Donnan Equilibrium

[@MedicosisPerfectionalis]

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[@mohitkandari6085]

When you understand something rather than learning something, you remember it for life. Thank you dr for helping me understand.

[@MedicosisPerfectionalis]

I couldn’t have said it any better.

[@nidhs_gupta]

Cannot explain how good it feels to finally understand. You sir are godsent.

[@MedicosisPerfectionalis]

Thank you 🙏

[@azalkibsi]

This is just amazing, Never enjoyed a medical video such as this one. Thank you for your hard work Dr.

[@MedicosisPerfectionalis]

My pleasure 😇

[@soumiaboudjemaa1179]

this is just incredible i really appreciate your efforts , thank you so much for making me not just understand , but also laugh the whole video you litterrally made my day

[@MedicosisPerfectionalis]

My pleasure 😇

[@angeljacob4620]

searched for this topic and just came across your video...It's the best video I have ever seen in my life !!!! THANK YOU!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@dynamite_being]

Simple and effective explanation is a symptom of someone highly perfused with knowledge📚

[@MedicosisPerfectionalis]

Thank you 🙏

[@MedicosisPerfectionalis]

Thank you so much 😊

[@deae3831]

I feel like im having a conversation with out saying anything. I love this, thank u dude

[@MedicosisPerfectionalis]

My pleasure!

[@ahmedkoraichi997]

U're just helping us to be great doctors thank uuu

[@MedicosisPerfectionalis]

My pleasure 😇 Please help me by sharing! Thank you 🙏

[@rijakhalid9011]

OMG you're amazing! Hope you can be the next Dr Najeeb hehe

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@rigormortis6981]

I wasn't even listening attentively but I understood it! Amazing!

[@MedicosisPerfectionalis]

Thank you 🙏

[@rs6731]

This was just magic..great work sir!!

[@MedicosisPerfectionalis]

Thank you 🙏

[@r.bishvajeet2820]

Love from India...explained well❤

[@MedicosisPerfectionalis]

Thank you so much!

[@bionium6976]

Sir i love you , i mean this channel is sucha boon to mee like i understood this concept so well , im a medical student from india i like your accent as well, like so active and inclusive

[@MedicosisPerfectionalis]

Thank you 🙏

[@joeramirez2156]

That’s legit! Love it man. Keep up the awesome work.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@joeramirez2156]

Yeah currently doing nephrology as I type this...you broke down some really good topics. I’ll def. be using your channel to help get through future blocks!

[@MedicosisPerfectionalis]

Awesome 👏 I am honored! Thank you 🙏

[@pratikshyalamichhane4326]

Ohh my god , I can feel the tone of my professor's today's class about this topic. And it was freaking same as medicosis explained how proffessors do .

[@MedicosisPerfectionalis]

Haha 😂

[@MedicosisPerfectionalis]

👨‍🏫 Physiology Playlist: kzbin.info/aero/PLYcLrRDaR8_eAjmngd289ghWijs2wfqnj

[@mataboras4816]

A really great video that helped a lot with understanding the concept. Much thanks!!!

[@MedicosisPerfectionalis]

Glad it was helpful!

[@bhatshahid5214]

Really unparallel Thank you sir Keep shining

[@MedicosisPerfectionalis]

Thank you so much 😊

[@vadimushakov5883]

Greatest explanation of one of the hardest blocks in medicine. Cheers!

[@MedicosisPerfectionalis]

Thank you 😊

[@anastasia2162]

OMG that is the best explanation ive seen so far!!

[@MedicosisPerfectionalis]

Thank you 🙏

[@justsamira4477]

Hi life saver.. thanks alot i loved this lecture.. it's very useful.. I'm preparing for USMLE step 1 🌹👍🏼

[@MedicosisPerfectionalis]

Awesome 👏

[@thekingofsomething]

I appreciate your work, though I have a couple inquiries Facilitated diffusion includes a channel thus it shouldn't be simple diffusion, it should be either the umbrella term passive transport or the more specific term facilitated diffusion. Secondly, regarding volume replenishment, when dehydrated you feel thirsty and havenmuscle cramps, the cells shrunk in the hypothalamus and muscle cells lost water respectively. Thus you can't only think of the IVF and Interstitial fluid alone when rehydrating, after all if water is lost, some ICF will help the ECF. Unless the patient you mentioned had absolutely normal water volume

[@CLEMENCEEELIAS]

8 Na+ ions are needed in the protein component

[@MedicosisPerfectionalis]

Excellent!

