Olink Podcast | Ep 15 Empowering breast cancer proteomics with genomics with Dr. Jochen Schwenk

Welcome to Olink Proteomics in Proximity Podcast!
Below are some useful resources from this episode:
Highlighted pre-print article: Malarstig A, Grassman F, Dahl L, et al. Evaluation of Circulating Plasma Proteins in Breast Cancer: A Mendelian Randomization Analysis. ResearchSquare 2023.04.04. DOI: doi.org/10.21203/rs.3.rs-2749...
Highlighted platform that was used to measure proteins in this study with a next-generation sequencing (NGS) readout (Olink® Explore 3072): olink.com/products-services/e...
Learn more about the consortiums or cohorts mentioned in the podcast:
UK Biobank Pharma Proteomics Project (UKB-PPP) is currently performing one of the world’s largest scientific studies of blood protein biomarkers conducted to date: www.ukbiobank.ac.uk/learn-mor...
Human Proteome Atlas (HPA) aims to map all human proteins using various omics technologies: www.proteinatlas.org/
SCALLOP consortium is a collaborative framework for discovery and follow-up of genetic associations with proteins on the Olink Proteomics platform: olink.com/our-community/scallop/
KARMA cohort is a prospective screening cohort for breast cancer in Sweden: karmastudy.org/ongoing-resear...
Swedish Twin Registry (referred as “Twin Gene cohort” in the podcast) is the largest of its kind, containing genetic information about ~87,000 twin pairs: ki.se/en/research/the-swedish...
Additional published articles and books mentioned during the podcast:
Hood, Leroy and Price, Nathan. The Age of Scientific Wellness: Why the Future of Medicine Is Personalized, Predictive, Data-Rich, and in Your Hands, Cambridge, MA and London, England: Harvard University Press, 2023. doi.org/10.4159/9780674293465
Suhre K, McCarthy MI, Schwenk JM. Genetics meets proteomics: perspectives for large population-based studies. Nat Rev Genet. 2021 Jan;22(1):19-37. doi: 10.1038/s41576-020-0268-2. Epub 2020 Aug 28. PMID: 32860016. pubmed.ncbi.nlm.nih.gov/32860...
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In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA), and more information about the assay and how it works can be found here: bit.ly/3Rt7YiY
For any questions regarding information Olink Proteomics, please email us at [e-mail] or visit our website: www.olink.com/
WHAT IS PROTEOMICS IN PROXIMITY?
Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas.