Does Topical Facial Estrogen Cream ACTUALLY Work for Anti-Aging?

[@dramirkaram]

Want to learn more about topical estrogen creams, and go deeper into the best anti-aging skincare practices you should be applying to your everyday life? Check out the KaramMD Journal: karammdskin.com/blogs/expert-advice/

[@anne-pv5ko]

THANK YOU DR. KARAM for FINALLY addressing this issue I’ve repeatedly posted on your videos. I will say after becoming post-menopausal after a hysterectomy from cervical cancer, HRT and topical estrodial cream has helped me topically on my face and other areas. However, I am under doctor’s care regarding HRT and estradiol cream for my post-menopausal symptoms. It is very important to have things monitored, but for me it is worth it. Nevertheless, as you have repeatedly said proper skin care including sun protection , diet and exercise are paramount. All have helped me tremendously to keep me youthful. Thank you for this video!❤🙏🏼

[@eugeniakyriakopoulou5212]

Dr. Karam, I listen to all your videos and take your advice, but I really think you should speak to specialised menopause doctors before attempting another video related to HRT. It would actually be a nice idea to have a podcast with Dr. Mary Claire Haver or Dr. Heather Hirsch and you can discuss all things HRT! Until then, there are several issues with the info you provide here. First of all, transdermal estradiol, even for systemic use, has NOT been shown to increase blood clot risk, which is why most doctors recommend the transdermal route these days. Secondly, only a very small precentage of breast cancers is due to a gene mutation, I believe it is somewhere between 10-15%. Most breast cancers are infulenced by factors such as lifestyle, breast density, age, parity, and so on. In fact, systemic HRT is recommended and proven to be safe for BRCA 1 and BRCA2 carriers who have had a oopherectomy. Furthermore, familial breast cancer is not considered a contraindication for systemic HRT. Now, why didn't anyone talk about this for the last 20 years? Well, because of the WHI and the panic it caused, which is only recently being resolved and more and more people are turning to HRT once again. Also, let's not forget estriol, why go with estradiol? Sure, estriol is a weaker form, and it will not have such potent effects as estradiol, but the risk of systemic absorption is a lot smaller.There are many estriol face creams on the market, and here (Denmark) vaginal estriol 0,1% (brand name Ovestin) is over the counter. And lastly, why choose between estrogen cream and all the other anti-aging ingredients anyway when I can just use all of them? Now, to be clear, I am not saying people should be bathing in buckets of estrogen without a doctor's supervision and advice, but let's stop villifying estrogen, please.

[@lisinbondi1240]

Really appreciate your balanced and informative response. Totally agree

[@passionatesingle]

Totally agree. I would never want advice from a person who isn't a gynecologist when it comes to taking hormones just like I wouldn't go to an orthopedic surgeon for advice on having heart surgery. Mind you there are many 'drs' on youtube giving advice about topics that are their specialty just like there are many I fluencers giving advice on subjects they have no knowledge about.

[@dramirkaram]

Thank you for your thoughtful comment and for being a longtime viewer. Eugenia.I appreciate your perspective and the depth of knowledge you’ve shared. To clarify, the discussion in this video is specifically focused on my views on anti-aging skincare, not as medical advice regarding HRT. While HRT has well-documented benefits, including for menopause management, my recommendations are centered around topical skincare solutions and the ingredients I believe are most effective for skin health and aging and offer the smallest risks. I completely agree that conversations around HRT should be guided by specialized menopause experts who focus on systemic hormone therapy. Ultimately, I always encourage individuals to consult with their healthcare providers when making decisions about hormone therapy. My goal is to provide skincare education and spark meaningful discussions while ensuring that medical decisions are made based on personal health needs and professional medical advice. Thanks again for engaging in the conversation!

[@laurenmayer4322]

I’ve used all the medicines you talked about for years- retin A - vitamin C - peptides and nothing has helped to the same degree as estradiol- there are companies like Alloy that compound it for you after taking your history, dr Karam if you would speak to an obgyn specialist you who specializes in HRT you will hear and hopefully understand a whole new perspective to using estradiol on the face

[@luismedina7461]

@@dramirkaramHi Dr. K, my wife has been using your skincare products for the past 3 years and she loves them! My wife also has used the estradiol face cream as well. She wasn’t required to take a blood test so she THOUGHT it wouldn’t affect her hormones/menstrual cycle. After using for 2 months, she noticed that her menstrual cycle was late, her mood was affected, & the cramps were worse when she finally got her cycle. She still has a bottle left and she doesn’t want to use it anymore. Every person is different, so good thing is to be aware of potential side effects. Thanks for sharing 😊

[@shelleynor]

After trying countless of products the only thing that made massive difference was Microneedling at home with an high quality device. (And daily sun screen ofc).

[@GlennaCoye]

What dermapen did you get?

[@loreleep.3764]

I use the M8 from Dr. Pen​@@GlennaCoye

[@lisacefalu6102]

Can you tell what derma pen you use ? Thank you

[@loreleep.3764]

@lisacefalu6102 I use the Dr. Pen M8

[@caroliner1534]

I do it each month with a .2mm, how often do you doit?

[@janinemelnitz2750]

The womens health initiative (WHI) study screwed up a generation of women. It was a horrible study. Topical and vaginal estrogen DOES NOT significantly increase the risk of blood clots because it is not metabolized through the liver. Oral estrogen is the culprit for this. There have also been several studies which have failed to show a significant increase in serum estrogen levels when a small amount is used on the face. If estrogen was such a bad actor...ie causes cancer, why isnt breast cancer more prevalent in 20 year olds when we are at the peak of estrogen production. If one is so worried about estrogen and causing endometrial stimulation then take prometrium which protects the lining of the uterus. I think estrogen can be one factor in a multi-faceted approach to skin care.

[@dramirkaram]

Thanks for commenting. When it comes to skincare, there are very few studies in general on estrogen and molecular biological changes with production of collagen etc, let along dosing studies against clinical effectiveness etc. The choice you make about what route you take can be very rewarding or a mistake. In general, I don’t see reason to chose estrogen creams over tried and true active ingredients. With them at least you know what you are getting and you know there is no systemic absorption. I offer my opinion based on what I think and how I view the subject. I am generally conservative and prefer tried and true approaches that are predictable and safe.

[@jasminecrandall2262]

I’m a big fan of yours Dr Karam, but I think you may have some outdated info here regarding HRT risks. The WHI study that created so much fear around cancer in HRT has largely been debunked. In fact, many OBGYN’s go so far as to call it medical malpractice. I’ve seen significant improvements to my skin with estradiol cream applied to both my face and hands. As a disclaimer, I also have regular blood work done as I’m an HRT patient in my early 50’s. There’s been no additional fluctuations by adding a topical estrogen cream. Just a friendly suggestion, try listening to a few clips with Dr Mary Claire Haver about HRT. She’s one of many practicing OB/GYN’s trying to educate on the pros and cons of HRT.

[@juliacrossen1438]

I don’t know why doctors Lee talking about this study. It was incredibly fraudulent.

[@aprilmouse8793]

I came to say this. This is outdated information. Please remove this video from YT!

