@wills.junks7]

@@merchant69420 What level are you? Iam level 35 Boss

[@merchant69420]

@@wills.junks7 I used to be lvl 99 boss, but some bitch took my car and House. Now I'm a lvl 1 crook.

[@dana8503]

Well I knew this guy was a something important because he's voiced by Akira Ishida, Akira Ishida wouldn't be pulled in to voice a random one bit background character.

[@RedHairdo]

Holy crap fantastic video of this episode!!! Loved literally every second of it!

[@croskerk]

Dr. Hopes: "What is happening here." Me: "Anime logic."

[@Lastlasagna]

There isn't an anime for it yet (and I don't know if there ever will be one), but you should check out the manga "Cells at Work Black" (called as such because of the Japanese term "black company", or a company that has unreasonable and outrageously difficult working conditions). It's basically taking place inside of someone that is actively putting their own body through hell and not treating themselves right, and you get to see all of the cells inside suffer and try their best to function.

[@cesarrentino4340]

I'm not finish reading it yet. But yeah, this one has the darker side of the story... 😶

[@TriceeXO]

Wow that sounds super interesting 😯

[@stormybabe88]

@@TriceeXO It is interesting! And kinda sad. It makes you stop and think about what you're doing to your own body, and what you are doing to harm it. There's a chapter that shows the reaction of the body to energy drinks and, while I don't drink them myself, I feel horrid because I'm a can-a-day soft drink drinker. And I put loads of sugar into my system which isn't good either.

[@TriceeXO]

stormybabe88 I’m a medical student so I kinda have a gist of what happens inside the body but seeing it in anime / manga form makes it all the more interesting. I’m looking forward to reading it 😍😍

[@kittyacedira5014]

I read the manga as soon as I read your comment & the result, it's quite scary... 😰 I don't want all my cell in the body suffering like that!! p/s: Now I know that all the characters is canon from this manga. I once see it in pinterest & I thought it's just some fan drawing. I don't know it come from this manga

[@formdusktilldeath]

So you're saying my cells are communists?

[@formdusktilldeath]

Mary Sue gulags were full of "comrades"

[@Trakesh]

You should specify whether you want it debunked from the perspective of the theoretical idealist 'communism' that has no basis in reality or the actual totalitarian globalist enslavement communism that is true communism. Its not that it would make a difference because neither sense of communism applies. But the method of debunking that they are in any way communistic is different.

[@formdusktilldeath]

I didn’t really expected to start an academic discussion about social theories, it was supposed to be a rather tounge in cheek comment.

[@sammarino7357]

It’s more socialist because there is no real dictator only working toward a common goal

[@LuizAlexPhoenix]

@@formdusktilldeath > Political joke in political times and enviroment > Political discussion > Surprisedpikachu.jpeg

[@Timelost_Techpriest]

So, using the police car analogy, the police car sees a passenger that doesn't fit on the bus and proceeds to fire an RPG and destroy the bus. :V

[@12mjk21]

police brutality is in all of us.

[@infernityable1369]

Akainu would be proud.

[@allflying3]

No, the police car ate the bus

[@TheBeatriz90]

Yes, but the police car just eat the bus If they are looking for the criminal with a picture.

[@wloffblizz]

Well, kinda, but the scale of the analogy is a bit off, like the "bus" is actually the whole cell here... more like, a policeman sees someone wearing a wrong color shirt and proceeds to shoot the person :V (and the NK cell just kills anyone who's wearing a raincoat to hide what color their shirt is.)

[@malikovajana]

Can´t wait to see your reaction to episode 7.

[@syrusalder7795]

Aww this was one of the best episodes. The shipping is real. I wonder if Hope has been converted to one of us lowly weebs by Cells At Work

[@ericacamacho8080]

Yay! Dr. Hope rescuing me from dreaded boredom!

[@deedeer7022]

I think maybe you would understand better if you searched for the 'Battle Maid' concept in anime. It's a type of 'killing machine' character who looks like the perfect Maid with the most perfect manners, and can often sometimes look like air heads. Except it's a cover for their real 'skills'. Here it's an 'english' (= well mannered) very attractive Maid with that air-head feeling in the way she speaks and also her mannerism. But she's without any doubt as skilled as a maid, as she is as an assassin.

[@felmargego2534]

I aspire to be one 😂😂😂

[@chiomopai2862]

"The macrophage eats old red blood cells." That's some promised Neverland type crap.

[@ShrooMIR05]

Its enlightenment time by the King of KZbin !

[@sorenmine7765]

He got PewDiePie as a guest star?!

[@landonwyndham979]

@@sorenmine7765 hes got PewDiePie as his bitch lasagna

[@Ole_Rasmussen]

That enthusiasm doesn't go well with your profile picture.

[@ThetrueHeero]

Anime is spreading even further

[@moistsquid741]

Deku

[@NovaLaMason]

*farther Further = literal or figurative depth Farther = distance

[@bionixvortex2]

i lost it at @5:55 .... blue alien in a cycle helmet LOL

[@plant5875]

hmm

[@anarchysquad8696]

Lmao

[@ridzyfrizy1350]

HAHAHAHA

[@GarrestheWarrior]

Red blood cell has protagonist hair. Basic Japanese animation trope, where the main characters are differentiated from supporting or background characters. It makes her stand out, signifying that she's different or special in some way, hence the cowlick and coloration. In Japanese culture, being a natural red-head is supposed to be special, considering most Japanese are historically black or brunette haired. It's seen in some of their folklore, and frequently pops up in anime storytelling. The cowlick is along the lines of the hair antennas from Love Hina, or the spikey hair seen in Yu Gi Oh, where the distinct colors also come into play. In short, sorry guys; her hair is simply a stylistic choice, not a medical reference beyond her being a red blood cell.

[@issybeer3814]

Hey, just wanted to say that my friend and I discovered your channel yesterday and when we found out that you had reacted to "Cells at Work" we got very excited. Your reactions have been amazing and it's so nice to see just how accurate most of it is, as well as the small things we didn't pick up when we watched the series ourselves. I'm so glad you're enjoying the series and can't wait for you to react to the other episodes! Also, my friend and I are studying French linguistics and Chemistry respectively, and at school we both did not like biology, but after watching quite a few of your videos, we both decided that if you had taught us, we would have liked the subject /a lot/ more. Can't wait to learn more!

[@SkyFlame27]

I loved the police car analogy. I've finished the whole series (the last couple episodes are awesome) but im not in anyway a doctor or a med student so a lot of these little reference are lost on me. Thats why I love watching this so much! You catch and explain all these little details in simple and easy to understand ways and it just enhances the viewing experience. I loved the police car analogy so much. Things I thought might have been creative liberties are actually some really cool references! Thank you so much for watching this series.

[@EmmaAppleBerry]

Lol its a shame you didnt use a wanted poster analogy for the cytotoxic t cell. Even though i understood the concept before your analogy thinking of it like that is pretty cool. Especially if you factored in facial recogniction type alerts lol

[@YokoshimaOfficial]

That cells diagram of ours should be sold as shirts merch. A very good and cute idea, to also boost education. P.S: Why do you have a sign at the back saying 'I Didn't think so'? I like it xD

[@olimakiella]

JakulaithWolff my eyes kept getting drawn to it too, lol.

[@knockoutroundabout]

First episode of this series got me to watch Cells at Work and now after every episode I come watch your reaction to it! It's like the perfect bookend that helps expand on what I just watched.