[@aridjb1302]

You save my life!!, tnx so much 💚😍

[@MedicosisPerfectionalis]

My pleasure 😇

[@naaengmann2117]

8 Na+ ions?

[@MedicosisPerfectionalis]

Yup 👍

[@snehamasuna8745]

Loved the way you explain ❤️❤️❤️❤️❤️❤️❤️❤️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@hinamushtaq1757]

Awesome.... it cleared my all doubts

[@MedicosisPerfectionalis]

Great 👍 Thank you 🙏

[@raaishzeeshan]

It was a blessing to scroll and tap on it.. just love the way of teaching. Last mint preparation of exam 😅 hope to deal with exam way more better.. thanks for this one

[@MedicosisPerfectionalis]

You’re very welcome!

[@d00mch1ld]

What the flip? This is the best explanation I have ever seen.

[@MedicosisPerfectionalis]

Thank you 😊

[@sheetalmahajan4150]

Perfect explanation

[@MedicosisPerfectionalis]

Thank you so much 😊

[@dr.amitgupta_]

Amazingly explained 😍😍😍

[@MedicosisPerfectionalis]

Thank you so much 😊

[@smdr5576]

DOPE! Thanks a lot!! very well explained

[@MedicosisPerfectionalis]

My pleasure 😇

[@mrtenbbh1670]

So good i really enjoyed your teaching.

[@MedicosisPerfectionalis]

Thank you!

[@rayansyed1714]

thank you medicosis. The answer is 8 Na+.

[@MedicosisPerfectionalis]

You’re very welcome!

[@gaebu68]

5:46 I don't understand why the sodium would want to go to the left. Surely, there are more negatives on the left to attract it, but also the exact same amount of positives to repel it. So why would you say that still overall it wants to go to the left?

[@janakayed7536]

Thank youuu so much !!! Couldn't have been clearer :)

[@MedicosisPerfectionalis]

I am honored! Please help me by sharing my videos with others!

[@fatimabushra1758]

Thanku Dr for such a nice explaination.. 8 Na+.

[@MedicosisPerfectionalis]

Thank you 🙏

[@sayanibasu__]

8 Na+ ions, btw thank you for such a nice explanation

[@abhisheksharma0426]

Your heart 💓 is history Your brain 🧠 is a mystery Your kidney is screwed Epic😂

[@MedicosisPerfectionalis]

Haha 😂

[@eloischill1391]

my woke irl professor has failed me and i needed this SO BAD thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@jessjames5530]

Thanks😊🙏🙏this was so good🙌🙌 You sound like L Lawliet from Death Note😍🔥🔥🔥

[@MedicosisPerfectionalis]

Who?

[@sburns90]

Wow, I wish some of the doctors I have dealt with in the past have watched your videos. If they did my family would probably be in much better health. I may have to show this to my family member's doctor, lol. I have some family members whose doctors don't understand dehydration and hypoperfusion, or so it seems. They say just drink more water (which makes it worse due to lack of electrolytes) and they assume it's normal to have low blood pressure, hypo-osmolar blood osmolality, Reynolds like phenomenon, dizziness, fatigue, dry skin, dehydration, and adipsia. Then even when we tell them plain water generally makes symptoms worse, then their answer is well all you need is more water. 😲

[@MedicosisPerfectionalis]

It’s sad 😔

[@sburns90]

@@MedicosisPerfectionalis what's really sad is the 8+ doctors from different medical disciplines, different health systems, and different states who still say drink more water. Even though it is plainly obvious the person is experiencing hypo-osmolality hypo-perfusion. It seems it is just too much to ask to get several liters of fluid to fill the cellular compartment and improve tissue perfusion. What a shame.

[@MedicosisPerfectionalis]

You’re right, bro

[@heartcomedy5]

Great video 👍

[@MedicosisPerfectionalis]

Thank you 🙏

[@astaghfirullah10000]

شُكراََ جزيلاََ .

[@MedicosisPerfectionalis]

:)

[@stevenshine6116]

This is AWESOME!!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@gerlaxhelili422]

Thank you! Great video

[@MedicosisPerfectionalis]

My pleasure 😇

[@indu6629]

Excellent explanation...

[@MedicosisPerfectionalis]

Thank you 🙏

[@hewaahmedmustafa8027]

You have a mistake, I think . what about Donnan Electrical Potential? If ions are equal in both sides there will be no electrical potential.

[@melomane6936]

Is x=3 Thank you for the video 😊

[@johnmarston8532]

Everything is superb except too many ads which destroy the focus on the topic...if possible, please try to fix.

[@jeroendewaal2652]

why isn't the example with "before equilibrium" also at equilibrium? The electrical gradient and the concentration gradient are both at 0 between the protein component and the non-protein component.