[@taradavis7742]

I am a big fan of Dr. Mary Claire Haver, as well as many others dispelling the myth behind those studies that resulted in the fear mongering around HRT. However, my biggest frustration is the information that isn't being discussed, which he spoke about around the five minute mark, & that is if someone has a genetic propensity for getting certain types of cancers due to mutations/variation in the BRCA1/BRCA2 genes. That drastically increases the risk of getting hormone dependent cancers- namely breast cancer that is estrogen dependant. That is a very real thing. I had two aunts who died from estrogen dependant breast cancer & I recently met a woman with estrogen dependant breast cancer who spoke of being disappointed because she wasn't a candidate for HRT. I am getting tested for variations/mutations in those genes & if they come back positive, I will be scheduling a double mastectomy ASAP. That won't stop me from revisiting the possibility of taking HRT. I'm praying that I don't have any issues & can get started immediately with HRT & all the wonderful health benefits as a result. 🙏🏼

[@ybigirl]

Yep. And, re cancers... my sister CURRENTLY HAS breast cancer and her MD has her on a topical vaginal estrogen to prevent "leaks". My sister asked about putting it on her face (since it is in the news) and the MD said it was fine since the topical is very low dose and doesn't go much further than the skin.

[@aprilmouse8793]

@ it’s good to hear that doctors are getting caught up on this information and I’m glad your sister is getting the treatment she needs.

[@jennybolter1102]

it all depends on the oestrogen cream used, Estriol 1mg for the vagina is the weakest form of oestrogen and has been proven not to alter levels in the body, please address this we women have had far to much scare mongering about our hormones

[@dramirkaram]

Because the consequences of being wrong are to serious and too high. So if someone gets a breast or ovarian cancer down the road and they were prescribed these creams it’s hard to disprove their potential impact on the cancer occurrence. More study is needed and that’s why most physicians don’t prescribe them if those history exists. Safety first.

[@psychologyphd9662]

Estrogen does not cause cancer metabolic dysfunction does. It’s complete bs without MD estrogen is protective- women’s estrogen sky rockets in pregnancy why on earth would the body do this grow a baby if it were harmful - move on use common sense

[@vickimouat8092]

I understand that any application needs to be monitored but it seems strange to me that women produce huge amounts of oestrogen until peri menopause and then post menopause where we have next to nothing. I can't see how a small amount of a low dose oestrogen cream could be anything but beneficial once the individuals risk has been assessed.

[@gailnightowl0423]

​@vickimouat8092 I think when our bodies stop producing estrogen we still need it. It helps with our bones, brains, skin, and so much more. This is where a hormone specialist can help, not a facial plastic surgeon.

[@primordialmeow7249]

@@dramirkaramExcellent answer Doc. Thanks. Signed, an RN

[@Theantinarc]

I asked my doctor and she said I was too young. I'm 44 and haven't had a period in 6 months. I went online. Yes it works and yes it's worth it.

[@sjonesblue]

Thank you for addressing this topic. I’m using topical estriol and estrodial and I see a significant improvement in minimizing fine lines.

[@dramirkaram]

Thank you for sharing your experience! It’s always great to hear when someone finds something that works well for them. While research on topical estrogen for skin aging is still limited, I respect that everyone’s skincare journey is personal. My perspective is that well-studied actives like retinol, vitamin C, and Niacinamide offer proven benefits without concerns about systemic absorption. That said, I appreciate the discussion and think more research into this area would be valuable for better understanding its role in skin health. Now you have the information I shared and can make the right decision for yourself with the guidance of your doctor. Wishing you continued success with your routine

[@RG-bd5fy]

Is this the actual or bio-identical?

[@rosamariav_09]

My dermatologist gave me an advice that reminded me of you! (here to replay) He said to take care of my skin and save for a face lift in the future! He could have gotten my money and do a lot of procedures! I appreciate your honesty. You are the best. Big fan here.

[@dramirkaram]

Thanks for sharing!!

[@OnlyPathToTheTruth]

I use it on my face, the top of my hands, and my chest. I had Leiomyosarcoma 21 years ago and it was hormone-receptive. A Radical Hysterectomy sent me into immediate Menopause. My hair thinned out quickly and I had all of the classic menopause issues. I use Estradiol and have for about three years. My bloodwork is fine, and I feel better. That is what matters to me. :)

[@StayGold_MrsE]

Did you get all of your hair back? All of my hair started falling out in the last year and a half my periods stopped in July and then it just went completely off the rails last summer and I got on estrogen patches and progesterone pills in Sept and I've been using estrogen on my face for the last maybe 9 months and my hair finally stopped falling out about a month after I stated the actual patches. The cream didn't change anything for my hair but my face totally improved. My hair was thinning and I swear if the wind blew it felt like it would just start falling out. I'm using Rogaine as I have been for a few years and I'm hoping it's going to come back because I've lost 70% of my volume and I only turned 56 last week so I'm hoping so. My blood work is perfect and my primary doc just wrote prescriptions for all of the HRT I was paying cash for with an out of network Meno doc and approved that I'm using the cream on my face also.

[@OnlyPathToTheTruth]

@@StayGold_MrsE My hair is a little better because I rinse it and soak it in protein water. My husband died almost two years ago. Got married last year and he died after a few months. I am to the point now that I do not care much about my looks, because I am so broken down. (My first love, my mom, and my son all died around the same time as my husbands. 2023 and 2024 were not nice to me.) Best wishes to you!

[@StayGold_MrsE]

@OnlyPathToTheTruth oh noooo I'm so sorry to hear all of this. I'll make mention of you in my prayers. I hope you experience health, healing and joy in life again as soon as possible. Big hugs❤️

[@dramirkaram]

Thank you for sharing your journey. It’s inspiring to hear how you’ve navigated your health challenges and found a treatment plan that works for you. Your commitment to listening to your body and working with your healthcare providers is admirable. I always encourage open dialogue with your medical team to ensure the best outcomes, especially when it comes to personalized care. Wishing you continued health and well-being.

[@sladlos]

@@StayGold_MrsEto avoid hair loss and recover density and quantity I highly recommend Musely hair pill. It has been a game changer for me.

[@beth6445]

Superlative overview. We can always rely on you for top-notch pro's and con's. Thank you for being so thorough...

[@dramirkaram]

Thank you… I try 😊

[@cjheadlee6994]

If estrogen cream is so amazing for skin, why isn’t is more known/popular? FOLLOW THE MONEY! Estrogen cream is relatively inexpensive. If it works as well or better than many Dr. ‘s famous ultra expensive creams, skin treatment companies’ a multi -hundred dollar creams, then those companies will lose$$$$!

[@cjheadlee6994]

Some of us cannot afford your trifecta but we can afford an approximately $20 estrogen cream.

[@StacieSchilling]

Dr Karam, I am a huge fan. However please stop this utter misinformation that topical estrogen can cause endometrial hypertrophy. In fact topical estrogen is used IN PLACE OF systemic estrogen in patients who have a history of BrCa and endometriosis. Some patients may also choose estriol instead of estradiol based on their risk factors. Please move on from the original Women’s Health Initiative (WHI) study results that were published in the early 2000s, when I was a Research Associate at the American College of Obstetrician-Gynecologists. Subsequently there have been numerous publications clarifying those results. Unfortunately the way those results were mistakenly extrapolated set Women’s health back for 20 years. I would never have expected you to be promoting misinformation about women’s health. So please stop this until you catch up with current science and more recent publications from the WHI.

