Endocrinology | Hypothalamus: Anterior Pituitary Connection

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
During this lecture we will be concluding our two part series on the hypothalamus pituitary connection. During this lecture, Professor Zach Murphy will be discussing the connection between the anterior pituitary gland and the hypothalamus, along with the hormones that are involved. We hope you enjoy this lecture and be sure to support us below!
References:
● Le T, Bhushan V, Sochat M, Chavda Y, Zureick A. First Aid for the USMLE Step 1 2018. New York, NY: McGraw-Hill Medical; 2017
● Marieb EN, Hoehn K. Anatomy & Physiology. Hoboken, NJ: Pearson; 2020.
● Boron WF, Boulpaep EL. Medical Physiology.; 2017.
● Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2). McGraw-Hill Education / Medical; 2018
● Hall JE, Hall ME. Guyton and Hall Textbook of Medical Physiology. Philadelphia, PA: Elsevier; 2021
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#ninjanerd #Hypothalamus #Endocrinology

[@ScottMortensen1]

What the actual F? I am very smart. So are my professors. This guy does laps around us all. He is a national treasure. No doubt, the best instructor I’ve ever had. Billion dollar Treasure this man right here.

[@owoeyepaul8995]

🤝International treasure

[@namataswabrah8477]

not just national but an international treasure...we love you and thanks alot

[@idimogumarycynthia6930]

@@owoeyepaul8995 qqqq

[@roronoazoro3204]

No one affected my life as much as Zach He has increased my productivity so much I’m so used to his explanation technique that today when my professor was explaining this subject he wasn’t explaining bad but I knew what I was missing which is an explanation which is not only reading slides and showing pictures but it’s drawing and explaining the drawing step by step then show me the whole picture that ease the remembering of what he has been explaining for me since the first minute unlike the slides which when the professor was explaining the third slide I had already forgotten what was explained in the first slide. Thank you thank you thank you zach❤

[@hassaanharoon2140]

hope he can correct your sense of direction, Zoro....

[@raenashaikh3377]

Now that I have seen a couple of your videos, I can assert that you maintain a fantastic quality of information and teaching style in your lectures!!! Immensely helpful to everyone interested in human hormonal mechanisms. Thanks a lot for your efforts and sharing this video!

[@alexandraandronik7479]

Please, don’t stop making these videos!!! You are king of teaching

[@IamAyOG]

Got a test today and have been listening to these videos and it helps everything in between. My professor is super smart but you’re super smart and make it easier to understand. Great explanations and communication.

[@jasec619]

I too am a medical student. Your videos single handedly got me an A on one of my tests

[@vln1985]

Amazing explanations... We are lucky to have these lectures on medical topics from an expert teacher like you..

[@user-rl5bi5lz5d]

Amazing you are really a thing ... thank u so much 🌸 I’m a medical student and ur videos always save me before exams

[@iiEXPLOSIVEORIGNAL]

I love your amazing videos. My diploma should say graduated from Ninja Nerd University! A small suggestion that would make this perfect is adding captions. I and most my friends like to listen to your videos at 1.5x or 2x speed and it's great but some of the names become difficult to make out. Another reason is me having a photographic memory so seeing the word in captions makes it stick. Keep up the good work! You're helping countless students not die of stress!

[@owoeyepaul8995]

Looking forward to NINJA NERD UNIVERSITY

[@tarikn.g.dabbous3323]

That's correct. Ninja Nerd University >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> med schools out there. lol

[@2YKSS2N]

thank you for sticking through the whole process of making this video

[@mohammadyaqoob7576]

U have stimulated my whole endocrine system with ur lectures U r amazing Myself an anesthesiologist.. R u a doctor???

[@nazneensyed100]

Me student of anesthesia

[@AnitaCorbett]

Beautifully presented - clear - interesting- MEMORABLE 🥇✅ Thank you

[@shairyjd]

I'm so glad I found this video. Really helps visualize and better understand the research paper I was reading about the HPA axis

[@Nina-mz7cq]

Your videos help me so much studying physiology ! I got 8.9/10 at my first partial, hoping to do as good or better for the second one !

[@irfanullah-uk3ks]

I am proud of your hard effort for student.Amazing lectures Sir.

[@Mssclark]

You have a gift. Thank you for this sir🙏🏽

[@sarahsdeal]

what do you do? these videos are incredible!!! holding my hand through school!

