Dr. Paul Offit Answers Our COVID Vaccine Questions

[@jdgower1]

This kinda stuff is hella useful for those of us who are interested more in science than punditry. Thank you.

[@1janelaf]

@Madasin ! interesting response. I'm one of the people that have horrific reactions to shots.

[@wendysimonetti4931]

I would love to get information regarding the safety of the vaccine for people who have auto immune disorders such as rheumatoid arthritis and lupus. Thank you

[@paulastorlie8438]

It is scary with autoimmune disorders. You just don't know how your body is going to react or hyper react. I have an autoimmune disorder. I took the first dose of pfizer. Time will tell. I did join the pfizer reporting option so hopefully if my body over reacts I will have a another place to report the side effect.

[@boonwarner]

I just wanted to point out that under the PREP act we are experiencing a public health emergency and the CARES act extends the PREP act to include Covid-19 which protects Pharmaceutical companies granting them liability immunity

[@Gangsta0wns456]

Zdogg is such a great science communicator. He always asks great questions. Keep it up, man!

[@RosyOutlook2]

Shills are so wonderful eh.

[@paulaarizona9108]

Agreed - he is genius in paraphrasing what his guests say and then asking them if what he said was accurate. This is incredibly helpful for science-interested folks like me.

[@EchadLevShtim]

So Brilliant that its too complicated to realize Vaxx are full of deadly Neurotoxic chemicals. You have to believe the LIE to support the Zdogg narrative.

[@Flutterby406]

@@EchadLevShtim thank you for being smart enough to see through his lies!! I wonder how much dog gets paid to lie to the American public about these kill shots

[@EchadLevShtim]

@@Flutterby406 He needs unrelentless trolling. This is someone who's ignorance is hurting real lives.

[@c5jp904]

The most important thing I heard was “I/we don’t know”. Because the one thing I’ve realized over the past 9 months is...nobody knows shit. Great podcast!

[@johngault8688]

We don't really know anything. The only things we really know is what we've convinced ourselves of. 30-years ago we knew a lot of "scientific facts", which have been disproven today. What facts will be changed in the next 30 years?

[@SDGreg]

@@johngault8688 I think you are confusing Scientific Facts with Theories or Hypothesis.

[@1janelaf]

C5 JP, we know more than we did however, the Chinese hate we Americans except for the ones that leave that God forsaken country and come here. They probably already have a vaccine & would see us die due to Covid or by financial ruin.

[@johngault8688]

@@SDGreg That's what I meant by, "The only things we really know is what we've convinced ourselves of...". Virtually everything we "know" is nothing but theories and hypotheses, but so many pass them off as fact. And then you got the issue of something being one thing to one observer, but a completely other thing to another observer. My head's going to explode... ;>)

[@Flutterby406]

@@johngault8688 I believe you're on the right track because vaccines kill

[@user-sh4sm9hw7k]

My concern is possible long-term effects, especially for children. How would we know if there's a side effect seen months to years after vaccination if we're only looking at two to three months of data?

[@MrShawn2526]

Long term effects from getting COVID and getting gravely ill are far more devastating in my humble opinion

[@user-sh4sm9hw7k]

@@MrShawn2526 Zdog asked a question about the effects on young people at 37:00 and he dodged that question. How common, or rare are these damaging effects on young people? I'd love to be able to compare the likelihood of possible long-term damage to my kids from covid vs a vaccine with no long-term studies with children.

[@alainacarroll1234]

@@user-sh4sm9hw7k I don't think he dodged the question because he's trying to be shady or underhanded.. It just literally hasn't been studied in children yet so there is literally 0 data for him to go off of and an assumption on something so sensitive would be irresponsible. To answer the question for adults, from my VERY basic understanding (with absolutely 0 formal education in medicine or even complex science so I could be far off) these lipids and compounds that are being used in most of the make up of these vaccines have been used many times and studied for decades this is just the first time they have been able to put the messenger RNA into it effectively to actually generate an immune response before your body metabolized the effective part of the vaccine. At the very beginning for the show he said something along the line of "all adverse events occur in the first 8 weeks." Again, I could be wrong. I have no real knowledge, this has just been my understanding of it after doing my own informal research and data collection. Your question is 100% valid though.

[@user-sh4sm9hw7k]

@@alainacarroll1234 we're a year into this pandemic and don't have any studies looking at rate of these long haulers? Not trying to be snarky.

[@alainacarroll1234]

@@user-sh4sm9hw7k maybe I misunderstood the question. I thought you were referring to long term effects of the vaccine not covid itself. I think it's so new and everyone has such different outcomes for everyone including the long haulers, it isn't fully understood. Not only that, I think right now much of the focus in the most brilliant minds in medicine are trying to do their best to find a way to stop or at least slow down the virus. I don't know that they have been able to do such in depth research on the long haulers. And from what knowledge we do have on the long haulers are that even months into this they're still suffering and only time will tell.

