Resveratrol - The Unfortunate (& Scandalous) Story

[@ChristFollower1111]

It took courage to call out Dr. Sinclair, a perceived “giant” in the anti-aging field. Thank you

[@DrBradStanfield]

Thanks for watching and leaving a comment

[@janearisage]

@Dr Brad Stanfield is there any validity for claims that Resveratrol increases Nitric Oxide production, improves genetic health, protects brain from cell damage and makes blood fats healthier? I purchased Resveratrol from Eternum Labs and these claims are on the container with further claims for Resveratrol on the website. Thanks for speaking out!

[@ZoomGadget]

Agree. I am done wasting my money on resveratrol.

[@ChristFollower1111]

@@SeriouslyWeirdDream beet juice lowered my BP, but it’s a shame that it tastes so nasty,.

[@levondarratt787]

remember, that even Doc Since. says - hey I am self experimenting on myself...There is a risk.. A lot of this stuff is theoretical! I think the disagreements are very important, to get to the truth! Colelctively - Berg, Ekberg, Stanfield, Sinclair.... all these channels are insanely good! They all could be related....even the names ..in a way...

[@mindvoyager2476]

this is why I subscribe to the Dr Stanfield channel. He has no fear reporting current studies bringing the largest of youTube whales or nutritional sacred cows into question... including his own past recommendations! He DOES let the facts "get in the way"; how admirable and edifying.

[@DrBradStanfield]

THanks :-)

[@rosevanderreijden]

Dr. Stan field is one of the best. I love Valter Longo too.

[@jeffjohnson5053]

What about NMN, is that effective??

[@mrpmac]

He's great. But I take him with a grain of salt. He is very bias towards "healthspan", so much so, that he compromises lifespan. He puts too much emphasis on consuming protein & muscle building, which is proven to promote ageing.

[@randobravo4335]

@@jeffjohnson5053 great question that is what Dr Sinclair preaches is the combination of nmn to produce nad+

[@funeats8201]

The way you caught Dr Sinclair in that lie was pretty great. Thanks for calling this out and bringing it to our attention. I will have a hard time taking him seriously now.

[@shellderp]

like all drug research, $$$

[@martinmccloskey2435]

Dr. Stanfield is now my go to guy for information on supplements and longevity. I used to follow Sinclair, but now have deleted all of his videos. Thank you Dr. Stanfield for being transparent, admitting when your wrong, and reporting the facts. Thank you!

[@Vedicarts108]

Your honesty and bravery on challenging such established beliefs have made me a loyal follower of your content. I already appreciated your passion for health, but now I also admire your tenacity as well.

[@craigh2222]

Although the ITP did consult with Sinclair, you didn't address the fact that they just gave the resveratrol to the mice in food without mixing it with fat. As Sinclair said, in their own studies giving it to the mice in regular food without fat didn't extend lifespan.

[@adrianboyddodd8007]

Surely David Sinclair should have volunteered such critical information to the ITP without being asked. After all he would have an invested interest in this trial showing life extention benefits under such conditions.

[@cloverhoof2682]

Exactly what I was thinking, the most interesting question raised. I'm still waiting on the punchline.

[@remingtonli611]

Sinclair is listed as one of the authors on the ITP paper: www.ncbi.nlm.nih.gov/pmc/articles/PMC3598361/

[@uelude]

They mixed it in the food (aka: chow) which has more than enough fat.

[@annwilliams6438]

@@adrianboyddodd8007 yup. But then hundreds of millions of dollars in buy out cash would shut most people’s mouths…

[@stevenr.2534]

Excellent review presenting all the relevant studies on resveratrol. Thank you 🙏. Certainly GLK wouldn’t have walked away from a billion dollar investment if they had hopes of it showing any positive effects on longevity. This video sure hasn’t helped your chances of getting Dr Sinclair on your show but your viewers appreciate your insights and integrity.

[@rosevanderreijden]

I don't think Sinclair has a chance if he debates Dr. Stanfield. The jig is up.

[@DrBradStanfield]

Thanks Steven

[@diamond_s]

resveratrol cannot be patented and it was superior to all the resveralogues synthesized. It threatens not just one drug but all drugs. That is why it is under attack by big pharma with plenty of trials designed to see it fail. It has extended the lifespan of multiple short lived species, including healthy shorter lived mouse strains. It has even rejuvenated human cells in vitro, researchers surprised and exclaiming it was practically magical the effect it was having. It has failed to extend lifespan likely due to NAD+ decline in longer lived animals, to overcome that it likely needs coadministration with an NAD+ booster. This is because sirtuins need NAD+ and resveratrol works via activation of multiple sirtuins such as sirt6 and sirt4.

[@rosevanderreijden]

@@diamond_s Dr. Stanfield - would you like to address this?

[@DrBradStanfield]

I’m not really one to buy into conspiracy theories. I prefer to focus on what the data from well conducted trials show, and to start to produce high quality data as well (through my rapamycin trial)

[@markrobertdevison1227]

Thank you for your explanation of the studies. You have covered this topic very well. Your video about Resveratrol before this one, is why I stopped taking Resveratrol. I had been taking it for at least 8 yrs and I'm glad I found your channel. Thank you very much Dr. Standield.

[@DrBradStanfield]

Glad you find the content useful Mark

[@markrobertdevison1227]

@@DrBradStanfield Always, I find all your videos useful. What I take instead of Resveratrol is a glutathione supplement. Not sure if you have done a video on glutathione but I would enjoy your take on it. Thanks and keep up the awesome work.

[@jianfrancisco3895]

From Subscriber in SE ASIA Simply switch to the Micronized Version with Olive Oil & its proven to be very effective. Follow Dr Sinclair is a rational decision. Many are jealous of his worldwide fame! JIAN & ANDREI PHILIPPINES 🇵🇭 SINGAPORE 🇸🇬 BELOVED MOTHER RUSSIA 🇷🇺

[@markrobertdevison1227]

@@jianfrancisco3895 I take a table spoon of Dr GundryMD's Olive Oil every morning.

