MTHFR GENE MUTATION Symptoms and health conditions (MTHFR C677T & MTHFR A1298C)

[@DrJanelleSinclair]

Do you think this genetic weakness may be affecting you? Or have you had yours tested? Let me know what you found and whether compensating for the weakness benefited your health. I'd love to hear.

[@robert12iosif35]

Hei you from london?

[@DrJanelleSinclair]

@@robert12iosif35 no from New Zealand 👍

[@cristinabereghi5625]

Hi Dr Janelle. What is the different between taking folate or folic acid as supplement for MTHFR C677T homoz? Thank you

[@DrJanelleSinclair]

@@cristinabereghi5625 methylfolate is the supplement that you want to take. It's the active folate molecule. Folic acid is synthetic and has to be processed by the body. The mthfr genetic weakness means that you can't process the folic acid molecule well into the active methylfolate that the body needs.

[@cristinabereghi5625]

Dr Janelle Sinclair thank you for your reply. I read that taking folic acid might actually be problematic in case of this polymorphism, but I have not managed to find the reasoning for this. Could you please clarify? Highly appreciated.

[@1258melody]

Drs don't take this into consideration at all first time iv seen a doctor actually informed about this

[@lms6137]

Explains my lifelong battle with depression....heterozygous A and C....

[@jeearr7082]

My doctor did an MTHFR Genotype Analysis (Blood Test) and my results say C677T mutation Heterozygous and A1298C mutation Heterozygous. I looked it up and it ticked a lot of boxes regarding my health. Thankfully I made several lifestyle changes many years ago, but I will be watching your other videos to see what you recommend. Thanks for this explanation. I’ve started taking an activated B complex and it doesn’t make me vomit like I did when I took a B complex once (before I knew I had MTHFR) I don’t generally eat bread, but if I do, I stick to gluten free (home made), trying to cut back on coffee, I only drank 2 cups a day, but now down to 1, trying to eat more fruits and vegetables, particularly the greens, and add in more legumes. I only got my results a few months ago and so I’ve only really started my journey. Will let you know more about the health benefits as I know.

[@shannonrunge2080]

Love your simple explanation of the MTHFR mutations. I have one copy of each SNP and I've found that adding in folate-rich foods (beans, lentils, asparagus, greens, avocado, etc) has had the biggest impact on my mental focus and energy levels. Still working on finding a good Vitamin B supplement.

[@DrJanelleSinclair]

Fantastic Shannon. I'll be doing a video next week on treatment considerations, so check that out.

[@gypsierose3611]

I always wondered why I craved beans. And all my health issues omg this has made my life make sense I no longer feel crazy

[@LumiStitch]

liver surpasses the amount of folate by a few times of the vegetables. 1 oz of raw pork liver contains 212mcg of folate, active form of B9.

[@JAMESGREGORYKULP1985]

I am 35 years old and I am on the Autism spectrum I have PDD-NOS. And I have a sacral dimple. And I am not sure if I have the MTHFR gene mutation. And I was planning on getting the covid-19 vaccination. But I have read that if I have the MTHFR gene mutation I should not take the covid-19 vaccination.

[@psi-ops1397]

my new best friend! Thanks for this. I checked out a few more of your videos relating to the same topic and have a feeling this is going to be life changing! Howdy from America (or what's left of it) :-P

[@tiffanyprice8319]

So my test results said, “This individual is homozygous for the C allele of the C677T polymorphism in the MTHFR gene.” So I would be considered to have a genetic weakness that functions at 100%?? Or because I am C/C I don’t have a mutation at all?? I guess I’m confused because it seems like you are referring to both of the MTHFR mutations as weaknesses. I also have the COMT met/met variation. And some of the things you have said align, but some of the things for the Val/Val seem to align as well. Would you mind clarifying? Thank you so much for your help!

[@BoxOfShockolates]

Hello, do you know if the C677T variant is sometimes linked to ADHD?

