MTHFR Mutation, Symptoms and Diet: What You Need to Know

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All humans have the same set of genes.
Our differences come from the tiny variations in those genes.
Those variations influence not only in how you look or behave different to others… But in how your body reacts differently to external factors.
Especially how it reacts to the foods you eat.
For example, some have great difficulty metabolising caffeine. For others, it could be alcohol.
Then there are the people who have zero issues with either.
This is because we all have certain genetic variations or “defects” that can influence how we metabolise certain nutrients.
One of the more common and potentially dangerous variations is known as an MTHFR mutation.
This gene variation can severely impact how well your body metabolises folate and folic acid. Both are forms of vitamin B9, required for numerous critical bodily functions.
Unfortunately, a fault in this metabolic cycle is linked to many serious health problems.
This video describes the MTHFR mutation and explores what implications it may have for your health and diet.
What You’ll Learn:
- What is MTHFR, the MTHFR gene, and MTHFR mutation?
- MTHFR mutation may increase the risk of cardiovascular disease and vitamin B deficiencies
- What about other disease states and disabilities, like anxiety?
- MTHFR symptoms of a problem
- Folic acid is a problem, 5-MTHF is a solution
- Folic acid, MTHFR and pregnancy
- MTHFR diet and nutrition recommendations

[@TheCuratorIsHere]

I've had disabling brain fog and was diagnosed with autism and adhd 2 years ago as a 40yo. I tried methyl folate and methyl cobalamin 2 days ago and ALL my symptoms are in remission!! This is so frustrating to realize no GP, psychiatrist, psychologist I've seen over the last decade investigate this. Instead prescribing SSRI for depression. This incompetence is out of control. Thanks for you video. I lost my career, wife and kids (divorce) and became homeless. All that could have been avoided with a genetic test and a $15 bottle of methyl b complex from chemist warehouse. Damn.

[@dancer1]

Omg

[@roseskavnak6671]

I’m sorry our health system screwed you over, prayers to you moving forward with life!

[@GhostOfRT300]

Be grateful that you found your cure, thousands of others may never get to know theirs. 🙏🏼

[@rosejustice1227]

I can't tell you how long I have been struggling with this and didn't know. I had extreme brain fog, lost memory, sores all in my mouth, my vitamins and minerals would stay low no matter my diet, high estrogen, high metal in my system, and extreme fatigue. I can't tell you how many times I've been to the doctor. I went to a functional medicine doctor. She knew immediately. I can't even believe it.

[@rosejustice1227]

I couldn't take birth control no one knew the reason why. It would make me develop huge cysts all over my breast. Make me vomit. Now I know it is due to this gene

[@chastidymayes6864]

I was just diagnosed with this last week!! This is the best informative video I've watched so far! Thank you!

[@PsychicPhoenixAngel1111]

What kind?

[@LILTRadio]

I was reading the article right before I saw this! Love it!

[@Joe_Leech]

Great job! Hope our resources help you more!

[@dianecorn]

Great information!

[@fluffylee41]

Thanks, Joe. Yours was a simple to understand presentation. I learned more from you than Ben Lynch.

[@Joe_Leech]

Thanks Elizabeth!

[@indigomelendez5903]

Great information thank you

[@Joe_Leech]

Glad it was helpful!

thanks for your informations !!

[@javihang5964]

ɷɷɷ Youuu Wontt Beliveee Guysss Howwww I Lostt Fattt Fastt In Justt 3 Weeksss With This Weight Loss Diet Visitt : - t.co/qKKnXk09RW

[@Joe_Leech]

You're welcome!

[@daliamacias8219]

I just got diagnosed and ty for your advice and help , I'm getting supplements And try my new diet

[@evannssugarbaby229]

I just gotten diagnosis with MTHFR mutation, this video helps me understand way better

[@youngtax7604]

me too

[@annabadcock312]

Thanks Joe. My son who has many behavioural and emotional issues, has just been found to have a double mutation on the Mthfr gene so I'm searching for answers that I can understand.

[@kelviannaepperson3677]

I just found out I also have double mutations that it along with vitamin B6 toxicity has caused small fiber neuropathy. I also was born with cerebral palsy.