[@jammin6816]

@@markrobertdevison1227 - it’s far better to take a glutathione precursor than glutathione so the cells can regulate the required quantity.

[@rudyhenderson5002]

Thanks again doc for the timely update on resveratrol. You are a beacon of hope in the medical field.

[@theancientsancients1769]

Ah last time i checked resveratrol along with Sinclair were dismissed over 10 years ago

[@DrBradStanfield]

Thanks Rudy

[@snowbear163]

@@theancientsancients1769 they were for people who read the science. But the problem is the KZbin University students who just watch videos and listen to promos don't know this. Sinclair still pushes it so people still do it. Even WITH all this data, people will still claim it's all wrong and that David Sinclair is right. It's almost like a cult of personality out there.

[@RelhamG]

I agree!

[@richfisher7000]

I have researched this myself as well and as someone who really WANTS to trust Dr. Sinclair and appreciates his mantra of aging as a disease it pains to say I agree that his lab is far too biased, invested and perhaps even invented to push this flawed narrative. I appreciate your follow up on this.

[@larrytate1657]

When they have an agenda they can twist the research to fit it. Crazy.

[@DrBradStanfield]

Thanks for the support, Rich

[@ConnoisseurOfExistence]

Yeah, I've always liked Sinclair too. It's disturbing to see this video here, but sounds thoroughly researched and sincere. I hope Sinclair will reconsider his findings...

[@Yaveren]

@@DrBradStanfield why not just drink fluorescent dye

[@phytopanacea]

@@Yaveren Haha, wait until the general public discovers how "virus isolation" occurs. Pseudoscience to the max and has no basis in reality.

[@jimmybaker4821]

Highly appreciated that u make a video on this controversial topic.

[@rontiggle8462]

This was an outstanding review. A lot of people have wasted a lot of money taking resveratrol for over a decade or more.

[@58christiansful]

I have been taking Resveratrol since November 2021. My anxiety disappeared and I slept much better - that was he first thing I noticed. Then my energy levels increased - my body seemed to start craving exercise. I don’t think I am imagining any of this. I have noticed no side effects so far.

[@aspireinspire8308]

How much of Resveratrol have you been taking? 500mg?

[@alfonindatube]

I experience profound benefits with Japanese Knotweed, but I understand that my case might be very specific. I don’t think this video necessarily implies that resveratrol as a compound has no therapeutic usage at all. For instance it appears that Japanese knotweed has some antimicrobial and immuno-modulating effects (whether that’s purely from resveratrol or from the combination of compounds I don’t know). Same as chemotherapy might be useful for some people.

[@heavenlymindedtrivia9148]

I've been taking it for over a year now and I too thought that I have been improving. I think somebody needs to look into GSK's real reason for paying millions for that research. If resveratrol is like the fountain of youth, the pharmaceutical companies will not want it to be popular with the public. No one would put it past a pharmaceutical company to pay to get rid of a legitimate fountain of youth when they make so much money from pharmaceutical drugs that keep people sick. They pay the researchers, Dr Sinclair looks unethical but he gets paid, and people stop taking resveratrol. It's a win for the pharmaceutical companies. Just a thought.

[@darkhorse7460]

As interesting as that is, it's anecdotal and nobody can verify the variables our data for said results. Thanks for sharing, though.

[@moosefox7799]

I am taking Resveratrol and have noticed better sleep, more energy, and clearer thinking and less arthritis pain. I’m hoping my blood work next month will show improvement as well. I’m not taking it for “the fountain of youth effect,” I’m taking it to see if I will feel better….and I do. I’m happy with it. I am on the Mediterranean Diet. Update: I had my blood work done and my physician was surprised at the good results. My A1C dropped significantly so I am no longer pre-diabetic. My cholesterol and LDL, which have been elevated for 12 years, came down about 15 points each which has never happened before and I’d only been taking Resveratrol for about 2 months. Overall, I’m very happy with the results. I will continue with it.

[@navybean1560]

Perhaps your best video yet ( I hadn’t seen your earlier video on Resveratrol). I have been taking Resveratrol for years and now I feel like a fool that has been duped. Thank you for the enlightenment. Keep up the good work.

[@Austinite333]

Resveratrol was the perfect excuse to drink more wine. The masses loved it.

[@jeffb.140]

The alcohol has probably more health benefits

[@hanig11]

Alcohol in any quantities is bad based on recent studies,so no excuses left .

[@jeffb.140]

@@hanig11 This is not true. It is quite a potent anti-rheumatic agent.

[@cipriantodoran1674]

@@jeffb.140 + it hepls lubricate social network and helps a bit with s*x life boosting!

[@Mario-forall]

Old school cardiologists also loved resveratrol. They use it as an explanation of why the French have lower CVD despite the high saturated fat intake

[@edisonclaro5363]

thanks Dr Brad. you really help the community anti-aging. You have the courage to face the real facts.

[@saltwell80]

Dont listen to Brad, you gonna ,ne stirred away from something good for your health,he's probably a dr that's working for the big pham.

[@chuckbecker8735]

Excellent investigative reporting Brad. Over the years so many folks were skeptical about resveratrol because both the grape growers and wine makers were heavily funding countless studies and issuing plethoric press releases. Andrew Weil, MD mocked it all decades ago.

[@Seek_Him]

Just Like they funded this research!

[@DrBradStanfield]

Thanks for the comment, chuck

[@ruenoak]

I agree excellent investigation. We need more people like you out there.

[@Bambotb]

@@DrBradStanfield many independent studies exist though ..including cancer

[@chuckbecker8735]

@@GizmoFromPizmo Good point. He used to be my number one hero in life until he went MSM..... drink wine, pro-fluoridation, pro-rice, eat soy twice a day, and just only stroll instead of exerting yourself.