[@vivienkittel3063]

Such important information made simple. Thanks Dr Janelle :-)

[@DrJanelleSinclair]

Thanks Vivien!

[@B1iss0ut]

Thanks Janelle. I think I might have one of these gene variations, but am going to test to find out. My daughter was born with tongue and lip tie (which has caused us all sorts of problems), which is what prompted me to look into this further, as well as depression and bi-polar in our family. Also - totally not related, but I just wanted to say I love the blouse you are wearing in this video :)

[@DrJanelleSinclair]

Thanks Rachel. Where do you live? I agree that you should get your genetics tested. Great idea.

[@B1iss0ut]

@@DrJanelleSinclair I live in Auckland NZ. Have ordered the Ancestry DNA test to get raw data, then planning to look at Stratagene after watching one of your other videos.

[@tiffanyguldi7564]

My test came back as having an intermediate risk for the C677T. I was muscle tested for MORS by systemic formulas. I took my kids to get checked too and they also have it so I started them on supplements too:)

[@danithegal]

Thank you for breaking this down so well for us! ☺️👏

[@konstantinosb9566]

Thanks for this video....you opened my eyes

[@josiahculley9877]

I have it the best treatment for it is Metagenics - ceralin forte

[@dvera6514]

Love your videos! Do you have an eBook or anything of that sort about MTHFR?

[@Ssosophisticated]

i have PMDD and i have 2 copies of the A1298C MTHFR, what kind of a dr should i be seeing?

[@sufispiritualhealingsandwisdom]

Dr. Janelle, I have both mutations as well as Ehlers Danlos Syndrome. Do you find a connection between these genetic mutations? Of the EDS & MTHFR mutations?

[@mspomeroyproductions]

This is a great question for which I’m also curious about. I have hypermobile EDS and tested positive for heterozygous 677 snip. Lots of symptoms.

[@n.c.6211]

This is the thing that is shouting at me, thank you so much for your precious info🙏🙏🙏

[@nachiketa3629]

Hi Doctor, are there any links to vaccinations and this mutation?

[@rumble5557]

But what is you have the CB6677 homozygous and you also have the upregulation for sulfur. So I would love to get more folate in my diet for my mutation but I friggin can't because of my upregulation with sulfur dumping. What am I to do? This is a serious problem for me. Causes terrible fatigue and anxiety. I've tried reccomended B supplements too like P5P and they make me feel like I'm losing my mind.

[@rolarola9134]

Que tal

[@LumiStitch]

this specific gene mutation has been also linked to recurring mouth and tongue ulcers

[@garethharkness1823]

Hi I recently got tested and have a homozygous mutation (tt) mao a r297r along with a homozygous mutation on mthfr a1298c. What would you recommend in using to treat these? Thanks!

[@LolaSmollz126]

What was the test called? Is it just lab draw?

[@outingsforoldladieswhoaren7664]

Well, how do I know what I am? What tests should I ask my doctor to order? I have chronic fatigue and fibromyalgia. I am sooo sick and tired of being sick.

[@tornadoe505]

In the US my dr got me the Genomind test. You can google them thats how i found out. Not sure if there is other blood work you can do. Im in a similar boat to you. Good luck.

[@betmikael28]

Thanks for the clear explanation! I thought everyone has a tongue tie?

[@DrJanelleSinclair]

Everyone has a small frenulum, but not everyone has a tongue tie.

[@moka100original2]

Thank you sooo much.

[@susiewilliams6981]

i have 1 copy of each and have stuggled with health issues my whole life. Intese depression when I was a teen and extreme IBS for as long as I can remember, specifically an intolerance to sulfur rich foods. Acne and folliculitis and now PCOS and hypothyroid

[@jamielynns6825]

Me too! I have one copy of both and have had hypothyroidism for most my life 🥺

[@desireefielder626]

Im wondering what has occured now since the very t#@!c jabs? As this would have been studied to do with mRNA.