[@dramirkaram]

The systemic effects cited are those they came up in the studies evaluating estrogen as a skincare product. Ideally, when you are using a skincare product you don’t want to see systemic effects especially if they aren’t intended. I am not misinforming anyone here… skincare product evaluation and pros and cons considerations. This isn’t a hormone replacement video. I am not sure why there is so much confusion on that. My conclusion is… the traditional actives are likely as good of not better if used with sun protection and consistency.

[@Jasapan-u4s]

Dr Karam, do you ever do any deeply discounted procedures? I so want help but, this is out of my reach. Your work is absolutely amazing.

[@lynn-suomalainen]

I obtained estrogen cream through the online prescriber (Ally). On my medical history, I disclosed that I’d had ER+ breast cancer with consequential bilateral mastectomies. The prescribing doctor said that this is not a contraindication and estrogen cream is ok for me to use on my skin. Sooooo… I will halt this treatment after seeing your video and do more research. Thank you!!!

[@csillam2658]

If in post menopause, estrogen cream is a danger, and can create brest cancer, than why we don't develop brest cancer in our 20' s..30's? Does women search for the main cause of brest cancer? From Dr Ryke Geerd Hamer and form Dr Gilbert Renaud you got all the answers about cancer and more.

[@dramirkaram]

I would definitely check they out with your oncologist. The ones I talked to before making this video universally said it was a hard no if there is a history of breast say especially Estrogen receptor positive. Again it’s risk vs benefit.. and that’s something each person has to assess for themselves

[@PierBuda-bw3gw]

People who have been using it on their skin report no change in their blood work numbers for oestrogen.

[@PierBuda-bw3gw]

Dr Felice Gersch is an expert in this field..she has a utube channel.

[@primordialmeow7249]

@@dramirkaramI second Dr. Karan’s advice. As an RN, it would be a no for me. Good luck beautiful lady. ❤️

[@Paoula]

I started using my estradiol cream on my face just a few months ago and saw that my fine wrinkles are much smoother looking.

[@dramirkaram]

Hi Paolua, thanks for sharing your experience! It’s always great to hear when someone finds something that works well for them. Research on topical estrogen for skin aging is still limited but I respect that everyone’s skincare journey is personal. My perspective is that well-studied actives like retinol, vitamin C, and niacinamide offer proven benefits without concerns about systemic absorption. That said, I appreciate the discussion and hope the information I've shared is helpful for you in making the best decision for yourself.

[@rachelg6799]

@Paoula are you using it daily, I have been using mine as well on my face but only once a week.

[@marymarr3]

Another helpful video! Would you consider doing a video about Red light therapy masks? Thanks! 😊

[@dramirkaram]

Absolutely!

[@marymarr3]

@dramirkaram Thanks! 😊👍

[@dorayoung1073]

In that video, can you include how red light and infrared light affects melasma? Thank you!

[@natachabezoukhov8553]

Je n'ai pas le courage de faire mon commentaire en anglais car le sujet est un peu compliqué. Pour ma part, j'ai 57 ans et je n'ai pas de traitement pour la ménopause, je suis passée au travers sans problème majeur. Le seul problème, c'est la sécheresse vaginale, j'ai une crème pour cela et j'ai demandé récemment à ma gynécologue si je pouvais mettre un petit pois sur mon visage, comme je le mets ailleurs, donc 1 jour sur 2. Elle m'a dit que c'était vraiment sans aucun souci! Aucun risque. J'ai de l'hypertension légère mais sous traitement et un Hashimoto donc le traitement aux hormones n'était pas très bon pour mon hypertension m'avait elle dit, sauf si j'avais commencé de suite, dès la ménopause. Mais je ne l'ai pas fait car mes symptômes étaient très légers. La sécheresse est venue 7 ans plus tard et j'ai commencé uniquement la crème localement. Ma maman et la maman de cette doctoresse ont pris un traitement pour la ménopause, ma mère pratiquement 25 ans, jusqu'au décès de mon père. Elle était tellement jeune grâce à cela et aucunes douleurs musculaires ou articulaires. Maintenant, elle a 87 ans et prend toujours son vélo pour faire ses emplettes. Les hormones,avec un bon suivi, nous gardent jeunes ! Il faut juste suivre les recommandations,les doses et consulter dès que quelque chose d'anormal se produit. 😊 Bonjour de France ❤ mesdames les américaines ! 🇫🇷🇺🇸

[@dramirkaram]

Hello from across the ocean! Thank you for sharing your experience so openly-it’s inspiring to hear how you’ve navigated menopause and found solutions that work for you. Your story highlights the importance of personalized care and staying informed about our health with the help of medical professionals. Your mother’s journey is a wonderful testament to the benefits of monitored treatments and staying active-it’s so impressive that she still rides her bike at 87! Thank you for your message and perspective. Sending warm regards to you in France!

[@sczyba]

Merci pour votre commentaire...en effet mettre tout ceci en anglais ne serait pas évident même pour l'ancien professeur d'anglais que je suis! et ça me fait plaisir de voir qu'il y a quelques Françaises sur le site, je me sens moins seule😆

[@HolisticSkinCenter]

I just had this question from a client last week! Thank you for explaining. Sharing!!!

[@dramirkaram]

You are so welcome!

[@jaynevalenti5200]

The research done on HRT replacement is extensive, and I think this video is going to scare women unnecessarily. I wonder if ur wife uses HRT replacement systemically as many educated women do, one of the benefits being keeping the skin supple. The amount of HRT absorbed when used topically is minimal at the most, far far less then any systemic (pill, patch) and my plastic surgeon and dermatologist both recommended highly. No one is saying not to use it to replace retinol etc.(or your cream), but in conjunction with it. I doubt anyone is bathing in it 😂. I usually find your information very on point, but I feel this video is misleading.

[@dramirkaram]

This isn’t an HRT video. This is a pros and cons of topical estrogen for wrinkles. This is a personal decision as is HRT and when one starts that they do have a proper history taken and discussed with their physician. I think the point you are missing is that this is a medical prescription treatment and needs to be treated as such. Data on topical is very scant

[@PierBuda-bw3gw]

If it very well absorbed topically on the body, but anecdotally many say if is not absorbed on facial skin and their blood work numbers bare this out

[@UterineBlackmail]

Which estrogen cream do you use on your face?

[@PierBuda-bw3gw]

@@UterineBlackmail I just sometimes take a tiny bit of my body creme and mix it with my moisturiser for face, but actually I find if your hormones are balanced in your body with biodentical you do not need to put it on your face.

[@mbrewer421]

So if it works, it competes with his Trifecta system. Conflict of interest here. I find it odd that he really stresses all the potential risks of this cream, but promotes his surgeries as though they are like a routine cleaning at the dentist. A facelift is considered a major surgery that has risks. Even minor surgeries have risks, but I don't hear him talk about that. He only shows his success stories, and the only negative stories are about mistakes other surgeons make. Keep in mind, these videos can give you some advice, but the goal of these videos (not just him, but the others on social media like him) is self-promotion. I'm not saying estrogen cream is safe, but I've heard positive things about it. You need to consult your doctor and do your own research. It's unfair to dismiss this out of hand and scare people instead of giving a balanced review.

[@GlamandFabQueenTV]

My functional doctors prescribe BHRT and its safe. For as long as bio identical.