[@margiejcupcakeprincess4711]

I am 70 and have DJD and Fibromyalgia and after this information I will be taking the vaccine 💉 if available to us meaning my hubby too. Thank you again and I am a retired RN of 30 active years so I am blessed to be able to understand the information but still totally amazed at you two and your ability to remember all this. Wow 😳

[@andytunnicliffe7223]

Blessed 🤮

[@thor9563]

Houses catch fire and burn. FIRE HOSES must be employed, reactively dumping mega gallons of water onto homes, destroying many things in order to save lives, the house and most of its contents. Fire Prevention is a Lifestyle of many proactive behaviors, practices of PREVENTION in order to eliminate the hazards of fire that can quickly spread and bring destruction and death. FIRE HOSE: Vaccination. Reactive. Gets the job done, with some risk of potential damage. Behavior change not required. PREVENTION: Proactive. Proven therapies Behaviors AND policies that promote the health of the Human Biome. Good for the body, good for Humanity. BOTH have a place in our world. Peace and Love to all.

[@lucille_3]

You both really are saving lives by speaking about the science. People will be more informed and make informed decisions leading to lives being saved.

[@David-oe1xj]

Thks Doc. I believe in ur science. My 92 yr old father is watching

[@kathytaylor3673]

Stop believing everything you hear. Research past vaccines. OMG

[@nancymueller6206]

@@kathytaylor3673 was that research “past” vaccines as in those vaccines in the past or “past” vaccines as in research beyond vaccines?

[@theferaltaint5065]

Yep that was my concern. Larger viral load exposures will quite possibly render this vaccine more or less inept, and the patients who get very sick are often times exposed to very high viral loads. Viral replication overwhelms lymphocyte production and drives it into the damn ground as the underlying cytokine storm gets brewing. Sure, this may help speed up the immune response in a small population group just enough to keep them out of hospitals, but it could also mask the symptoms that would drive a declining patient to the hospital in a timely manner. If you skip from infection directly to mRNA that is coded specifically for sars-cov-2, you will of course reduce the length and severity of body aches, fever, etc. in those who are still going to get very sick-at least initially. And if this doesn’t prevent infection/spread, I’m not sure what we are truly accomplishing if most people are going to do fine when they get infected. We need to be focused on how the hell we are going to keep people out of the hospital, and that’s not going to come from something that doesn’t actually prevent infection/spread. I also wish we could focus more heavily on using machine learning to study ways to fight back against this on the front lines. A vaccine is all well and good, but what we really need people focused on is the worst of the problem: the patients that get ridiculously sick due to comorbidities, age, genetics, or some other unknown factor filling up our hospitals so fast we can’t treat them and everyone else. We need something that can stop these storms or at least something we can prophylactically threat patients with early in the end of phase 1 or early in phase 2 that will slow cytokine production. The immune response, not the virus per say, is what is burning us out on the frontlines. I just don’t think a vaccine is a viable solution the immediate problem right now, but that could be my emergency department mindset bias. To me, focusing on a vaccine is like focusing on finding the perfect harmony of vent settings while your patient is crashing and you haven’t even dropped a tube yet. Fuck the vent settings. In the war against COVID, need medical science equivalent of dropping a 7.5 ET tube on an acute respiratory failure and bagging until we can get them stable. We need shorten hospital length of stay. We need to keep patients off AVAPS and High-Flow. We need to keep them out of the ICU (well now just filling up the ER with ICU patients). I don’t see how this is going to do shit about that other than fill people with a lot of false hope and make them even more reckless than they are already. “I’m vaccinated so I’m immune.” Now bring forth the “bullet proof” army of asymptotic spreaders. It’s setting us up for another misguided mission accomplished moment, and we are all already exhausted.

[@missmeggie6461]

I agree with you 1000% Well said. ✌️👏👏

[@KrustyOhh]

I think we have to trust that a sufficient population has already developed minimal adequate memory T cell capacity. The unknown and real elephant in the room is the immune capacity development that was undocumented from initial virus infection (some time in fall 2019) through to initial serious global lockdown policy (April 2020). We can’t forget this virus spread unchecked for at least 3 months to half a year without any significant mortality rate increase, and until it breached senior home installations.

[@missmeggie6461]

@@KrustyOhh 🙏 THANKYOU Oh and Paul Offit...your an effing criminal 😤

[@moondustgirl2132]

Dr. Paul mentioned about herd immunity being achieved only through vaccines. What about the 1918 Spanish Flu pandemic though?

[@christineritchie8014]

i'm a nurse in a SNF and don't want to be forced to take a new vaccine. Im not an anti vaxxer but my physician friend's won't take it until it's been given for at least 6-12 months.

[@Bl6jdbdhdn]

@DM584 way to treat a “healthcare hero.” A-hole.

[@michelle.l.b.]

@DM584 excuse me? Who the f**k do you think you are? We have no idea yet if the vaccine is safe and you're telling healthcare workers what to do?! GTFO.

