Doctors overlook how significantly this impacts your health | 24 - HSM #4

[@gdok6088]

Thanks for another excellent episode Matt. I'm a retired medical doctor in the UK 🇬🇧 and I completely agree with you that the current medical approach (in Westernised countries) to 'healthcare' is actually primarily reactive disease care and that pisses me off too! We need a paradigm shift to a culture of personal responsibility, preventative healthcare and the detection of deficiencies and disease at a much earlier stage by increased use of effective screening - DEXA scanning being a good example. Great channel :)

[@mannmstorm]

Thank you for another interesting podcast! Can you please explain why your optimal b12-range (750-1300 pg/ml) is so high? The studies I could find associate even lower b12 with an increased all-cause mortality risk (B12>400 pg/mL, n=5571, Flores-Guerrero et al. 2020). Please comment the recent February 2024 study: "The origin of vitamin B12 levels and risk of all-cause, cardiovascular and cancer specific mortality: A systematic review and dose-response meta-analysis". Here is the results chapter from the abstract: "Twenty-two cohort studies (92,346 individuals with 10,704 all-cause deaths) were included. A linear trend dose-response analysis showed that each 100 pmol/L increase in serum vitamin B12 concentration was associated with a 4 % higher risk of all-cause mortality in the general population (adjusted HR 1.04, 95 % confidence interval CI 1.01 to 1.08; n = 8; P non-linearity = 0.11) and a 6 % higher risk for all-cause mortality in older adults (adjusted HR 1.06, 95 % CI 1.01 to 1.13; n = 4; P non-linearity = 0.78). Current evidence was mixed for the association between serum vitamin B12 concentration and cardiovascular mortality and was limited for cancer mortality. The meta-analysis of cohort studies showed a positive association between a high serum vitamin B12 concentration (>600 pmol/L) and all-cause mortality (adjusted HR 1.50, 95 % CI 1.29 to 1.74; n = 10; p < 0.01), CVD mortality (adjusted HR 2.04, 95 % CI 0.99 to 4.19; n = 2; p = 0.02), except cancer mortality (adjusted HR 1.56, 95 % CI 0.82 to 2.95; n = 3). Similarly, serum vitamin B12 concentrations (400-600 pmol/L) were associated with increased all-cause mortality (adjusted HR 1.34, 95 % CI 1.10 to 1.64; n = 9; p < 0.01)."

[@danieljrgensen133]

Never heard b12 supplementation was associated with risk. Being a member of the B vitamin family, any excess b12 intake should just be excreted through the urine. And thus, overdosing should not be possible....to an extent. If your an idiot about it, anything can harm you. I don't have time or will power to go through the data you provided....but would be interesting to read Matt's reply to this! 🙂

[@mystrength5640]

@@danieljrgensen133I was researching this Today.. I’m sure low Stomach Acid won’t be helpful.. especially after aged 60.. Many Pharmaceuticals deplete B12 and with Bowel diseases less B12 gets absorbed! And after 60, more Supplementation of B12 should be obvious!

[@Deffine]

What were they measuring? Active B12? Cyanocobalamin? Hydroxocobalamin (natural form)?

[@michael-qp9xd]

Hi - I too seen a couple studies showing similar as u mention that high levels of b6 and b12 having issues for increasing cancer risk. Also less serious but still issue increase in acne. So not like many say that water soluble vitamins so body urinates out excess - this not found true in some studies. Better to dose these b vitamins at 1 to 3 x rda rather than the 40x in some standard b complex supplements.

[@faza553]

Increased self-governance is a key factor in maintaining optimum health. Hygienic Autonomy: A Manifesto: the liberty to declare myself sick; the liberty to refuse any and all medical treatment at any time; the liberty to take any drug or treatment of my own choosing; the liberty to be treated by the person of my choice, that is, by anyone in the community who feels called to the practice of healing, whether that person be an acupuncturist, a homeopathic physician, a neurosurgeon, an astrologer, a witch doctor or someone else; the liberty to die without diagnosis. BRAVE NEW BIOCRACY: HEALTH CARE FROM WOMB TO TOMB , By: Illich, Ivan

[@danieljrgensen133]

Great take on vitamin deficiency Matt! 👍 Even a bit entertaining to see Matt showing some emotions(getting pissed off! 😁). Being somebody who measures and monitor things in my daytime job, it's thought provoking that I didn't use this approach when supplementing my diet. I just assume I'm getting enough by the RDA levels stated on the product label on the supplement I'm taking. Bad approach? 🤔😉

[@BarryBPruett]

Good overview and clear example of our sick care system focus on disease rather than health. I would have included magnesium in the list as most people are deficient.