[@Pixiekindnurse]

My anecdotal story is that it has provided a significant improvement to the dryness to my face.

[@karenalexander8249]

Thanks for this review! I’m no to estrogen cream, yes to tretinoin, vit C, Niacinamide and red light mask!

[@dramirkaram]

You are so welcome!

[@donnadornbusch6738]

Thank You for your honesty… a few Dr’s on KZbin does share your knowledge . Keep this link playing!!!!

[@donnadornbusch6738]

Does Not share…

[@dramirkaram]

Thank you for watching!

[@neelambhatty17]

This is a very very important topic that you’re talking about today. I am 44 and going into my perimenopause just started getting hot flashes so one of my nurses suggested me these topical estrogen and progesterone. I felt the difference the very first night more than a week into it and then I’m using it twice a day and instead of using one full pump I’m using halfthe morning at night my hot flashes are almost gone. I don’t want to be on hormonal therapy, but you’re saying this can be a replacement confused if I don’t use the topical one that I have to do with my hot flashes. Also that Nurse has been using topical estrogen for over 10 years now and I love her skin.

[@dramirkaram]

I believe you are making my point. Your improvement of hot flashes (indicating absorption in your blood) while using estrogen cream is what I was referring to as a potential undesirable effect of a skincare product. Not everyone wants or should have the hormone in their bloodstream is the point I was making in the video. I am glad it’s working for you. Helping your skin while helping your symptoms of perimenopause.

[@dianak490]

​@@dramirkaramAnd NOT Everyone wants to drain their bank accounts buying your products when they can easily afford estrogen creams! You literally just made a fool out of yourself in this Video! 😂

[@taml2024]

Yes 👏 thank you for letting ppl know what could happen. I was on HRT the pellets and at 52 I had a heart attack. Healthy 52 who works out, eats healthy…. Too many influencers are pushing estrogen/HRT without explaining that it’s not for everyone and what could happen! Menopause stinks, I’m going through it ….. but I’d much rather go through that than another heart attack!!!

[@dramirkaram]

Thanks for sharing 🙏🏻

[@stroppyscot]

I would love to discuss this directly with you - I have been a subscriber for years so no agenda here. I am a British Menopause Society Advanced Specialist and Consultant Gynaecologist with more than 30 years experience in the specialty and run a very busy women’s health and menopause clinic in the UK - I like to think I know what I’m talking about!! I genuinely believe that local E2 facial creams will be the next stage in facial/skin age maintenance. Personal experience backs this up. There is a huge synergy in women already on HRT - and we know form many scientific studies that the risks of modern systemic gold standard body identical HRT regimes are virtually negligible. There has also been off licence use of oestriol vaginal cream safely applied facially for many years. This is safe when used vaginally even in breast cancer patients as there is no systemic absorption. I’m advocating proper scrutiny and review by physicians exactly as you would offer for Tretinoin and other POMs and not the “Wild West” which some propose. I believe nothing will enhance collagen like oestrogen! Happy to have a frank discussion which I’m sure your audience would welcome!

[@maramao6202]

Thank you for your comment. I am very afraid of menopause because of all the effects (bone issues, skin etc) and I would like to know what to do to prevent the side effects and remain healthy. What I honestly don't understand is why, for a body that is used to high estrogen levels for 40 years without problems, mantaining similar estrogen levels should be a problem.

[@SarahB-re5gp]

If estriol vaginal cream isn’t supposed to absorb systemically per my gyno, isn’t it fair to say if used on the face it will not absorb systemically either?

[@stroppyscot]

Spot on! Exactly the point.

[@dianak490]

Thanks for commenting but Don't hold your breath...he will never contact you bc his Deep Pockets will start emptying 😊

[@stroppyscot]

Sadly - many of these comments are simply wrong. I’m a UK based menopause specialist and gynaecologist with years of experience and can confirm that topical oestrogen performs way beyond other skin care - without significant risk. It’s all the bad and inaccurate information about HRT which is so disappointing and unnecessary. This has HIGH reward and LOW risk…..

[@dramirkaram]

Thanks for commenting and please recognize I mean no disrespect… but I haven’t seen a single study that exams efficacy of estrogen creams against a comprehensive skincare routine using well deceived actives (retinol, vit c, niacinamide, HA, lipids, botanical lighteners). In fact, there is very few studies in general on estrogen and molecular biological changes with production of collagen etc, let along dosing studies against clinical effectiveness etc. The choice you make about what route you take can be very rewarding or a mistake. Personally, I don’t see reason to chose estrogen creams over the above actives. With them at least you know what you are getting and you know there is no systemic absorption. Not everyone is ok with that possibility. Some just want there skincare to be skincare. If you question that there is absorption.. you should have a look at the studies. Again… I think the information in this video is clear enough to allow the person to think for themselves. I offer my opinion based on what I think and how I view the subject. I am generally conservative and prefer tried and true approaches that are predictable and safe. We are talking about making skin look more youthful after all.

[@SusannaCampesan]

@@dramirkaram I don't believe this was written by Dr Karam due to the bad grammar used: "there is very few studies"... "Some just want there skincare to be skincare". Or at least I hope it wasn't him! 😂

[@donnabattle8987]

I have one of those creams you held up in my stack of "Not Interested" It will stay there. Thanks for the tip!

[@dramirkaram]

You are so welcome!

[@cynthiabonot3049]

Thanks for the info doctor

[@sarra5206]

That was amazing information thank You for your time ❤

[@ccic1855]

Thank you for this great video!🌟 you are right it’s not worth the risk! Especially since there’s so many other options! Have a great day🌈🌟

[@dramirkaram]

Thanks and you too.

[@resi2120]

Thank you for this great and informative video, helped me a lot!

[@dramirkaram]

Glad it helped!

[@somewhereovertherainbow1984]

You are perfectly correct. That is why estrogen cream can be dangerous in early age, or with hormon related cancers in the patient's life or in the family history. In perimenopause, if the patient has syndromes related with perimenopause, low estrogen level can be detected by blood test, or in menopause, the HRT is used on the skin, patch is more safe (for dosaging reasons), but cream is acceptable also. And it has a dosage limitation. And estrogen level have to be checked regularly. And the safe zone is not even the top normal range. HRT has a lot of positive effect if it is used correctly, not just on the skin. HRT is used for decades now. What is new in this topic, if a patient want to use the cream on her face. It is not a moisturizer... A lot of dermatologist use it and prescribe it. Vaginal estrogen cream on a face- it is not a good idea. But after a consultation with a dermatologist, prescribed in a right dose by a pharmacy formulated cream, and a continous control by a gynecologist and endocrinologist (in my country a gynecologist often have a specification for endocrinology as well), it can be relatively safe to use. The effect for the skin, if a skin is estrogen depleted, can not even compare the use of actives like retinol or vitamin C or etc. It is shocking. The actives do not make miracle with the skin, plastic surgery does, but most of the people have not and will not have enough many for a good quality facelift. To treat an estrogen depletion caused skin damege, skin aging is affordable. But it can not be safe, just if it is in the right hands. Dematologist, gynecologist and endocrinolgist is necessary for the safe use.