[@samanthachan1176]

@DM584 I too am a health care worker and would never speak to my peers the way you did. Prevention of infection shld be the critical endpoint for these vaccines but none of the leading candidates require prevention as their endpoints for success...at most it will only reduce the severity of infection. I've already be infected back in March and the only symptoms I've experienced is a mild fever for half a day. If people are lining up for them, by all means, but why should anyone who is not wanting to get it be subjected to this ongoing trial?

[@samanthachan1176]

@DM584 www.ncbi.nlm.nih.gov/pmc/articles/PMC1119465/ if you want to place your faith in a pharm company that could do this to human life...by all means, jab away. I rather listen to fellow physicians working in the frontline. kzbin.info/www/bejne/iqKbhIuFd95gatk btw, you sound like every other virtue signalling narcissist who thinks wearing a mask driving in a car and posting black images on social media makes you a "good" person

[@rebeccashields9626]

@DM584 this vaccine has only been given to 20,000-30,000 people for 2 months. Being healthily skeptical isn’t unreasonable. I am a front line nurse and am willing to get it but I won’t have my kids get it for a few years and once a few million people have had it. Don’t be a dick.

[@lastscout1607]

My concern is for longterm effects. Not short term acute concerns. Fertility, autism, effects on children etc

[@docreber]

I've watched so many virology videos and hands down, this was the most informative video I have ever watched. Awesome job . Loved your Q&A. Gonna go edit some of my previous social media posts now.

[@chrismahl9369]

My question as a person who has an autoimmune disease (Hashimoto) my question is whether this vaccine with its “brand new mRNA mechanism” might cause even more autoimmune problems in people who already have autoimmune problems? PS. I’m an nurse who is NOT an antivaxer, but I do have trepidation about this brand new technology coming out so quickly

[@bestbandari]

Excellent question.

[@terrihop8880]

Hearing this information is very reassuring! Thank you Dr. Z! 👍🏻

[@maljones6308]

Geat video but really disturbing - You have to keep wearing masks and socially distancing even if you have had the vaccine... I understand the arguments but surely we have, at some point, got to return to some semblence of normal society - How long is that going to take? How long can Govt's keep spending money at the current rate?

[@ZDoggMD]

Hi Mal, I FEEL YOU ON THIS! As we get more vaccine data on efficacy of preventing transmission etc and the case numbers drop, I'm pretty confident we'll get back to a semblance of normal soon. There is an end point in sight so don't despair!

[@TheMomseloc]

Dude. You got a reply from the man himself. Awesome!

[@maljones6308]

@@ZDoggMD Thanks for the reply my friend. I totally agree that we need more vaccine data on efficacy of preventing transmission. It is such a shame that Pfizer and Morderna (as I understand it) only tested people in the trial for Covid if they self-reported symptoms. It would have been so much more informative if they had tested the total population in the trial for Covid every week. I'd have been especially interested in seeing how the numbers for asymptomatic positives in the placebo group compared with the vaccine group. That would have told us so much more about the spread of the disease.

[@4everyoung24]

May be a dumb question but if we can still spread it after vaccination, how will this help tamp down the disease?

[@haydukethor]

because if most people are vaccinated even if exposed they wont get really sick. It's not clear or established if you can shed the virus even if vaccinated. The answer is "we dont know". Thats why its so important for all of us to get vaccinated.

[@lawanam7201]

Is there any research shown public yet on the possibility of the vaccine causing excessive flares in patients with autoimmune conditions? I know some people along with the typical immune response from even the flu vaccine can also have a flare triggered; so with this vaccine possibly triggering a LARGER immune response is there concern for those patients to possibly go into flares?

[@r0sal3sr]

What are the effects of cells uptaking this additional mRNA and being hijacked to produce the target antigen proteins. Premature apoptosis? On what scale?

[@Naomi-br7rh]

I am also thinking about this. If the protein is presented on the surface of the cells which it is produced in, won't this initiate attack from T killer cells and apoptosis? Does anyone know about this or whether it is relevant, I am very interested!

[@candlestick8880]

@@Naomi-br7rh Also are any of these surface proteins making it away from the injection site? I wouldn't want my immune system killing neurons or something less renewable...

[@Naomi-br7rh]

@@candlestick8880 I have only basic knowledge of immunology so may not be correct, however my first thought to this was that they probably cannot cross the BBB. Anyways, I have looked it up and they can - "memory T cells can cross the non-inflamed BBB or BCSFB using specific molecular keys and gain access to the cerebrospinal fluid (CSF) drained ventricular, subarachnoidal and perivascular spaces. If these pioneer T cells encounter their specific antigen on antigen presenting cells strategically localized immediately behind the brain barriers, reactivation of the T cells will trigger a local inflammatory response, leading to the stimulation of the BBB. The activated BBB will then provide novel traffic signals allowing for the entry of large numbers of circulating inflammatory cells into the perivascular spaces and finally across the glia limitans into the CNS parenchyma, where they progress to initiate tissue injury." source: www.researchgate.net/publication/227715130_T_cell_migration_into_the_central_nervous_system_during_health_and_disease_Different_molecular_keys_allow_access_to_different_central_nervous_system_compartments

[@Vingalinga]

It would elicit an immune response that could indeed be CD8 T cell mediated. However this would obviously not cause systemic apoptosis and would only effect the local mRNA infected cell

[@Vingalinga]

@@candlestick8880 that's not really how it works.

