Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

In this episode, my guest is Dr. Mark D'Esposito, M.D., a neurologist and professor of neuroscience and psychology at the University of California, Berkeley. We discuss the brain mechanisms underlying cognition and the forms of memory required for focus, productivity, planning and achieving goals, and learning. We discuss neurochemicals such as dopamine and acetylcholine and how they can be leveraged to improve cognitive functioning. We also discuss concussion, traumatic brain injury (TBI), Alzheimer's, and Parkinson's disease, and ways to restore or slow cognitive decline by using pharmacologic, lifestyle and behavioral protocols. This episode provides a modern understanding of cognition and memory and actionable tools to optimize brain health and function.
Thank you to our sponsors
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Dr. Mark D'Esposito
Academic profile: bit.ly/49wwPMo
Lab website: bit.ly/3I4Sxev
BrainHealth project: bit.ly/3SEiZ3w
Publications: bit.ly/3T4AH1J
X: / mtdespo
Journal Articles
Cognitive and attentional mechanisms in delay of gratification: bit.ly/49zpHPL
Inverted-U-Shaped Dopamine Actions on Human Working Memory and Cognitive Control: bit.ly/3UdfWBP
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey: bit.ly/4bBqMI9
Clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for the treatment of cognitive deficits in “Long-COVID19”: bit.ly/42IuviW
Estrogen Shapes Dopamine-Dependent Cognitive Processes: Implications for Women's Health: bit.ly/42G4xwF
Ongoing dynamics in large-scale functional connectivity predict perception: bit.ly/3SMFT92
Other Resources
BrainHQ: bit.ly/3I6y5d6
The BrainHealth Project: bit.ly/3I591Dm
Neuroscouting: bit.ly/42IpZB8
Huberman Lab Episodes Mentioned
Nicotine's Effects on the Brain & Body & How to Quit Smoking or Vaping: go.hubermanlab.com/GpyRhoQTYT
Tools to Enhance Working Memory & Attention: go.hubermanlab.com/s7LQP1bsYT
Dr. Matthew Walker: The Science & Practice of Perfecting Your Sleep: go.hubermanlab.com/psVAPrDqYT
How Psilocybin Can Rewire Our Brain, Its Therapeutic Benefits & Its Risks: go.hubermanlab.com/ggl7TvJuYT
People Mentioned
Brian Levine: Professor Dept. of Psychology, University of Toronto: bit.ly/49h05qz
Matthew Walker: Professor of Neuroscience & Psychology, UC Berkeley: bit.ly/3UK2Ags
Michael Merzenich: Professor Emeritus - Neuroscience, USCF: bit.ly/3T4rSoD
David Hubel and Torsten Wiesel: Nobel Prize (1981): bit.ly/3T6SPYQ
Emily Jacobs: Associate Professor of Psychology, UC Santa Barbara: bit.ly/3T0AaOa
Art Kramer: Professor Emeritus, University of Illinois Urbana-Champaign: bit.ly/48l4982
Eddie Chang: Professor of Neurological Surgery, UCSF: bit.ly/3SLsjmd
Karl Deisseroth: Professor and Psychiatrist, Stanford: stanford.io/49BQmuG
Sepideh Sadaghiani: Associate Professor of Psychology, University of Illinois Urbana-Champaign: bit.ly/48CagoF
Timestamps
00:00:00 Dr. Mark D’Esposito
00:02:08 Sponsors: Maui Nui, Joovv & Eight Sleep
00:06:23 Brain & Frontal Lobes, Prefrontal Cortex, Executive Function
00:10:31 Frontal Lobe Development, Children
00:14:12 Rules, Context & Impulse Control; Learning & Goals
00:21:45 Focus, Improving Executive Function
00:26:04 Connections & Top-Down Signals
00:29:02 Sponsor: AG1
00:30:29 Frontal Lobe Injury; Emotional Regulation
00:37:26 Smartphones, Social Media
00:44:37 Working Memory, Dopamine
00:52:59 Sponsor: LMNT
00:54:22 Dopamine Levels & Working Memory, Cognitive Tasks, Genetics
01:00:03 Bromocriptine & Working Memory, Dopamine
01:06:21 Guanfacine, Neurotransmitter Levels, Pupil Dilation & Biomarker Tests
01:12:46 Bromocriptine, Olympics; Pharmacology & Cognitive Function, Adderall
01:19:27 Concussion, Traumatic Brain Injury (TBI)
01:25:22 Sleep, TBI, Concussion & Executive Function; BrainHQ
01:31:57 Aging & Frontal Executive System; Brain Health
01:39:26 Tools: Brain Health & Boosting Executive Function, Books
01:47:26 Alzheimer’s Disease, Genetics, Pharmacology
01:51:48 Parkinson’s Disease, L-Dopa; Coping with Alzheimer’s; Nicotine
01:58:37 Estrogen & Dopamine, Cognition; Tool: Physical Exercise
02:04:43 Tool: Mindfulness Meditation & Executive Function
02:10:31 Brain Networks; Modularity
02:17:08 Modularity, Brain Indices
02:22:53 Psilocybin; Transcranial Magnetic Stimulation
02:30:16 Zero-Cost Support, Spotify & Apple Reviews, KZbin Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter
#HubermanLab
Disclaimer: www.hubermanlab.com/disclaimer