[@marylane4323]

Nutritional yeast (non synthetic) supplements may help provide good amount of B vitamins. I have been taking a supplement from Dr. Berg for 5 months and feel a lot less depressed and unstable.

[@victorcabral4121]

Great video. Thanks from Brazil.

[@Joe_Leech]

Our pleasure!

[@angelfiremimosa]

Thankyou

[@Bitachon]

8:38 - "Gene's load the gun, environments pull the trigger."

[@GhostOfRT300]

Your genes load the gun, diet and lifestyle pulls the trigger. “Let food be your medicine and medicine be your food”.

[@user-mk7df1xo8o]

Thaaanks!

[@WikiPeoples]

Really great, objective discussion.

[@groberts6498]

Its a load of bullshit

[@marypiver4040]

I also was diagnosed with mthfr!!!

[@feedadditivemonogastrics5792]

Hi Joe. Please in your pathway diagram at 1:13 we see that Glycine produces or affects MTHFR! Please how is this so? Where can I found information in this respect? Looking forward to your response. Thanks.

[@joannfreedman1625]

What do you think of low dose naltroxine LDN? I'm hearing great things about it!

[@musictosoul]

Thanks very much for posting this.... It's really overwhelming when you find out you have an MTHFR mutation.. the term mutation adds alot of stress.... I'm going to watch this multiple times. Very well done and greatly appreciated!!

[@Joe_Leech]

Thank you for watching our videos! Hope our resources help you more.

[@milenagotch2504]

Good job. Great overview. Thank you.

[@Joe_Leech]

Glad it was helpful!

[@cherylrangel5613]

To those who don't think it's real you don't need to do anything if you don't want to. But if you don't want many problems that may take years to manifest and taking a little extra care with dietary selection and some supplementation is worth it in my opinion. You'll know your errors when you find out your arteries have plague it or you miscarry or develope any of many other issues. I hope your children don't get autism after a vaccine or are born prematurely and have cerebral palsy. It's not a joke. Best wishes.

[@karlayork877]

This was good up to the point where you claimed that "a deficiency in folic acid could be linked to MTHFR..." That is akin to saying one has a headache due to an "aspirin deficiency". Folic acid is not only NOT true folate; it is useless and damaging to those with MTHFR mutations. There is so much misunderstanding out there regarding MTHFR; there is absolutely no excuse for anyone who claims to provide information instead providing MISinformation.

[@pamelabarker5719]

you didn't listen, he said the opposite.

[@HeleneLouise]

He said a deficiency in folic acid. I had the same reaction@@pamelabarker5719

[@versewriter8123]

Folic acid is a man made chemical. It is useless until it's converted into the active bioavailable form by the cell enzyme methyltetrahydrofolate reductase. Up to fifty percent of people are compromised in this gene & the conversion is seriously compromised. As the synthetic folic acid attaches to the cells' receptors & can't go any further it blocks even natural folate from entering the cells. The wisest solution is when supplementing is to take methylfolate or folinic acid if the former isn't well tolerated due to a ramping up of methylation which can be uncomfortable. Btw - if this does happen it can be stopped very quickly in its tracks by taking niacin (or niacinamide if the flush is intolerable)

[@evabortelova5066]

Why is this topic not widely spoken if it is that common? It is the first time I hear about that.

[@PsychicPhoenixAngel1111]

That's what my family said but I've nearly died from it more than once. They taking it more serious now. I had saddle oulmony embolism from it at 21 yrs old. They didn't think I would live. It covered my lungs left to right I couldn't breathe and was hurting my heart and I still struggle every day with this mutation and insurance doesn't pay for it since it's generally supplementation aspects can be bought online or such but not everyone reacts the same to whatever size doses of these too so it's hard cause it's like what 300 bucks for a visit and a lot of people can't afford it I wish we could change this cause people are dying and hurting so much from this and can't afford the testing or certain things of researching. I struggle hardcore from food sensitivities, skin sensitivities and more issues. God bless u. I'm glad u posted ur comment and were curious. Thanks for wondering. The more people wonder about it or look into it and talk it,the better.

