Rapamycin's possible SIDE EFFECTS & BENEFITS | 8 - RF#3

[@optispan]

We enjoyed answering many of your questions on our recent R-Files AMA episode: kzbin.info/www/bejne/iGPbqnV9ZaiApc0. Feel free to comment there with more questions-we will keep doing these!

[@ZoeyKs]

Thank you. I just started taking sirolimus in November for recurring post-Covid viral myocarditis, which first happened after the vaccine in 2021 and then several times since after any virus, with Covid being the worst trigger. It's too early to tell, but I'm hoping this will improve what I think is an underlying immune dysfuction and correct the problem. I very much appreciate people like you and other scientists making this sort of information available.

[@TwistedPsilo]

This sounds like exactly what I've been going through although I have not gotten a diagnosis. Seems to have all started after the 2nd pfizer vaccine. After I recover (first time taking 2 years, second time 8 months) it seems to return anytime my immune system is engaged. I'm almost positive its returned this 3rd time after exposure to mold which I really hope is not the case.

[@ZoeyKs]

@@TwistedPsilo yes, our stories are similar. Diet/lifestyle changes and metformin have helped lessen the severity of my episodes and symptoms, but have not been a cure. If you can see a cardologist and get a diagnosis, there are some medications that can help control it. I'm going to continue with the rapamycin and hope it works. I should mention I had an unusually inflammatory reaction after 10 weeks of taking just 4-6 mg of rapa per wk, which might be due to my immune dysfunction. So I've stopped for now, but plan to restart at 1 mg/wk and monitor CRP closely. Good luck, I hope you can find a solution.

[@lawnmower11]

Sorry about your vaxxxcccine injury.

[@ats89117]

I'm surprised that reduction in fungal infections wasn't included in the survey. My chronic toenail fungus disappeared when I started using sirolumis (10g twice a month) and I wasn't surprised because I was familiar with its discovery as an antifungal medication, but I would be interested in seeing if others have noted this effect...

[@rosalynsimpson298]

I had the same toenail fungus reduction. Was pleased to see my toe look normal again after many years.

[@grahamswett6430]

Been taking 4 mg weekly for years. I had toe nail fungus and had to take other measures to get rid of it. So unfortunately I did not have your experience.

[@moodiali7324]

@@grahamswett6430 perhaps due to dosage difference?

[@jonathonmills3563]

As a recent Rapamycin user, I find your podcasts informative

[@TheBroSplit]

where do we get it

[@newyorkskier]

Very useful study despite the caveats. I am 70 and live a vey unhealthy lifestyle (bad food, lots of alcohol, lack of exercise, overweight, demanding work). The only positive healthy thing I do is bouts of intense cycling for many hours once every few months. At 70, things look good for me from a health point of view,. I have been taking rapamycin for the last 3 or 4 years, but I also take a lot of other things like occasional D+Q treatment and host of other things like NMN, NA, acarbose and what not if not regularly (my discipline is quite poor). I have a suspicion that rapamycin and NAD boosters keep me healthy (since I started taking NA - now switched to NMN - 10 years ago and I noticed a difference in my cycling performance)

[@michelsamson3689]

wonderful as always--- thanks for doing this

[@optispan]

We're glad you like it--let us know if there are any particular topics you'd like us to cover.

[@carter5945]

some things id love to hear your opinion on: 1. are low protein diets still ideal for lifespan (in lab animals) when controlled for methionine intake? 2. i've heard it said that rapamycin is *just* a CR mimetic. Is this true? Would CR + rapamycin be redundant? 3. which life extension techniques do you think compliment one another (in that they prevent/reverse aging by different mechanisms)? For example, do you think TERT and rapamycin would get much greater lifespan extension in mice than either one alone? 4. do you think senolytics have promise? if so, how do you explain the fisetin ITP trails showing no lifespan extension? 5. if you had 5 million dollars to spend on any longevity study you can think of, which study do you think would get you the most bang for your buck? great episode by the way! love the podcast.

[@mkaeberlein]

We're working on an episode that will collect all the questions asked here, including these, and cover them in one shot. Stay tuned - MK

[@carter5945]

@@mkaeberlein awesome!

[@MsElaine122]

sarcopenia is a huge debilitator in old age as is poor bone health. Just my studies, I see no avoiding nutrient dense diet all the way to death that includes Dr Gabriel Lion's advocation for protein/kg of weight; 1.5gr protein / kg

[@nicholasboyd-gibbins9763]

Really great work

[@rogehnimunoz4327]

Thank you so much for this info. I’ll start taking rapa probably next, next week. You enlightened me. God bless.

