Why Peter Attia Changed his mind on METFORMIN

[@Sandra.Viewer]

“The master key of knowledge is, indeed, a persistent and frequent questioning.” - Peter Abelard

[@rogerbird5665]

Peter Abelard said that about 700 years ago. He is absolutely correct when it comes to external, objective matters. We call it science now. When it comes to internal, subjective matters, what St. Augustine of Hippo said about 1600 years ago: "Knowledge and experience comes from persistent faith."

[@alant383]

@@rogerbird5665 Hmmmm .... not sure that faith is an objective source of scientific knowledge, or how to use it .... Our understanding seems to have changed (thankfully) in the last 1600 years.

[@rogerbird5665]

@@alant383 Science is fantastic and appropriate for objective matters. There is no substitute. But for subjective matters, it isn't worth shit. If you disagree, tell me all about consciousness, where it comes from, how to make it, what it is made of, how we improve it (keep in mind WW1 and WW2, etc.).

[@alant383]

@@rogerbird5665 Consciousness is the subject of psychological study, We could argue how scientific that subject area is at great length. There is no doubt that psychology is at least partially an analytical science. But subjectivity is by definition a matter of opinion or at least a person's viewpoint. And everybody is entitled to their PoV - imo. :-)

[@rogerbird5665]

@@alant383 Trivialize it even though without it NOTHING EXISTS.

[@rossbabcock3790]

"Doctors put drugs of which they know little, into bodies of which they know less, for diseases of which they know nothing at all." -Voltaire

[@robynhope219]

Voltaire is outdated. We know a lot about drugs today. Metformin has been around for decades and researched for anti-aging. It's all good, but of course, like any drug, it has side effects.

[@georgeporter5665]

I loved your presentation, making complex Topics understandable. I also appreciate shorter videos like this. Thanks

[@DoctorBoz]

We are trying … I sure like to talk -- so this is amazing how short we got this!!

[@BeckyJB888]

❤love this example! About 20 years ago I refused metformin. I began not eating sugar and started eating whole foods. ❤ apparently that wasn’t enough because today I’ve gone keto for great results. I am reaching for longevity. ❤❤❤❤thank you again Doctor!!!

[@e.j.oneworld]

What is your ApoB level? With Keto for over 10 years, mine was 178! And it’s a major factor risk for atherosclerosis according to Peter Attia….

[@JasonActualization]

​@@e.j.oneworldPeter has yet to discover that ApoB in and of itself is not causal of atherosclerosis.

[@zibtihaj3213]

Exactly … mine is 87 and I am trying to lower it also ( not on Keto )

[@loneranger7573]

@@e.j.oneworld If your thyroid hormones arent up to snuff, your lipos will be off. Check your thyroid, and consider HRT as well if you are over 50, male or female.

[@christinehebiton4126]

Look into Dr Ken Berry

[@robertstancliffsr9575]

I began taking metformin when I was 35 I am 80 now and still taking it. I take 2000 mgs daily and have no kidney damage, no low B-12 or any other side effect, except possibly in the last few years, constipation. On the other hand, that could also be just getting old. There is a reason for the old people and prune juice jokes. It's easy to fix with a stool softener or laxative as needed. I am also 5 years older than the next oldest member of my immediate family lived to be. I have no idea if metformin has anything to do with that. I still take it and see no reason to stop............Excellent drug for me that allowed me to eat more of what I like with no problems. I still do pushups and other exercises and try to walk daily, although nowhere as far as is recommended. So far so good. My blood test results are always good...... Something else I do "wrong" and have since "Tab" came out in about 1950 is drink a diet soda or two almost every day. I like them and see no reason not to. If the artificial sweetener is going to kill me now 80 is a pretty good run, and right now I am doing fine.....

[@刘龙-r2l]

Bless you.

[@sabda01]

One week bhane ko chha

[@robynhope219]

I take metformin the last two yrs bc I have adrenal fatigue which accelerates aging, and metformin slows it down. The side effect for me is I'm less hungry, which is a bummer bc I'm underweight 🙁

[@martinlutherkingjr.5582]

I began smoking when I was 3 years old, I am 80 now and still smoking. Right now I am doing fine….

[@robynhope219]

@@martinlutherkingjr.5582 what kinda parents let their 3yr old smoke 🤔

[@leslietascoff9784]

Fantastic! Thank you for summarizing the reason that Attia stopped Metformin. I heard him talk about it but it sounded more complicated. Your explanation was perfect for me! 😎❤️

[@audis4bb]

I'm a biochemist and the problem I have with Peter Attia is that he loves pharmaceuticals, including statins. Statins has significant side effects, including but not limited to increased risk of type 2 diabetes and Alzheimer's and he's still recommending statins in spite of this. He never mentions Niacin which works just as well with none of the side effects. Some common side effects of Metformin include nausea, vomiting, diarrhea, stomach discomfort, and headache disorder. Berberine works just as well with none of the side effects. If I didn't know better, I wonder if he is a consultant to some pharmaceutical company like Scott Gotlieb, former FDA commissioner with revolving door and big paychecks from Pheifer. Attia does not like saturated fats and spews the big Agra propaganda that saturated fat is bad and PUFAs are good this is just incorrect. Check out: Shawn Baker, Paul Saladino, Anthony Chafee. Anyone that pushes pharmaceuticals as opposed to natural alternatives I'm very leery of.

