Great interview esp for someone who doesn’t know much about cell senescence, informative video

I believe Bryan Johnson did this with his father that had quite good results. For how long?

Don't understand what you're saying? What's the result of doing this?

In answering the question about dosing of rapamycin, my understanding had been that you advised taking it for 10 weeks, and then taking a break for 6 months or more. Is that still the case?

Matt, I very much appreciate your honesty, especially because I believe you are a longtime friend of Brian Kennedy.

clinicaltrials.gov/study/NCT04488601 what about this one its in humans?

thanks for you hard work :) we really need it

Matt, In my opinion, this has been the most interesting interview you have done so far, Professor Aduti Gurkar was effusive and graceful, with no ego, just putting forward excellent information. For me, as a layman, it was very timely as I have been researching all the science on age related autoimmune illnesses and immunosenescence, becaused in September last year at the age of 62, I was diagnosed with IPF an autoimmune type, called nonspecific interstitial pneumonitis (NSIP) with all sorts of secondary autoimmune manifestation like sjögren's syndrome, antisynthetase syndrome, myositis, polymyositis. The IPF diagnosis is 3 to 5 years life expectancy. It's as though my body is attacking me from the inside, but to look at me you wouldn't know it, I look younger than my age, and within 5kg of my body weight when I was 25 and do HIIT exercises, and have always eaten a balanced healthy diet, nothing processed only fresh vegetables and meat, never take away food, I was a fitness fanatic in my youth doing martial arts. What I do know is that we all age at different rates, and for some, we have to fight our genetics, if we're to extend our life span. It's a role of the dice at birth. I am now following research done by the Paul Nobel Lab at Cedars Sinai Hospital in LA, into pulmonary fibrosis where trials on mice and in vitro cells resolved the fibrosis due to finding that the ZIP8 (SLC39A8) zinc transporter not functional, stopping zinc getting to the type 2 alveolar cells to repair the fibrosis. The challenge is to reactivate the zinc pathway to the lung. They found that combining the zinc supplementation with NMN and Resveratrol significantly increases the zinc getting to the lungs cells and the resolution of the Fibrosis. The research paper is available online. This has created my obsession to understand and dig deeper into age related illnesses and what is happening to the ageing immune system and increase in autoimmune diseases as we age, I learnt about senescence cells and Senolytic supplements, and given the IPF life expectancy, I am willing to hope against hope that the Noble Lab treatment is worth a shot in the dark, I have also added Lipsomal Quercetin, Lipsomal Fisetin, Pterostilbene and EPA DHA Omega-3 to my treatment. The dosage I'm taking is very high, double the recommendation, including the zinc. I feel better than I did when first diagnosed and my pulse ox reading is now better, a solid 97 or 98, last year I was lucky to get 93 or 94, my 6 minute walk tests are about 700 meters, any faster and I would be running. The confirmation if this treatment works will be in March / April next year when I have my second lung CT scan, to see if the fibrosis is growing or receding. Could you PLEASE interview leading research scientists working on autoimmune illnesses and its relationship to the ageing Immune system, I think there must be a link between autoimmune illnesses and the lingering senescence cells causing autoimmune illnesses, which are common as we age and affects our health-span. Please have Aditi Gurkha back and explore this fascinating subject more. It would be great if you interviewed Professor Paul Noble of the Noble Lab at Cedars Sinai Hospital, he is a pulmonologist doing research over the last 25 years, he does do interviews and the human clinical trials of the zinc, resveratrol and NMN has recently begun. Thank you, Matt, and keep up the good work, Enrico, Melbourne Australia. Cheers.

Thanks for letting us be the fly on the wall during high level conversation of these giants ❤