[@Savage2Flinch]

I really love the technical level at which you pitch your videos. Simply explained, but not dumbed down. Thank you!

[@MikeG-js1jt]

EXCELLENT Report Dr. Brad............. excellent!

[@VitalyGG]

This study was performed to investigate the effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was performed with 56 patients having T2DM and CHD. The patients were randomly divided into two groups to receive either 500 mg resveratrol per day (n = 28) or placebo (n = 28) for 4 weeks. Resveratrol reduced fasting glucose (β-10.04 mg dL-1; 95% CI, -18.23, -1.86; P = 0.01), insulin (β-1.09 μIU mL-1; 95% CI, -1.93, -0.24; P = 0.01) and insulin resistance (β-0.48; 95% CI, -0.76, -0.21; P = 0.001) and significantly increased insulin sensitivity (β 0.006; 95% CI, 0.001, 0.01; P = 0.02) when compared with the placebo. Resveratrol also significantly increased HDL-cholesterol levels (β 3.38 mg dL-1; 95% CI, 1.72, 5.05; P < 0.001) and significantly decreased the total-/HDL-cholesterol ratio (β-0.36; 95% CI, -0.59, -0.13; P = 0.002) when compared with the placebo. Additionally, resveratrol caused a significant increase in total antioxidant capacity (TAC) (β 58.88 mmol L-1; 95% CI, 17.33, 100.44; P = 0.006) and a significant reduction in malondialdehyde (MDA) levels (β-0.21 μmol L-1; 95% CI, -0.41, -0.005; P = 0.04) when compared with the placebo. Resveratrol upregulated PPAR-γ (P = 0.01) and sirtuin 1 (SIRT1) (P = 0.01) in the peripheral blood mononuclear cells (PBMCs) of T2DM patients with CHD. Resveratrol supplementation did not have any effect on inflammatory markers. Four-week supplementation of resveratrol in patients with T2DM and CHD had beneficial effects on glycemic control, HDL-cholesterol levels, the total-/HDL-cholesterol ratio, TAC and MDA levels. Resveratrol also upregulated PPAR-γ and SIRT1 in the PBMCs of T2DM patients with CHD.

[@VitalyGG]

At baseline, peripheral blood mononuclear cell H3K56ac values among the SIRT-1 tertiles did not differ. At trial end, SIRT-1 levels were significantly higher in patients receiving 500 mg resveratrol. At follow-up, patients were divided into tertiles of delta (trial end minus baseline) SIRT-1 value. Significant reductions in H3K56ac and body fat percentage were found in the highest tertile as were increased TAS levels. A multiple logistic regression model showed that the highest delta SIRT-1 tertile was inversely associated with variations in H3K56ac (OR = 0.66; 95% CI 0.44-0.99), TAS (OR = 1.01; 95% CI 1.00-1.02), and body fat percentage (OR = 0.75; 95% CI 0.58-0.96).

[@Dgunztube]

Thank you Dr. Brad. It’s amazing how all the data is there but can still be hidden. Your research is so helpful.

[@DrBradStanfield]

Thanks, glad to hear you found the video useful

[@strangerthings88]

@@DrBradStanfield why don’t you reply to any of the people questioning you Brad??? You were soo quick to judge David for ‘ignoring you’, yet you ignore every single comment even with direct evidence against your piss poor half truths because you’re full of bs trying to get famous for making up controversy. It’s pathetic.

[@5ervalkat192]

This is incredibly helpful. When you first debunked the life extending effects of Resveratrol, I tossed my pills. I stopped taking Basis, which is a product with NAD that includes Resveratrol in the formulation (replaced it with Lipo NMN from AlivebyScience). The last thing I need is to blunt the effects of exercise at my age. I greatly appreciate your in depth reviews of these papers. It saves so much time!

[@chrislapiana8392]

Great video. It conflicts with my initial belief and warrants change. It's nice when published data presented in a clear way can change your mind. Science is not perfect. It’s often misused; it’s only a tool, but it’s the best tool we have. Self-correcting, ever changing, applicable to everything: with this tool, we vanquish the impossible - Carl Sagan

[@DrBradStanfield]

Thanks Chris

[@billbucktube]

I'm under the impression that the original resveratrol study used extra virgin olive oil as a carrier and it turned out to be synergistic and vital to it's effect. Subsequent studies did not use extra virgin olive oil and didn't get the same results.

[@janicemarticorena2482]

I thought so too but maybe I missed something

[@popothebright]

We're splitting hairs now.

[@billbucktube]

@@popothebright In order to duplicate results you have to split hairs the way it was originally conducted. When the Harvard research is done with a particular olive oil and studies "trying" to duplicate it don't use any oil at all it is not useful and may be actually fraudulent. When an oil soluble nutrient is administered with water the nutrient is not as available for digestion. One must split hairs in the exact way the original study did in order to have a valid opinion and/or results.

[@johnr4962]

@@billbucktube I agree... Also my understanding is that low dose vs high dose have the opposite effect... low dose for logevity and high dose for cancer fighting... looks like they were using high dose which doesn't produce the longevity effects

[@billbucktube]

@@Joyces-Favorite-Art-Tutorials Sinclair has stated that the type of fat matters. In his experiment he settled on specifically extra virgin olive oil. When others use “some fat” and get different results it is no surprise. There is a lot of evidence that EVOO is synergistic in action.

[@RK-ww5sj]

Thank you for this video. Sharing negative but balanced data on the popularized interventions in the "alternative" health space are very hard to find. This is a most valuable video!

[@DrBradStanfield]

Glad you enjoyed the video

[@pablieto-veganson]

you have earned my subscription with this one video. never heard this other side of the argument regarding resveratrol.