[@victoriaarcturus203]

More Importantly than not getting an active form of methylfolate, the manmade synthetic form “folic acid “ isn’t used & circulates in the body becoming toxic, a big problem since foods & pregnancy supplements are fortified with it

[@kevinherron6051]

If you are compound heterogeneous at what rate do you process folate?

[@lisathebeautician6489]

There’s a supplement called SAMe...does it help with this mutation?

[@youthfulanti-ageing-jeunes774]

This is fantastic, very informative. Thanks for explaining MTHFR in such a clear way. I thought I was to avoid both folate and folic acid, which I have been doing for over 7 years now. Oh dear!

[@Joe_Leech]

Thank you for watching our video!

[@giulialawrence3663]

I've been taking methylfolate, B6 and methylcobalamin for about a month, and giving them to my kids, since they have at least one copy (heterozygous). That's a certainty since I am homozygous. I am also sensitive to wheat & gluten but not sure if that is at all related.

[@marylane4323]

Do not take folate it will build up and be toxic to liver over time. Can not be synthetic. Has to be methyl folate.

[@MsMOLLYKINS]

I have lupus macular degeneration and latest is hereditary spastic paraplegia . So so much more but I found this so interesting. Drs have wanted to do genetic testing on me but they have t because every time I have some health free time something pops up , right now it's my pancreas again but I have had bowel and gut issues since birth. I haven't been able to absorb vitamins and nutrients for at least 16 yrs .i have b12 injections every three months and take Vita d Anyway really interesting thanks so much xoxo

[@tammyplourde2859]

great video. If your homocystein levels are good, would this mean you don't have the mthfr mutation?

[@sharlesb7735]

My homocysteine levels have always been good and I have mthfr, I’m in my 60s.

[@Elizarge]

Just got a gene test back I am C677T hetergeious. Originally tested for gene compatibility with antidepressants. What shocked me about this is the complications and symptoms associated with C677T. I have an autoimmune disease, depression and fatigue. I'm shocked to find this connection to my disorders. Hoping to take advantage of this knowledge.

[@nutritionbybrittany]

how were you able to test gene compatibility with antidepressants? im wondering the same thing to determine the best medication options for myself.

[@Elizarge]

sorry I just got this reply. Any doctor can order a Pharmacological gene assay. My neurologist ordered it but my psychiatrist also offers in now. they swab your cheek and send it out. Hope this helps.

[@virginiajames5426]

I have homozygous MTHFR c677. I was on setraline for about three months but honestly if you eat 3-5 servings of veggies a day and take cod liver oil, vitamin E, D, B12/folate, an organic folate multi vitamin and fish oil omega 3- you should be good without an anti depressant but that is depending on if you have mild, moderate or severe diagnoses. Have you tried the natural way?

[@Miss_PANDAS]

Beans and legumes are certainly not advisable for anyone to take if they have this gene mutation and experience gastrointestinal symptoms or have an autoimmune disease. In these conditions the gut is permeable (leaky gut) and beans, legumes and all grains contain many compounds, (used for defense against other insects) that irritate the gut lining, further damaging the enterocytes (the cells that line the small intestine and help us digest and break down food) and widening of the tight junctions that keep the gut intact. Furthermore these compounds can form in our tissues, causing toxicity throughout the body and act as anti -nutrients, preventing us from absorbing the nutrients in the plant sourced foods and other foods we eat. If anyone here has this condition please look up the Autoimmune paleo diet and the ketogenic diet. These diets are focused on reducing inflammation, repairing the gut, healing the body and restoring health through the main consumption of animal products. There is also a plethora of science backing everything up and shows why we absorb nutrients far more effectively through animal sourced foods rather than plants.

[@dj-fe4ck]

Animal foods cause leaky gut, not beans. The countries who eat the most beans have the lowest rates of autoimmune diseases. Paleo diets are extremely dangerous

[@FrauleinSchmuck]

You are so right, Vina!

[@tiffanylaurenz]

I DONT KNOW WHO TO BELIEVE ANYMORE I JUST WANT TO BE HEALTHY WITH MY MTHFR MUTATION :(

[@elizabethostenberg6007]

Would sprouted beans act differently?

[@rebeccaschmidt5519]

actually both do.