[@OoOo-qz3fn]

I have mtfr a1298,c snd and other 5mutations of THROMBOPHILIA test . always i felt tired after i ate some foods but recently i started feeling really bad when i eat some foods i have headache and and deasy .i can't walk straight and i can't breathe with beans and artichoke after 3-4hours i ate them.IS THAT ABOUT the folate is in these foods snd and i need to take felicine which is methylation?

[@OoOo-qz3fn]

My mutations is c.1298A>C eterozygos

[@neurologicalworms]

So many people creating KZbin content about MTHFR mutation , they're basically saying that the mutation is a load of nonsense. That its all hype and nothing beyond. Noone here is stating this , but I am just going to rant. My pregnancies were tough and this is what led me to finding out I had this mutation. My babies had severe inner uterine growth restrictions due to my mthfr and factor 5. It really scared me , esp with my first. She was born at 33 weeks , 3 lbs 2 oz. I would not wish for any new momma to get the surprise at 3rd trimester that their baby is not growing right for unknown reasons and to prepare for NICU. They could not even assure me that She would be stable after delivery. I was told to also prepare that she may need to be immediately taken to receive proper attention. I thought I did something wrong and blamed myself so i isolated so to avoid sharing this news with friends. I thought the worst , that It was like i had killed her somehow. Its stupid sad saying it even now. . I know so many wonderful woman have to grief much deeper losses in their pregnancy / delivery stories.... I recognize I was nothing but blessed and i definitely dont intend to victimize mysellf. It is just that to say mthfr is essentially NOTHING is realy ignorant. It clearly isnt nothing. . . I also do believe this may be why i have such chronic depression. Im here to learn more about it and plan to test my daughters for it too, as it might be a big factor to understanding & supportung them properly.

[@tundeannadioszegi4645]

My sister is heterozygous for both mutations. I read that has the same effect as being homozygous.

[@DrJanelleSinclair]

Yes you are right

[@fergfergable]

You've probably answered this somewhere else, but how do I find out if I have that mutation? 23andME?

[@DrJanelleSinclair]

Yes 23andme or ancestryDNA testing

[@fergfergable]

Ok! I did call 23andMe after I messaged you but they said they don’t? Maybe I’ll try ancestry. AnyLabNow is a company in my area and they do it for$150.

[@DrJanelleSinclair]

@@fergfergable ancestry DNA will give you DNA data on a large number of genes like comt. It's unlikely that your local lab will do more than 1 or 2 genes for that price

[@fergfergable]

Thank you so much Dr Janelle :) so glad I found your channel!!

[@DrJanelleSinclair]

@@fergfergable my pleasure. Glad you found me ♥️

[@nadinesokie9]

Dr. Sinclair I have 677T and A1298C I had 23 and me . +and - on both of these genes. Should I supplement with these.

[@DrJanelleSinclair]

Have you checked out my free report on the topic? Please read that and then if you have any questions feel free to ask. www.drjanellesinclair.com/mthfr

[@Truerealism747]

Never new about tongue Tye's got top and bottom fybromyalgia symptoms OCD from birth hope u can reverse

[@alonmatthews7264]

Thanx for sharing :)

[@scottfleetwood1991]

What if you have one copy of both genes? Is there a synergistic affect?

[@DrJanelleSinclair]

Yes. Check out my comprehensive report www.drjanellesinclair.com/mthfr for more info

[@LouiseKingston-x5p]

Jermaine Glen

[@jasonmaurer6714]

I have acid reflux and 677T mutation. I quit gluten and dairy but i still get it at the moment ugh

[@tundeannadioszegi4645]

I have the same mutation and also have problems with digestion.

[@TayDaley]

Try cutting out carbonated beverages and spicy foods doing that for me has worked. Dairy makes no difference

[@yma1233]

What do you do for your babies/toddlers who inherited the MTHFR CC gene? I feel so guilty 😫 How do you compensate for young children?