[@NinjaNerdOfficial]

+Sarah H. We are so happy to hear that Sarah! Keep on studying and tell your class mates!

[@echexgenny4058]

Woow ,after a long time of hustling to understand hypothalamus,guy broke it down in just an hour.i appreciate @ ninja nerds great work really🎉🎉🎉🎉🎉🎉

[@paulinepainvin258]

you are a genius; Everything is so much clearer with you ! Please Never stop, you are the best med university 🤩

[@mosesnchimunya8136]

I can't compare you with my lecturers,you are a Ninja Nerd indeed,thanks alot.

[@josetrujillo738]

Thank You Zach! Thank You Rob and Kristen!

[@user-zu1dm2my4i]

You are a hero! The best teacher I have ever had (I am into my second master's degree in Nursing) and you are the best there is! THANK YOU!

[@drjerry1492]

Easy, To the point & interesting lecture...Thanku soo much sir .. God bless u 👍

[@HCEI]

This is really good! I have just seen this today and I'm impressed.💯

[@ydelge1614]

You are amazing!!! Thank you so much; make med school so much easier🙌❤

[@sacchrine_]

Isa kang alamat! Love from Philippines ❤

[@ruling_2844]

I wanna be say thankss a lot to you. I am a vet student so ı have limited sources and my profs cannot tell the lecture cleary . Their slides is so confucing source so because of this that uni life is like a hell to me before ı met your chanel . Thanks a lottt ❤ videos are about more human medicine but some basics is same . That part is enough to me for a beginner or maybe intermadiate level to this major.

[@Salvietem]

this is my favorite youtube channel ❤ ❤

[@bhawnasharma7635]

During breast feeding, prolactin secretion is increased......so breast feeding and estrogen should inhibit the release of PIH...right?? Then the sign must be negative By the way.....great explanation sir...lots of love and respect from India

[@nikolaognjenovic743]

Thats what I thought too

[@JokermanMaria]

I think he meant that breastfeeding, estrogen leveles, birth controls leveles are stimulating the production of prolactin.You are right, there should be a negative sign on the effect of dopamine secretion

[@thejoyofstudying5408]

yeah zach was talking about prolactin so yeah the sign should be negative

[@dr.notsostrange9449]

Love your lectures !! Thank you sooo much

[@vaishnavigolwala9860]

Really the incredible videos this are... Thnk u so much for teaching in such a wonderful manner... This really makes all the concepts crystal clear.. Thnk u really a lot. .

[@rozhinarazavian8392]

The part that you muted the original sound and put your voice again on video was kinda interesting. Thank you for your videos. You make this world a bit better. :)

[@ayushibhardwaj7929]

Thank you🤗 very nice lecture you cleared my concept on NPO Only suggestion plz give us time to take screenshot at the end

[@niazwali8169]

amazing sir g ur the best medical teacher and Dr we creates more subscriber for u sir

[@user-oe9nc9ex1w]

you are really helpful, thank you !!!!!!

[@pragatigupta8094]

Amazing way of explanation...love from India🇮🇳

[@yashaswanipatwa99]

Which college??

[@dennishead7290]

Spectacular!

[@riyanbabar8416]

Phenomenal lecture 👌

[@learn2789]

Amazing , thank u so much boss 🌹❤️

[@armina.a]

Thank you so much! you are the best ❤ BTW those neurons are sooo funny and cute!❤

[@learningdesire9740]

Thank you sir ❤

[@zahraaalani3890]

Zach should be put in a museum

[@muneerbhaiyat9777]

Do you have a video on positive and negative feedback?

[@georgepaul6240]

Excellent video

[@user-kf9qs8ls3b]

فدوة لربك ع هذا الشرح

[@simasarevic823]

Dude when Zach starts talking about the inhibiting versions of hypothalamic hormones, the sound of the video doesn't match the visual. But a couple of seconds later it's fixed.

[@harshitapandit206]

lol thanks for this comment,i thought im having some kind of visual error! XD

[@gesund6275]

Thanks for the video, but you didn´t mention what stimulates the GnRH Cheers

[@MeraMohameddrd38]

Subhan Allah ❤️🥰 So beautiful 💚💚😇

[@codrut913]

YOU are best bro !!!!