[@Bitachon]

5:22 - good vid...I don't think folic acid is the same thing as folate though...

[@lauralenau590]

Folic acid is the synthetic form of folate that those with an MTHFR mutation cannot process.

[@ldjt6184]

Why is it dangerous?

[@zakariaabdullah9429]

I would like to know if vitilligo is linked to MTHFR mutation?

[@evienoble9101]

vitiligo is an autoimmune disease and MTHFR mutations are linked to having an increased risk of developing any or multiple different autoimmune diseases

[@KEVINE81382]

What if your Folate levels are toxic?..mine have been 21 and 24 on my last two blood tests. My B-12 levels are great.

[@marylane4323]

Probably the synthetic folate can not be used by your body. It builds up and becomes toxic to system. Has to be a natural source of folate (nutritional yeast for ex). Most folate is synthetic, produced using protroleum (like most vitamins made in labs) and other absorbed by our bodies.

[@leannshort2211]

A list of FOODS not just medications to stay away from would be helpful. I can’t seem to find anywhere that is conclusively just a list of foods to eat and foods not to eat… 😑

[@Joe_Leech]

Tap here and I can send you the FODMAP food list in messenger (there's no way to do it here on KZbin) m.me/dietvsdisease?ref=w14958164

[@avaalsubai8404]

He’s a naturopathic doctor not a naturopath. Please know the difference. Naturopathic doctors attend a 4-year medical program and residency and act as primary care physicians in some states.

[@marypiver4040]

It's very frustrating because not many drs. Know about this mutation and when one of their patients is diagnosed wirh it by another Dr. They don't look into it!!!

[@Joe_Leech]

Thanks for sharing!

[@im2918]

I read that AC1298 homozygous doesnt lead to elevated homocysteine levels, only the other MTHFR mutation does. Is that accurate?

[@Joe_Leech]

MTHFR (methylenetetrahydrofolate reductase) is an enzyme that plays a crucial role in folate metabolism and the conversion of homocysteine to methionine. Mutations in the MTHFR gene can lead to altered enzyme activity, which, in turn, can affect the body's ability to process homocysteine. There are two common MTHFR gene mutations that have been studied: C677T mutation: This mutation is associated with reduced MTHFR enzyme activity. Individuals who are homozygous (having two copies) for the C677T mutation may have elevated homocysteine levels. This can potentially increase the risk of certain health issues, including cardiovascular disease and neural tube defects in pregnancy. A1298C mutation: The A1298C mutation is another common variant of the MTHFR gene. However, research suggests that this mutation is not as strongly associated with elevated homocysteine levels as the C677T mutation. Some studies have even shown that it may have a more limited impact on homocysteine metabolism. It's important to note that the relationship between MTHFR gene mutations and homocysteine levels can vary from person to person. Not everyone with an MTHFR gene mutation will have elevated homocysteine levels, and other factors such as diet and lifestyle can also influence homocysteine levels. If you have concerns about MTHFR gene mutations and their potential impact on your health, it's a good idea to discuss them with a healthcare provider or a genetic counselor. They can provide personalized guidance based on your specific genetic profile and help you make informed decisions about your health and any necessary interventions or dietary modifications. Additionally, they can help you understand the latest research findings and their relevance to your individual situation.

[@garysimone4977]

I understand 5htp a good vit B supp

[@Joe_Leech]

:)

[@shauncampbell969]

Damn somebody's cute All the best Shaun of NYC

[@JandG2]

Excellent source of dietary folate is liver! You forgot that one!

[@OoOo-qz3fn]

I have MTHFR a1298c eterozygos but my folic acid and B12 is in good levels,so why have bad symptoms when i eat recently some foods?,and it is look like i have brain stroke , don't feel my belly my leg me neck head back coming and goes these symptoms and after hours feel ok again?whats that?is it a symptom of MTHFR?

[@Joe_Leech]

Nothing! The reasons why people develop diverticula or diverticulosis aren't well understood. If you feel a flare up coming on, reduce fiber especially from skins, pips, seeds etc and go and see your doctor

[@emilycole6453]

Have you been checked for hemiplegic migraine disorder?