[@lagarde2011]

I've always had high cholesterol though I've never been close to being overweight and I (usually) have a decent diet, exercise, etc. A couple years ago I had a blood panel done and the total cholesterol was 280 with a high LDL being the driver. GP told me to start on statins but I said I wanted to try niacin and I pointed out that my triglycerides were very low so I wasn't worried. GP told me that niacin "doesn't work" and he's never had a patient suffer side effects from statins. Hard to believe, but whatever. He seemed not to understand the implications of the triglyceride numbers. I took niacin for 4-5 months before getting a new panel which showed my total cholesterol and LDL each down around 40 points. Mind you, I hadn't made any real changes to my diet, though the niacin does suppress appetite, which was a happy surprise. Despite the results, the GP still insisted that I start on statins. I changed doctors.

[@AstwoodF]

Niacin does work, but it depends on how low you need to lower your LDL. Not defending Peter here, but in his book, he doesn’t really disparage Saturated fat, and he says that the studies are inconclusive on PUFAs and MUFAs. Given the literature out there, his recommendation is to favor MUFAs.

[@Jojo-o6o6w]

Once I found out Attia was a fan of statins and other pharmaceuticals I stopped paying any attention to him.. it told me all I needed to know about his depth of knowledge and understanding.

[@mey7579]

Niacin has plenty of side effects as a family member of mine found out the hard way. He had skin flushing, a rash, and stomach issues.

[@Jojo-o6o6w]

@@timbo8366 ur weird

[@MrBrianDuga]

I appreciate the translation of Peter Attia's technical language.

[@mariejones7136]

I take berberine which lowers my glucose along with keto diet and I use it since I'm cancer survivor..It works .I also fast .

[@bseidem5112]

Scientists have discovered the ivermectin cures 15 common cancers.

[@jeffreyjohnson7359]

Berberine does essentially the same thing as metformin, but it is less effective because it isn't absorbed as well. I take both.

[@mathieskoljasuszkiewicz242]

Me too. And sauna and cold showers weekly. Green tea, curcumin and many other supplements and herbs

[@Tumaini94]

​@jeffreyjhiw do you take it? Together or separately? I started taking it but is not working!!!

[@Tumaini94]

Where do you buy it? The one I bought is not doing much on me....

[@jorgegonzales9815]

Disappointing Dr. Boss to hear you are/were a fan of Attia. Guess nobody is perfect. After listening to many of his videos I don't listen to him anymore. He seems unable to explain issues without a lot of medical mumbo jumbo which I think makes him sound arrogant. Thanks for your friendlier more down to earth explanations that we can use to keep healthy.

[@danielhancock6188]

I have been on metformin for 10 years as a type 2 diabetic. As I have learned more about the metabolism, I have been reversing my diabetes. I'm still on medicine, but my A1c was 5.5. But metformin has made me B12 deficient. I am working hard with my diet so that I can eliminate metfomin. I believe it is slowly killing me because it has caused me to be anemic.

[@George-lz6ue]

A single teaspoon of dried yeast flakes a few times a week significantly boosted my B12 levels.

[@terfalicious]

@@George-lz6ue And it's yummy! I put it in my yogurt in the morning - gives a nice, nutty taste!

[@RhondaWills-o9q]

I think you should be able to come off Metformin now with that GREAT A1c number. Congratulations! What A1c score is your doctor looking for before taking the Metformin prescription away?

[@hevesat1920]

@@George-lz6uewow, that is amazing. I heard about it from Dr. Berg but did not know it was so effective

[@danielhancock6188]

I don't know what A1c my doctor is looking for. I was on 6 different prescription drugs. I am now down to 2 - metformin and gllipizide. I was told I could drop my blood pressure medicine. I am moving in the right direction.

[@Jojo-o6o6w]

Once I found out Attia was a fan of statins and other pharmaceuticals I stopped paying any attention to him.. it told me all I needed to know about his depth of knowledge and understanding.

[@grayrabbit2211]

My GP has actually never written a single script for a statin in his practice. Then again, he spent many years in a research lab before heading off to medical school, so he actually has an understanding of how the body really works.

[@Initium1000]

You sound ridiculous because you’re not medically trained and not a single person cares about what you say.

[@ShadowWhispersStories]

@@Initium1000 You sound ridiculous because you’re not medically trained and not a single person cares about what you say.

[@Initium1000]

@@ShadowWhispersStories so I’m a Facility Administrator (do you know what that means?). And I worked in pharmaceuticals for 10 years previously. Feel dumb? You look it.

[@jerseytony1]

@@ShadowWhispersStories Not being Big Farm brainwashed is a blessing

[@hu6860]

I took Metformin from 2016 to 2021 and it damaged my kdney that caused me skin rashes almost all over my body. It was killing me slowly. Then because of skin problems, doctor advised me to take statins which really I thought Im going to die soon. Ive did a Big U TURN. From Dr. Tan, I started listening about the low carbs diet which can reverse diabetes. Then start listening to different doctors. Finally on June 2022, I decided to stop these meds and do the LC, ketogenic and fasting. Its nearly 2 years now, thank God Im still alive. Not perfect LC or ketogenic but I reduced carbs, sugar, bread, pasta or any foods that contains sugars. Feel energetic and positive. Now, Im back again to low carb after holidays. So far I can even walk 2-3 hrs a day without getting hungry

[@JJ-vp3bd]

any updates on diet and medicine?

[@SalemSnow1]

I doubt it you're probably taking like drugs or alcohol that damage your kidney

[@rancancookcanoy9768]

Another great video. thank you. My doctor wanted me to take Metformin, but I decided to reduce my carb intake to less than 20 carbs per day.

[@DoctorBoz]

You win

[@colinmacdonald5732]

Is that the same as limiting yourself to 20 Oreo cookies?

[@colinmacdonald5732]

Is that the same as limiting yourself to 20 Oreo cookies?

[@colinmacdonald5732]

Is that the same as limiting yourself to 20 Oreo cookies?

[@colinmacdonald5732]

Is that the same as limiting yourself to 20 Oreo cookies?

[@deirdrewalsh1134]

My Father used to say over and over to me -…”remember if in doubt, the answer is NO” As far as Mainstream medicine is concerned, it’s pretty good advice.

[@mfaracing]

Totally agree. In a word: wisdom.

[@area51z63]

My father always said, do not take your medical advise from doctors who lost their license for committing fraud like Annette Bosworth did

[@robynhope219]

If in doubt, leave it out🙂

[@garygjl9036]

your father isn't a scientist, doctor, a guru, a new age idealistic, a shaman, likely a bleeding heart republican. so do what floats your boat and leave the rest of us to our success with metformin.

[@garygjl9036]

@@mfaracing bullocks.

[@marinabrantner6415]

I was started on metformin when I was diagnosed with type 2 diabetes. A1C at that times was unmeasurable because it was so high. My blood sugars and A1C improved. Metformin was stopped when I developed chronic kidney disease due to asprin and ibuprofren use over the years. MD stated my blood sugar would likely be high. They were actually lower. Later a read a review that concluded that in a lot of people the metformin passed through the body and was never absorbed.

[@uberpekes]

The only real things I care about doing for health are 1) Eating healthy (which is a minefield of debate) 2) Lots of cardio (more low intensity but high included as well) 3) Strength training 4)7-8 hours sleep 5) Time restricted eating. Those are my 5 pillars I guess. And there are most certainly other things you can do but imo the science/doctors recommendations change (this vid is proof) too frequently.

[@BeefNEggs057]

Avoid things that spike blood sugar above 120. More beef. Less veg with their defense chems.

[@jeffreyjohnson7359]

Although I do some TRE, it's not really showing benefits in studies aside from reducing calories. Another important thing, which I don't really do, is stress reduction, for example through meditation. Also, a few key supplements, like Omega 3, D, and perhaps a multi (there's a lot of others that have some evidence).

[@meatdog]

So does Berberine do the same as metformin in blocking the O2 and producing lactic acid????

[@Lulu-kt6gr]

A little less oxygen to your muscles is not going to hurt you and might even help. As long as you’re not feeling extra tired, you’re fine. Adjust your dose if you are tired.

[@Thunderstick-y8h]

Wouldn’t even a little less oxygen to your muscles negatively affect athletic performance ?

[@seascape185]

@DrBoz I have COPD it’s very bad . I’m asking is all my work in carnivore for nothing? I mean sometimes there is not enough oxygen to go to the mitochondria? I’m 112 but ii was 136 . I’ve never been that heavy but I was fat 155 ate cRbs alcohol smoking . Thfen I havnzeatrn carbs for 15 yrs or alcohol.stop sun and smoking .Anyway what can I do to know ?Thank you for all that you’re doing. 😊

[@ioioiotu]

@@Thunderstick-y8h You can either have maximal athletic performance or maximal longevity, just ask steroid users :)

[@dr.shadmbbsdphmasco]

Berberine is better than metformin

[@ariston5433]

I have been on metformin Er for 7 years. I was getting diarrhea from it at the 2000 mg dose but since I have cut it back to 1500 mg a day that does not happen. I just went to my Dr. and all my bloodwork was good. I eat right watch my portions, exercise and take care of myself. I am 70 and walk an hour a day and when the weather is bad I walk on my treadmill, I am of normal weight and not obese. I have had high blood pressure since I was 20 years old and weighed 99 lbs. I had hyperthyroidism in my 30s and had to have RAI on my thyroid. So now I have to take Synthroid. Between my thyroid , menopause, I gained weight and was unable to lose any weight so my endocrinologist put me on metformin ER. I immediately lost 8 lbs by doing absolutely nothing. It helped control my appetite too. I wish I was one of those health food superstars that doesn’t let a single processed food molecule touch my lips and only the purest Alpine spring water fill my glass. I do watch my portions, watch my carbs and try to stay away from processed foods. My blood work came out normal no bad cholesterol or high triglycerides, my glucose levels are good too. I hardly ever get sick with anything so I feel fortunate.

[@bill9989]

I take metformin and I'm not diabetic nor pre-diabetic. Here's why. Before metformin, my fasting (morning) glucose stayed around 90. After metformin, my fasting glucose is around 84. Alzheimers disease is sometimes called Type 3 Diabetes. I don't want Alzheimers disease. The association between AD and prolonged high blood glucose is very strong. Furthermore, do a little mental exercise: Search "metformin and X" where X is any ailment, disease, or condition you think of. The results are very positive for metformin. Finally, Lactic Acidosis is a rare but well known danger for metformin. However, taking Vitamin B12 usually reduces or eliminates that danger. Obviously, I take B12. It has a fairly long half life in the body so I take it a couple of times a week.