[@omkarchavan5940]

I am also having the same question

[@Qamaramed]

Un grand merci à vous , où je peux trouvez la 2ème vidéo pour savoir la réponse ? C est quelle playlist ? X= 8 ( avec 6 protéine dans plasma ?)

[@MedicosisPerfectionalis]

Thank you! This is is the PHYSIOLOGY playlist!

[@xavierxrc]

Is there something I'm missing? The protein content in the body is higher intercellular than extracellular. So water will want to move inside the cell according to this. However, it's extracellular sodium that prevents this.

[@rudramodha6048]

What!!!!! You know Dr najeeb 😱

[@MedicosisPerfectionalis]

Of course!

[@doughnut469]

One question. When Water flows to the Protein compartment, wouldn't it dilate the Ion concentration thus the Donna's Equation would never be stable and Water would flow to protein compartment until the cell looses all his water and die from lack of wetness or from greediness of the thirsty protein compartment? I feel like Donnan must be stopped

[@SaraAhmed-gx2jd]

Please doctor, what's the application that you use 😊❤

[@keziaint1533]

wait soo like the donnan effect happens when there is hypoperfusion in the body?

[@ankitasaha7425]

First one yaay! Haven't watched video though . 😂 Watching ...

[@heartcomedy5]

Nice

[@MedicosisPerfectionalis]

Thank you, Ankita!

[@MedicosisPerfectionalis]

Thanks, Dr. Q

[@nidhs_gupta]

Small doubt - plasma volume is around 5L and total body volume 42L. Doesn't that make the ratio 1/8th instead of 1/4th? Since whatever fluid we administer being isosmotic will get equally distributed between ICF and ECF?

[@DrApurvaCV]

I have the same doubt

[@AhmedMostafa-hl9yl]

okay... firstly, plasma is 3.5L and it represents 5% (3.5/42) of total body water Secondly, Fluid wont move if no one tells it to, its lazy. Fluid moves from plasma to Interstitial fluid due to hydrostatic pressure, but to move to ICF, it would need osmotic pressure. The infused fluid is isotonic which means it has same osmolarity as ICF, so there is no osmotic pressure, so water will not move into the cells or we would all be dead from our cells bursting doofus. Joking, sry

[@mohamedabomera5598]

Can I get the chance to work with you as a translator to your content ? I am a medical student from Egypt

[@Qamaramed]

Please what's the name of this playlist ??? 😊😊

[@MedicosisPerfectionalis]

PHYSIOLOGY

[@ranjitk9115]

The non protein compartment should be interstitium not cell. Gibbs donnan equilibrium is actually explained btw protein compartment (cell) and non protein compartment interstitium. Am i correct. Plz correct me if am wrong.

[@ankitasaha7425]

At this point I have only one confusion if I should call you Dr Sir or Sir Dr :) It's because you are a great teacher and I guess rather I'm sure you are a doctor too . Anyways video was great understood everything ! ✨

[@MedicosisPerfectionalis]

Thank you so much 😊, dear! I have an MD, but I don’t practice...I just teach :)

[@ankitasaha7425]

@@MedicosisPerfectionalis I see . Pleasures all mine Sir .

[@MedicosisPerfectionalis]

😊😊

[@maimuna20]

So cool 🧡

[@MedicosisPerfectionalis]

Thank you 🙏

[@MohammadRezaFayyazi-c8s]

I think the first consequence isn't correct. In the picture "after equilibrium", there is no electrical gradient because the electrical sum of ions in both sides is zero. And the only force on sodium is just the chemical gradient which leads to disturbance of equilibrium😕 I think what is showed as equilibrium is wrong

[@CHEH_tf]

Bro thank you for this

[@MedicosisPerfectionalis]

My pleasure 😇

[@qondohmbokwana9013]

"all kinds of gains"- The Hodge twins

[@MedicosisPerfectionalis]

Yeeeeaaaaaaaaahh!

[@abdeldjalilbenaissa3397]

earned a sub brother

[@MedicosisPerfectionalis]

Thank you 🙏

[@abdeldjalilbenaissa3397]

@@MedicosisPerfectionalis really you should know that you are helping people from all the world to become doctors and we apperciat what you doing love from algeria

[@nayantarabiju1928]

Thank youuuu😭

[@MedicosisPerfectionalis]

My pleasure 😇

[@mobenkane2075]

Isn’t that #1 is facilitated diffusion? Because Chloride is facilitates through protein channels.

[@oxell4925]

I think the answer to the question is 8 Na+ ions!

[@ahmedmousa3358]

ابداع🔥

[@MedicosisPerfectionalis]

:)

[@roro47308]

+8 particales of Na

[@drramoray9057]

Bro make vedios on cvs . Request bro.

[@MedicosisPerfectionalis]

Alright, my friend.