[@Maddie9185]

I am always optimistic, it’s better than being a pessimist.

[@hugomaritz692]

Some research indicates it's about equal.

[@user-sh4sm9hw7k]

28:30 how did SARS-COV-1 and MERS disappear without a vaccine?

[@LoanwordEggcorn]

Mostly aggressive quarrantining and isolation, as China did with SARS-2.

[@RyanHellyer]

He was referring to wide spread diseases and wiping them out by allowing them to spread. I think a better comparison are the flu strains that come through on a regular basis, then just disappear.

[@stephenoleary925]

Sars 1 never got beyond a few thousand people, and it wasn't as easy to spread because you didn't start shedding virus till you were symptomatic, so much easier to spot people before the spread it, sars covid2 is spread by presymptomatic people also.

[@thehotgates1424]

They're not exactly sure what happened to SARS-CoV-1. Most likely it mutated to the point where it's still circulating, but is now asymptomatic (Dr Carl Heneghan): kzbin.info/www/bejne/bGaunX-ubLagZrM

[@TheMomseloc]

MERS has not disappeared. The vaccine for SARS1 wasn't pushed because it went away. This is the lesson learned. The SARS1 vaccine should have gone forward and everybody should have gotten it because then we wouldn't be facing SARS2. We need this vaccine so we can be ready for SARS3.

[@m-at-the-w142]

As an RN, I feel it is prudent to maintain my skepticism toward all things not yet proven. But being a skeptic is not about blindly rejecting everything that is presented to you, it is simply about not blindly accepting everything that is presented to you. What was presented to me, in this video, was a thoughtful conversation that included some really good (and just as importantly, honest) questions, accompanied by what I thought were very good, honest answers. I especially appreciated Dr. Z's incorporation of sone contrarian questions that I myself would have asked. I also appreciated the thoughtful and honest responses to those questions. Amazing video.

[@syjwg]

Good questions! Watching this two years later and the answers from Paul was probably his knowledge at that time.

[@junyuzhang414]

How do u measure efficacy ? Is it just by the ab titer ? R the subjects exposed to COVID positive patients ? How does the social distancing might confound the efficacy if we r doing that on top of the vaccine ?thanks !

[@denisefallin8042]

I wondered too. I'm guessing that info will be in report that's going to be avail to public dec 8

[@michaelnamisnak6149]

Comparing a large enough population that is equally matched and make sure the statistics flush this out. Can’t expose people purposely as that is not ethical.

[@wendysimonetti4931]

Thank you so much Paula for responding! I would be interested in knowing if you have a response as well.!

[@JoshuaPaulKing]

Thank you so much for the content. Very honest and applicable. This video will make a difference.

[@kathrynsavage4121]

Thanks Dr. Z for bringing common sense to this. One concern I have is whether there is evidence in the trials that would indicate safety for people with underlying health issues that would tend to increase risk for serious illness if they are infected with the virus?

[@maxine7861]

Offit skirted the question about auto immune, looking away, distracting from it... and also dismissed man vs woman immune response question. That definitely made me concerned... All his other answers were stated with direct eye contact and with conviction. Overall great video and thank you

[@dacisky]

Thank you for bringing him back. Excellent program!

[@candlestick8880]

I will get this vaccine. I still am concerned: How do we know these mRNA/lipid nanoparticles won't get to remote sites? I'm certain most of the vaccine will remain at the injection site but how many particles would have to be taken up by a neuron or cardiomyocyte to be attacked by T cells? Or a fluke injection into a vein? Each cell in the body would only see a couple particles but how many spike proteins does a cell have to express before an important cell is killed?

[@CCB249]

This is one of the most interesting discussions I have heard all year. Thank you for this discussion.

[@gingerinthedesertcreations]

My friend who's in the trials had the same reaction when she started feeling awful.

[@markmunyui]

Curious what else your friend said about the experience

[@lindsayball7299]

Has she since caught covid? There is talk on pathogenic priming so you get sick when meet the virus in real life.

[@TheMomseloc]

Sounds like she was ruminating.

[@ginaragone7035]

@@lindsayball7299 I think they addressed that; didn't call it pathogenic priming but addressed it....I've watched three of these zdogg videos in a row though, so I might be confused.

[@rhondablake3283]

I am not in the medical field so I look to people who are . I stumbled on your sight about a year ago purely by accident and continued to watch and I am so thankful I did. Thank you for being that Dr. The one who is honest, trustworthy and one who I feel has his stuff together. I will be taking the vaccine with no worries and so will my family. Thank you for helping people like me understand and to all the Scientists who worked on this vaccine.

[@TheXev]

An important question a friend of mine is asking that I would be interested to know more about if possible: If COVID is mutating fast, does this RNA style vaccine help against different strains, or do we need to produce a different vaccine at a fast rate to try and stop this?