[@DoctorBoz]

Metformin lowers blood glucose … the price you pay is to grind on your mitochondria- the sugars are lower … but not because you’re healthier … they are lower because of what you’re doing to your mitochondria… Alzheimer’s is called Type 3 Diabetes because of the tax your body pays from the elevated blood sugars and the ensuing grind of your mitochondria. My approach = lower the sugars without the med.

[@bseidem5112]

A Doc in AUS cured ALL his Alzheimer patients whether in a facility or in a private residence with a strict keto diet (Dr Berg, KZbin).

[@mfaracing]

@@DoctorBoz You are the best!

[@bill9989]

@DoctorBoz But there are other reputable medical and longevity experts who say the mitochondria stressing that you advise against, is actually a positive in that it either strengthens the mitochondria or induces it to make more (or both). Similar to the stressing effects of exercising. Edit Update: I'm a 74 yr old male. My A1c is 5.1 and my Insulin is 7.6 (less than 18.4 is considered optimal). Since I started metformin I've lost 20 very stubborn lbs and got my BMI down to "normal."

[@garnerblair5179]

Lack of folate and b12 will cause issues with methylation and homocysteine. Take a look at homocysteine and dementia. Not good .

[@kathy5438]

Dr. Ben Bikman also has a lot to say about NOT using Metformin and the issues and problems associated with using it.

[@maesc2001]

My dad has been on metformin for 42 years. He’s 92 and running circles around me. 😅

[@刘龙-r2l]

Bless you

[@JJ-vp3bd]

Bless you

[@yennyjen5742]

Good to hear that. I am 37 yrs old and dr prescribed metformin. I been afraid to take it. I I keep hearing about it messing the kidneys or giving another issues

[@robynhope219]

Hard to believe when so many of us have bothersome side effects.

[@maesc2001]

@@robynhope219 As you said: so many of us; not all apparently.

[@DCGreenZone]

Berberine potentially for PC. >>Yeah, after taking Metformin, I felt the the affects on my heart and stopped after a day or two and that was in my early 30s. Now Berberine has helped my heart and I can feel the difference. Both being pretty apparent. Berberine is a way better choice than Metformin. What’s interesting is that I have been taking bio-available Berberine 500mg 2X per day. I have literally not been sick with even a cold whatsoever since I’ve been taking it daily for over a year 🤔

[@Tumaini94]

I am trying, taking it 3 times a day but still high....

[@PulinAgrawal]

Sorry I do not have the time to verify what I am saying, but I thought that 2012 study was done only on diabetics. Meaning that they couldn't have said anything about mortality of non-diabetics as suggested before 2:04 in the video. Also, I thought that 2012 study suggested that people taking metformin had a lower mortality, hence for longevity.

[@nancykowalczyk2070]

Please don’t assume most of us aren’t interested in the deeper scientific knowledge…….its what I’m MOST appreciative of learning.’

[@Boilerking76123]

Metformin was the first diabetes medicine that gave me stomach cramps and diaries. Had to quit it after first week

[@RhondaWills-o9q]

It's poison.

[@war-painter]

I was in love with it for the first 18 days and 9 lb weight loss, immaculate regularity every day on time until three days ago when bloating and constipation hit me. Now the weight I lost is coming right back! This is so unfair when I don’t feel like eating, I’m soooo bloated and miserable. Awful drug.

[@galinarovensky3921]

Thank you so much for the detailed explanation. Do you believe Berberine is as dangerous as Metformin, in terms of reactions? Could you provide any information or opinion about the use of Berberine?

[@jameschesterton]

It is insane how doctors are taking prescription drugs without fully understanding the implications.

[@Jojo-o6o6w]

Once I found out Attia was a fan of statins and other pharmaceuticals I stopped paying any attention to him.. it told me all I needed to know about his depth of knowledge and understanding.

[@09mubarak]

same @@Jojo-o6o6w

[@oldwaltonian2476]

@@Jojo-o6o6w A very good move on your part, I would say. We need to stop getting sucked in by these 'doctors' and their constant 'see-sawing' over what pharamcuetical drugs and 'natural' supplements we should and should not be taking for optimising our health.

[@Rob-vl1vc]

What's so unusual about people taking medications that haven't been proven safe long term? It happens over and over and over again. Doctors prescribe them every day.

[@melry5460]

Dr David Sinclair also takes metformin even though he’s not diabetic

[@gabygutierrez8366]

Hmm I have taken Metformin for over 14 years due to PCOS, and I love how it balanced my symptoms…. And it helped me to get pregnant and everytime I stop taking it my symptoms start again…. So I got back to it…

[@patricktrussell7465]

What is PCOS ? Nice abbreviation .

[@dezaiire23]

@@patricktrussell7465PolyCystic Ovarian Syndrome

[@sabinekoch3448]

@@patricktrussell7465polycystic ovarian syndrome

[@kristinro7226]

Polycystic Ovarian Syndrome

[@audreydurham7442]

I stopped taking taking metformin after nearly a year due to a terrible cough when I did not have a cough at all !! Lactic acid reflux to the extremes!! Now I have none !!

[@Calidastas]

"It might not have done what we thought it was doing" should be the motto of the medical industrial complex.

[@MartyRaaymakers]

Thanks for making this easier to understand. Good video 😊

[@dr.sabircholas6074]

Thank you Dr annet for this insight. I think we have to wait more for future studies. Im a pulmonologist do you think a state of Latic acidosis could be beneficial as weight training produce lactic acidosis and is it helps in some pathways that promotes health and likely longetivity .