[@bent7190]

An episode about skin health would be great

[@hobbes14]

Agreed

[@TandemSKITTLEZ]

👍

[@pietbiertappertje4529]

Indeed!

[@szymon9234]

yes sir

[@irfansheikh3046]

+1

[@Niloufarsaber]

‏Dr. Huberman, I just wanted to take a moment to express my deep admiration and appreciation for your exceptional work. Since the day you launched your podcast, I have been an avid listener, eagerly absorbing the valuable insights and wisdom you share. Your ability to articulate complex concepts in a clear and engaging manner is truly remarkable. In fact, I have dedicated a special notebook solely for jotting down the profound ideas, quotes, and thoughts you express during your podcast episodes. Your passion for your work shines through in every episode, and your commitment to sharing knowledge and empowering others is truly commendable. The impact you have had on my personal and professional growth is immeasurable. Thank you once again for your remarkable work. You have truly made a positive impact on my life, and I am grateful for the opportunity to learn from someone as knowledgeable and inspiring as you. Niloufar from Iran

[@Outliveathletics]

I think this person speaks for more than themselves 🎉

[@IG_Playglenthomas]

I thought I was the only one that has a special notebook for Hubberman episodes. This podcast is a definite game changer

[@zisco_7714]

Mashala chghd hal dashti english benevisi khaharam😂😂

[@user-oi4qr1ly4c]

😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊

[@needheartranken]

What changed my cognitive to the fullest was the utilization of focused vision (like manually telling yourself to focus on what you see and not wander off) and being in the present moment (to the point of telling yourself that past and present is an illusion). It's like a superpower!

[@dimaknopf]

If that's the case cats should be the most cognitively advanced creatures on the planet.

[@Quick--]

Sounds like the work of Eckhart Tolle

[@needheartranken]

@@dimaknopf Aren't they? They don't give a damn, man, haha!

[@Zoomo2697]

"The eighteenth Century thought itself to be the age of reason; the nineteenth century thought itself to be the age of common sense while the twentieth century can only think of itself as the age of uncommon nonsense." G. K Chesterton

[@TedMarq]

😂

[@BarbaraMurphy-rd2wo]

No mention of the "The End of Alzheimer's" books by Dr Dale Bredesen. It is working for me after repeated head traumas over most of my 66yrs. Your dawn/sunrise walks out in the countryside were a gamechanger for me. thank you.

[@cmauro7912]

I appreciate the content of that book very much. However, I believe it could benefit from a more accessible writing style, especially for readers with shorter attention spans (like mine). Dr. Huberman’s expertise as a technical communicator is commendable, and I recommend that if he were to bring Bredesen in that he have a summary of the book set in his memory, and to steer the interview to make the all-over-the-map points more digestible to the audience, as I would hate to see people turned off to Bredesen's concepts just because he does go all over the place with it in the book.

[@sambadi782]

An episode about brain damage would break the internet. Concussions and how they affect people in general, martial artists etc. A topic not spoken enough of.

[@royalbloodedmutt]

It might just be a short snippet, but that little bit about estrogen and dopamine is information I’ve been looking for for 15 years! My hormones have been wreaking havoc on my cognitive functioning for a very long time to the point where I am barely functional. I’ve still got a long way to go to get my life back, but this is a major piece of the puzzle! Thank you for having conversations with experts that we don’t the ability to converse with ourselves, and helping us understand the latest research!

[@thedarkriver1]

After Huberman taught us how to regulate and control our dopamine I have been experimenting on myself. What an eye-opener!! It's also been a longtime coming for me as well! Understanding dopamine would resolve so many issues in this world.

[@ericajackson2380]

Dr.H - I studied Polysomnography, and your content has expanded my knowledge on the brain and how it works. I love your podcast. Youre a blessing to all. May God continue to bless you.