[@workingTchr]

I'd like to hear a comparison between rapamycin and anti-IL-11.

[@thedicktator]

Very informative, Thank you. I am still debating on using it

[@chuckding5590]

Love the content. But please reduce the frequency of switching between front view - side profile ;)

[@optispan]

This is done to hide cuts within the video, but we have been working to reduce the amount of camera angle switching in the more recent videos!

[@davidwoods1622]

one side effect that I've read about that wasn't mentioned. Is that rapamycin hinders muscle building.

[@Nelis1324]

If you low dose cycle it, it shouldn’t really impact that.

[@bigbear7567]

I noticed in the list of symptoms there was difficulty breathing and it would have been nice and useful and informative if you would have let us know as to how common was that symptom as it is a very scary one.

[@szghasem]

I've tried to milk all there is from Rapamycin (R) scholars like yourself and Peter Attia. Many questions remain though. I've heard comments like "having canker sore is proof R is working". However, I've gone for months without any sore and other times painful ones that go away (on the same weekly dose). How much R per week is too high? (probably is an individual thing?) Are there symptoms indicating mTorC2 inhibition as well as mTorC1, or by then it's gone too far already? Some people test for levels of R in the blood, others use blood markers like red blood cells to indicate negative effects. Are there a list of tests that are a better indicator on R's effects? Is there any idea as to how many people are using R for longevity? Are companies like Pfizer showing interest to off-label use? Given the overwhelming evidence, are insurance companies showing any interest? I can imagine billions saved for them, and are they not a good potential funders of studies? Will you run for president and make R readily available to everyone for free? 😉

[@edenakasha7574]

I feel the same way, I don't really understand why people are pushing are pushing for side effects and if they are experiencing some benefits from their dose, why keep increasing?

[@moodiali7324]

@@edenakasha7574 no body knows what exactly is the correct dose for humans including matt himself, we will need clinical trails to confirm this

[@andrewboss2018]

I don't think Brian can overstress just how limited these findings are given there was no placebo control as well as immense healthy-user bias. If anything, this is a early proof of concept for Rapamycin's safety in intermittent doses. I say this because I already see self-proclaimed "gurus" sharing this video as if it's groundbreaking information. It is not.

[@penguinlieo4723]

mTORC1 inhibitor: everolimus, this one is much better than Rapamycin. 5mg QW x 6.

[@bassnote61]

In the COVID data you presented, how was vaccination status accounted for?

[@mkaeberlein]

Yes, although only whether vaccinated or not. We did not consider number of boosters, brand of vaccine, etc. Nearly 90% of the participants were vaccinated and there was no difference by group (users vs non-users) or sex - MK

[@jaakdefour7741]

Has anyone done statistical analysis on the large number of organ transplant patients who have been taking R for decades versus organ transplant patients who have taken other drugs. Although these people are all very sick maybe such an analysis can reveal improved relative healthspan and lifespan?

[@worldtraveler691]

Heard you say that you cycle rapamycin. Reasoning for that? I have taken for 7 yrs, 2nd patient, Dr Green, but never cycled. Have only taken weekly continuous. What am I missing Dr. Kaeberlein? Thanks

[@Always-xl9db]

How old you were when u started taking? Any side effects? Also, I was wondering how you avoit all mTor activating foods/supplements, containing leucine, glycine and such Thank you in advance!

[@worldtraveler691]

@@Always-xl9db 70 yo in 2017. Only side effect is mouth sores very rarely. 6-10 mg weekly. Keep glucose, weight, and B/P low along with exercise.

[@moritzmariathoma]

Interesting and thanks for sharing. I saw Dr. Green 9 months ago, I'm his 1400th (or so) patient. After 7y, do you have any effects you attribute to the rapa, such as a slowed down aging process since taking it compared to peers?

[@VladdyDaddy369]

I have a question which noone seems to be able to help me get answered. I'm hoping that you might have some insight please... What is it about chronicly inhibiting mTOR through the daily use of Everolimus that can negatively impact lipids (triglycerides and LDL) despite of eating ultra clean? If you are not able to answer, I completely understand. I just had to ask... Thanks!

[@HvdHaghen]

Are there people in the Rejuvenation Olympics taking rapamycin? One would think a lot of them would have tried it and those who used it would be in the top of the competition in case their result would be positive in the tests.