[@DrJanelleSinclair]

There's no reason to feel bad. You can't change your babies genetics and you didn't make them that way. You are an awesome mum for caring. You can give your child a small amount of b12 and folate or a child's multivitamin to help. 💕

[@yma1233]

@@DrJanelleSinclair Thank you so much!

[@bernadettejones2491]

@@DrJanelleSinclair my gp put me on 5mg of folic acid I was on it for 5 years does mthfr effect b12 as well I've got numb tingly toes and fingers do the same I feel ill I take sublingual b12 liquid I still feel ill thanks

[@profile_01]

So prior to synthetic folic acid being put in foods and supplements , having the MTHFR mutation was absolutely no different from everyone else, because there was no folic acid and everyone needs natural folate anyway? Isnt it more like a modern folic acid disorder then?

[@tundeannadioszegi4645]

Well people were not getting enough folate then either bc. It is difficult to get it all from the diet.

[@toni5543]

It's like egg and chicken. What came first. The inability to use foliate or thwack of foliate made us loose the ability to use it?

[@saulostucky1461]

Should I take folic acid and folate or just folate if I have MTHFR? Thanks

[@DrJanelleSinclair]

Avoid folate. Ideally take methylfolate/mthf. Folinic acid is okay if you don't tolerate methylfolate/mthf.

[@naniahmed6835]

I have mthfr mutation heterozygous c677t Factor v leiden mutation heterozygous Should i take folic acid or folate

[@rayellejohnson9961]

I’m confused. I thought they said to avoid artificial/inactivated folic acid

[@sarahcouture1202]

Im so confused! So my data says my genotype for C667T is A/A. What does this mean?? Please help!

[@DrJanelleSinclair]

A and T are sometimes used interchangeably. your code isn't C or G right? TT means you have two copies of the "mutation". This should help www.selfdecode.com/gene/mthfr/

[@kimdecovich1198]

@@DrJanelleSinclair so if I have wild-type (C/C) for the MTHFR C677T, what does that mean? I'm confused too. Thanks :)

[@tundeannadioszegi4645]

@@kimdecovich1198 the wild type cc is the normal type, no mutation.

[@fionastaats6249]

It would be nice if you could the percentages for people that are compound heterozygous. I was tested back in 2004 after 2 fetal demises. I have followed the research as they have discovered more. People that are new to finding out may not realize that being compound heterozygous is considered as serve if not more than homozygous because yellow on both charts doesn’t look bad.

[@jakesanin1]

We allready know what that is we need cure,people are suffering but nobody is doing anything

[@DrJanelleSinclair]

Maybe watch my second video then 😊 it's all about how to address it

[@renatabazzani1987]

Perché non parlate in italiano

[@phxman7519]

I have a question for you. I am a 44 year old man who had sex with a woman a few days ago. I pre-ejaculated as I have erectile dysfunction from type 2 diabetes and came within seconds of me being inserted into her. I know that it is a slight chance of getting a woman pregnant from pre-ejaculation as I read online, but I know it is still possible. I also have a major blood clotting disorder where I am homozygous for MTHFR and heterozygous for Factor V Leiden. I have had multiple clots to my leg and my lungs and am on Warfarin for life for which it is a high dosage. The woman I was with has no clotting disorders that she is aware of. Based on my clotting disorder alone would a woman have success with a pregnancy?

[@hepthegreat4005]

can the woman get pregnant if you have a blood clotting disorder? yes. she doesnt have the disorder and your semen isnt in blood.

[@tamfx2138]

@@hepthegreat4005 Is she pregnant?

[@samezzieni4750]

WHICH MEDICAL SCHOOL YOU ARE GRADUATED FROM ?

[@DrJanelleSinclair]

As I said I'm not a medical doctor. I am a doctor of biochemistry (PhD) and been working in the natural medicine field for over 15 years. My doctorate was from the Basel University in Switzerland.

[@ScottTaylor-k4g]

Gonzalez Christopher Jones Edward Gonzalez Susan

[@BradleyOdelette-w5r]

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