Entresto (Sacubitril / Valsartan) Explained, the Good and the Bad: Side Effects and How I Use it.

I explain Entresto (Sacubitril / Valsartan), a commonly used medicine, for heart failure due to weakened pumping function. The Good and the Bad about Entresto.

[@2steaksandwiches665]

Great comments and spoken with knowledge and patient friendly. Thank you! ALso, love your drawings. Simple yet effective

[@michelecarmichael8834]

Excellent, thorough explanation, yet brief! All medicinal videos should mimic this format. Thank you VERY much!

[@ezzaddeenalshuaibi6679]

Truly Amazing… Well organized and systematic explanation.

[@Inevid]

Thank you, Dr. Ritter, for your comprehensive overview of Entresto. Your insights on its mechanism, dosing, and effectiveness were invaluable. It's comforting to learn about the positive impact on reducing death and hospitalization rates in individuals with low pumping function. Your candid discussion about potential drawbacks, such as angioedema and the high cost of Entresto, adds a practical dimension to the information. The comparison to enalapril in the Paradigm HF trial provides a clear understanding of Entresto's benefits, although the caution about potential bias in a drug company-sponsored study is noted. Your practical approach to dosing adjustments and cost-saving measures demonstrates a commitment to personalized patient care. As someone keen on staying informed about heart medications, I would appreciate more insights into emerging alternatives or complementary therapies in future videos. Thank you for sharing your expertise with the community. Looking forward to more valuable content from your channel.

[@BB-lp5jg]

Nebenwirkunk bei mir;muskelschmerzem haut juckreiz kopf juckreiz augen trübung fusssole schmerzen vergesslich konzentrieren puls 48/54 schlaflosigkeit tagsüber müde habe es abgesetzt und mache seit 3 monate dr,esselstin ernährung.am anfang war es schwierig und jetzt fühle ich mich mega.laufe mit meinem hund viel.👋🏻👋🏻👋🏻👋🏻grüsse aus der schweiz🇨🇭

[@w4yland3r27]

This was extremely well done. Clear, concise, and simplified with pictures. I wish you ran our journal club... =)

[@Santos-ek8md]

My 76 yo mother just began Entresto. Your video helped me to understand more than what council I rcv’d from her primary 💯

[@charlesmonah2382]

Thank you for the info, I'm currently taking enstresto, and I must say it's doing thee job

[@jimmymorgan5981]

watching the video made me feel better about taking it. I just started taking Entresto about one week ago. thank you

[@tomheartwood7059]

iS JIMMY STILL ALIVE?

[@ghulamahmed5323]

Thanks for your valuable information sir

[@PeterGlaab]

This was excellent - very clear

[@bartrobinson2103]

Good to see you again Doc! Another good presentation

[@CardioGauge]

Thanks Bart!!

[@jenmacdonald2467]

Incredibly helpful video! Had a pt not restarted on this med post surgery and hospital discharge ( had been hypotensive with a mild hyperkalemia from AKI). This helps me to understand the mechanism of this med. Thank you!

[@joea363]

Entresto improved my LVEF from 25% to 53% over the course of one year.

[@lonniecole1435]

That's better than usual!

[@lonniecole1435]

That's better than usual!

[@joea363]

@@lonniecole1435 I am a genetic patient. My cardiologist told me that generic patients respond best to the medications. I am actually 6 med inclosing Entresto.

[@schoc13]

OUTSTANDING!

[@joea363]

Plus a beta blocker, Jardiance and a diuretic along with three other scripts.

[@ACoupleStoners]

My wife just started taking this at only 36 years old. You're information helped me understand what's happening better. Thank you, we're so scared.

[@mefirst4266]

HE DOES NOT KNOW SHIT !!!!!

[@e11vn27]

This information was priceless, simplicity at its best. I'm on a higher doses of 49/51. we'll see the affects with blood work.

[@edm1852]

amazing video... thank you so much

[@NancyFiocca]

Your video was extremely helpful I think you were meant to make videos pertaining to heart health not only you are a good doctor

[@richt6353]

Thank you for your honest discussion of the drugs.

[@CardioGauge]

Thanks Rich T!!

[@yeonychoi9434]

wow, I just started HFC, this video helps me, Thanks Doc.

[@cahoonm]

Thank you. I got off Entrestco due to cost. I am on Valsartan now. Thanks from Texas

[@knuftobor]

How do feel now?

[@williamtaylor9368]

Careful with valsartan (Diovan). Hopefully you have bi-annual bloodwork. I had heart failure in 2010. I did/do not have high blood pressure. However my cardiologist prescribed valsartan, he said it will aid the heart in recovery. The day I picked this up, the pharmacist told me this is a wonderful drug but in 10 or so years your kidneys will begin to fail. Forward to 2024, I am in stage 3a kidney failure and recently have a reduced heart ef. I am stopping the valsartan on my own to give my kidneys a break. I check my bp daily, and again have never had high bp. I get quarterly bloodwork. I have had covid twice, am a type 2 diabetic that came about after initially starting the heart failure meds. Good luck and God Bless.

[@cahoonm]

@@williamtaylor9368 Thank you so much for sharing your personal story. I got off the Valsartan and back on Entrestco . My WF was 68 after PET scan up from 37 after my stunts were in. The cost has come down. You have been through hell it sounds like. I am pulling for you brother!

[@cahoonm]

@@knuftobor I am sorry just saw this. I got a ultra sound which claimed my EF was at 45. Cardiologist insisted I try to figure a way to pay for Entrestco and get off Valsartan. I did that. 4 weeks after my Ultrasound he had me do a nuclear PET scan. That said I as at 68 EF! I feel good. Baby aspirin makes my skin get blotchy and least little nick I bleed like crazy. I feel as good as I can at almost 74. Wish you the best. Last my cardiologist would not bad mouth Valsartan but did say Entresco was the preferred treatment. I take it twice a day.

[@byrdeelou3682]

Have prescribed Carvedilol and Erntresto together? With any good or negative benefits?

[@mayragonzalez6605]

Thank you for the information I'm on this medication seems to help me alot had a EF of 20% to 35 % now God Bless

[@CardioGauge]

Thanks for your post, Mayra!

[@dmcclure21]

How long did it take the medicine to go from 20% to 35% I just got out the hospital with 20%

[@mrspo3163]

How long did it take you to get to 35%?

[@mayragonzalez6605]

@@dmcclure21 3 years

[@mayragonzalez6605]

@@mrspo3163 3 years

[@lsmith2519]

I have been on ENTRESTO since August 2019 and this is the only useful area that I have seen. It has increased my EF fron 35% to 50%. I wished it did not cost so much. Thanks for the idea of cutting the pill in half. I will ask my doctor to write the prescription to double so I can cut in half. Very helpful.

[@orni99]

Wow! How long did it take you to go from 35% to 50%?

[@orni99]

but did you have a heart attack?

[@mixc8]

I wish I could get my EF up to 50% I stay between 35/40 %

[@gillc9773]

Read about plant based diets and heart disease❤

[@mixc8]

@@gillc9773 Thanks Gill I will...

[@issanymenchavez7157]

Mom is using entresto for almost 3 years..luckily shes doing great😊😊

[@davidyummus6259]

Novartis did offer a one time free 1 month supply to any patients having Insurance trouble when getting an RX filled & a Pharmacist should know about the procedure. My question is: Can anything be done to treat the failure & improve the Ejection Fraction Rate without the use of Pharma Drugs ?

[@marguitvaldez4792]

Entresto is produced by Novartis in Malaysia, it costs approx. $500 per month. If you can buy prescriptions overseas, check out Brazil. The cost of the same dosage of Entresto, also made in Malaysia, is about $12 per month. I forgot to mention this, the medication from Brazil is packaged in blisters in Italy, making it more expensive than the one in USA that is sold unpackaged. I am sure it is sold in Mexico also for a fraction of the USA price, not sure about dosage availability. Be safe!

[@louisescholtus4393]

Thank you so much for explaining all this. We are deciding what to do at this point. The cost is terrible! Is it worth it?

[@RubinaMerchant]

Taken into emergency due to breathing problems. Was given too much oxygen that almost killed me, scan and MRI done diagnosed with Heart Failure, had to discharge myself out from the hospital as they kept increasing my dose of Furosemide due to pulmonary odema. It made me so ill I could not stand. My kidney pain was unbearable. Came home in an uber! One of the last meds they gave was Entresto it seemed to help slow my heart rate and was able to walk enough to get out! Was confused if I was still supposed to have bisoprolol and this video has clarified it. No beta blocker. Trouble is if you check yourself out, you get treated like shit and don't get meds etc so am on my own now, looking for private care as opposed to NHS

[@SuperLittleTyke]

Diagnosed in the UK in late November 2023 with heart failure and reduced EF between 25% and 35%. Main symptom was breathlessness, but angina-like pain was what prompted me to call an ambulance. Spent five days on acute cardiac ward, am now taking a large cocktail of medications, including Entresto 49/51. I feel considerably better. Minimal breathlessness, if any. I can walk up and down the high street in my local town with no problems, visit the shops, and do some shopping. I am male, 77 years old and had a 3X CABG IN 2013.

[@willgaukler8979]

... best of good news I hope you continue to feel better ... 74 here CHF since 2014 ...

[@mayragomez4446]

Can you tell us about clonidine next?

[@lianecornils8733]

Thank you Lord.

[@pbohearn]

It’s 2024 now and I just started on this medication. Is there any update since four years have passed in terms of as people take it longer? has the price gone down? I live in Portugal as a legal resident so my cost are really minimal including the fact that I am going to get a “upgrade “on my pacemaker to include a defibrillator that’s paid 100% by the country. Not so bad.