[@dramirkaram]

Very well said! Thank you for sharing your thoughts 🙏🏻

[@Saby217]

The OTC bioidentical estrogen creams have no medicinal properties,. Creams given under prescription as HRT by compounding pharmacies do. OTC are like a placebo that might make you feel and look a little better but do nothing for your estrogen levels. I actually went through two tubs of the exact one flashed at the beginning of this video before starting REAL HRT. Only doctor prescribed HRT impacts hormones. In the right doses as per test results and symptoms, prescription HRT is effective for overall health. Yes, the topical otc variety must be combined with a vitamins A, B3, C, E etc regimen for any lasting positive impact on skin.​@dramirkaram

[@kimberlymarcero6850]

Thank you for a balanced overview of a very complex topic. At age 43, I was using a very low dose estriol cream prescribed by my gynecologist for some perimenopause UTI issues. I was fit, metabolically healthy with no family history of any associated potential risks and was told by my doctor that overall “I was the perfect candidate” for a problem free experience using this mild treatment modality. Well 2 months in I had a stroke… Thankfully I fully recovered. Even doing your due diligence is not full proof. Things are always a risk vs. benefits and sometimes there are unknown factors at play. Many, maybe most won’t have this happen to them. But it’s good to really evaluate if it’s worth the risk if there are effective alternatives. Things could have gone very differently… I thank the Lord I’m here today! 🙌✨💫

[@air282]

Thankyou Doc 🩵 appreciate this.

[@dramirkaram]

My pleasure!

[@rapptherese]

Thank you!

[@janenuss6]

Yikes! Probably not worth it. I’ll stick to retinol. Thanks doc

[@dramirkaram]

Thank you for watching!

[@Michele-rva]

Thank you for this !

[@dramirkaram]

My pleasure!

[@staceyraymond7682]

I am using this and am on my 2nd bottle, you make a good point on increasing the usage, I am tempted. I have had no luck with retinol my skin hates it, and Vit C is also irritating, just going with something not irritating. Thanks

[@denisemcdonald829]

Have you seen any noticeable results yet?

[@staceyraymond7682]

@ I don’t think so

[@denisemcdonald829]

@@staceyraymond7682 Thanks for your reply.

[@dramirkaram]

Many people find retinol challenging to tolerate, which is why I developed the Trifecta. It features Encapsulated Slow-Release Retinol, designed to deliver powerful results while being gentle enough for all skin types. Similarly, our Quench Vitamin C Serum is formulated with three stable forms of Vitamin C, making it effective yet gentle-even for sensitive skin-unlike many products that rely on ascorbic acid, which can be irritating. If you're using an estrogen cream, I recommend consulting with your doctor to ensure it's the right choice for your needs and not causing any unintended side effects and only using it as prescribed. Prioritizing a personalized and medically guided approach is key to achieving the best results for your health.

[@PatriciaStambaugh]

Great advice you give to us all if we will just follow it 😮thanks

[@Pinkhair332]

Hi doctor. Thank you for the information. That is really enlighting. Doc what do you think of this cream related or effect the melasma skin?

[@MiAeLippold]

Im Felling Much Better!!

[@vannesayjeff]

I thank you for your advice, I think it’s going to save a lot of people that will be misusing the products. I will continue with the save approach to a beautiful skin that thanks to you I do on a daily basis ❤

[@tootsmagoots8656]

Thank you for the information

[@dramirkaram]

My pleasure

[@lorraineshoemate9430]

Does this apply to topical ESTRIOL too? I know it's a weaker form. This is the form that is from My Alloy and Musely. You didn't mention this. Thank you!

[@dramirkaram]

Yes, that would fall into the same category and my advice would be the same.

[@lorraineshoemate9430]

Thank you for responding!😊

[@janetcatching199]

Thank you so much! 😊

[@dramirkaram]

You're welcome 😊

[@katherineohara960]

Thank you for the video and the information and your concern for this use. Anecdotally, I am a bio identical hormone user, this is my choice and for my health over 15 years, this is what has helped my health (so opinions on that are not welcome as I am dealing with my own health and my results). Aside from that I discovered through curiosity that the estrogen I was using on parts of my body - when I used on places like my lips eyes - seemed to rejuvenate my skin. Now I get quarterly bold work and have for these 15 years. I think it’s worth women to consider that the levels of estrogen we have when young could never be matched by a topical cream. I also use your skin care and gotta be honest A there is no way I could run into my face the amount to put me at risk. That said - I use your skin care but I’d love to see more long term research to the interesting results I’ve seen in myself.

[@dramirkaram]

Hi Katherine, thanks for your comment and for sharing your experience. I completely respect that health decisions, including hormone therapy, are personal and best guided by individual medical needs. It’s great to hear that you’ve found a regimen that works well for you and that you’re also enjoying the Trifecta. More long-term research on estrogen’s effects on skin aging would be valuable. I am committed to providing the best science-backed skincare solutions and truly appreciate your insight and engagement in the conversation!

[@Trizz358]

At what pont in my skin regimen do I apply hyaluronic acid?

[@lyudmilalev1917]

Agree! Thank you ❤

[@AnnaBeyoglu-o4i]

I am sure in 20 years these issues will be fully sorted and understood. No one should jump and risk their health for a smooth skin.

[@dramirkaram]

Time is always the best test which is why I opt for tired and true ingredients with well documented results.

[@stephaniew.1357]

I was already doing the trifecta you recommend. My dermatologist prescribed a low dose steroidal and retina A compound and it has made a noticeable difference in skin suppleness and fine lines-wrinkles. I will be getting hormone levels checked again soon but I have not had any side effect mentioned and she did confirm family history. I did not do a genetic test 🤔

[@monicawarfsmann4672]

you are right considering the risk of estrogen. Not every women is a candidate for HRT and not every women can use it over a long period. Estriol is very good for the vagina and bladder, as you have mentioned and has to be used forever . But the higher concentraded estrogen can be much more dangerous . I also would prefer your TRIFECTA etc.

[@beverlyw6881]

I am post menopause, hysterectomy with ovaries spared, no breast CA in my or family history. I use Retinols and Niacinamide. Vitamin C serum makes me break out. 🥺 I am also getting my hormone levels checked. I also get micro-needling. I added Estriol cream 3 months ago. I feel it’s too early to call it one way or the other.

[@Sara-ue6np]

Very interesting! I’m on HRT and I use estriol (half a pea size) on my face. My hormone panel hasn’t changed since I started the estriol, so I guess for me it’s safe (or doesn’t affect my bloodwork/hormone levels). As I understand, the other two forms of estrogen, if used topically, can affect me systemically?

[@dramirkaram]

Thank you for sharing your experience, Sara. Estriol is considered the weakest form of estrogen and is often thought to have a lower systemic impact compared to estradiol or estrone. However, absorption and systemic effects can vary from person to person. It’s great to hear that your hormone panel has remained stable, but as with any hormone-based treatment, it’s always best to consult with your healthcare provider to ensure it aligns with your individual health needs.

[@Sara-ue6np]

@ Thank you so much for your answer!🙏🏼 And that’s why I wrote ’for me it’s safe’. Hormones are nothing to play around with!

[@orasherman1818]

Thank you 🙏

[@J-ellO]

I had a complete hysterectomy at age 27. I am now in my 50s and have never had estrogen replacement medication. How would this affect me if I started using estrogen as a skin supplement thank you.

[@anniea3261]

You should see a menopause specialist, you might be a candidate for hrt (hormone replacement therapy)... It's really wonderful for a lot of women.