[@anirudhsilai5790]

Really interesting and insightful! Dr. Offit might be your best guest of all time

[@francesco5581]

ZDoggMD you should make an interview to Zach Bush MD. A different point of view of the whole situation (totally 100% scientific) .

[@dystoniaify]

What type of MD? Not trying to be sparky. Genuinely curious. I looked but can't figure out if alternative medicine, osteopath, or similar or ìf medical

[@dystoniaify]

Found my answer. Not saying I don't believe in his approach, but not a comparison that would convince this audience. There's plenty of quotes from moderna,Pfizer, and MSM approved doctors who clearly say they have zero idea about long term safety. Also, look at the forbes article i posted in the comments. Whether right or not doctors like the one you mentioned hold less weight in the public's minds.

[@francesco5581]

@@dystoniaify Why ? he is totally for a bigger approach to the problem and he is one of the best scientific minds . I dont agree 100% with what he says but would be nice to hear 2 different opinions that debate . I like a lot zzdogg but sometimes he is too much "hey guys trush science , we know and you dont" , BUT science is formed by 1000000 different opinions and theories itself . Basically Zach Bush says that viruses like that one are a product of a stressed earth, the more we get vaccines and artificial things the more we detach us from earth biome and virome causing worst effects in the long run (i am dumbing it down a lot !!). And his approach is 100% scientific nothing "alternative new age" .

[@FlawedSociety]

Question: so he metioned the need to form Memory B & T cells, I am on Ocrevus, a Multiple Sclerosis infusion that depletes your B-Cells to help prevent it from attacking your mylin sheathing. Does this mean if you deplete your B-Cells will you not form Memory B-cells? Is my MS infuion going to counter act the vacine?

[@BrauckMan]

That is a great point, my wife is on the same treatment. I think we have an appointment with her neurologist later this month. Will definitely ask this.

[@robbjr7879]

My understanding is that Ocrevus and other monoclonal antibodies which are anti CD20 (a protein expressed on most B cells) do prevent most patients from developing antibodies in response to a vaccine. One paper I read found that some patients do develop some degree of immunity with vaccines but that it was dependent on the timing of the infusion and the amount of antibodies was less than control and methotrexate patents. It's definitely worth talking to your doctor about it though, I think there would still be a benefit to getting the vaccine.

[@Garfinkel64]

No liability for the vaccine makers. Have either one of you seen a consent form for this vaccine?

[@ashleymarie6682]

Excellent easy to understand explanation. Thanks for posting this.

[@AmandaBrookhaus]

Better PR team for the immune system! Yes! That's actually what I tell my patients - the response is good because it means it is working! =)

[@michellereid3571]

That's my theory. I'm a nurse and have stared covid in the face. And after 12 years of nursing I trust my body more than these scientists who thing a 2 month study means it's safe.

[@Kevsweets]

Thank you Z & Paul!!! ❤

[@apalparikh3299]

Awesome. To the point. All right questions and excellent answers

[@pirateslife4me]

Dr Z, I've followed you and shared you gladly through all the Coronadventures. I joined the hero registry but was never contacted to trial a vaccine. I contracted covid myself the third week in October and have since cleared it, tested positive for the antibodies and test negative for the antigen on the many tests I must now take, choice weekly, to get into nursing homes to do my hospice RN work. My question: by taking the Pfizer or Moderna MRNA vaccines are we not essentially becoming third phase trial participants? I've heard you say you do not want to take the vaccine yet and you will let us know when you do. I have also read I cannot take the vaccine if I have had the virus itself. I appreciate you and your work!🧫🧬🧪🔬

[@soodabehzolfaghari5482]

The question i gave is if cytokine storm is the response to virus’s spike protein , then theoretically making spike protein could lead to cytokine storm?

[@erikgroves5814]

Theoretically, but not practically. Part of the cytokine storm is the runaway production of the protein due to rapid viral replication, but in this case, you don't get that out of control protein proliferation because you don't have the underlying virus driving it. I think it was in one of the earlier videos on mRNA vaccines, where it mentioned that you wanted to maintain the delicacy of the mRNA so that it could produce direct the cells to produce enough protein to generate the immune response, but not enough to generate something like a cytokine storm. The protein production due to the mRNA instruction is more like an event not a recurring process.

[@toddklopfer5258]

I really hope a lot of people watch this video with an open mind. This has really helped me understand vaccines and the particulars of Covid 19. I am not a scientist and often the technical stuff just confuses me. I think I got about 90% of this subject. Please people share this video.

[@sharonc8138]

Not sure if you had him on your show yet but can you speak with Dr Marik about his MATH + protocol.

[@juandp8265]

Could you link the studies about fever and vaccines response? Thanks

[@---Joy---]

Very informative. Ty both for doing this. More plz.

[@paulineprojectlove]

This was a BRILLIANT INTERVIEW!! Encouraging, educational, and even funny!

[@Hhh842]

Are there any contraindications to receiving the COVID vaccine? Thanks for all you do Zdogg

[@chriswithersphotography]

Did you go live or edit this first? You should ask your zoom guests to record a better quality of audio from their smart phone and send it to you to sync up to the video. Would be nice to hear them more clearly.