[@andrewbetancourt3114]

Dr. Huberman, Your recent episode on "Optimizing Cognitive Function and Brain Health" deeply inspired me. As someone who sustained a traumatic brain injury (TBI) at the age of five during a mountain accident and is currently navigating college with ADHD, I find immense value in your insights. As a science major, I face significant academic friction, yet your podcast offers practical strategies that resonate with my circumstances. Your dedication to neurobiology and brain health improvement is profoundly motivating, and I am eager to apply your recommendations to manage my TBI and ADHD symptoms better. Thank you for your impactful work, which serves as a beacon of hope for individuals like myself striving to overcome neurological challenges and achieve academic success. Warm regards, Drew

[@jamieriedel97]

What are your takeaways?

[@jamieriedel97]

& wish you all the best!

[@cherylnathanodette]

As an adult female of a certain age who wants to retain as much cognitive function as possible this was insightful. I'm keeping my brain active by taking up new tasks, languages, a musical instrument and still doing online games, covering memory, focus and enjoying every minute of these podcasts so thank you for the knowledge you impart.

[@Markus451]

Here's something important to aid your brain health goal: much more powerful than any of the good techniques you mentioned is something unexpected: exercise of all kinds. I forget which episode Dr H. discussed this but he was very clear: when you're simply using your body, such as walking through a forest, the brain effect is much larger than, say, doing a language puzzle.

[@user-kp7xg1yi6k]

Thanks for your personal adaptive mental balance andto

[@user-kp7xg1yi6k]

I am trying to learn biochemistry. I am 65 and pleasantly retired

[@Justrolln]

Hello Dr Huberman, I’ve gained so much knowledge from your efforts in this podcast- thank you. If you would consider having me on I’d really enjoy the conversation. I was hit by a truck while training for an Ironman in 2009 and became a paraplegic. Since then I finished Ironman Kona in 2012, went to Alpine skiing world champs in 2017, and have represented the US archery team since 2017. I am the current Paralympic champion, world champion, and national champion for recurve archery. Lots of things we could unpack on how to overcome challenges. Keep up the great work. Kevin Mather.

[@user-ly2gr9nf5u]

Strong work with this one, and truly all of them. Just a thought- would you ever consider an episode on longevity/ wellness for people in high stress and 24-hours-a-day working environments? Personally, I am a paramedic and a mountain guide, but, I imagine many of your listeners are military, nurses, police, emergency physicians, etc. Any lifestyles that it is hard to optimize the pillars of mental and physical health. I see many colleagues suffer and compensate poorly which in turn affects patient outcomes, empathy, etc. I believe such an episode could benefit not only frontline workers and our ability to sustain a career that we love, but it would also have massive trickle down effects to patients, families, healthcare systems, justice systems, and society as a whole. Rock on

[@HavarNamar]

First thing on Tuesday morning (Mongolian timezone), I directly go to Huberman Lab podcast with a lot of excitement. Thank you so much for making our lives much better!

[@ak9itrainingacademy]

Super excited about this episode! As a cancer (chemo) survivor who still struggles 10yrs later with memory issues from it plus lifelong ADHD I love these kinds of episodes! ❤️

[@crt300]

ive had memory issues my whole life when i was 8 these guy made me drink this weird chemical from mexico that makes you forget but since i was stilll devolping and i had alot of it my memory was destoroyed.. but i got brain damaged not to long ago and my brain healed and gave me a new dopamine receptor and i had a floo of very intense memories of my life that i never thought of crazy it was a gift in a way ecxept the memories filled me with some regret because my memories i forgot about people i cared about and never pursed more of them i just forgot complety

[@adilsheikh1401]

Great. What were some key points you got from an ADHD point of view?

[@cmauro7912]

​@@adilsheikh1401 I got ADHD and love giving unsolicited opinions. There is a need to get an Gene test and to see if the Dopamine receptors are at fault prior to taking medicines. There is also genes for acetylcholine, hormones, and norepinephrine (sp?) as well as melatonin receptors that are implicated in symptoms amounting to ADHD. Also some of us have too little Gaba. Another neurotransmitter not mentioned yet in the podcast. People point to dopamine but we also have cortisol levels that rise and stay high with hard fast workouts. Not conducive to remaining calm during the day. Lest you do like Goggins and tire out the agitation. Run for 5 hours? Testing for neurotransmitters in Alt Health claim to be accurate. Yet in conventional medicine there is no such thing. "Neurotransmitter test? No such thing." They say we are wasting money taking these tests. It's a matter of getting to the right naturopath or open minded Doctor. Some even use the Braverman Test. I heard this episode 2 days ago and I could have sworn there was more info in this re ADHD. I don't forget the info. Just where I got it from. Something about how the Dopamine has a lot of ebb and flow almost like our behaviors have a mind of their own.