[@pomanprod]

My running performance decreased after taking metformin for 6 months. Specifically I had trouble doing sprints. I read that it reduces mitochondria formation so I stopped metformin. I take berberine instead.

[@robynhope219]

Berberine has same side effects, only milder.

[@Linda-xr8zw]

As a prescriber, if someone needs to start medication for high BG what would be your first choice? Metformin has always been encouraged as a first line med. I appreciate the information in the video. I under stand Keto works , albeit by varying degrees from person to person. But some people do not have the means to initiate keto lifestyle changes for a host of reasons.....

[@YeshuaKingMessiah]

U can do it No excuses

[@y00t00b3r]

you mean people have a host of reasons for not initiating lifestyle changes that are available to everyone.

[@Linda-xr8zw]

@@y00t00b3r well as an example, some people are opposed to eating meat and dairy for religious or political reasons. Keto is not going to work for them.

[@y00t00b3r]

@@Linda-xr8zw Avocados, olives, macadamia nuts, pecans... It wouldn't be easy, but it would be worth a try. You can't help the un-helpable. You might have to resort to metformin if switching to a whole foods diet was not adequate.

[@jobrown8146]

People need a motivator (for me it was learning that you can go blind and get kidney damage) as well as education (learning the various methods that are available so they can choose). If people don't know that it is possible to remit diabetes by changing what they eat then they aren't being given choice. If they are educated and then choose not to change their diet then they have made an informed decision. I remitted my diabetes in less than 3 months just by changing to low carb. When I was diagnosed with diabetes, my GP wanted me on metformin, a statin and also see a dietician (in Australia). I said no to the drugs and that I would try diet first and told her that you only change one thing at a time. At the follow up appointment when I got my blood test results I said to her that I hope from now on she suggested diet before drugs. If I had taken the drug/s and changed my diet I think that the drug/s would have been assumed to have made the difference or contributed to the remittance and I would possibly have ended up on them for life. ALL DRUGS HAVE SIDE EFFECTS.

[@Aviation_Professional]

Wise choice!!! Ray Peat nailed this down decades ago...! RIP Dr. Peat

[@boromirofmiddleearth557]

interesting video. thought about taking metforminbut didn't. don't take statins. doing a sardine fast right now. As a Norwegian American I prefer King Oscar wild caught brisling . Doing well! start weight 275 lbs down to 272 lbs on 2nd day. looking forward to doing your program Dr Boz!

[@ariston5433]

I have been on Metformin Er for 7 years. My endocrinologist waited several years before putting me on it. I could not lose weight no matter how much I tried . I have hypothyroidism due to RAI being given to me for hyperthyroidism. I was on antidepressants for many years and then menopause hit me and I was hungry all the time no matter how much I ate. I have since quit the antidepressant, and have cut down on the metformin. I watch everything I eat , exercise every day. I went to my Dr. two weeks ago and my blood work came out normal on everything. The Dr. told me that my weight is fine too. I really do not want to get off off the Metformin because I do not want to be hungry all the time. Sorry I am one of those defective horrible people who has to take meds for my thyroid and blood pressure ( I have had high blood pressure since I was 21 years old and even had it when I weighed 99 pounds. I wish I could be one of those perfect people who could just pop a vitamin and be healthy food superstar.

[@Eldorado66]

@ariston5433 first of all, it's important to acknowledge the incredible resilience and dedication you've shown in managing your health conditions. You've been attentive to your body's needs, making adjustments as necessary, and that’s no small feat. It's truly commendable that your recent blood work shows everything is normal and your doctor is satisfied with your weight. This is a testament to your hard work and careful management of your diet and medication. Please don't be too hard on yourself by thinking of yourself as "defective" or "horrible." It's crucial to remember that our bodies' abilities to process foods and supplements are largely dictated by our genetics. Each person's body has its own unique needs and responses, especially when it comes to managing conditions like hypothyroidism and blood pressure. The fact that you require medication doesn't make you less than anyone else-it simply means you're taking the necessary steps to care for your health. You're doing everything right by monitoring your health, staying active, and listening to your body's cues. Keep focusing on your health and well-being, not on an idealized notion of perfection. You are strong, capable, and worthy of self-compassion. Continue to advocate for your health as you've been doing, and take pride in your journey. You’re not just surviving; you're thriving, one step at a time.

[@Dalf-x5m]

@@Eldorado66 what a lovely reply. I agree with you !

[@whitGGG]

Thank you for explaining in a way that we can understand.

[@painfreebiology]

The electron chain is on the inner membrane inside the mitochondria, not the outside.

[@Ant88889]

I heard something even on mainstream that metformin use showed increased danger. I will look it up. Just the side effects were not just the problem. New studies showed other dangers.

[@greggbambu411]

I'm sticking with metformin for anti aging. It keeps glucose and insulin low. Thats a great thing for longevity.

[@robertstancliffsr9575]

I'm 80 now and have been taking metformin for type 2 diabetes for 45 years. It has caused me no problems. Not going to say much about the longevity effect I hit about 90......but, I am currently 5 years older than the second oldest member of my immediate family lived to be............

[@Soliaipix]

Would it have helped to take B-12 with the Metformin?

[@robertstancliffsr9575]

Yes..........

[@medusa1340]

Definitely

[@robynhope219]

Yes, also CoQ10

[@robertstancliffsr9575]

I had my B-12 checked after years of Metformin and it was in the middle of where it should be. However, I now take a B-12 supplement anyway because it is not going to hurt anything...