[@geo-wi4tv]

This is a great conversation! really helps people to feel reassured when they will get vaccinated!

[@traceyjohnson822]

Daughter had Guillain Barre in 2017. Are any of the vaccinations being studied in people with this history? Would love to hear if vaccination is possible. Thank you for helping us keep informed.

[@englishfrog]

The one question that immediately springs to mind, given that the regulatory meeting is right around the corner. Have Pfizer and Moderna been allowed to redact data out of what is being provided to regulators? As an example information on those who drop out of the trials......basically will regulators see EVERYTHING or will the Pharma Cos be able to withhold information under the guise of it being to protect business interests.

[@paddykiernanmusic]

I'm reading Ben Goldacres "Bad Pharma" at the moment and he brings that up a lot.

[@TheMomseloc]

I find it compelling that people make comments and ask questions prior to listening to the entire video. I wonder. Have any of these people ever attended a lecture? you don't raise your hand until the lecture is completed

[@heidimay5629]

Please answer. If a person is infected and have a symptom of loss of taste are those the persons that are more likely to have vascular disease then those that were infected and didn't have that symptom?

[@Coffee_Lover-s8n]

Can you tell me about the efficacy of Moderna vaccine?

[@margiejcupcakeprincess4711]

I am always amazed that people are so fast to believe quacks and yet do not believe our brilliant professionals.

[@dwphl1953]

Thanks for this informative discussion. This is great stuff and a real public service. I also have followed Dr Yo on KZbin since the beginning of this and he has interviewed many researchers who are active in the autoimmune response. One of these guys is Dr Bruce Patterson who has studied the cytokine response for several decades. I encourage you to take a look at his work. Thanks again. Stay safe.

[@kimbers1238]

I would love to know how the testing worked. I know of someone who was in the trial and they gave him either the vaccine or placebo. And then just lived life normally. He is a young man. So how would they know if it worked? Maybe he didn't even come into contact with covid

[@carl13579]

True, but that's the beauty of a double blind trial. The percentage of people who didn't come in contact with covid will be the same in both groups.

[@yes_that_dolly]

They know it worked because they look at what happened in the big groups. Suppose 10,000 people got the vaccine and 10,000 people got a placebo. After two months, suppose 100 people in the placebo group got sick, and only 5 people in the vaccine group got sick. Now, if the vaccine did nothing and was ineffective, you’d see about 100 sicknesses in that group too. The groups would be about the same if the vaccine did nothing, right? But in this example, out of 100 potential sicknesses (if it had done nothing) the vaccine prevented about 95, because you only saw 5 sicknesses. You’d say it was about 95% effective.

[@WellnessHacker]

I think his point is, it’s pretty easy to manipulate the outcome. What if more people were “younger” or healthier in the control group....? This is NOT an exact science, unless it is, but in this case, it can’t be because of exactly what he is saying. And we have seen NONE of the data yet to tell us how young people were, how healthy, where they lived.... etc etc, so we can discern how accurate this seems. Also, some of the answer are so subjective, like group a got “very sick” v. Less “sick” in the vaccine group... that seems easily manipulated until we see real data.

[@lindsayball7299]

Exactly, not many under 60 without comorbidities develop bad disease.

[@robinstanley6008]

I had 36 hours of flu-like symptoms that sent me to bed after my 2nd pneumonia vaccine. My doc's response :' Oh great! You had a strong immune response'. 😍

[@Tobie44]

So how long do you think we’ll have to keep wearing masks and social distance after vaccinations start? The

[@Rhythmsonido]

These vaccines if they are safe and they work will have to be taken frequently or as frequently as the virus mutates. The mask mandate and closures had probable good intentions before becoming a political, economic, and medical mess. So the virus is here to stay. What do you suppose is the real solution? It ain't the vaccine...

[@tonyv3427]

All elected officials and medical establishment people should forfeit their paychecks until businesses are allowed to fully open.

[@lauraanderson7358]

the ends justify the means ???????????????????????/ since when ??????????????????????????/ :(

[@justingrannell8271]

Thanks Dr. Z. This is the best interview on vaccines that I have seen. Answers a lot of very important questions. As a family medicine physician I am very curious as to what your thoughts are on the following: if you have 50 million doses of a vaccine given the severity of the pandemic wouldn’t it be better to vaccinate 50 million people once and then worry about their second booster dose later as opposed to vaccinating 25 million people with both vaccines? I know that’s not the way it was studied but in theory I feel like we would start to see improvement in numbers sooner by going about it that way.

[@ZDoggMD]

Hi Justin, Paul mentioned that they'll review the data on the immune response from a single dose in the large phase 3 trial; if the response isn't good enough, then single dose may not have enough effect to be useful. But the opposite may be true as well.