[@cmauro7912]

In my opinion as someone with ADHD. It's lacking in explaining the neurotransmitters and how they affect memory outside of the same old Dopa . Like it's being steered away from Gaba, Cortisol, which both affect anxiousness which messes up my Working Memory. Etc. I agree with genetics testing. Melatonin receptors are lower in ADHD yet sleep was mentioned for better memory it did not explore the brain with less receptors for melatonin to start with. Also, Cortisol levels, as many with ADHD do have issues dispersing it. Keep in mind this is not a specialist in ADHD and Neurology. Yet I wish more specialists did pick up a copy of Edward O Wilson and read Consilience. Too narrow of a speciality does impare ones peripheral vision and thus create drugs that don't address the true issue. 🤔

[@adilsheikh1401]

@cmauro7912 Wow thanks for your insight. You mentioned a book. Is that good for people with ADHD?

[@janayleonard4524]

I found your podcasts a month ago. Putting as much as I can into action has been a real life changer. Thanks

[@justin.baer_]

Thank you very much for your work, Andrew Huberman!

[@NozomiChan-fy8gu]

Dr. Huberman, please accept my sincere appreciation of your continuous efforts regarding this podcast. I would never be able to approach the nonstop-evolving negative complexity of my life circumstances without the language base I primarily build with your unintentional involvement. English vocabulary by itself creates enormous barrier for post-graduates being marginalized by emigration. The use of it - is another level of an issue which explodes by frontal lobes impairment caused by spousal mistreatment and psychological abuse. If not for your consistency I would have no example of normality. No pattern of speech to measure my adequacy by on certain topics. Thank you. Please, be and do ..as you are 😊

[@KL-ni9ju]

Best part of Mondays

[@ethimself5064]

What causes a neurological blockage of the Stimulants for those with ADD/ADHD? apparently up to 20% of these people have this blockage. I have searched far and wide for many years and Zero. Thanks

[@keo1221]

I'm 5 years post injury, fainted and fell onto the back of my head. I look pretty normal until I'm not. can go from speaking normal to not finding words or getting them out, balance can get wonky if too tired or in a busy and loud environment. Thank you for talking about PPCS! It's not understood by most docs, and that goes for most neurologist s. Brain training has helped me relearn simple math, spelling and improve memory. You could devote an entire episode on mTBI, such as how age, number of previous TBIs, being female, hx of migraines all affect the rate of recovery. Thank you so much for all your good work.

[@TraciC23]

Thanks for this! I always appreciate neurology-based episodes. That said, I'd love to see an episode of how TBIs can affect vision and the treatments to fix the resulting issues (asking for a friend) and/or one on functional disorders, such as Functional Neurological and Functional Cognitive disorders. Thank you!

[@edrow7403]

As someone who is deeply interested in brain science and executive function in particular, I want to say how valuable this episode was to me. I will be revisiting it. Thanks to both Dr Hubermann and Dr D'Esposito!! 🎉

[@SD-kp6fj]

Thank you for making these podcasts available for those who simply want to learn. Your uploads are greatly appreciated Dr. Huberman.

[@user-kp7xg1yi6k]

Yes

[@adrianagiraldo9315]

Hubermondays💪🏽💜🧠. My Mondays have been FOREVER changed 🧠

[@kalebwilliams615]

I have been a subscriber for over a year and love your diligence and the thorough information you provide. A topic that is becoming increasingly relevant in our society is that of EDCs. I would love to see you do a full episode on Phthalates/BPAs and other Endocrine Disrupting Chemicals. I enjoyed Dr. Shanna Swan’s work on the subject matter and think many people would benefit from you giving it your time and attention!

[@ustreetuniverse]

Enormous thanks to Dr. Mark D'Esposito for validating Persistent Post-Concussion Syndrome & its devastating physical & psychological impacts (1:20:50). I'm at 3 yrs post-TBI & he is spot on re attitudes & lack of interventions for this invisible injury (not unlike Long Covid). We need more like Dr Mark in the field.

[@Gutwrenched]

I had a really bad concussion during college sports And physically I was fine but mentally I was messed up for about a year and a half very cloudy couldn’t think straight, my grades went down because I couldn’t keep focus. Sort of brought a lot of chaos or thought I was just being careless.

[@jentiforest424]

I definitely have symptoms of adhd and as I work from home I struggle with procrastination and focus. Since last year I've taken up spinning/running in the mornings and find it so much easier to jump into work when I get back on the mornings when I've exercised ❤

[@resistapathy]

Thank you for a useful comment.