[@StarvingMyselfToLIFE]

So. How does he or anyone determine what damage may have been caused down stream because of this disruption of a normal bodily function and how to repair it. Taking a foreign synthetic drugs to prolong the life of a any living species doesn't seem logical on its face, but what do I know?🤔

[@chazwyman]

As a general rule I avoid medication taking for non critical conditions. My only exception is Allopurinol since getting gout is not nice and taking Allopurinol is preventative. My next question is do I have a deficiency? This way I ended 4 medications, and am more healthy for it.

[@Hai-t9e]

I am prediabet, taking metf since 24 until now 55.

[@wesleycardinal8869]

Interesting. My wife recently went on to metformin at our request. She has MS and I was encouraged by a study from Cambridge Uni in conjunction with researchers from the Uni of Melbourne that found a reversal of damage in rat studies with fasting and metformin. I would have liked to see her take on fasting and I have Dr Boz's book on the Keto diet and her mum. But she's not interested in serious fasting, and I can't change her mind. But the fact that metformin was also shown to give the same benefits was encouraging. It's still early days for her and we will have to wait and see if there's any improvement.

[@RhondaWills-o9q]

Berberine, an OTC supplement has been proven in studies to be as effective as Metformin, or better, without all the side effects of Metformin.

[@loneranger7573]

Consider this and do your own studying: Many women go into remission from MS during pregnancy. Why? becuase of high levels of Progesterone. Progesterone helps build Myelin sheath. if you live in the US, you can get Progesterone cream at any drugstore. or order online. I take it as part of my HRT. 200 mgs Prometrium.

[@suemcdermott5230]

Have you researched Dr Roy Swank’s diet? No fasting but very low fat diet. Scientific results for 50 years were mostly very positive.

[@amberelizabethjensen4489]

Estriol, (E3), has been shown to reduce MS Plaques in the Brain. It's OTC in the USA. Purchase at Health Food Stores.

[@war-painter]

@@loneranger7573 - Make sure she doesn’t have breast cancer in her family. Everyone loves to say “ just take HRT” but it’s very easy to get breast cancer and I have several family members who died after doing HRT.

[@Tinfoilhat311]

Muscle cramps, bloating, and other issues did it in for me. I stopped taking it and completely revamped my diet and exercise program, and my bloodwork is good. The main reason for type 2 diabetes is diet. The food being sold in this country is horrible. I focus on single item ingredients and am so much healthier for it.

[@YouTuber-ep5xx]

1) Think long and hard about taking ANY pharmaceutical. Unknown/unintended consequences. 2) Get your nutrition right for you as a human. 3) Don't blindly take your doc's word on anything. Use YT for second opinions.

[@isuriaravinda8211]

Appreciate your descriptive short video. Metformin caused muscle camps as well.

[@frankforshage1730]

Disclaimer: Not all people are alike and affected the same. That being said, my doctor put me on Merformin X 3 a day for elevated blood glucose, A1C of 8. After taking it for several years my blood glucose continued to rise, even with modifications of my eating. Fast forward to today, I weaned myself off Metformin and my blood glucose readings and weight dropped, to the point of being declared non diabetic. Best my doctor could figure is there was something in the Metformin that I was allergic to, causing inflamation, causing my blood glucose to elevate.

[@joannekerr8839]

I'm a T2 diabetic and I've been taking a small dose of metformin (500mg) every day - would this size dose, going on what you're saying above, be contributing even in a small way to me feeling tired/lethargic every day ?

[@l.s.3066]

Stop taking Metformin for a few days and see how you feel, then you can draw your own conclusions.

[@robertstancliffsr9575]

Hard to separate if it is metformin or just being 72. (I'm 81 now and I feel tired a lot, I think that comes with getting old.....

[@javierruiz1710]

All of my experiences, Mac Foreman were contradictory to what you're saying, my blood sugar went up higher. I'm Mack format. I got off the mac foreman, my blood sugar went down on mcmormon, I felt weak and helpless, and I could barely walk off mac foreman, I could work everything you're telling me, is the opposite from my experience

[@1607rosie]

I tried metformin a few years back I hated it everytime I took it I got diarrhea. Luckily I went on line and to see if there was anything else I could do. I learned being on a low carb diet worked. It been tough road but I keep working at. I can keep it around 5.5 -5.7 a1c. So if your on it you don’t have to be. I firmly believe low carb is the healthy way to eat.

[@frankh.5378]

Diarrhea is only for few days. If you go over week or two, your body gets used to it. I have been taking it for last 2 years daily (500mg)

[@PierreDybman]

I a t'ai Berberine, an a no tie ect

[@ioioiotu]

There was also the alternative of slow release metformin that has a much lower chance to cause diarrhea.

[@MarkHolmes]

@@ioioiotu I take 1000-1500mg of metformin ER (extended release) per day and have never had diarrhea issues and I've been taking it for at least 15 years

[@IonTrone]

Attia is another one of the irresponsible fairweather health influencers like Gundry and Saladino that sound 100% certain on something and then with the same certainty they say something different, and then something else different, and so on. Only constant thing with them is profit :)

[@robynhope219]

🤔

[@sampotter4455]

Shouldn't the common sense starting point be: don't take any drug unless you have to?

[@mohamadvarnasseri3129]

I have been on keto diet but my sugar went high Doctor gave me metformin. I don't like it, what should I take instead of metformin?