[@mmgraff1]

Sinclair says over and over that Riz Verital must be taken with fat and NMN should be taken with it. He quotes resveratrol is the pedal on the car, and nmn Is the gas could you please speak about that

[@derrickmickle5491]

Then how do you square the GSK trials where they tried to improve absorption of resveratrol and failed? Just taking it with fat doesn't improve the absorption of and is a red-herring argument.

[@mmgraff1]

@@derrickmickle5491 I don’t Square I was asking I need help I’m not a scientist

[@brentdundee]

I use Resverotrol and it has increased my exercise endurance ..when I don't take it I feel flat ...it must be taken with fat ..I take mine with yogurt. It definately works.

[@levondarratt787]

could be something else....I'm sure you take 50 other things...and being in a good mood and believing it , makes me work out better too! lol...

[@sandrakillalea1150]

@@levondarratt787 You’re SURE he takes 50 other things? Wow. You’ve decided his derived benefit is state of mind? Your powers are AmAZiNg.

[@WW-ob7ek]

@@sandrakillalea1150 exactly! He's super sure though. Like wow!

[@jimmyb4982]

Heard of the placebo effect? Interesting, positive effects have still been observed in subjects even when they knew they were taking a placebo. How bizarre.

[@NebraskaWriter]

So... where do I buy "Fluorescent Dye" pills?

[@JFRA24]

Beat me to it.

[@mastbio9444]

The power of the peer reviewed system is a beautiful thing.

[@jaimemarun2841]

I understand Dr Brad Stanfield's genuine interest in having enough clarity on this Resveratrol issue, but in order to understand one set of data and be able to compare it to another set of data we need to make sure they are in the same context. I believe that the information presented is incomplete. It does not mention the context in which these tests were carried out and whether they are the same ones that Dr. David Sinclair mentions... that everything is due to scientific rigor.

[@levondarratt787]

how much more complete doe sit need to be?

[@vonwolly2]

Well I totally agree with you. My father has severe memory problems we have been giving him a gram and a half of resveratrol every day with olive oil. We have seen a tremendous improvement in his memory. He is able to function at a much higher level. According to the research out of Australia resveratrol decreases brain aging by 10 years. It has done wonders for my father.

[@prosewat99]

There’s no way that GSK just walks away from a billion dollars and they have an army of scientists. Use your head.

[@frankasafscimone3920]

Yes, many thousands of people have reported benefits, especially with NMN and oil. I have followed this for years and read of so many instances of people getting younger. It cannot be a coincidence. You can prove anything with studies and I think Dr Bran Stanfield has a bee in his bonnet.

[@aellingham2742]

Right. Those studies are over a decade old and since then Sinclair has started studies on monkeys. Also,i was reading an article that suggest the $720 may have more to do with GSK still pursuing resveratrol as a PRESCRIPTION DRUG. Which could make multiple the amount of over the counter. They stopped the two execs from Healthy Lifespan from selling the over the counter brand at cost as a non-profit

[@rickclark1372]

Ha- I am halfway through my first bottle of resveratrol, so this seems like a good time to stop, thanks so much! At my advanced age I assume any further level of replicative stress is something to do without. Looking up recipes for spinach Greek yogurt dip now.

[@madsencc]

Thank you, thank you. I am so tired of "scientists", doctors, etc. doing a little research in labs and then rushing to profit from it by founding companies, etc. Well, unfortunately, I have sometimes bought into it. I now see that I have wasted a lot of money over the years purchasing resveratrol. I appreciate your willingness to expose the supplement hypes.

[@DrBradStanfield]

Thanks for the comment Charles

[@vibhaspalding6457]

I appreciate dr Brad Stanfield research and retracting the research on the usefulness of resveterol. I have just bought 2 bottles of the stuff from different sources. Both bottles are unopened. One of them, I already started the process of returning it. The other maybe a little awkward, as bought from USA. I live in London, UK. I do not wish to undo my last 3 months of exercise regime outcome, that I have achieved, after my hip operation and sciatica.

[@victorloya1590]

I'm also sick of this f***ing KZbin doctors , for every study that says something is healty there is anothet saying the oposite

[@pascalrode5306]