[@anonymous-ds4ix]

I have put into practise. Your methodology in learning skills dr huberman, and i am grateful to you for all the amazing results .. thank u from the bottom of my heart

[@rcmunro22]

My mother just underwent a Brain Tumor removal for a Metastasized Lung Cancer that was in her right Frontal Lobe Cortex. Good timing, finding the information very interesting. The Neurology Team described the area as her personality center generically so learning all the nuances of what the Frontal Lobes do has been enlightening. Shes doing well now, I got her into a Clinical Trial with some of the latest technology, and shes doing quite well overall. Thank you Andrew & Mark for making information like this available to public so we can all grow a little wiser.

[@antonyliberopoulos933]

Thank you Dr. Huberman and Dr. D' Esposito, for offering this particular compilation of brain mechanisms. There was a wide variety of helpful pointers.

[@Photon-X]

I just started listening to your podcasts and I have never been so intrested in a podcast thx

[@Timelapse-so3hc]

Thank you so much for finally covering traumatic brain injury.

[@EN-yc4fw]

Dear Dr. Huberman, I have an immense respect for what you're doing. Could you please make a video on facial twitches, frequent blinking, making convulsive throat sounds, especially in children. What causes these when no ADHD, or Epilepsia or Tourette are diagnosed. How they can be cured both medically or, even better, with some behavioral routines. Is there a link between them and social media, devices and TV time? IS there an age when these twitches are particularly frequent? Maybe some supplements can be useful?

[@iamskaars]

My brain got healthier just seeing the notification of this episode 🔥

[@joannhood7478]

Nice!!😎😊

[@armablue7914]

Thank you for bringing Dr. Despacito to the podcast! Very excited

[@mariee.5912]

D'Esposito. 😂 Despacito means slow in Spanish.

[@armablue7914]

@@mariee.5912 I know, I was joking! But still a great episode.

[@mariee.5912]

@@armablue7914 I figured. 😆

[@TopHillsongWorshipPlaylist]

My wife is 8 months pregnant and as she was driving today, she got involved in a terrible head collision accident. Her car was pushed away 15 metres away while she was inside. I thank God she survived and the baby is okay. God is great.

[@Nibor.L]

This was an excellent podcast with Dr. D'Esposito. He was brilliant and his kindness came through the conversation and made listening very enjoyable. Some guests have an aggressive or angry tone voice or do not speak clearly and makes listening difficult. I have shared this podcast with my friends and colleagues. Thank you so much for ALL the wonderful podcasts you provide, A.H.!

[@JackTol]

Saw you live a few days ago in Sydney on Sunday. I just wanted to thank you for being such an amazing force for positivity and such an amazing science communicator. Loved the bit where you had to keep your word with Lex about crowd interaction and those jokes about the guy who yelled out “DMT” were great as well. Love your work, keep it up! Much love! ❤

[@quintinparks5534]

Thank you my friend, for helping us to understand ourselves as well as the world around us a little better.

[@dee468]

Wow, what an enlightening presentation. Thank you so much.

[@lucretiasulimay1968]

Morning 🌞✅, work out ✅ coffee ☕ listening to another amazing podcast between two incredible minds ✅ thank you, have a beautiful day 😊😊

[@fodilamra]

I'm really looking forward to this episode halfway through thank you 🙏

[@LostArchives-mk4mj]

Thank you sir for spreading knowledge! Love from India! 🇮🇳

[@abramisme]

Always a great day when Andrew uploads

[@susworld129]

After working shortly at a nursing home and visiting some very big Alzheimer's villages, I got it in my head that the movie 2001 from the mid 60's was the beginning of the, don't think I'm totally insane, the beginning of the Alzheimer's plan to get rid of older people along with their wisdom in a seemingly natural way. Alzheimer's does turn people into helpless newborn's, again. Also, thank you for all the time that you both put into this very informative, easy to understand conversation. It's maybe more relevant to humanities future than is imaginable.

[@philippkolligs964]

I’m a listener from Germany and I really love your Podcast. Thank you so much!

[@Dialektiker]

Great!, thank you. I love learning concrete information about how the brain works and which area is involved in different tasks.

[@pinkabubbles]

Hi Andrew, Can you do an episode on the science of social skills? Why some people don't have the ability to hold a conversation, read the room and why some people have charisma, lots of friends etc

[@silviyatotevska4518]

I am very thankful for this video. I have a son who has severe brain cells loss due to patalogical pregnancy and no body ever explained to me how his brain works and what should we work on to help his brain improve. That video is treasure to me. Thank you❤

[@JessePlessis]

I love to hear what the Huberman Lab would came up with if they did an episode on focal dystonia and related conditions ("the twists" for gymnasts or "the yips" for golfers etc.) ... a lot of musicians including myself would be super curious about best practices following a diagnosis because a lot of us are flying blind here. Love the show, love the guy, keep being awesome.