The intro feels like an epileptic seizure

🎯 Key points for quick navigation: 00:00 *🕒 Intermittent fasting and time-restricted eating might not have health benefits beyond caloric restriction.* 01:30 *📋 Different tiers for ranking health interventions: A as essential, B important, C may need more research, D not worth it for most, F not helpful.* 02:39 *🦷 Regular dental visits and oral care are essential for maintaining health.* 03:37 *🧪 DEXA scans are important for most people's health routine.* 04:47 *🧊 Bioimpedance scales are not worth most people's time unless essential.* 05:28 *🏃 Fitness wearables can be valuable, but not essential for health.* 05:56 *💉 Regular blood work is important to know key biomarkers for health.* 06:10 *🩺 Multi-cancer early detection testing is valuable but not essential for everyone.* 07:32 *💊 Epigenetic age testing is not proven to be beneficial and falls in the "not worth your time or money" category.* 08:14 *💊 NMN supplementation falls into the "could be harmful" category due to lack of conclusive evidence.* 09:37 *💊 Resveratrol may not provide significant longevity benefits and has mixed evidence of potential negative effects.* 11:36 *🧬 Rapamycin (Rapa) falls into a category worth considering for some individuals, but not essential for everyone.* 13:06 *🌞 Vitamin D3 optimization is crucial for overall health and longevity.* 14:58 *🧬 Genetic testing, like 23andMe, provides valuable insights for optimizing health.* 16:36 *💤 Sleep is an essential pillar of health and should be prioritized for longevity.* 17:04 *🥗 Intermittent fasting and time-restricted eating can be useful tools for weight management, but not proven to have additional health benefits beyond caloric restriction.* 20:33 *🍽️ Caloric restriction leads to weight loss, which can be achieved through various strategies like dietary restriction or tracking calories.* 21:53 *🔄 Time-restricted eating and intermittent fasting primarily work due to caloric restriction, not specific health benefits beyond that.* 22:37 *🦴 Caloric restriction can lead to increased lifespan and health span, particularly for overweight or obese individuals, as it helps achieve a healthy weight.* 25:53 *💪 Resistance training is crucial for maintaining muscle mass as you age, alongside cardiovascular fitness, which can be obtained through intense resistance training as well.* 32:08 *🍷 Moderate alcohol consumption may have some benefits, but overconsumption can be harmful to health, emphasizing the importance of balance.* 41:36 *🧔 Some effects of substances like steroids are permanent, while benefits are temporary.* 42:31 *💊 It's important to find the optimal levels for sex hormones, as deficiencies can lead to various health issues.* 43:12 *⚖️ Replacement therapy for low hormone levels may have more benefits than risks, especially for aging individuals.* 44:22 *🩺 Regular hormone level testing from the 50s onwards can help determine the need for replacement therapy.* 47:14 *🧠 Cognitive function tests can provide valuable information, but responses to results may vary from person to person.* 49:07 *🏃‍♂️ Lifestyle factors like diet, exercise, and sleep play a significant role in overall health and may mitigate cognitive decline risks.* 50:54 *💡 Certain genetic variations, like the E4 variant, may influence the effectiveness of interventions for dementia prevention.* Made with HARPA AI

thanks for an interesting episode. Could you please look into Mitrochondria transplantation?

Can i take lysine to prevent canker sores that you are more likely to get when on rapamycin?

Awesome topic and convo! Have learned a few things already halfway through

Is there a known reason why some of the control groups have big differences in livespans?

Super interesting interview, thanks!

Curcumin phytosomes, Liposomal Apigenin, CAKG, Fisetin, etc. Already in the marketplace. Excellent paper on them on the NIH site.

Great talk right at the forefront of the aging science.

Great to hear Gurkar say that she talks to everyone about what she's studying. We need that kind of cross discipline discussion. Great interview!

Welcome to Santa Barbara. Hopefully the fog will lift soon!!😂

How can we hear Matt's talk at this conference to which they refer.

Deeply inspiring that such gifted scientists are wrestling with these questions. Aditi Gurkar is a gift to the scientific community ! Question question question toward discovery. THANK EACH OF YOU for investing your lives in this field.

Still prefer the previous intro

Thanks Matt an unusually interesting interview !!!

Another banger! Hoping the algo spreads your work far and wide.

Do you know of any doctors in Australia, NSW, who are up to date with this research?

Enjoyed this format for lunch learning opportunities. Thank you

Really?! You sound equally stupid calling a banana the same as a Snicker's bar. Bananas not a healthy food? Fiber, potassium, etc. Use a green (underripe) banana that has higher resistant starch content or frozen banana to prevent ripening and promote resistant starch, if you are someone that obesses of glycemic response. You go on to name groups that have metabolic imbalance or pre-diabetes, those are groups that should be taking steps beyond worrying about bananas. --- This video just stands as an example why a research scientist shouldn't be mouthing off about nutrition on social media. Not your wheelhouse.