[@OoOo-qz3fn]

@@emilycole6453 The problem after long search with doctors came from stomach cause the central nervous system has bit sore from gastric acids i had.So i know now, thank you for caring.

[@esperanza10123]

I was diagnosed with this a handful of months ago and I got prescribed folic acid tablets. Will that do any harm? One of my other issues is gastrointestinal and an autoimmune disease so I have a LOT of food allergies. So I'm allergic to all of the foods you listed that were high in folate bescides mangos. If I ate one mango a day I would start getting sick from it around 3-4 days later; if I were to skip a dose of my daily meds it would probably be a day or a day and a half. So will the folic acid tablet be okay?

[@LivingLifeWithLisa]

esperanza10123 I have 2 copies of MTHFR and have been taught, by my doctor that Folic acid is BAD for us. 5- MTHFR is the proper folate for us, if the diet is not possible. I am not a doctor, but a patient. Best wishes to you and your journey.

[@rebekahdonnelly2844]

Folic Acid is a bad idea if you have this gene mutation. You need to take L-methelfolate, the methleated (natural) version that can pass the blood brain barrior. Synthetic Folic Acid can make your symptoms worse as it blocks other nutrients from passing the blood brain barrior.

[@cherylrangel5613]

My dr gave me 4 mg a day and it made me much worse. I was severely low on B12 I found out later. Prescribing Folic acid without checking B12 level is basically malpractice.

[@cherylrangel5613]

And folic acid is bad. Methyl folate or folinic acid are ok

[@dragonfly111cute]

did you go over the compound heterozygous?

[@dragonfly111cute]

+Joe Leech (Johan) AWESOME thanks :-)

[@starflower666]

if my serum folate is good does this mean i dont have the mthfr gene?

[@starflower666]

thanks, i ordered a low dose methyl folate for now i have not been taking any folic acid or folate in any supplements and do not eat fortified foods so maybe its accurate i will get a 23 and me test sometime

[@starflower666]

that doesnt sound like an inexpensive test

[@sasham.947]

I have mthfr

[@ladyinthewater1045]

My doctor put me on 4 mg of folic acid bc I had two miscarriages. I do have them the mthfr gene mutation .when I questioned him that I read I need to take folate in its activated form he told me it was a marketing scheme and he said it didn't matter which one I took. It matters a lot to me bc I have had two miscarriages but I don't know what to do. Please help

[@Joe_Leech]

It should not matter to him which form you take, so he should be happy to try it. You could ask for a second opinion at another doctor

[@ladyinthewater1045]

Diet vs Disease - Joe Leech thanks for replying:)

[@ladyinthewater1045]

Kreegrrr thanks...I know right

[@virginiajames5426]

Same here. I had three miscarriages. I take Garden of Life organic prenatal vitamins with FOLATE and Seeking Health B12 /Folate. Dr. Ben Lynch's supplements.

[@marylane4323]

Unfortunately doctors do not get much education on nutrition. So I would follow your own research and not take synthetic forms of folate. Maybe educate him with an article or two 😉.

[@sumutalal]

So if i have a1298c mthfr mutation, should i take folic acid? Or the 5g folic acid?

[@shirleyodonnell6717]

No folic acid

[@chrismyers9951]

Never take folic acid (synthetic) always take L - 5 - Methylfolate form.

[@227olalola]

Thank you so much for this video. I like watching Dr. Lynch but I also agree that I just can't trust what he says because he doesn't have the actual studies linked to back it up. Thanks for letting me be scientifically sounds!

[@foogentog]

I keep seeing from professionals that high dietary folate causes methy trapping and you only want to do that if you are overmethylated (which is rare).. I'm confused now

[@Joe_Leech]

Perhaps mixing up folic acid with folate?

[@foogentog]

thats probably what it is

[@unknownmr5718]

I don’t have high homocysteine but all the other symptoms. Can I still have MTHFR mutation??

[@Joe_Leech]

Yes it is possible but best to discuss with your doctor and get the gene test done.

[@unknownmr5718]

@@Joe_Leech Is 23&me enough?