[@mkaeberlein]

Personally I would not put much faith in the "rejuvenation olympics" for anything about my health. I don't know how many folks have or have not used rapamycin there, but why would you trust a non-scientific website comparing results from on an unregulated commercial test of questionable precision and accuracy measuring a single molecular metric of aging? - MK

[@HvdHaghen]

@@mkaeberlein David Pascoe and Bryan Johnson use rapamycin. Michael Lustgarten not. I did not find much info about the others. I think TruDiagnostic and MyDNAge do their best to calculate the biological age. There is a lot of data and computer power to calculate someones life expectancy compared to the average humans. I would certainly do those tests if they were not so expensive ($500 and $300). There are tens of thousands biohackers experimenting and if certain medicines or food supplements do prolong lifespan, it will show up in the Rejuvenation Olympics before it becomes clear in the statistics about centenarians.

[@stevenpatterson794]

CAS 54915-44-7 and CAS 53123-88-9 are both associated with the active ingredient rapamycin, but they are different in the following ways: 1. Molecular formula: CAS 54915-44-7 has the molecular formula C44H69N9O12, while CAS 53123-88-9 has the molecular formula C31H59N7O12. 2. Molecular weight: CAS 54915-44-7 has a molecular weight of 729.07 g/mol, while CAS 53123-88-9 has a molecular weight of 531.24 g/mol. 3. Structural formula: The structural formula for CAS 54915-44-7 is different from that of CAS 53123-88-9. 4. Synonyms: CAS 54915-44-7 is also known as rapamycin, CAS 53123-88-9 is also known as sirolimus. 5. Applications: Both CAS 54915-44-7 and CAS 53123-88-9 are used as immunosuppressants, but CAS 54915-44-7 is also used as an antifungal agent, while CAS 53123-88-9 is used as an anti-cancer agent. 6. Manufacturers: CAS 54915-44-7 is manufactured by Pfizer, while CAS 53123-88-9 is manufactured by Wyeth. In summary, while both CAS 54915-44-7 and CAS 53123-88-9 are associated with the active ingredient rapamycin, they have different molecular formulas, molecular weights, structural formulas, synonyms, applications, and manufacturers.

[@lucycooper55]

I haven’t done the 6 mg weekly due to to taking methotrexate 20 mg weekly along with cosentyx injections 150mg every 2 weeks for an autoimmune. I take 1 mg twice a week to try and stay safe. Would love to take more but wonder how well methotrexate, biologicals and rapamycin could work synergistically together? Too much?

[@errrin1]

Is there any benefit to titrating up? (I.e. 2mg per week for a month, then 4mg the next, then 6mg.)

[@moodiali7324]

if i understood correctly: u do not take Rapamycin continously like many ppl do on weekly basis (on 10-12 weeks then u off for 6 months), why?

[@TheBroSplit]

I heard your frozen shoulder story and by God I have the same thing. I can work and at some point, it gets lubed up enough to workout. Pain stays after for some time after my overhead presses, bench press and lateral raises. Where can I ( 37 yrs. old ) get rapamycin? (I signed up for your Optispan trailblazer study too btw). Thanks!

[@moodiali7324]

have you agreed to pay 25K to be included in this study?

[@TheBroSplit]

@@moodiali7324 no

[@Vic-dk1tf]

Would Rapamycin do anything for someone age 80 with advanced Alzheimer’s?

[@rayquaza6791]

If you have Alzheimer’s the best thing to do is to stop your exposition to methanol and formaldehyde (jams,tomato sauce,fruit juice,aspartame,canned fruits,tobacco,beech wood smoked food,UHT milk) Also drinking a little alcohol can protect you and stop methanol from converting into formaldehyde.

[@hoffmancapote]

What is your opinion on Rapamycin and its tendency to lower lower testosterone. I have taken Rapamycin but because my testosterone is on the lower side I have always been wary of continuously using it

[@moodiali7324]

did u measure and compare testosterone levels before and after taking Rapamycin?

[@hoffmancapote]

@@moodiali7324 Before but not after but noticed a loss in libido after taking it for just over 2 months. Will take it again but not continuously. Lowering of Testosterone is a known problem with Rapamycin, if you look on Rapanews there are a few people who have experienced it

[@penguinlieo4723]

intermittently. ON 6 wks, OFF 4wks

[@hoffmancapote]

@@moodiali7324 well not after it but just felt that it had impacted my testosterone levels because for a couple of weeks after I stopped taking I noticed morning erections had stopped

[@Lonor77]

Why do users get more mouth sores? Does Rapamycin lower the immune strength?

[@focusedstudying8993]

Yes it does, but usually only in the beginning. I have kidney tumors and take everolimus, which is also an mTOR inhibitor like rapamycin, to slow their growth. My doctor told me the immune system would indeed be impaired, and I would get mouth sores in the beginning.

[@dharma__3]

FATIGUE. Many people report fatigue taking weekly rapamycin, sometimes reducing it helps but not always. I'm trying to stay on it.