Dear Brad First of all, I’m a big fan and appreciate your publications and critical analysis very much. Without having a medical background, I heavily rely on content like yours to define my personal (longevity) supplement stack. My comment is a summary of an opinion I gathered from a friend at Biolytica and I would love to hear your response, as we don’t think you are covering the story of Resveratrol as objective as it could (and probably should) be - concluding “There’s no human data of health benefits with resveratrol” and “There’s human evidence of harm”. Most of the supporting studies and anecdotal references to podcasts you mention are dated 2008-2013ish. Doing a pubmed search for “RSV and SIRT1”, filtered to only “Human RCTs”, deliver numerous studies that used RSV doses between 150mg and 500mg. The 3rd study (Kitada et al) used Piceatannol not RSV. They were all published 2017-2020 (which is noteworthy since these are far better human RCTs than your quotes which are many in vitro and they are all older studies). Hoseini A, Namazi G, Farrokhian A, Reiner Ž, Aghadavod E, Bahmani F, Asemi Z. The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease. Food Funct. 2019 Sep 1;10(9):6042-6051. doi: 10.1039/c9fo01075k. Epub 2019 Sep 5. PMID: 31486447. Beijers RJ, Gosker HR, Sanders KJ, de Theije C, Kelders M, Clarke G, Cryan JF, van den Borst B, Schols AM. Resveratrol and metabolic health in COPD: A proof-of-concept randomized controlled trial. Clin Nutr. 2020 Oct;39(10):2989-2997. doi: 10.1016/j.clnu.2020.01.002. Epub 2020 Jan 13. PMID: 31996311. Kawamura K, Fukumura S, Nikaido K, Tachi N, Kozuka N, Seino T, Hatakeyama K, Mori M, Ito YM, Takami A, Hinotsu S, Kuno A, Kawasaki Y, Horio Y, Tsutsumi H. Resveratrol improves motor function in patients with muscular dystrophies: an open-label, single-arm, phase IIa study. Sci Rep. 2020 Nov 25;10(1):20585. doi: 10.1038/s41598-020-77197-6. PMID: 33239684; PMCID: PMC7688653. Kitada M, Ogura Y, Maruki-Uchida H, Sai M, Suzuki T, Kanasaki K, Hara Y, Seto H, Kuroshima Y, Monno I, Koya D. The Effect of Piceatannol from Passion Fruit (Passiflora edulis) Seeds on Metabolic Health in Humans. Nutrients. 2017 Oct 18;9(10):1142. doi: 10.3390/nu9101142. PMID: 29057795; PMCID: PMC5691758. Asghari S, Asghari-Jafarabadi M, Somi MH, Ghavami SM, Rafraf M. Comparison of Calorie-Restricted Diet and Resveratrol Supplementation on Anthropometric Indices, Metabolic Parameters, and Serum Sirtuin-1 Levels in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial. J Am Coll Nutr. 2018 Mar-Apr;37(3):223-233. doi: 10.1080/07315724.2017.1392264. Epub 2018 Jan 9. PMID: 29313746. Batista-Jorge GC, Barcala-Jorge AS, Silveira MF, Lelis DF, Andrade JMO, de Paula AMB, Guimarães ALS, Santos SHS. Oral resveratrol supplementation improves Metabolic Syndrome features in obese patients submitted to a lifestyle-changing program. Life Sci. 2020 Sep 1;256:117962. doi: 10.1016/j.lfs.2020.117962. Epub 2020 Jun 11. PMID: 32534040. There are 4 more RCTs that are relevant… cited below: Zemel MB. Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. J Med Food. 2020 Nov;23(11):1129-1135. doi: 10.1089/jmf.2020.0105. Epub 2020 Aug 4. PMID: 32758058. This one was promising - combo lower dose RSV, leucine and NAD+ precursors incl NMN. Like most of the promising RCTs, this one showed benefit in subjects with MetS or obesity, subjects all had some imbalance. This one compared normal and slightly overweight subjects - some promising results, some not: Roggerio A, Strunz CMC, Pacanaro AP, Leal DP, Takada JY, Avakian SD, Mansur AP. Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration. Nutrients. 2018 Jul 21;10(7):937. doi: 10.3390/nu10070937. PMID: 30037068; PMCID: PMC6073749. Another “promising” RCT: Bo S, Togliatto G, Gambino R, Ponzo V, Lombardo G, Rosato R, Cassader M, Brizzi MF. Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation. Acta Diabetol. 2018 Apr;55(4):331-340. doi: 10.1007/s00592-017-1097-4. Epub 2018 Jan 12. PMID: 29330620; PMCID: PMC5851693. Based on the available data we have to question your research objectivity in this very case. It is long known that RSV and many other mild pro-oxidants increase genes to upregulate production of enzymes that have powerful red-ox, inflammation modulation value through the process of hormesis. Context is critical - and nutrigenomic supplementation must be tested in human clinical trials not petrie dishes. The hormesis issue explains why healthy people might not benefit and why adding 2 xeno-hormetic effects like RSV and exercise might result in too great a pro-oxidant effect (especially more athletic/higher intensity exercise). I don’t try to support or protect any opinion or claim made by David Sinclair. I just try to understand the function and benefits of Resveratrol for myself and my surrounding. Best, Pascal

[@lorena6248]

Give this man his respect. His name is Dr. S, he wouldn’t be able to critically analyze and provide you this free content without that degree.

[@OLExGREG]

I really hope Dr. Stanfield replies to this. I'm pretty confused why he has been so anti-resveratrol the last year or so... I'm certainly convinced that it's questionable whether it activates SIRT1, but the positive effects in many of these studies can not be dismissed on the basis of the presence of the fluorescent reagent.

[@stuarts5301]

Thanks for the research on the subject Pascal. I too would like to see Dr Brad’s comment on the current studies and their findings.

[@catman4471]

@@OLExGREG Dr Brad is trying to make a name for himself as if he has something to prove, he seems to be totally anti-sinclair and touts info gained from elsewhere, unlike sinclair who is hands on and looks visibly younger as he gets older.

[@strangerthings88]

He won’t even address comments like these. Notice he hearts all the ones praising him like just below this comment and literally ignores everyone else. He’s just a narcissist trying to become relevant by making up half truths.

[@seanstumpf4190]

After watching most of your videos the only thing that stands true for extending your life is eat in moderation, eat healthy, and exercise. I've dropped almost every supplement because of your videos. I appreciate your channel. Thanks so much.

[@AnotherproblemOn]

And fasting?

[@manmoth4]

He goes over plenty of supplements that should have benefits for healthspan and/or lifespan. We know K2 lowers the risk of arterial calcification, for a start.

[@armandodibattista971]

Totally agree, stop to illude ourselves with easy solutions, supplements are not effective for longevity at this time. It’s just business. Lifestyle is the only safe and reasonable intervention, and for me, It should be done with common sense and moderation, in any form. Not drastic fasting or extreme diet, these are Riskier than helpful.

[@starfox300]

NAD boosters and AKG, Rapamycin seem to be very effective in lifespan extension.

[@DrBradStanfield]

Absolutely Sean

[@anttihaikala8263]

Thanks a lot for this video - planted a seed of healthy suspicion in me. I'm so happy KZbin's algorithm suggested this to me even I needed to dig quite deep into the suggestions.

[@vaivaivaiful]

Wow, you've made some very good observations. Just shows once again that you cant blindly trust no one.

[@hdiponzio]

Thank you so much for this. It was very timely for me as I was getting ready to add resveratrol to my vitamin regimen. I appreciate you so much. And I am so disappointed in David Sinclair. I watched your other video of him blocking you. Very troubling. I thought science was about learning and challenging each other. Keep doing what you're doing. I appreciate you!