[@Mashallll12]

Why don't u like it it's works

[@DukeLitoAurelius]

Zero mention in this video of Metformin dosage used in the cited studies.

[@ioioiotu]

Sure a complete block of the electron transport chain will cause death, but there are good reason to believe a partial block prolongs life as an exercise mimetic and hormesis.

[@yveshenry1978]

Hi Doc, any mention of Berberine's mechanism of action? It seems to have many benefits with no down side. If Berberine can control blood sugar as well as Metformin, why would anyone take the latter?

[@MarkHolmes]

I have tried Berberine vs Metformin. Didn't do a thing for me, so I'm a bit suspicious of all of it's so-called "benefits"

[@Sub0x-x40]

something about it upregulating your insluin receptors after a short duration lead me to believe that if you didnt have diabetes, a short stint on metformin could be good used sparringly

[@vincentengongoro2705]

First of all, messing around with a car engine that's engineered to be as good as it can get from the factory, will inevitably result in a possible up side.. and a possible down side. The human body is no different.. If its not broken why would anyone try and fix it, or adjust it.. Taking a blood sugar drug when you don't need one?? Stupidity at its highest form. Second, I am type 2 and I took Metformin for years with practically no decrease in my blood sugar. I tested my blood while I was on it and tested it after I stopped taking it and found about a 5% difference (in the drugs favor), that said, with a very small amount of exercise and some corrected dieting and taking a cinnamon pill daily, I reduced my blood sugar by 75% from its high.. Third, on its own label, Metformin says one of its potential long term side effects can be onset of dementia or Alzheimer's.. so why would anyone in their right mind take this drug when they don't need to start with?? Too may YT gurus out there..

[@bjo179]

How do you measure lactic acid and what is the optimal range of values/units?

[@tankthearc9875]

i been taking it 7 years i lost weight over the years and i look younger then i am

[@Mashallll12]

How much mg per day?

[@dfgroup]

After watching this I wonder if the way methylene blue bypasses this fist hook up and delivers more to the fourth in the process, if this negates this metformin issue. Any thoughts?

[@WickedLowCarb]

I’m not a fan of Attia nor his “theories”. He is a proponent of PKS9 inhibitors if LP(a) is high. I was told my high LP(a) was genetic and diet would not lower it. At this time I was vegan about to go back to vegetarian (am now ketovoire). In 6 months I lowered it by 50 points just by eating saturated fat in cheese and eggs. 6 months after that it was down 100 points - to 46 - through diet alone. I just don’t find him credible at all. And BTW: I fit the criteria for LMHR, which he doesn’t agree with either.

[@mariejones7136]

He did a video where he said he drinks alcohol every day but I heard someone say Dr .Boz drinks ...dunno

[@kinpatu]

@@mariejones7136 he drinks alcohol, but makes no claim it's a health benefit. He's pretty clear on that distinction.

[@kinpatu]

I have seen similar results regarding Lp(a). I've tested 3 times with results from 76 nmol/L to 123 nmol/L. I'd say Lp(a) is primarily genetically determined but can be shifted a bit with lifestyle and nutrition.

[@mariejones7136]

@@kinpatu But why would a health advocate drink alcohol??

[@kinpatu]

@@mariejones7136 Presumably because he enjoys it. He's also stated he eats cake on birthdays I believe, while readily acknowledging it's suboptimal for health. If you're going to hold every health advocate to an ideal standard, you won't find any that meet it, although many will claim to. At least Attia is up front about what he's doing that isn't ideal.

[@hmmm..2733]

I gotta say…you’re equally as nerdy as Attia and his gang….That’s why we love you!!

[@e.j.oneworld]

What’s about Dr.Attia’s belief on ApoB??? Is it still credible????? I started taking PCSK 9 for my ApoB which is 178 this month…..

[@musicofnote1]

I just stopped taking Metformin, had been taking it since around 2014. I took it together with Berberine and got the same blood sugar results as without. Now, as i wrote, I stopped taking it when I started taking 2gr of Myo-Inositol/D-Chiro-Inositolat each meal and before going to bed. Blood sugar rates are holding steady. Not going down but also not raising. What I'm really curious about, is what its long time effect on LDLs will be. I reduced my Ezetimib/Rosuvstatin-Mepha 10 mg/10 mg by 25% when I started Myo-Inositol/D-Chiro-Inositol. We'll see in the end of June. BTW, I am doing this with knowledge and approval of my GP.

[@austinfrazier7325]

I’m a little weary of Peter Attia. I’ve alway gotten the “too smart for his own good” vibe.

[@jimwilson5202]

This doctor did not present any doubled blind placebo group study to support their " Theories ".

[@forrestgrunt]

Metformin is known to be mitotoxic. I have a super rare gene mutation that causes monogenic diabetes (MODY4). This is rare on a crazy scale, but the other thing the mutation does is supress my mitochondrial complex I . Misdiagnosed asT1, LADA, T1.5 and finally T2, (thank you gaslighting medical community) I was on metformin for years and years. I was on it when it was still glucophage, before the patent ran out. Unfortunately, it was killing me, too. Already having compromised mitochondria, the metformin was choking down what little I had. When measured I had less than 30 percent of my complex I, with a proliferation of mitochondria...common as they try to compensate. My lactic acid and ammonia weree chronically elevated. When I met with my mito specialist the first time, she told me to drop the metformin immediately. It was still another decade before DNA caught up to get a firm diagnosis, but here we are. The mutation on PDX1 caused the MODY4 diabetes and is proven to cause mitochondrial complex I deficiency. MODY1 and MODY3 are also shown to have connections to mito problems. Metformin just exacerbated it to the point my kidneys were failing with a eGFR below 30. Two weeks after stopping metrormin and beginning the prescribed "mito cocktail", my kidneys were back to the low side of normal. In another two weeks I was fully inside the normal range, where I have remained. No drug is a miracle drug. What works for one can kill another. I would know, as this drug, in my situation, was contributing heavily to an early demise. No thanks, I'm not ready to leave yet.