[@Newday1187]

Could you please talk about mitochondria transplantation as a rejuvenation biotechnology in one of your episodes? Promising and great results obtained by scientists in the field such as Dr. james mccully, Dr. Giuseppe Orlando,Dr. George Wu, Dr Anna Krasnodembskaya in addition to private sector companies (e.g., Mitrix, Cellvie, Minovia). I enjoy and appreciate your podcast ❤🎉.

[@ats89117]

Looking at the chart of B12, D and Omega-3 levels, the 'too high' category is so rare that it is not clear why it wouldn't be easier to just give everyone supplements. Maybe this wasn't the best example for the test, supplement if necessary, and retest strategy...

[@erastvandoren]

Most people can safely take 30 IU/lbs of D3 to be in the optimal range. Just don't forget to monitor your calcium - if calcium shoots too high, then either reduce calcium intake or O3 intake. B12 needs to be taken by everyone on a plant-based diet and by everyone over 50. And Omega-3... just take it! I take 1500 mg of DHA+EPA as algae oil (less heavy metal/PCB contamination, better for the environment). DEXA is just an overkill. Most people know they are overweight.

[@Krunch2020]

I think you’re on to something. There seems to be no risk of 5000iu of vit D. 2 grams of fish oil has no downside. What is the appropriate dose of B12 for the general population?

[@erastvandoren]

@@Krunch2020 Age dependent.

[@NicholasOdinson]

Great episode! 🐬

[@juicebox853]

Love the channel. Thanks Matt.

[@ats89117]

Here's an interesting experiment. Suppose you had blood drawn and submitted it as two different samples to the same analysis lab. How much variation would there be in the results? How about if the analysis was done by different labs? The test, supplement, and retest is obviously dependent on the availability of accurate testing. It would also be a problem if the test was heavily dependent on what you consumed over the past few days...

[@erastvandoren]

That's a problem which the medical science is completely unaware of. I've studied physics, and I'm horrified that researchers in the medical field have no idea about measurement uncertainties. I think most research is overoptimistic because of this.

[@livingsmart]

I just had this discussion with the guys from Siphox Health Labs. Apparently it all depends on what equipment/assay is used and what historical drift through FDA they had, but the final difference can be up to 50% between labs. So it's important to ask your doctor what labs he has the most experience with, when ordering a test.

[@peterz53]

Agree on testing and primary care. And test, tweak, and repeat until dialed in. Have been paying out of pocket for extra blood work for over a decade. Worth it. Dialed in Vit D3 on my own based on information from vitamin D researchers (living in sunny state of Florida like I do doesn't cut it). Started using the Omega 3 index about 2 years ago with first result being just under 8%. I only supplement about 500 mg epa/dha per day, sardines or salmon once or twice a week, nuts, and whole plant foods for all other (eat nothing that walks on land).

[@oesdscied]

Great episode, thank you for the content and for focusing on the importance of preventative medicine. I am curious, you have many of the pillars of Leroy Hood's of System Biology 4P medicine. Personalized, preventative, predictive, and participatory. This approach really resonates with me, and I participated in Arivale's consumer program a few years ago and then they closed which was unfortunate. It seems like Optispan is in this same niche. How have you at Optisan been influenced by his work and companies like System's Biology and Arivale?

[@hoffmancapote]

Great video on preventive care rather than fix it after it goes wrong

[@sandybayes]

Have you looked into Taurine? Plus, I am unaware of any medication that will improve bone density. There are plenty that will maintain it, however.

[@mikespector2]

Forteo is supposed to improve bone density.

[@bob-ss4wx]

Couldn't agree more with the doc from the UK.

[@ryan_the_red_4907]

Very direct, actionable info, awesome

[@andrewboss2018]

I'm surprised Magnesium wasn't included, as Mag insufficiency is estimated ~40%. That said, the body controls mag pretty strictly, so true deficiencies may not be easy to detect.