[@gabymalembe]

Since I can’t read scientific papers, I’m in a weak position to decide which brilliant scientist is right when they don’t agree.

[@lizmallen3461]

Would love to see you interview Sinclair for his response. He always says “I will always tell the truth.” I have trusted him unwaveringly. What is the truth???

[@Violetswirl]

The thing that really bothers me is Sinclair flat out lying about not being consulted on these studies that show RSV does nothing to extend life. He just lies about it and hopes no one will actually look into it. That is not the first time he has lied about such things. This person cannot be trusted, he is simply not a quality source of information.

[@carolinemarie44]

I suspect that Sinclair sells these products he pushes.

[@amritdhillon2650]

Another great video. Admire your honesty . I was about to place an order resvertaral

[@alex_rogan]

Glad I found your channel as I’ve just been introduced to this stuff. Interesting about the Resveratrol absorption issue and normal food because I heard Sinclair say recently, and I think this may be his “work around” to validate it, that it is best to pair it with intermittent fasting and taken every second day not every day. Standing on its own you think great, ok, that’s the protocol . But hearing it now in light of what you’ve found makes me see it in a very different light.

[@simonfoo8684]

Thank you Dr. Brad for going through the research papers and podcast to provide an updated information on resveratrol.

[@jiriwiesner]

This is sad especially for an ex-scientist such as myself. When I was in science I never tried to lie about my results. The results weren't there. I failed and left science for good. But that's life.

[@chilloutmusicoasis]

That has been my experience as well. It's so easy for someone like Sinclair to deceive laypeople who are not familiar with the ins and outs of basic research.

[@jesuisravi]

"Science" should not be blamed for what soi-disant scientists do in its name. Science is like religion, most of the devotees are anything but saints.

[@invinciblesummer4114]

One of the best videos from Dr. Stanfield I've seen. Thank you. I love this channel.

[@keithhaken172]

I stopped taking it a year ago. I honestly spotted Syclair as a potential snake, years ago. And we all know how Harvard has turned to a shitty indoctrination camp. Thanks Dr Brad, you’re great. 💪 $720,000,000.! wow that’ll generate some bias 😜

[@jamgamber0]

Thanks for your dedication Dr Brad. This is great information. Just, threw my resveratrol down the toilet.

[@stevengasssr3010]

It works. Look at your facial skin before and 3 hours later. Skin glows and is more full. No doubt

[@gaberosenfeld4525]

Beautiful. Thank you for all your hard work Dr. Stanfield. Absolutely wonderful investigation. Bravo.

[@olasaltasm]

Great vid! What are your thoughts on why after so many years, no one has done more studies on resveratrol mixed with fat? Since this is Dr. Sincalir's main calim for dismissing all these studies and justifying his results.

[@elaineremains]

that's what i was wondering, there seems to be sinclair talking about fat and not being consulted on it, then sinclair BEING consulted, but only on DOSAGE and not fat

[@delaneyondreams]

@@elaineremains So has no one replicated his studies or studied Resveratrol by mixing first in fat?? No One?

[@elaineremains]

@@delaneyondreams not that i know of! but of course i don't know all. however i remember seeing dr sinclair on a video interview a few years ago, and he spoke of the FALL of resveratrol, and how he stayed in bed for a couple of years, but in the end, he was vindicated.. so these studies could be from the FALL and not from the triumphant come back.. tho i have never seen that interview with sinclair again... maybe it was with tom bilyeu... not sure...

[@DrBradStanfield]

We’ve got human data showing harm when supplementing with Resveratrol. If absorption was the only issue (which it isn’t) then how did those trials detect harm? Also, the idea that GSK threw away ~ $1billion dollars simply because they didn’t think to mix resveratrol with fat is outlandish when you think about it

[@elaineremains]

@@DrBradStanfield you have a point about GSK, i was wondering about that myself, but i wondered if this was some sort of conspiracy lol as far as the trials detecting harm, that COULD be about resveratrol being 'like brick dust without fat'.. brick dust sounds harmful lol i can't take resveratrol, coz of gastrointestinal problems, but when i did, i took it in high doses and i swear i was looking younger, so i can't say i know what is going on

[@mr.2Creative]

Thank you as always for a very informative video. Please keep us posted about the latest research on NR, NMN, Niacin, TMG .. Basically your supplement stack. Many thanks.

[@jcgmba98]

It is sad that scientists and business people have to re-learn the same lessons they’ve learned before. For example, sunk costs should not, under almost any circumstance, influence future investments. Also, separate your personal identity from what you are studying or investing in. Its tale is as old as science itself and as old as business itself. Just the latest iteration.

[@davidwho7847]

Wow! Thank you, Dr. Stanfield. I watched both video's and am very impressed with your reporting on this topic. Please keep up the great work!

[@LatterDayData]

I love your channel and I really appreciate your manner and willingness to explain these things. You are saving lives. At the same time, I have a question that I really want your insight on. What I want to ask is important but it will take me a minute to unpack - please bear with me. I recall David Sinclair stating in an interview that studies involving resveratrol routinely store it at regular temperatures instead of keeping it refrigerated, and he said the researchers aren't respecting the molecule in the way they treat it - and he said resveratrol can actually be harmful if allowed to go bad (if I remember correctly). If he is right about that (for sake of argument) could it be possible that it makes a difference? I remember reading in a book about oils by Udo Erasmus that the story behind snake oil salesmen might be more complicated than people think. Because, it was derived from a chinese water snake that has higher levels of omega-3 than salmon - but omega-3 goes rancid if not stored properly and can actually be harmful if rancid. So, it's possible that fresh snake oil was actually relieving inflammation but when bottled and carried from town to town in the hot sun, it went rancid - losing its benefit. Interesting, huh? Then, as science progressed, but before the discovery of omega-3 having anti-inflammatory benefits, snake oil developed a reputation for being a con, as scientists said essentially that we were beyond these superstitious ideas and that oil is just oil, there's nothing special about it.