Dosage Even if we accept the proposition that the dosage used here would only be equivalent to 1.5g for a human, the recommended dosage for NR is generally 250mg for a human. So if you were to ingest a dosage 600% higher than recommended, it follows that the kidneys may show some sort of inflammatory pathway activation. This is not shocking but rather common sense. And in general, if the bottle recommends taking 1 pill per day then don't take 6 pills per day and if you do well then your kidneys may need to clean up your mistake. Further, when the authors state "this dosing of NMN is still a more realistic model for the potential for excessive self-dosing, which is enabled by the current availability of many NAD+ precursors as over-the-counter supplements" they are showing bias, suggesting that it is NMN as a compound that is inherently problematic rather than people choosing to massively overdose NMN being problematic. I hope to one day read a legitimate study where more reasonable dosages are used and then we will see what if any harmful effects result from NMN. And I do understand that the bias on this channel is toward rapamycin, the "gold standard for longevity interventions", though I would hope in future to see clear, unbiased reviews of published research. Although I laughed out loud at Matt's reaction to saying Sinclair's name (that was classic), there is nothing to be gained by emulating his behavior even in the limited sense of conducting biased reviews of scientific studies.

Love that you’re shining a light to all the longevity and lifespan BS out there and a voice of reason. Thank you 😊

I take Rapamycin and believe that dietary protein and calories can activate mTOR, but I don't want it activated it because that works lessen the effects of Rapamycin for autophagy. So,, I fast 36-40 hours when taking Rapamycin.

I'm doubtful that bananas are bad for you in any way!: Whole food! Fruit! Natural! There are so many other foods in the US that are the reason for this 99% of population being metabolically ill. Bananas are the least of the problems in US diet.

I heard this first from Rhonda Patrick. I gues you should also scold her publicly! Invite Rhonda and the authors to discuss the study. (And also the tiktoker)

How to convince your doctor to prescribe you RAPA?

I had excellent results taking it for Hypertrophic Cardiomyopathy. I hope to have a positive report in October.

Several of these people are metabolically sick. Who cares about their opinion.

Thanks Matt for orabiomedical, i think it's a great initiative!

Rhonda Patrick podcast and science behind saunas??

I have a theory that our ancestrals always did make fire. So they were constantly heated for hundreds of thousands of years. Therefore, if that heat was bad, natural selection would select species that didn't use fire; But most probably that heat was good in some way and then heat is good for us. other possibility is that has no effect, wich intuitively doesn't make sense.

In the context of Rapamycin vs resistance training would it be possible to discuss the following review in a future episode? www.ncbi.nlm.nih.gov/pmc/articles/PMC6659995/

Great episode, I liked the term avoid overengineering if data is lacking.

If you are interested in longevity, ,Bunny, why would you smoke or drink alcohol ??? If you smoke (tobacco) or drink more than two drinks a week- and probably smoking less marijuana (or none) makes sense as well. I mean, are you really wanting to maximize your life span or not. By the way, for myself, I use very little alcohol - usually a mouthful of alcohol held in my mouth while chewing a 325 mg of aspirin. For pain. But I am not totally committed to maximizing my age. I do time restricted eating and try high protein and avoiding food that tastes sweet. But under stress, I do eat ice cream. I am stressed- One of my granddaughters (( mother of three )) was shot breaking two ribs, damaging one lung, and cracking her scapula. She was always going to survive. We now know she will not lose the lung, and they took out the bullet Monday before last, though that wound is still draining. An excuse, I would say, for stress induced comfort eating. I have also lost 40 pounds over the last three years, since adapting this lifestyle. If I can manage to not drink, smoke, or gain weight at my age (( I am 76, )) Buck up, Mr. Bunny, you can decide you don’t need booze and tobacco.

The authors of one study claim to have found that C15 (an odd-chain fatty acid found in whole-fat dairy) can provide the same benefits that rapamycin can; and possibly even more.

Great information again! Do you know anything about Raoamycin for ME/CFS? It’s hypothesized that it is an autoimmune disease with autoantibodies against m. choline receptors. Maybe it has potential

I am wondering are there some rapalogs that would be use as a supplements for humans instead of rapamycin itself?

Hello, thanks for the Q&A - I haven't seen much regarding the use (or cessation) of rapamycin during conception, pregnancy and whether or not long term use would affect/influence sperm health or epigenetic factors that may be passed to offspring either through the sperm or egg (or both). Is there cause for concern with no turning back if an individual starts rapamycin prior to starting a family or is there data from transplant patients suggesting that it is not much of an issue?

Nmn is not d tier

Thanks for another episode. Just saying: I prefer the previous intro.

Does azithromycin have the same benefits as Rapamycin

Matt what dosage of niacin should I take to increase Nod levels ?