[@karthikisr8]

it's like Rowan Atkinson's teaching me

[@laxmihalam6068]

Now let's go to wisdom baby❤...fallen in love with you sir Okay so I must say this video is just awesome...thank you soo muchhhh

[@MedicosisPerfectionalis]

Most welcome 😊

[@hansmenares3850]

science and capitalism, my favorites :)

[@partomeraji3084]

briiiiiiiiiiiiiiiiiiiiilliant

[@MedicosisPerfectionalis]

Thank you 😊

[@drpepper7801]

Lol first time watching your videos... You have a sharp mouth lol

[@MedicosisPerfectionalis]

Haha 😂

[@nanneboyinapranavi1060]

x=8 because the produt equals that is 2'x=16 x=8

[@vishantsingh325]

what about+ve = -neg in each compartment?

[@srijoni1237]

@@vishantsingh325 they match too . There are 6 plasma proteins and two chloride ions so 8 neg so there must be 8 positives

[@vishantsingh325]

@@srijoni1237 ah yes. :) Thank you Bear

[@vishantsingh325]

By any chance, are you from Water field?

[@srijoni1237]

@@vishantsingh325 If that’s a place then I’m sorry I haven’t heard of it.

[@dungnguyentrung8135]

nice bro

[@riyatripathi6893]

8 sodium ions

[@mahbubamaria1742]

Will the value of "X" be 14?

[@MedicosisPerfectionalis]

Nope

[@sevinch6304]

N o i c e

[@MedicosisPerfectionalis]

Thank you 🙏

[@ashujnn]

How to increase platelet count through food. My father tested positive for covid 19.he is normal.his platelet count is 60000, daily it is fluctuating.

[@MedicosisPerfectionalis]

Hey Ashu. I am sorry to hear that...It must be hard on the family. Does your father have bleeding symptoms?

[@ashujnn]

@@MedicosisPerfectionalis no bleeding. No temperature

[@MedicosisPerfectionalis]

Talk to the doctor, because the lack of bleeding symptoms may require no treatment for the 60,000 platelet count. Other labs need to be taken into account...Please talk to his doctor!

[@snehamasuna8745]

The answer is 8

[@MedicosisPerfectionalis]

Excellent

[@aneesmusic7174]

Answer is8

[@MedicosisPerfectionalis]

Yes

[@jeskaisekai_6785]

X= 8

[@MedicosisPerfectionalis]

Why?

[@jeskaisekai_6785]

@@MedicosisPerfectionalis becuase the product of NaxCl in the protein compartment is equal to the product in the non-protein compartment so 2×X=4×4 -> X=8. Also the difference of Na and Cl in the protein compartment is 8-2=6 and this excess of positivity is balanced by the 6 (negative) plasma protein particles in the protein compartment. (I think this is the right answer but anyway I really wanted to thank you, even if english is not my first language I find very easy and enjoyable to watch your videos; this channel is a blessing xD)

[@MedicosisPerfectionalis]

Awesome 👏 You’re excellent!

[@bichadiva6717]

U R A LEGEEEND IT TOOK ONE LECTURE AND MANY HOURS BEHIND WRITTEN LESSON AND STILL DIDN'T GET IT MEANWHILES I COULD GET IT IN 15 MIN 🤯🤯🤯 Edit: btw answer is 8 Na+

[@MedicosisPerfectionalis]

Thank you so much for your kind words!

[@aminaassbayou85]

i love you

[@MedicosisPerfectionalis]

Thank you 😊

[@Apostate_ofmind]

bloody hell, i understand

[@MedicosisPerfectionalis]

:)

[@excitementsoflife5110]

8

[@sat1327]

Wow

[@MedicosisPerfectionalis]

Thanks 🙏

[@joseireyessoto9747]

I can't find your name :( Whoa are you?

[@MedicosisPerfectionalis]

It’s a secret 🤫

[@joseireyessoto9747]

@@MedicosisPerfectionalis it need to cite your wonderful wisdom in an assignment 🙂

[@mukajii]

My answer is 8 Na

[@rolf6868]

Damn myself if this video isn't perfect XD

[@MedicosisPerfectionalis]

:)

[@yumxhtutkai8591]

Ohh eight

[@MedicosisPerfectionalis]

Yup 👍

[@mohamedazaarudeens1311]

8 Na

[@mohamedazaarudeens1311]

Product of Na and Cl inside protein compartment= product of Na and Cl inside non protein compartment 2 x X = 4 x 4 2 x X= 16 X= 16/2 = 8

[@arathy592]

Plz give me class...and not qnz..plzz🥺🥺😁😁

[@MedicosisPerfectionalis]

What’s qnz?