[@locdlife1205]

You should DEFINITELY consult your GYN. Hormone therapy is warranted/needed if you had a complete hysterectomy. Among others, the benefits include decreased cardiovascular disease, osteoporosis to name and few

[@dramirkaram]

This is a topic best discussed with a specialist, as I cannot provide medical recommendations of that kind. My perspective specifically pertains to the use of estrogen creams for anti-aging purposes.

[@J-ellO]

@@dramirkaram thank you so much for this.

[@J-ellO]

@ thank you so much! 💜

[@CarmellaNYC]

I use your line and have added the topical estrogen and my skin is improving!

[@dramirkaram]

I'm glad to hear you're using the Trifecta and that your skin is improving! As I mentioned in the video, if you do opt to use topical estrogen I suggest consulting with your doctor to asses the potential risks vs benefits.

[@CarmellaNYC]

@@dramirkaram Thank you so much! If ever I opted for surgery you would be my number one choice!

[@SarahKotri]

A great video about the pros and cons. You ask the question why hasn’t this been used over the past 30 years then.. well, we haven’t been receiving the gender specific research we deserve over that time. It’s taking women demanding better for this to be considered seriously really in the past year. Your point about more research being needed is exactly what we want! More information to understand the role estrogen plays in all our female organs is needed so our doctors can be educated on it and not use outdated or incorrect studies to guide our healthcare. I agree that we should be cautious about this on our skin given the points you’ve made but a large percentage of us peri/menopausal women are literally tired and unwell from the lack of medical research being done and are taking matters into our own hands and becoming our own test subjects. We’ve been forced into the private hrt clinics and jump at any new products that might help us. This is probably not the best approach as you point out but this is the frustration and desperation level. Thanks for providing the pros and cons. We’d love conclusive research to back it up.

[@dramirkaram]

I am not sure why this is a HRT.. I deal with the manifestation of aging and most of them happen around menopause of course. Surgery addresses the laxity and the skincare I discuss addresses the skin. When people are using solid skincare and practicing sun protection menopause doesn’t impact the skin. It just doesn’t. There are 70 year olds who have better skin than some 40 year olds because they have been doing retinol, vitamin c etc etc for most of their adult lives. That’s what inspired me to create a comprehensive skincare product (Trifecta) that had all those components in there and was easy to use. I can’t speak to anything other than that… my specialty is rejuvenation of the face and skin. HRT isn’t my thing and this video wasn’t about that. It’s about choosing the best approach for you. My research and opinion is expressed in the video.

[@SarahKotri]

The reason patients are asking for estrogen cream is because women are being lead to believe that our peri/menopausal skin will respond to the use of this product because we are estrogen deficient. I mentioned HRT because many of us who are in this phase of life are looking for help as all our organs seemingly need estrogen to stay healthy. You’re saying that’s not true yet you also say you don’t know (much) about menopause. That’s problematic in terms of the education you receive and many doctors and nurses I’ve talked to acknowledge they have received little to no education about it. What if the information you’ve learned from has been biased towards men’s skin and anatomy and maybe there are differences for females that haven’t yet been studied much? I hope that explains why women see a connection between this cream’s use (to reduce the effect menopause has on our skin) and HRT research and usage. I agree after using good skincare and sunscreen for many years along with occasional lasers that skin can look younger and behave younger but we are being lead to believe this will also help. You’ve shown its risks well.

[@teresae1687]

He is giving his professional opinion. The option to speak with a gynecologist is a good idea if what is offered here is not enough.

[@dramirkaram]

Exactly. I offer my opinion based on what I think and how I view the subject. I am generally conservative and prefer tried and true approaches that are predictable and safe and share my views so people can make their own informed decisions. Speaking with your medical provider is always an option.

[@lizbethluna6253]

Thanks for the info, I always think why still doesnt have more investigations and the hype of this ingredient when is very important? May be is not that effective

[@dramirkaram]

It will be interesting to see if there is more research done in the future but, at the moment, I tend toward well-established and researched low risk, high reward ingredients for my skincare.

[@lindajanefyvie9267]

Will stick with tret vit c niacinamide,multi peptide &SPF 🙌

[@karriehigley4776]

Thank you so much!

[@dramirkaram]

You're welcome!

[@marie-franced7211]

Dear Dr. Karam. This video just arrived when I was wondering about this topic. Also what about if you are already taking HRT with oestrogen in it, risk of too much oestrogen ? Thank you !

[@dramirkaram]

Hi Marie, I haven’t seen a single study that exams efficacy of estrogen creams against a comprehensive skincare routine using well received actives (retinol, vit c, niacinamide, HA, lipids, botanical lighteners) so personally, I don’t see reason to chose estrogen creams over the above actives. If you choose to go that route, I suggest you speak with your medical provider about your personal history and the potential risks.

[@marie-franced7211]

@ thank you very much for your reply. Not at all, i don’t want to use oestrogen on my skin. I am 100% ok with your views and I will probably order your products even if I live in Europe, hoping that the custom fees will not increase too much…

[@zuzanahruba3794]

Thank you!

[@dramirkaram]

Thank you for watching.

[@ggfarmgirl8350]

Hard to have a conversation about the pros and cons of estrogen cream without addressing the missing progesterone in women as we age. Need progesterone to balance estrogen.

[@afrozashirin7171]

Very disappointing video. He just intentionally skipped a very important information. The topical vaginal esteodial or estriol used for face are not systemic. A lot of research, both old and recent support that. Why he skipped that information. That information just invalid a lot of points and concerns here he made.

[@dramirkaram]

People aren’t using that they are commonly getting these creams compounded by independent pharmacies using a variety of concentration and mixtures.

[@maramao6202]

What I fail to understand is why when we have high estrogen levels as young women, we are ok, and the estrogen used to replace the one we lose should create problems?

[@monicaledesma4084]

It doesn’t

[@RG-bd5fy]

I believe estrogen during our younger years is there for a purpose. When our changes occur, it’s that time. For some reason our system doesn’t acclimate positively and this happens. Women on BC can get E+ cancer because they are overloading on estrogen. I guess post-menopausal women taking this is “overloading” as well.

[@tonilublin8969]

Thank ypu for covering this topic. I have used estrogen on my neck for 5 urs and have definitely seen improvement. I use Trifectia and was wondering how long do I need to wait between waxing on my.face?

[@dramirkaram]

Thanks for sharing. No more than a couple days

[@jenniewilliams1668]

Thank you Doctor. I do use estrogen on my face and I use essentially what you recommend, minus the peptides. I have been closely following developments in approaches to menopause- Mary Claire Haver, Kelly Caspersin, Louise Newsome etc etc and am always learning. You present a more cautious viewpoint, a very important set of questions. I would love to use your Trifecta because i have developed a trust in your guidance, but the monthly cost is prohibitive for me. Warmest regards Jennie

[@dramirkaram]

Hi, Jeanie thank you for the thoughtful response. I understand the Trifecta is not an option for everyone. You might consider trying just the Illuminate if it's more in your budget. If not, it's great that you've found a routine with all the active ingredients you need and works for you.