[@marilyn6905]

Inquiring minds anxiously AWAITING your comment on Peter Attia's decision to STOP FASTING...& his estimation of his 20# MUSCLE LOSS over 5 yr Fasting practice with ??? associated Benefits.

[@jimb3457]

Yea....he does look a little wimpy, kinda like David Sinclair and he takes metformin.

[@theancientsancients1769]

Is this the same case for Berberine?

[@justincase5272]

My doc prescribed 4 Metformin a day. No way! Diarrhea. So I take 1 a day, along with 2 Berberine. Same results.

[@Floating.Swords]

I learned something new and valuable today. Subscribed!

[@silversulu]

I wonder if Berberine has a similar impact, given that it's also a mitochondrial impact very similar to metformin.

[@robynhope219]

I stopped my 500mg Met for a week to see how i feel...no difference, so, as of today, i'm back on it. I am not diabetic. I take Met for anti-aging bc i have chronic fatigue and am a senior. However sadly, i cannot take the recommended 1000mg/day...too bothersome.

[@stufen11]

Wow, Dr Ted Naiman said this a number of years ago. I have never known him to be wrong. Nice video Doc.

[@DoctorBoz]

Thanks! Glad you enjoyed it

[@robynhope219]

There really should be a spokesperson who answers ppl's Q's...I need to know if I can get any effect from 500mg Met, bc I cannot take higher dose...thnx.

[@DoctorBoz]

Some questions have too many missing variables to answer. This is a case & point.

[@evvvaugros]

Dr Boz!! Help! Is this true of inositol too?

[@tedjackson426]

Thanks for the video. Small point, but ETC's are located on the inner mitochondrial membranes or cristae, not the Outer membrane as you stated.

[@toddswanson9549]

This is not a clear explanation. Is she saying “increase mortality rate” when she means “lower” mortality rate? Very confusing.

[@mrmiss8062]

Meds are made to be good for a specific prob but could always be damaging to something else.

[@VernCrisler]

Metformin didn't help me. Only Mounjaro got my A1c under control. I went from an official A1c of 11 (with Metformin, highest dose) down to an official A1c of 5.3 (with Mounjaro, 5 mg).

[@DoctorBoz]

Wow. That’s impressive - how long did that take?

[@VernCrisler]

@@DoctorBoz About 7 months, May 2023 to November 2023.

[@DoctorBoz]

You win. That’s awesome!

[@TerryMurray-i4c]

Is this the same for Berberine?

[@robynhope219]

I wonder why u never mention Dasatinib, a senolytic and anti aging.

[@Estuardo305]

dammed, if you a diabetic taking metform and dammed if your a diabetic not taking metformin. im sure the dose of the metformin plays a role.. i got to do a lactic test now.😢

[@MasterofPlay7]

what do you think of methylene blue? it makes the mitochondria works more efficiently

[@KayFlowidity]

3:00 👌👌👌 4:15 Lactic Acid

[@rickguymon7702]

Is he still a shrill for statins? His take on statins has me questioning his advice.

[@DoctorBoz]

He does not hate statins … he does not take statins … and offers other meds that lower LDL … so his love for statins is “meh.”

[@aaarrgg50]

What are other meds besides statins .. thx ☺️

[@lilareed2320]

Dr Boz…ok so if im doing keto and now carnivore…how is it that my aic is 5.7 and on carnivore its 6.0. My naturopath wants me on barberine or metformin. Ive lost 40lbs - why is BS still high when not taking in carbs?

[@zvikaso]

Maybe due to gluconeogenesis.

[@infersage1329]

I went to a weight loss clinic and they prescribed me, Metformin. I ended up being allergic, I guess because my feet swelled up and broke out in hives.

[@robynhope219]

How does he compare to Dr. Nir Barzilai?

[@outerbanks854]

My niece...the nurse....is worried about my keto/carnivore diet...she want me to consider TMAO....testing

[@michaelberman3648]

Will berberine result in an increase in lactic acid production as well?

[@war-painter]

Will berberine help to lose weight/appetite or will berberine cause constipation and bloating like Metformin? I can live with occasional diarrhea, although that was never really an issue.

[@newyorkskier]

I also like Peter Attia's shows. He is quite analytical. But I have to say I word of Nir Barzilai over Peter's on this particular topic. When it comes to muscles, I must admit Peter knows the literature well and also has some novel observations of his own

[@BLR1GBattlemaster]

Didn't they also show that Metformin decreases exercise tolerance? I'm sure it's related to the lactic acid build up issue. That's why I'm hesitant to take it.

[@joseph72588]

Some don't take Metformin on exercise days.

[@robynhope219]

Yes it does, many feel fatigued.

[@robynhope219]

​@@joseph72588exercise days are all days.😮

[@danielwiederkehr5163]

so, should a diabetic take or not take metformin? is there an alternative?

[@jn3750]

Annete, have you ever published any peer reviewed articles?