[@laurencipoletti8586]

Dr. Huberman, I appreciated the brief discussion on TBI and what occurs in the brain as a result of TBI. As a psychology doctoral resident practicing exclusively in neuropsychology, one thing I've noticed (at least in my geographical area) is the lack of communication and collaboration between psychology and neurology/neurobiology, etc. I would love to see a future episode on TBI/mTBI - in psychology, the literature I've read and the supervision I've received has largely said that an mTBI in a healthy child/adult does not and cannot cause any long-term cognitive problems, and any reported cognitive problems that occur 3-6 months or longer after an mTBI are somatic in nature. I would love to dig deeper into this and hear from experts in neurobiology/physiology whether these claims are supported or not, and it would be great to hear more about TBI/mTBI generally from the biological lens rather than from the psychological. These lectures greatly contribute to my overall understanding of health and wellness, and I'm excited to be able to use the information both personally and professionally. Thank you so much for doing these lectures for us!

[@olgazavilohhina6854]

¡Hola Profe!Another brilliant episode. Definitely one to rewatch. Thank You for all Your hard work.

[@dharmatycoon]

I read a couple of D'Espositos review papers & was pretty impressed by the work. Nice to see that he's such a pleasant & knowledgeable person in person as well!

[@leekyoverhere]

Love these intelligent and digestible conversations. I can tell you guys know your stuff because of how you're able to simplify communication and explain the connections. I love the brain talks

[@casrun1oleary410]

My diet, specifically cutting out sugar and processed foods have the biggest impact on my ability to have sustained focus and concentration. The minute I go back to a junk food diet I'm back to ocd, adhd like symptoms.

[@resistapathy]

Thank you for a useful comment.

[@cherylnathanodette]

Ouch, some painful conditions mentioned there, hope anyone struggling with memory loss are getting help. With so much to remember my head throbs, notes notes more notes, just remember to update any changes and watch they don't get moved or altered. Cheers both Dr. S.

[@rayah_v_dc]

Thank you so much for expanding public knowledge on brain health. I experienced a TBI in Nov 2018 and have been a prolonged recovery journey since then. Before the injury, I was an avid book reader and athlete. After it, I lost the ability to both run/dance, drive and read due to extreme nausea, fatigue and visual issues. Your podcast is one of the things that has kept me hopeful and motivated to stick with weekly neuroopthamology PT sessions. It’s taken over 5 years, but I can do 30 minutes of gentle yoga again, walk for 30 minutes , read in large print for 30-40 minutes and drive for short distances. I determined to return to my full capabilities again. Thank you again for all that you do-having free access to cutting edge research and science has been life saving for me.🙏🏽🙏🏽🙏🏽

[@xamarchild4994]

Thank you for all the free, and extremely resourceful information

[@user-qv4ze8zm4h]

Thanks for pointing out the primary problems in our sosciety with frontal lobe disease.

[@muhammadumarfarooq7487]

I'm deeply appreciative of the knowledge and insights you've shared through your work. It has been a beacon of positivity, guiding me away from a tumultuous sea of anxiety, fear, and countless sleepless nights. Your podcasts have been a transformative force in my life. I would be keen to hear your thoughts on managing allergies, as they are causing sleep deprivation and the subsequent haze of drowsiness from antihistamines. Despite having food allergies, my bloodwork does not indicate any intolerances. However, upon experimenting with supplements discussed by you in one of the pods, I've begun to suspect that my allergies might stem from poor gut health. I'm now on a quest to understand this better and would greatly value any in-depth insights you could offer on this matter.

[@csillatalamasz196]

Much appreciated the discussion about TBI; and as one delve deeper into the realm of paediatric TBI it becomes evident that the recovery process is considerably more complex than initially perceived. The phenomenon of the pruning brain attempting to regain functionality adds an extra layer of intricacy to the already complicated landscape of childhood TBIs.

[@user-qv4ze8zm4h]

It's amazing TBI which can be caused with just severe shakes can cause death or disability.

[@ramoned7580]

As a tbi victim i really appreciate this and the other work you do man!

[@Spinks345]

Thank you Andrew for the great content as usual, and thank you Mark for coming on the show. In future episodes, I would love to hear more about what your average person can do to improve working memory. The scientific dialogue is interesting, but for most people, it will be in one ear out the other. Practical actions that anyone can take, however, connected to easy to understand objectives, those tend to stick.