[@justingrannell8271]

@@ZDoggMD Yeah, I completely understand that, however I’m not saying that a one dose wouldn’t necessarily be optimal but my question is really more geared towards whether or not it would be better to get double the amount of people their first dose and get the second one maybe 2 to 3 months later as opposed to only vaccinating half the amount of people with both doses. Again during this pandemic my main thought was hey, we have 50 million doses: let’s get 50 million people their first shot just to get a jump on things and finish them up with their second shot later as opposed to just completely vaccinating half that amount of people with current studied 2 dose regimen.

[@supersosiska]

In other words: I'm partly not worried that I'd die from that virus. I'm more worried I won't die from the virus... 😯

[@RavishingSailor]

Pretty much makes sense. Get this virus and probably live but there is a 0.001% that you can die, however if you live, you’ll have to deal with a pandemic that is real however came about out of shady business and so on. It’s wonderful seeing scientist work their asses off to help humanity. What’s more interesting and independent from science are the billions that will be made and how Amazon, target, Walmart, McDonald’s have actually had massive profits during this pandemic but joe shmo has been put out of business.

[@twingrandmasreadstories2404]

Dang Dr Zdogg your lighting is perfect!

[@maf1350]

It is said in this video, mRNA has been researched thoroughly before (?) ARE there other mRNA vaccines for humans which have been released before or are successful in Phase 3 trial?

[@adammann4839]

Where can we review the testing data he referenced in the video that he said would be public?

[@peachBloom]

Adam Mann the testing data has NOT even been released to the media. The only thing Fsizer and Moderna said about 90% effectiveness of vaccines were press releases! Self proclaimed success rates not giving data on side effects or frequency of adverse reactions. Apparently, Dr. Offitt has access to that data now.

[@00solman]

Doctor Z any chance you could do a cliff notes on this and break it down for us in layman's terms? Lots of great info. Lots of it way over my head.

[@aviy93]

One of your best interviews yet!

[@stevenpepperell6555]

Go and watch the deposition of his colleague stanley plotkin ?

[@mle9852]

Thank you

[@Garfinkel64]

What would we use to treat vasculitis with? I wonder if dexamethasone would work? Perhaps while we’re at it maybe we could give some anticoagulation for a little while.

[@НереальнаяАвстралия]

thank you!

[@spicysalsaking791]

Dr. Paul, can you have guests talk more about how, at least for Pfizer, since only 8 out of 170 total participants were symptomatic positive (162 placebo 8 vaccinated), how on earth can say much about things like "if you do get infected, it's way less likely to result in extreme symptoms relative to placebo," when the n sample of vaccinated participants who ended up symptomatic positive is only a value of 8? How can they assume anything that utilizes only n samples of 8?

[@michellew3932]

Fever is certainly not our friend when you’ve had a child have 2 Fibral seizures, last one was when she got H1N1 and was hospitalized in 2009! Because she spikes so fast my drs have always said to treat with fever reducers.

[@patty-cf7jj]

Well obviously, but he’s talking about the typical person.

[@michellew3932]

@@patty-cf7jj yes obviously!

[@MsSunstoned]

Can we address what happens with mRNA vaccine with someone who has mulitple autoimmunity syndrome ... our immune systems can go rogue at any time creating a cytokine storm or nfactor kappa B, etc. No one had addressed this population of people, CoVid & this mRNA vaccine. My doctors is the past have never recommended a vaccine with this disease. I want this vaccine, I want to be around my friends that are old. Thanks in advance. Love your show & the conversations.

[@ramneekmathur]

Your content and more importantly, context - is invaluable. Don't give up what you're doing Zdogg. You're leading a ship you are unaware of.

[@Diorella_scent]

Again, thank you so much for sharing this information. Much love ❤️ from Australia 🇦🇺

[@luaybarakat7647]

How long will vaccine immunity last?

[@Float4Fun]

Excellent understandable science presented covering so much in one show! Thank you for sharing this wonderful news!

[@mmorga13]

We have lots of data, although varying, on the mortality rate. However, we need solid data on morbidity. True to what Dr. Offit said, the death rate is not nearly as worrisome as the significant health burden this virus will place on individuals and society for years to come. When the data presented most often are essentially death rate vs recovered rate, it seems easy for many to deduce it's simply not that dangerous. When will we have studies looking at long-term effects? Having information on the risk of long-term health sequelae, even from mild-moderate disease is just as important as the mortality rate. Survival is not synonymous with a return to your previous health state.

[@monykalynf3604]

agreed-but that is true from ANY illness. It is just that covid is being put under a media microscope so it is the ONLY one that has EVER mattered. For instance-currently the prevalence of this "dangerous virus" causing viral myocarditis is NOT any higher than general population viral illness per my stepdaughter-a world recogonized researcher in this. It is just we are LOOKING for it EVERYWHERE now. She is developing a blood test to check for this

[@jovid7]

Paul is completely wrong. People do mount an immune response to the lipid nanoparticles. In fact this has been what has held back the entire mRNA field for over a decade. The toxicity and hypersensitivity to the lipids has always been the major challenge. None of the mRNA companies have ever published papers on this because it looks awful. All of us who study genetic vaccines know this though. Hopefully in a few days I will be getting a different type of vaccine in a clinical trial that causes non of the side effects associated with mRNA vaccines.