[@lillebrowning2231]

Always helpful and informative - thank you for your input. I started topical estrogen (im also on HRT) about 6 months ago. Jury is still out on the efficacy of it on my skin. I will keep using it and see how things go for another 6 months 🤷‍♀️

[@dramirkaram]

Thanks for commenting and sharing! I haven’t seen any studies that exam efficacy of estrogen creams against a comprehensive skincare routine using well received actives like retinol, vit c, niacinamide, HA, lipids, botanical lighteners etc. I don’t see reason to choose estrogen creams over the above actives so I hope you're also using a comprehensive skincare system! With them at least you know what you are getting and you know there is no systemic absorption. I am generally conservative and prefer tried and true approaches that are predictable and safe.

[@pamelakrueger7353]

Thanks for your information. I was under the impression that Estriol cream (being the weaker version of estrogen) on the face was "safe" and was not systemic. Is this incorrect?

[@dramirkaram]

Thanks for your question, Pamela. Estriol is considered the weakest form of estrogen, and while it is often marketed as having minimal systemic absorption, it is not entirely non-systemic. Some absorption can still occur, depending on dose, frequency, and skin permeability.

[@user-js9gn2hw9s]

I dont have an problems with wrinkles, but a bit with slight jowling...not too much. I would prefer something uninvasive, can you recommend? Also, was thinking maybe a lower face lift...thoughts? Appreciate any feedback you could give. Thank you!

[@dramirkaram]

If your jowling is very mild, radiofrequency microneedling + collagen-stimulating skincare like the Trifecta are a great start. If you want dramatic, lasting results surgery might be needed, especially if you’re noticing laxity beyond just mild jowling.

[@user-js9gn2hw9s]

@@dramirkaram Thank you so much for taking the time to reply to my question and offering your expertise. It means a lot.

[@dammar117]

Only a facelift will fix jowls. Radiofrequency can actually cause them. Happened to me.

[@user-js9gn2hw9s]

@@dammar117 What did you get done to give you jowls?😱

[@dammar117]

@@user-js9gn2hw9s An at-home RF device. I got it to prevent jowls, and instead, it caused them.

[@francebergeron7390]

In the Whi stydy the increasing Rick of Brest cancer was related to the combination œstrogènes and progesteron. Œstrogen only may be safe . Espacially in topic the absorption is minimal.

[@dramirkaram]

I hear you and as I've mentioned in other comments, I'm not making medical recommendations on HRT but rather sharing my opinion os the use of estrogen creams for ant-aging. While everyone has their own preferences, I personally favor tried-and-true skincare approaches with well-documented benefits and no systemic absorption concerns. Some prefer skincare to stay in the realm of skincare, and that’s a valid choice. At the end of the day, my goal is to provide clear information so people can think critically and decide what’s right for them.

[@judithsmith6181]

What can help with lumpy skin on inner arms ? Please help .. I’m exercising..

[@alexv5349]

Is there an equivalent for men ? Does topical testosterone have any effect on the skin ?

[@shannonlynnmomof3]

Such a timely video, my story, I am post menopausal and on systemic menopause hormones, estradiol and progesterone. I have had no issues. I went to one of the well known tele health sites and for the estrogen face cream. They say it's not systemically absorbed. I was using it for 4 months and suddenly got breast tenderness and some minor spotting, it literally was feeling like I had increased my HRT but the only difference was the added face cream. I have obviously stopped the face cream. I am curious if this is happening to other women.

[@dramirkaram]

It’s not outdated at all. The data doesn’t exist to support its use in people who have a history of these cancers. In addition to a thorough reviews of topical estrogen and skin. I have literally asked several practice gynecologists, cancer gynecologists, and medical dermatologists and the hands down consensus they would never prescribe exogenous estrogen in any form in patients with this history. So I have to go with that. I am here to share. You can’t get this without a prescription anyway so hopefully a good medical history is taken and ultimately the choice is yours like everything else right? It’s just a personal decision if the benefits outweighs the risks.

[@shannonlynnmomof3]

@ I don’t think it outdated, maybe this reply for another comment. I wish I had seen this video before I went and signed up with one of these online companies, now I’m dealing with these issues.

[@barbarastarr8791]

Similar to my experience; prescribed for gyn problems, breast got tender, spotting, weight gain ,sluggish. Felt better when I discontinued it. Was to use the estrodiol vaginally. Not for me anymore.

[@shannonlynnmomof3]

@ thank you. Glad I’m not the only one. And really am curious how many more ladies are experiencing the same since there is such a big push for these anti aging estrogen facial products

[@reginaw5085]

Hello Doctor, I have a question: I am on HRT anyway, monitored by my gynecologist. I use systemic estrogel on my arms. Would it do any harm if I use some of it on my face, without increasing the total amount? I understand your point that there is a danger of overusing. The question is, does it even make a difference on what body part I put systemic estrogen? Or is estrogel even helpful to face skin? Thank you.

[@dramirkaram]

That's definitely something you need to speak to your gynecologist about. In general, I do not recommend using a prescribed product for anything other than what it was prescribed for.

[@dramirkaram]

Probably best to ask your doctor but skin is skin as far as absorption I would assume

[@reginaw5085]

Yes, thank you!

[@Saby217]

​@@dramirkaramAgreed, apply as doctor prescribes for best absorption. Positive impact on overall skin (not just the face) happens automatically as hormones come into an elevated balance. Separate regimen exclusively for face.

[@angelinaperfumes]

The alternative will be to come to you for your amazing face-lift but not all women can afford it unfortunately....

[@dramirkaram]

I completely understand that surgery is a significant investment and not the right choice for everyone. That’s why I offer a solution in the KaramMD Trifecta, which is a more approachable starting place for achieving healthy, radiant skin. It provides comprehensive skincare that targets the key elements of skin aging-repair, rejuvenation, and protection. It’s an effective way to enhance your skin’s appearance and health without the commitment of surgery. Many of our customers find it to be a great option to see meaningful results and build confidence in their skin

[@jennifermccullough775]

I had an estrogen positive tumour so i won't be using it.

[@dramirkaram]

Yeah I think that’s good decision

[@kathybriggs1299]

I do agree that you can’t be haphazard with Estrogen levels and need them them checked regularly. There is a lot of new research that shows the benefits of estrogen and debunks the 1990 study -which was done poorly and showed a .025% increase of cancer in the test group, which is statistically insignificant. The bloodclot study showed an increased chance of bloodclots from 19 out of 100K to 26 out if 100k some say it’s a almost 50 % increase, I still say 7 out of 100k is insignificant. HOWEVER, you do need to be treated with HRT under the care of a doctor who is up to date on how to do it. Smearing it on your face or taking huge amounts of Phytoestrogens like soy and flaxseed cause issues.

[@wendypatterson6091]

I've had my blood drawn. Zero change. Now does my skin look better, absolutely. Zero systemically absorbed estrogen changes. The reason it's not used is because all those other treatments one can offer are money makers. Estrogen is fairly cheap.

[@Eden639]

There is financial interest in supporting the estrogen creams or other anti-aging treatments. I hope the other doctors that are mentioned in the comments supporting estrogen creams are not selling them or are affiliate marketers. For me cancer is a risk I don’t want to take. Wrinkles are not killing anyone. Prefer to save my money for surgery.

[@dramirkaram]

I agree that everyone should assess the risks and do what's best for them with the information they're given. Thanks for watching and being part of the conversation.