[@charles13773]

I'm loving mondays because of you ❤️

[@traceybutler5420]

I've said this before, you need to loop in Dr Paul Conti. Trauma changes the brain and I think we are missing a key aspect of decision making skills. How I interpret reality is completely different than I did before I discovered your podcast and Dr Conti. As Dr. Conti stated 95% of our behavior sit in our subconscious which is what drives our decision making. Each week I think you've done the best podcast and the next week it is more fascinating than last week. Thank you for all you do!

[@mymom9466]

Amazing and I haven’t even listened yet but I know it will be and it’s exactly what I need to understand more about! Thank you!

[@Anneepperson]

Thank you for this episode and really ALL of your work. I absolutely love your podcast and have become a stronger person in so many ways with your guidance through science. I would love an episode to discuss pediatric brain tumors (L1) focusing on regrowth, multiple surgeries and how this can stress the brain. What can a patient do to strengthen the brain even without major symptoms. Thank you!

[@shirintobie-paul3501]

Thank you Dr. Huberman, team, sponsors and supporters.☀ Thank you Dr. Mark D'Esposito.

[@Abhishek-zb3dp]

Thank you so much. Would love to see a discussion specific on how to keep your immune system strong!

[@silviamazariegos7976]

Ew.😮😃😀😶‍🌫️

[@MindNow]

The first song that popped up into my mind is Despacito 😅 Thank you Andrew for making the world a better place ❤

[@sonals2021]

Oh I'm glad I'm not the only one singing despacito 😂

[@Lucas-md4dz]

jajajajqja😅

[@yasminhussein7705]

omg same! hahahahaha

[@betsybarrett7987]

Would love an episode with Aida Habtezion MD on ulcerative colitis, specifically in teens , and best treatments for UC

[@will9482]

This podcast changed my life.

[@lynnettegipson9960]

I appreciate the ongoing education we get from your podcasts. Thank you for your efforts on our behalf. Not only do you present and clarify information to us well, your interviewing skills are also a talent that we benefit from. I am hoping some day you will interview Benjamin Bikman, Phd.

[@kellylambert9084]

Such an informative conversation with Dr. D'Esposito! And, I agree that Michael Merzenich deserves the Nobel for his innovation in the field of brain plasticity-based therapeutics!

[@Bill0102]

I can't get enough of this. I read a book with a similar topic, and I couldn't get enough of it. "Unlocking the Brain's Full Potential" by Alexander Sterling

[@appino210]

I moved from Kansas City (17 years there) to Barcelona 2.5 years ago and learning a new culture, language, friendships, and a city layout was like a nonstop firework show in my brain for months. I would encourage anyone to start a foreign language - not just on an app like Duolingo but watching tv in the language, trying it with a friend, or even getting a coach. My brain was working its best and converted into my business and other areas of my life. Ps I went from listening to zero of your stuff to now a top 2 show for me. You replaced two other podcasters! As a premium member, keep up the great work sir. -Jon Appino

[@neotrnty4717]

We dont care about you

[@ralphnasr8288]

Can you do an episode on Tinnitus as there are no significant studies on efficient treatments The realm of this condition stretches over far more than just ear health since mental health, psychosomatic symptoms and physical conditions are all part of it. Would be so helpful for us ❤🙏

[@IamEnergy20]

Yes I got tinnitus last month and since then I am hearing constant high pitched sound. I have one very imp exam in two months. I believe it's was because of using headphones all day. I hope they will make some helpful video about it.

[@bhvnraju8493]

Interesting medical conversation, Thanks to both of you for sharing and making us to understand 🙏🙏

[@jessicalunacampos4044]

Amazing conversation, thank you 🙏

[@emirflows]

Hi, Andrew. Firstly, thank you for your amazing work. Your podcast has become one of three podcasts that I listen to every week. Secondly, I wanted to make two episode requests: 1) An episode/series on diet/nutrition that dives into the various diets (omnivore, vegetarian, vegan), what people should consider if they fall into each of those categories (e.g. vegans need to supplement with Vitamin B12) as well as a deep dive into hotly debated foods such as eggs, dairy and red meat; and 2) An episode (or even a video) on what a typical day looks like for you, including what you eat, what you supplement with and your routines/rituals. Thank you

[@dawiser1]

I think both of these have been done already

[@mariepierreski]

An episode on overgrowth of Candida would be amazing. ❤

[@telleray]

Hi Dr Huberman - as per other comments, a massive thank you to all the work, you and your team do on the pod. It really is of massive benefit! I’ve been a listener since the early days, and I’ve gone through all your prior pods. I don’t think there is one on connective tissue (ligaments/tendons), and associated issues such as tendinitis et cetera. If you are able to cover this at some point, it would be absolutely amazing!