[@erastvandoren]

Magnesium deficiency is not easily measured, most Mg sits in the cells and the bones.

[@carolfox4454]

The hospital I worked at required vitamin D testing as part of our annual physical.

[@newyorkskier]

Great talk. Very informative

[@Santa-ny1yp]

There is the consideration that omega3 and vit d are fat soluble and should be taken with fat. B12 is water soluble and can be taken with water. Even though omega 3 is fat, I've seen scientists who study it say you still need to add fat.

[@erastvandoren]

Not really. Optimal absorption of vitamin D3 happens with 10 grams of fat, without fat it's just 15-20% lower, and with more fat, it's lower too. 10 grams is not much.

[@ryan_the_red_4907]

Flavored liquid fish oil is the easiest way Ive found to hit my daily EPA + DHA goals. Also flax oil for ALA. I put both in smoothies or on yogurt

[@erastvandoren]

Algae oil is even better (higher DHA, less contamination, more sustainable source).

[@ryan_the_red_4907]

@@erastvandoren Awesome thanks!

[@incognitotorpedo42]

Insurance companies won't cover DEXA Scans more than once every two years, I'm told. I think it's crazy not to get one at least every three years, and more often if you're osteopenic. My wife's doctor let her go for five years without one, and she was post-menopausal(!) When she finally got one, she was frankly osteoporotic. Kinda malpractice, imho. I really don't understand the hesitance to use something as cheap, harmless and easy as that.

[@mikespector2]

I get dexa scans for bone density. However, they do not show body composition - muscle, fat, etc. That must be a different kind of dexa scan, which likely (unlike bone density dexas) is not covered by insurance, and is less common.

[@mdavid1955]

Is there a general nutrition panel that can get? That will cover these?

[@cactuscanine3531]

Physians are often limited on tests by what insurance will pay for. For example, Medicare generally will not pay for apo b.

[@bob-ss4wx]

I believe Matt said the tests were about $120 for all three tests. Whether insurance pays for the them or not, shouldn't the doctor advise them!

[@bob-ss4wx]

I'm glad you mentioned that deficiencies can be corrected with Food.

[@mikespector2]

I looked at my recent Vitamin D results. (I take 2000 iu daily) 32 ng/dl. So low by your 60-100 range. . However, the reference range listed on the test result is 20-50 (UCLA medical) It even says "potential adverse effects greater than 50 ng/dl". Is UCLA medical incorrect in their listed range? What research does your listed ranges come from? Thank you.

[@patriciagriffin1505]

I’m surprised Iodine wasn’t mentioned as most souls are deplete in Mag and Iodine

[@Krunch2020]

We’re almost to a multivitamin!

[@gemagel20]

Omega-3 Index Test? How do you ask for this. Can't find it.

[@glennthorn367]

love your hair piece

[@gutchiespencer2714]

Are you a doctor or just some random hater???🤔

[@Sousaquasesosia]

Hi Matt, could you clarify which omega-3 index you are referring to? Is it the one provided by "omegaquant", which measures the index of the amount of omega-3 in the MEMBRANE of one's blood red cells?

[@livingsmart]

omegaquant lists >8% as optimal, so most likely it's the membrane

[@sandybayes]

When eating fish, do you not have a concern for plastics and mercury? Aside from that I'm a vegan and eat a wide variety of whole foods.

[@workingTchr]

If they're so easy to supplement and you just excrete what you don't need, why not take it just to be safe?

[@gemagel20]

So, if you get a dexa scan and you find out that you have high adipose fat. I don't think there is something you can do to target abdominal fat specifically??

[@erastvandoren]

fasting

[@gemagel20]

@@erastvandoren I am not certain. At least there is no research to show this.

[@erastvandoren]

@@gemagel20 Not true. 1. "Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16"

[@gerhardmeister4693]

I don't see Omega-3 offered at Labcorp or Quest. Does this test have a different name?

[@livingsmart]

omegaquant at amazon

[@gerhardmeister4693]

@@livingsmart Thanks!

[@user-ud9ep6ym7r]

If promoting your own business would keep me healthy?