[@levelupmaya5217]

There is 3 types Estrone (E1) is the primary form of estrogen that your body makes after menopause. Estradiol (E2) is the primary form of estrogen in your body during your reproductive years. It's the most potent form of estrogen. Estriol (E3) is the primary form of estrogen during pregnancy. pills given to women have high concentration during many years this is the big issue because it goes through liver the other one are topical is they giving it for vagina … and are bio similar

[@sadberaimamovicbasic6112]

I've been using phytoestrogen cream (Pueraria mirifica, Dioscorea villosa, Foeniculum vulgare) which also contains hyaluronic acid, vitamin E and citric acid. It helps me with hot flashes in premenopause. I put the small amount on my inner thighs and elbows, neck and stomach. I didn't know that it could be used as an anti aging cream. I am on retinol, vitC, hyaluronic acid and niacinamide that I bought in separate packages and use as you instructed in your previous videos.

[@dramirkaram]

Thank you for your comment! I haven’t seen any studies directly comparing estrogen creams to a comprehensive skincare routine with proven actives like retinol, vitamin C, niacinamide, HA, and lipids. Additionally, research on estrogen’s impact on collagen production at the molecular level is still limited, and clinical dosing studies remain sparse. My perspective is that skincare should be predictable, safe, and backed by strong evidence, which is why I lean toward well-researched ingredients that offer reliable results like the ingredients you mentioned you're already using in your routine. I would suggest you stick with that and only use your prescribed cream for it's intended use.

[@sadberaimamovicbasic6112]

@dramirkaram thank you! I share the same opinion! Best regards!

[@primordialmeow7249]

Great patient teaching Doc. 70 yo RN here. I’ve dabbled in BOTOX, a few fillers and laser when making the big nursing bucks in Cali. 10.5 years post-menopausal now. Used BHRT for 1.5 years during “the change.” The time of life that was difficult for me regarding the emotional and physical changes related to aging was mid to late 50s when I would have considered some targeted plastic surgery. I am a skin care freak who is often mistaken for 60 which I enjoy. Lots of breast CA scattered throughout the fam. My decision: There comes a time when many of us lucky ones see aging as a privilege. I am at that beautiful place. Therefore, I am a hard NO to topical cosmetic estrogen for skin care. I will stick to my actives and an and a couple of home devices that have science behind them. I do not have FOMO.

[@dramirkaram]

This is all great and good for you!

[@clarebennett4894]

What are your thoughts on taking Evening of Primrose Oil?

[@Saby217]

Its good for hair, skin and nails

[@dramirkaram]

If you're considering taking Evening Primrose Oil, it's best to consult with your healthcare professional, especially if you have hormonal conditions, are on medication, or are prone to skin sensitivity. While some people swear by it, others may not see significant benefits.

[@clarebennett4894]

I have been taking it for 35 years and have only now heard that it is bad for you, but I think I have had good effects from taking it. My question is do I keep taking it or not??

[@jennicrow2946]

For me, zero results with estrogen cream so far. Focusing on crepey under eye skin.

[@dramirkaram]

Thanks for sharing!

[@tamiz8895]

It triggered migraines for me, so I stopped using it.

[@dramirkaram]

I'm sorry that happened!

[@dorothywonderbread7480]

I do it, 1/2 pea size of estriol cream at night, no more. just 4 months in, so no verdict yet as I believe real change in skin is noticable only after 6-12 months of use.

[@dramirkaram]

Thank you for sharing, Dorothy. Consistency and continuity are essential for any skincare routine so time will tell. I personally don't believe estrogen creams offer the same low risk, high yield results as tried and true active ingredients like Retinol, Vitamin C, Niacinaminde etc so you might consider incorporating those into your skincare routine if you aren't already.

[@dorothywonderbread7480]

@ Of course they are! I also had a vertical this fall. Best I’ve ever done. I’m low on estrogen as I’m 52 and I monitor my levels every 6 months. I’m dead serious about my skincare. Thank you for an excellent YT-channel!

[@Counterbalance_]

But you said nothing about phytoestrogene, ingredients such as soy isoflavones.

[@dramirkaram]

Even less available data on efficacy etc

[@Counterbalance_]

@@dramirkaram , thank you for replying! I know people who swear by it and see some improvements after starting to use products with that type of ingredients. So, I really wanted to know an expert's opinion.

[@stephanied.k.3589]

I thought progesterone usage through topical cream was routinely used in Europe...no?

[@dramirkaram]

Topical progesterone creams are available in Europe, but their usage varies by country and individual medical practice. These creams are often marketed for alleviating menopausal symptoms, improving skin elasticity, and other hormone-related concerns. However, the effectiveness and safety of over-the-counter topical progesterone products remain subjects of debate. Anyone considering the use of topical progesterone creams should consult with a healthcare professional to ensure safety and appropriateness based on their specific health needs.

[@looovegoodmusic]

This is old news re WHI.

[@dramirkaram]

I appreciate you sharing your thoughts! This is skincare we are talking about. Not HRT. Recommending people consult with their physicians and making sure they don’t have any medical issues before starting a prescription medication will never be outdated recommendation.

[@looovegoodmusic]

@@dramirkaram Certainly. I should have mentioned that WHI research (or rather its interpretation) is what I was referring to. Thanks for educating us.

[@kaybalkunas]

Don't forget he has a skincare line for sale

[@dramirkaram]

How could anyone forget I speak to it in the video. The components in the Trifecta address every aspect of skin aging and the results speak for themselves. Have a look at the 3rd party testing results in the website. Additionally, if you or anyone don’t want to use the KaramMD Trifecta.. then go out and get the components and piece together a routine. Trifecta just make it all very easy and the formula compatible with the over 20 ingredients in those 3 steps.

[@bellakim9404]

The estriol creams that is sold through a lot of online pharmacies, etc in my opinion is hype. The other ingredients in such creams contain Vitamin C and hyaluronic acid that induces changes and plumpness in the skin that wasn't seen before due to the lack of. Estriol in my opinion and many other highly noted hrt/obgyn specialists states estriol is the wrong form of estrogen to produce youthfulness to the skin on the face. It's a dream sold in a bottle with many desperate women. Hrt and proper skincare, sleep, diet, and excercise with minimum stress will keep you glowing.

[@dramirkaram]

Thanks for sharing your thoughts on the topic, Bella.

[@verachagas2670]

Better to be safe ! Just use trifecta 🙏

[@michelles2299]

I tried it but the smell and thickness of the cream was pretty annoying so I just stopped using it on my face at night, by the way not long enough to make any difference to my skin

[@dramirkaram]

I hope you have a consistent, comprehensive skincare routine that you like. That's the best foundation for long term youthful looking skin.

[@milenabellotti9771]

I have always followed your advice 100% but you just lost me.

[@StaceyTully]

Can estriol make melasma worse?

[@dramirkaram]

Yes, estriol (a weaker form of estrogen) has the potential to worsen melasma, though its effects may vary based on individual factors. While not everyone will experience worsened melasma with estriol, if you are prone to hormonal pigmentation, there is a possibility of increased pigmentation risk.

[@StaceyTully]

@@dramirkaramthank you

[@DM-dy9cw]

Looked into it lately . Called my OB and got estradiol %1 vaginal cream. On my face after serum every night with tretinoin 1%cream. Skin Never looked better. No reason for expensive products.