[@danieljackson9671]

So good Doc. Thank you so much.

[@JaneAtwellRobinson1825NY]

I had all my vaccines and still got measles. It seems more risky to take a chance on some new vaccine with God knows what kind of long term side effects AND still get Covid if I can "just" get Covid. Not that I want to get Covid... Maybe I will wait and see if anyone has my sort of reaction to the vaccine... I really am not sure yet.

[@yayamakeup01]

This is amazing thank you so much for your educational and entertaining content!!

[@takyram96]

Thank you so much for doing this interview and taking the time to look at this data for your patients and your audience. Every single time I watch a new video you make, I learn something new that helps me evaluate my personal risk and understand the spread of viral diseases in general and SARS-Cov-2 specifically. As an average Jane, it makes a world of difference to me.

[@user-mm6ii3yh9w]

Did anyone catch the name of that lawyer that Dr. Offit mentions at about 46:12 ? cant find her anywhere

[@CanineArtsCenter]

At 16:40, did he mean to say Cov 2 instead of Cov 1? I replayed to that part a few times and couldn’t understand it…

[@listentwice]

Awesome interview!

[@maf1350]

I did not quite get, DID the FDA get the real and complete data before releasing the vaccine or will they still be evaluating the data?

[@bravotwozero]

Z Dogg. Are you lining up to get this vaccine or not? We all want to know.

[@TheMomseloc]

And I'll be right behind him. I had SARS1 but I will still take the vaccine because I want to be ready for SARS3.

[@patty-cf7jj]

I believe he has said he would once he’s convinced it’s safe. He definitely won’t be first in line.

[@miken7629]

I have a question. Vitamin D affects the way RNA works in the body, and since Pfizer is an RNA based vaccine, is there a negative or positive relationship between the vaccine and vitamin D levels?

[@heathermiller4420]

"It causes lost of taste and smell because it enters the brain." Whoa. 👀

[@ginaragone7035]

Yeah....big wakeup call. Virus goes to everything with a blood supply.

[@TheMomseloc]

I had covid and never lost my sense of taste and smell. Maybe it didn't enter my brain? LOL

[@zaurakdigis]

This is the thing you cannot get the idiots to understand, getting the infection can decrease your life expectancy and give you disease in essentially any organ without symptoms of infection.

[@zaurakdigis]

@@TheMomseloc , and how many tests have you had evaluating your kidneys, lungs, heart, or liver. Do you know your baseline function?

[@monykalynf3604]

So do other viruses-just that we don't have that in media every goddammed day. As for the myocarditis-the prevalence is NOT any higher than any other illness/virus-per stepdaughter who is world recognized researcher in this! so either offit isn't aware of this or doesn't care . In fact there was a study enrolling people who WERE NOT covid positive but had a viral illness where taste/smell were diminished/gone-hmmm haven't heard the results of that now have you? I applied to enroll but wasn't sick at the time-need to go find that email to see results...

[@gwenhyronemus1129]

Where in the list do funeral directors getting the vaccine? We deal with going into the covid units to pick up the dead and embalm. We also work with the infected living family members. Why does no one list us as getting the vaccine?

[@patty-cf7jj]

Would you be considered a frontline worker? I think that is considered a priority.

[@macdaddy8011]

As opposed to protein immunogen vaccines, mRNA vaccines requires our "self" cells to use their machinery to produce a "foreign" proteins. Any time you utilize genetic material as an immunogen, there is the potential for host cell integration and recombination. Those vaccinated need to be assessed for integration and persistence of spike protein expression over time. It is irresponsible to think that we understand all the risks associated with mRNA vaccines, given the limited research and actual use. Personally, I'll be waiting for more data - time will tell.

[@manuelmoraleda9285]

Please ask Dr. Offit if the Intradermal route with just one tenth that of the intramuscular was tried and studied. Hepatitis B vaccine gives a better response INTRADERMALLY.

[@sharonc8138]

I wonder how this vaccine has been completed so quickly when the world is waiting so long for other vaccines. AIDS virus is first to come to mind.

[@zaurakdigis]

Watch the whole video, it answers that question. To begin with it an easy type of vaccine to produce in which has been researched for a decade.

[@sharonc8138]

@@zaurakdigis Will do. Had to start a corned beef for Sunday supper! Thank you

[@terrymore2968]

Hi Dr. Z. Do you believe the immune system of a 50 year old male on Keto, who do intermittent fasting, do not have insulin resistance or have any comorbidities, will fight the virus effectively?

[@TheMomseloc]

On one of his recent videos he discussed how lifestyle trumps genetics.

[@WilliamChan]

As someone who had a suspected case of COVID-19 early in the pandemic (late Feb into mid March), I am really curious about the data on people getting one of the vaccines after having tested positive before. Just wanted to make sure it wouldn't make it any less safe. Thanks for covering that point!

[@lindsayball7299]

Why take it if you have had it.

[@newgtguy]

Did you get a serology test yet? You may be at the top of the immunity scale already.