[@fpbuenosaires]

Dr. D'Esposito's is again an excellent informative podcast. My question is on the dyslexic brain. Is how does it relate to the average brain in relation to the topics covered such as modularity, concentration, and so on. Please consider a podcast on dyslexia, the neurological differences (pros and cons), and how to address them. Thank you again for your fantastic podcast.

[@PaolaVillalba-zi5ck]

Thank you Dr Desposito and Dr Huberman! Great episode. I was delighted that mindfulness was mentioned. Can we please get a podcast about mindfulness ? ❤️

[@GulyasKata]

Only heard the intro but I love this episode already.

[@beverlyhillsdentist]

Dr. Huberman, thank you for your hard work! My son is on the autism spectrum and loves waking up to your nsdr 10 minute recording every morning. It would also be nice to listen to an expert and find out what the resources are for high functioning autistic young adults so that they can prosper and become a part of society and contribute to it. We, parents struggle with this everyday…(Hope you read this) thank you :)

[@kam8837]

Thank you for giving us the precious knowledge. Please make an episode on bad breath/halitosis and how to get rid of it 😢

[@forestman8729]

Hello Andrew I have learned a tremendous amount from your videos, i work in the healthcare sector myself and have been able to improve my own life and those of many people through your knowledge. Thank you very much for that! Caring for a patient who suffers massively from HPPD syndrome, unfortunately it is still fairly unexplored. It would be great to see a video from you about this syndrome that many people suffer from. Thank you very much and greetings from Switzerland

[@user-kp7xg1yi6k]

Dopamine Nation is an incredible book. I am two-thirds through reading, and hopefully, I will finish tonight 🌙

[@court8420]

Wow such a great talk! Thank you both.

[@user-rs1yb1ej1e]

love this podcast

[@rainingheavily1]

I haven't watched the entire video yet but I found this helpful to everyone, many thanks for sharing such interesting information.

[@amslb6487]

Hello ! First of all I would like to thank you for your dedication to making science accessible and for the tremendous impact your work has on those eager to expand their understanding of the world. Secondly I would love to hear Jessie Inchauspé on your podcast. She is a biochemist at the origin of the glucose revolution. Also known as glucose goddess on the social network. I look forward to continuing to learn from your podcasts!

[@dr.vijaiyalakshimipraveen3590]

I had always been watching and ogling at the morning Sun with my cup of tea. It's my thing from childhood as I grew up in a government quarters that faces the beach in one of the French colonies in southern India. It's a habit now and I am married to another beach city while being so fortunate to have a beautiful terrace with a lovely garden that's facing the east! It makes me feel so grateful to listen to you stress the importance of watching morning Sun each & every podcast. My Q is that - these days while watching my morning Sun, I also see your face and hear your voice 😅😂. Is that okay? and are you okay with that?

[@SabrinaAngel]

Thank you, gentlemen 👏

[@nataliarudenko8709]

As always - very interesting and inspiring! Thank you!

[@user-ok1xq5qm9t]

Best channel on youtube. Thank you, Andrew

[@everyonesalama4447]

Thanks again for another awesome show

[@clementohadi8682]

Please do an episode on the most frightening experience the human consciousness can go through : DEPERSONALIZATION/DEREALIZATION DISORDER

[@austinsimpson2265]

Excellent topic and guest. It could be helpful to have a neuropsychologist come on the podcast for topics such as this given that we receive specialized education and training in brain-behavioral relationships, with a particular emphasis on cognitive and emotional functioning. We also are trained in both assessment and treatment (cognitive rehabilitation, therapy), as well as functional neuroanatomy, hence there may be an opportunity to have both a more nuanced and comprehensive discussion about various cognitive disorders and their behavioral manifestations. We often work closely with neurologists and other providers to assist with differential diagnosis, monitoring cognition over time, and provide treatment recommendations. I know for a fact that your podcast immensely enhances my practice as well as many other neuropsychologists I know, so THANK YOU!

[@versia-sebja]

I met bromcriptin only in purulent surgery to inhibit lactation by mastitis, and i can say patients were not inspired of this treatment because of side effects. You know, i am also very engaged into idea to improve neuroplasticity easy and safe. Now i think it is possible to do without psychedelics, only with use of mental exercises. Sure i want firstly check all possibilities we have, and particularly is it mix of different practice from "west" and "east" neuroscience, but i think it is really something important. My english is not enough good to discuss it yet, but i work on it. Thank you for great job! And sorry for mistakes:)

[@Jaaaaaaaaaaaaaaaaaaaaz]

Hello Andrew this Jasmine your faithful listeners from Paris. Many thanks for your informative and enlightening podcasts-being very skeptical about all the crazy information found on the internet, I would really like to have serious and reliable information on vitamin D. Merci d’avance 👍