[@elenagisellebarajasrojas1233]

i loveee your videos, thank you so much. I have one question, isn't somatostatin secreted in the paraventricular nucleus? 🤔

[@ViolaMaster]

There is a typo @14:45, breastfeeding inhibits Dopamine release because Dopamine inhibits Prolactin, otherwise great video, thanks!

[@t4_2g]

What about estrogen and bc pills?

[@ViolaMaster]

@@t4_2g Estrogen will stimulate the Anterior Pituitary to release prolactin for breastfeeding. However, once it reaches so high, the prolactin will actually inhibit GNRH from releasing FSH and LH, essentially negative feedback. This explains why it's harder (but not impossible!) to become pregnant again while breastfeeding d/t anovulation. As for OCPs, it depends on the type and concentration of estrogen/progesterone/progestin.

[@honeybellebuzlucay5867]

I was thinking the same, thank you!

[@ViolaMaster]

@@honeybellebuzlucay5867 no problem! 🙂

[@troybonner91]

11:20 "Thought we wouldn't notice. But we did." - Tony Stark Great video! You're helping me ace my A&P classes, sir.

[@kameliasali9639]

I thought that something was wrong with my laptop lol

[@adilmajeed5256]

Is there any role of supraoptic nucleus in the stimulation of TRH

[@jemimahcansancio1249]

Hello may i ask what references you use for your lectures?

[@niazwali8169]

but i have a question to ask sir what other activities do u do especially in hospital

[@ciaralama]

Very effective lecture.....love from Nepal,🇳🇵🇳🇵🇳🇵🇳🇵

[@zainaziz1269]

Love from Pakistan

[@jshtaway1]

Can you please give us a screen of the finished white board so we can screenshot what we've learned to help us remember!!!

[@victoriagoetz9002]

awesome thanks ninja nerd

[@ranipatidar353]

Sir is gonadotropin releasing harmone relase from pre optic nucleus or arcuate nucleus?

[@mananchawda]

great video ...

[@amryosry4910]

excellant!

[@wicterwterr4245]

Boom! Another topic on finger tips.

[@aashishchaudhary4620]

GnRH IS Released by preoptic nucleus or arcuate nucleus.. i found on one book that it is released by arcuate nucleus.. i get confused please clarify me sir?

[@hamdlaraib6221]

Wonderful

[@ahmedhussainijs]

where there are inhibitory versions of each hormone, shouldn't there also be a releasing version of Prolactin inhibitory hormone(dopamine?)

[@hashimshaban2367]

U r a science wizard 🙌💕🙏💥✨👑💫 doctor

[@josetrujillo738]

Sweet Deal!

[@rowlandwickramathilaka2516]

love from sri lanka !!!!!!!!

[@usamakhan5679]

Thanks, sir

[@2YKSS2N]

you are the best

[@tonystarkim9288]

thanks sir

[@pelmanyabocho2947]

Thank youu

[@syedrizwan960]

Please can you do other physiology lectures like on GIT and brain and netvouse system please please

[@lakshmankumar1263]

In your previous video u said its arcuate which does releasing factors and inhibitory factors and now u turn to pvn

[@Mission-Omega.]

TnQ sir♥

[@suzanagjidiaj1470]

Why does the preoptic nucleus look like Madam Hooch, the flying instructor at Hogwarts 😭

[@mr.epinephrine6845]

😂

[@manarosman452]

thank u sourabh

[@alaaelshiekh4516]

Thanx man

[@hamzehyacoub8575]

Hi! thank you.. how can breast feeding stimulate Dopamine which decreases milk?! you wrote it has a + feedback on PIH (Dopamine)

[@SanyuAEWhite]

So, take my words with a grain of salt, but I believe what he was saying is that normal levels of Dopamine inhibit the lactotropes. So normally, there is a low level of prolactin in the body. BUT, when there is a low level of dopamine, the lacotropes are no longer being inhibited, and so they produce higher levels of prolactin. Which I believe is why women commonly experience the "baby blues" at around day 4 or 5 of thier baby's life, because this is when the thick, fatty, colostrum transitions into white breastmilk. Breastfeeding and nipple stimulation also increases the production of Oxytocin, the "cuddle hormone" or bonding hormone.

[@colmkelly8978]

I think the analysis at the end may be misleading at 15:05 , you said breastfeeding increases PIH which isn’t a secondary stimulus

[@DannyJay-dz7xj]

i was thinking the same thing, thank you for pointing that out!