[@mv8908]

Interesting

[@trentriver]

Excellent work, Dr. Brad. I have noticed that since starting resveratrol, my workouts have suffered - through it all in the garbage after hearing this.

[@kevingold1091]

Great video Brad. Thanks for this excellent review of why resveratrol is actually... less then useless. I had been putting off taking it because of some concerns I had, and this is the first time I have seen those concerns deeply addressed.

[@harrybretschneider6343]

Ditching my resveratrol. Thank you for your video.

[@rustinpeace7466]

Sinclair's calm delivery and elegant speech certainly won me over on resveratrol. Thank you for exposing the science that was already there to show the guy is no longer scientifically motivated.

[@DrBradStanfield]

Thanks for watching and for leaving a comment

[@rayquaza6791]

one thing is certain and is that he rehearsed his commercial spitch well

[@NobbisLover]

I think he will become more motivated as the years pass by and time runs out. But first he is a salesman, thats obvious if you hear him talk .

[@pikantnomie1894]

Probably financially motivated, he is finally honouring his ashkenazi ancestors lol .

[@whyc2094]

@@pikantnomie1894 based

[@negvey]

This is why I luv your channel, pure science no ideology

[@vonwolly2]

Well my father has memory problems and we have given him resveratrol and it has made a great difference in his memory and ability to function. According to the research out of Australia resveratrol reverses brain aging by 10 years. Let's wait to hear David Sinclair's response lets not be too hasty.

[@matdan2]

Wouldn’t this surely had shown up as a positive effect on lifespan in tests?

[@rayquaza6791]

it is because of the acetylcholinesterase inhibitor effect you have multiple herb and substance with the same effect without the bad.

[@mv8908]

@@rayquaza6791 explain please

[@sanaconmantra]

From the testimonies that i have read everywhere is those who have health conditions seems to really benefit from resveratrol. Is your dad still ok taking it?

[@faisal-ca]

@Dr Brad Stafield : This video is valuable and informative. Thank you for conducting research.

[@monabommarito7126]

Thank you for always being on top of research. Love your videos. Very informative.

[@cocolocs99]

Wow…Dr Brad! Excellent critical review and analysis on the latest research available on Resveratrol benefits!!! You are a HERO in the anti-aging community!!!

[@colinbenfield326]

Mind blowing! Worked in the supplement industry and wondered why the wonder nutrient virtually disappeared. Incredible story thanks

[@ianfowler7787]

I got a bottle of resveratrol back in 2010. Kept up my normal exercise routine during the cycle, but ended up getting some really bad inflamation in my left elbow about half way through the bottle that caused me to stop training. I had no reason to think resveratrol was the cause, but I figured better safe than sorry & stopped threw out the rest of the bottle. I was just thinking "Its been about 12 years, maybe I just got a bad batch before. I should give it another chance" I loaded up my Amazon cart, ready to go, but then thought I should at least see what other people are saying about it on youtube before I pull the trigger. I'm glad I found this video. That would have been $30 down the drain & possibly kidney failure. My mom is currently recovering from kidney cancer, so I really shouldn't be messing around with this stuff. Thanks for the information!

[@mimand1]

Very well done doc. We need more of this about supplements and disease. Tanks a lot.

[@annemuller4499]

Thank you so much Dr. Stanfield for digging deeper and explaining further your opionion! 🥰

[@eyebrid]

I looked into resveratrol studies and accepted that life extension and nootropic claims were unsubstantiated, but decided to take it because of a noted reduction of TMAO, but that's completely negated by raising cholesterol, and blunting the benefit of exercise is unacceptable. Buh bye resveratrol.

[@DrBradStanfield]

Thanks for watching eyebrid

[@BryanHocking]

Pycnogenol

[@rosevanderreijden]

@@BryanHocking I continue to take pycnogenol I've been taking it since I was a teenager.

[@Albundy11373]

@@rosevanderreijden I took pycnogenol on and off a few times and it makes my muscles twitch. I try to search online to see if that’s one of the side effects but I found nothing. Just wondering if that has happened to anyone else.

[@BryanHocking]

@@rosevanderreijden rad

[@elprofeccpuravida2717]

Thank you Dr. Brad for looking out for us and taking the motto of do no harm. There are always agendas associated with resources that the public doesn't always see, thank you for showing us the information. Thank you for your ethics in really helping people.

[@Frazer247]

"Objectivity" is the true characteristic of a "real" scientist. Thank you, Brad Stanfield, for being a real scientist.

[@christopherburns2303]

This channel has the most honest and reliable information on the internet.

[@karlint39]

Quite a thorough, amazing, and convincing video. I've been taking resveratrol for a while, and I've got a new bottle ready to go, but it's going in the trash. With supplements (or even with medicines for that matter) there isn't always research to show their effectiveness, or in cases like this one, researchers are motivated to show certain results, not to find some objective "truth." I'm especially curious to see if my cholesterol will improve after I quit, and if I will see more effects from exercise. If new research ever comes out that reverses the conclusions here, I would consider taking it again, but until that day, you've convinced me to ditch it. Thank you -- this was clearly a lot of work to put together.

[@Michael_RareZebra]

Thanks for keeping it real. Haven’t visited in a few months but really enjoy your channel.

[@PaulThomas-qb9cx]

Dr. Brad: Maybe I missed it, but did those later studies on mice attempt to deliver the Resveritrol with fats, as Sinclair advised? I was unclear on that. That would at least show that the catalyst was a factor.

[@jeremy.hernandez]

I watch both your channels, you and Sinclair, I'm so glad we have another expert opinion on this! Thank you!!!

[@Fearzero]

What we need is a study on resveratrol taken in conjunction with NMN as Sinclair says that's key to get the most out of NMN's benefits.