[@giulialawrence3663]

Very helpful! I know for a fact that I have these gene mutations. There is so much hyped up nonsense out there, mostly coming from naturopaths and others who don't really know what they're talking about. I really dislike that kind of scaremongering. If I eat a folate-rich diet I feel awesome. Problem solved. ;)

[@dancer1]

You can get all those things in meat

[@alanorjeandunaway3415]

I didn't claw my way to the top of the food chain to eat vegetables.

[@greenfield1944]

you didn't mention liver as a source of folate?

[@radedjordjevic8638]

Can mthfr affect low libido?

[@Joe_Leech]

Hmm, this isn't something I have done research on, sorry. If MTHFR causes low B12 then it could have impacts on energy levels in general which could have knock impacts on drive for many activities.

[@RadagonTheRed]

You are mispronouncing the letter H. It is pronounced *aitch* not _haitch_ despite it perhaps seeming counterintuitive. Normally I wouldn’t say but considering the subject of this video being MTHFR it really does stand out.

[@daxdowding727]

Actually, he is pronouncing it correctly with an Australian accent. We follow the correct English pronunciation.

[@Noor-jw2tn]

@@daxdowding727 agreed

[@juliadixon4810]

He's Australian. Geez.

[@aeroslimatic]

Are vaccines not affecting the gene pool?

[@carolfederoff4272]

It's disturbing that you had to act like Dr. Lynch isn't an authority when in fact he is. He always backs up his reports with research and states when it is a theory rather than proven fact. Naturopaths actually know more when it comes to nutrition as that is what they study where as our medical doctors, unfortunately and to no fault of their own, do not. Please don't bad mouth the doctors that can actually be a help to many.

[@hollyphelps5755]

I have his book Dirty Genes ❤

[@GhostOfRT300]

💯

[@marlenevejrich8092]

Great info just like Lynch but you are also not a doctor either!

[@Joe_Leech]

Thank you, Marlene, I hope the video helps you.

[@sasham.947]

I just wanted to watch this vid because I was bored

[@telahquemere6100]

i liked your talk until you tried to bash Dr. Lynches work- he did the research and is still a doctor whether natural or medical. So tired of people liek you that come on you tube and think you know by practicing how to say things and then discrediting research of valid health professionals- not ok- i watched Dr. Lynch on this topic- hes the best and gives great advice- he also has the genetics- and wrote the book. did you write a book? or have a practice?

[@staceykersting461]

Talking too fast makes it hard for me to understand what yer saying. We have dif' accents, so your words aren't very clear to me. Rapid speech causes them to slur tgthr!

[@akcommercialdivers9726]

The listener can change the tempo of the video by clicking GEAR icon to the right of the CC logo (bottom right) and change the tempo to personal preferences. Hope that helps.

[@groberts6498]

Why does the idea of completely fruit cake and nutter territory with a whole heap of totally unsubstantiated claims come to mind. Totally unbelievable the whole lot of it.

[@lucillelaico8146]

Get tested and see if you still feel the same way.

[@tarekhammami4813]

G Roberts I agree . I am homozygous mthfr c677t mutant carrier and was tested at mayo . No one told me to do anything about it . In fact, the dumb dr prescribed iron pills with folic acid and cyonocobalamin . I don’t think any of these charlatans know what they’re doing, it’s Just a business , Everything I’ve looked up , is some wacko suggesting things anc it’s from a specific company like supplements or their lame book It’s such hogwash . I’m riddled with symptoms but there is no way to do anything about it . No one knows anything at all and so many are getting tested by 23andme and other fruitcake places then going to wackos and getting on weird regimens . No rhyme or reason .

[@teresahill406]

There are multiple substantiated research studies from around the world on this mutation and its connection to several conditions. These are scholarly articles from scientists and doctors around the world. How can it be "unbelievable"? One gets a blood test and get your confirmation if you have it. Doctors are also using this test to help determine which ADHD meds are appropriate. You'll have to actually do some research, which it is clear you have not done or you would know that it is indeed your claim that scientific research disproves.

[@teresahill406]

@@tarekhammami4813 folic acid bad; folate (B9) good

[@groberts6498]

@@teresahill406 Did you get that dribble from your buddy Bud Spencer?

[@stephen1371]

You're really cute!