[@ibrahimabdullah1133]

Is there a prolactin releasing hormone??!

[@abdiwelimohamedali3164]

Awesome

[@DaveBuikema]

Wouldn't breastfeeding, high estrogen levels, and birth control pills, all inhibit PIH release?

[@ahmadarabiat4333]

Dave Buikema right ?!?! I checked that 1000 times 😓😓😓

[@med8615]

right?

[@edilbertoramos3045]

If PIH is inhibited prolactin is produced w/c is necessary for milk production. Therefore, breastfeeding can inhibit PIH because breastfeeding promotes prolactin release. Estrogen & Combined Birth Control Pills can inhibit milk production. Which means they can trigger PIH.

[@thefenerbahcesk4156]

@@edilbertoramos3045 Estrogen inhibits milk production? Also if their breastfeeding, wouldn't they need more milk (not less)?

[@saroabd4437]

He said they can influence PIH. That means either inhibit or stimulate.

[@nyile012]

GHRH and somatostatin is released by ventromedial nucleus no?? and Arcuate nucleus releases prolactin inhibiting factor or dopamine???

[@ibrahimabdullah1133]

prolactin inhibiting hormone is dopamine

[@drumarhayatofficial1735]

Sir you don't mention anterior nucleus in supra optic reagion.

[@404sdn]

Can we get the notes of this topic sir…?

[@akshayraj2920]

Love From INDIA

[@naierafathy9102]

Alright, we're moving 5:58 ❤❤❤

[@kekhrievorsuohu1827]

We have Jr Najeeb here 👍👍👍

[@kaustubhjyotidutta]

My request is after you done drawing step aside for a sec so that I can take a screenshot please and thank you

[@musakhanmedicalenginee890]

Thanks sir ,buy i have question,, I'm confused, anterior pituitary gland have different types of cells? because you(sir) say this specific signal which come from hypothalamus to stimulate that specific type of cell ,to secret that specific Harmon

[@lukasschopf374]

Yes, in the anterior pituitary, there are different cell types that produce the respective hormones and also have receptors to respond to corresponding releasing and inhibiting hormones: - Somatotrophs produce and secrete growth hormone (GH). - Lactotrophs produce and secrete prolactin (PRL). - Thyrotrophs produce and secrete thyroid-stimulating hormone (TSH). - Corticotrophs produce and secrete adrenocorticotropic hormone (ACTH).

[@caitlynnichols3632]

What is the difference between the follicle stimulating hormone and the luteinizing hormone?

[@NinjaNerdOfficial]

+Caitlyn Nichols hello! Check out our video on the ovarian cycle in the reproductive playlist.

[@caitlynnichols3632]

thank you :)

[@fakihaahsan4699]

amazingggggggggg

[@93shreelakshmihs]

🥳😍

[@yasminali7578]

I’m a little confused, this video is second in the playlist series.... but It seems like you’re continuing off from another video. So this can’t be the second video in your endocrinology playlist series. Can you link me the previous video of where you seem to be continuing off from?

[@NinjaNerdOfficial]

+Yasmin Ali hypothalamus-posterior pituitary connection

[@NinjaNerdOfficial]

kzbin.info/www/bejne/Z2TceKp6dtuVh6s It is in the correct order now, thanks

[@yasminali7578]

Ninja Nerd Science thanks so much!

[@16borabora]

Hormone check plus male blood test results:can Graves' disease cause this ? Dhea :11.500(0.44-13.40) Follicle stim hormone:4.17(1.50-12.40) Luteinising hormone:3.63(1.70-8.60) Total testosterone:17.1(7.60-31.40) Free testosterone calculated:0.247(0.30-1.00) SHBG :57.7(16.00-55.00) Free androgen index:29.64(24.00-104.00) 17 beta oestradiol:76.8( 41.00-159.00) symptoms:low mood ,low libido ,anxiety...I was diagnosed Graves' disease 2008'..

[@alishaingram4824]

0opiior8rine

[@ayoungperson3408]

Genesis is to music what you are to Physiology simply supreme

[@16borabora]

Can dopamine deficiency cause low TSH 0.01 (graves disease) .....

[@ibrahimabdullah1133]

how ?

[@TheUlumpa]

Anterior pituitary #1

[@moonlight8854]

Excuse me, doesn't breastfeeding inhibit PIH?

[@LUX711]

13:00