[@scottpreston5074]

Very good point: synergistic effects.

[@Vibetribe8]

I have absolutely no clue why this video was recommended to me but the more I listened the more I found myself gravitating towards this information.

[@garyhoward4064]

Could it be that once you sold your “Resveratrol research” company for 720M, you may then be tempted to do anything possible to continue make it look efficient..

[@spillledcarryout]

Thank you Dr. Stanfield. Thank for your courage and integrity.

[@BrandonByers]

Thank you for the video. Was there an attempt by David Sinclair to differentiate between taking resveratrol with a “normal diet” vs taking it with olive oil or yogurt?

[@scotte9384]

The olive oil or yogurt just provides some fat for it to dissolve into.Fat soluble supplements are MUCH better absorbed when consumed w fats.

[@BrandonByers]

@@scotte9384 Thanks. My question is whether DS is saying Resveratrol works with fatty options vs a normal diet. He seemed to attempt for that distinction in his clip but from what I could tell, this video ignored that detail.

[@erisd8452]

He was directly consulted on the dosing. Can’t imagine he wouldn’t have mentioned, let alone stressed the fat absorption enhancement. He’s always yammering on about it whenever he’s promulgating the compound on podcasts, while not lying about his involvement with the study.

[@wtpwtp]

Thank you so much for clarifying this for the general public!

[@bullfighter6951]

Thanks for clarifying the erroneous study that has unfortunately been sat on by David Sinclair. Now, he can reply, and since he has a regular podcast, any failure to respond directly to the following studies you mentioned would indicate his scientific acceptance of the rejection of his Resveratrol claims.

[@Samucacamilo]

This is one of the best overviews on the whole resveratrol drama

[@anoniem9518]

Thanks Brad! It would be a good thing David Sinclair would share his thoughts on this on your or his channel. David Sinclair could be wrong on Resvertrol, but he still is educating and sharing his knowledge about longevity to the masses. That is a good thing and that is why I admire smart people like you and Sinclair. That's also why I am a loyal follower of you and David.

[@rosevanderreijden]

What does Sinclair share with the masses? Because the repeats the same tropes over and over, ad nauseam. Funny how this "world -renowned longevity scientist" is just discovering the benefits of a WFPB diet. He never misses an opportunity to name-drop however. 🤔

[@HeleneLouise]

You did a fabulous job on this video. I am grateful for your efforts at informing people like me.

[@janeh1226]

Thanks so much for your unbiased and open-minded investigating into studies of resveratrol, Dr. Brad. This is a very brave thing to do when so many will have vested interests to deceive the public when large sums of money or status is involved. You have our support in finding out the truth.

[@DrBradStanfield]

Thanks for the support Jane

[@jazzyhalf]

Thank you for this video, it was enough to get me to stop taking resveratrol myself. Been taking in for about a year now and don't notice anything different in my blood work or mood or just overall.

[@gillesprevost9975]

Well done. That's what médecine should be all about... Truth, not business! Well done Brad. Keep on doing your best to investigate for the benefit of others

[@PCSalesStaff]

This guy is also raising money on this very page and selling merchandise. Why should we believe him?

[@Thinkaboutit84]

Thank you for your diligent work and the significant fact you shared. Please keep working on these longevity endeavors.

[@peterz53]

Sirtuins are supposed to be NAD+ dependent, so modulating NAD+ should keep surtuins expressed to desired levels without need of supplements (speculation). Afterall, they perform various functions and having suboptimal exprsssion of surtuins, as with many other genes, should work against our health and possibly longevity. I am more interested in SIRT6 which, if I remember correctly, Vera Gornunova discussed as being very useful in reparing double strand DNA breaks, which is impiicated in aging.

[@drSamovar]

Its great you've shed light on extreme claims for resveratrol, but it would have been REALLY helpful to let those of us know that may have supplies of it, of any other valid uses for it.....SURELY it is of "some" measure of benifit for something/anything, perhaps duodendritic recovery spans?...

[@TheVdalmontes]

A few weeks into taking a small dose of trans resveratrol I developed joint and muscle pain, to the point I thought I might have a neurological or autoimmune condition. After my bottle ended and i didn't buy more, I noticed all the symptoms stopped. Regardless of who is right in this discussion, I think it's more than safe to say there is no miracle substance, especially not for everyone.

[@PratikPatel-lo7ux]

Yes i have same problem after 15 days starting back pain. Now i want to stop it.

[@OkdudeCoolStory]

Thank you for cutting through the noise around this supplement.

[@tommyleejohnson7308]

Really world class detailed analysis. I will cease using Resveratrol supplements immediately. Well, not entirely. I do plan to continue consuming moderate amounts of wine and grapes. Lol

[@abhishekprakash4793]

Kudos to your effort Man !! . I had huge respect for David Sinclar for his study on resveratrol but this vedio is eye opening . Thanks for putting this together . God bless you in your efforts

[@littlevoice_11]

In David Sinclair podcast this week he was still talking about resveratrol as a proven anti ager

[@scottpreston5074]

Clearly we need more research to address these questions.

[@rhlogic]

I have 5 pills left, getting rid of them NOW. You just saved me money, as I was considering to step up my intake.

[@francoistourigny3006]

It’s not ethical from David Sinclair to keep silent about your intervention on resveratrol! I hope you could make a interview with him soon! If he have the courage to put the real cards on the table! Appreciate your incorruptible spirit Brad.

[@therichieconway]

He still claims to be taking it!

[@Seek_Him]

This is government funded!!! Who the heck wasn't to increase yeast & worms!!

[@zbridgjpxupzm]

It is crystal clear. Sinclair is a scammer.

[@DrBradStanfield]

It would be great to have him on the channel

[@Adel3625]

@@DrBradStanfield Please invite David to your channel. He must compromise. Thank you

[@ccamire]

Very good review of the history of the product. I am sure you spent hundreds of hours to prepare us this summary.