[@jeffreyhorenstein1275]

Thanks for the video! What were the death rates in the original study for patients on placebo (not just the ACE inhibitor), or did they not do that, and if so, why not? Also, you didn't include examination of the ejection fraction as part of your follow up. What sort of increase in ejection fraction, if any, do you see? Will you keep a patient on the medication if they do NOT have an increase in ejection fraction? Thanks very much for your help!

[@CardioGauge]

Hi Jeffrey, I will try to answer your questions: For the big Entresto study there was no placebo group, because medicines like enalapril had already been proven to be superior to placebo for this type of patient. I think what you are getting at is what is the likelihood of benefit of entresto over nothing. To get to that number, we have to use the old studies of enalapril (or similar medication) vs placebo which date back 20+ years. The average mortality benefit of enalapril or similar over nothing was 1.3% per 1 year. The entresto study had 2.8% mortality benefit over 2 years. So you are looking at about 2.7% decrease in mortality per year with entresto over nothing. There are a bunch of assumptions baked into that, but there will never be a study of entresto vs placebo. Really we can't multiply that 2.7% per year of treatment, that simply isn't known. So for example if someone takes entresto for 10 years, i don't think we can assume the mortality benefit is 27% absolute reduction. As far as EF goes, that was studied in PROVE HF trial, where Entresto was associated with increase in EF of about 9% in absolute terms (compared to Ace inhibitor or ARB) over one year of treatment. I consider that study kind of a garbage trial though, it was not blinded, all kinds of risk for bias, and other issues. In my experience, EF does not improve much with entresto. I think it works in a different way. It causes urination of fluid in a way that is less damaging to kidneys than usual diuretic therapy. But that is just a guess. Many patients do not have increase in EF with entresto, however, they still seem to benefit by feeling better, and staying out of hospital. So I keep patients on entresto, typically regardless of what happens with their EF. I have a love-hate relationship with the medication. It helps some, but it is no cure. Some patients don’t seem any better on it compared to the old standby lisinopril. And it is so expensive, it is hard on the patients when they are paying big bucks and there is no guarantee that it will work. There are definitely some patients who do great with it and have an impressive response. Thanks for your questions, and best wishes!

[@tomheartwood7059]

BECAUSE THIS POISON ALMOST KILLED ME

[@embededfabrication4482]

why are doctors so sure about this stuff when they've been fined hudreds of millions in the past for illegally marketing to doctors, prominent researchers and doctors say the trial was rigged and....recent clinical trials where they compare it to generic valsartan show it's no better, maybe even worse. what makes them so sure?

[@AAtta-3286]

Doctor I can't thank you enough . My wife is on Entresto 24/26. By asking her cardiologist to change to 49-51 and cutting tablet in half saved us 1/2 the cost on our Part D plan copay AND prevents her from entering the donut hole of Medicare Part D. God Bless you!!!

[@gordonwellard1415]

I get all my HF medications including Entresto free..as a senior citizen in the UK...Your government prefers to spend taxpayers money on weapons..

[@willikranz8402]

Entresto ist nicht teilbar, lesen sie den Beipackzettel.

[@huston126]

is the benefit/NNT the same for all doses?

[@lilyfucsia25]

Can a 67-year old female patient take this medication for high blood pressure? She hasn’t got any heart attacks

[@huston126]

a combo agent at max dose vs. single ACE (enalapril) at half its max dose + plus run in period to weed out anyone who could not tolerate max dose of combo agent... Dr. Vinay Prasad does a good job of scrutinizing the data.....

[@michaelmcwilliams8409]

Is there still a place for digoxin in the treatment of HF?

[@knuftobor]

25% to 52%. I am taking Entresto & Carvedelol. The EF was 9 months after starting Entresto. I was told my Kidneys were functioning properly however, I have been having sharp pains which I think is my kidneys and I have itching on my hands a swelling ankles. I have low blood pressure. No other noticeable symptoms but I am concerned about Kidney failure.

[@faheemhussain9375]

Which dose do you take? Because my doctor suggested me to go from 24/26 to 49/51. Even though I’m far better than before

[@winstoncammock3684]

Thank you, you gave me increased clarity please don't stop making videos. I wanted to know does any medication ever improve your ejection fraction level or is there a way to do it holistically. Entresto and jardiance together help to improve your ejection fraction level? Also if you know, how well do non-white people fair on these medications? Either way, I appreciated your candor.

[@winstoncammock3684]

This video(kzbin.info/www/bejne/n5O6f4Cgor9sbtU&ab_channel=wellnowdoctor) gave me all information that I didn't get in yours.but yours is still good. Especially understanding of congestive heart failure.

[@tomheartwood7059]

AMAZINGN HOW MANUFACTERED DATA AND PROMOTION, WHEN ALMOST KILLING ME 2 TMES IN 40 DAYS!

[@mariuslives8250]

Took entresto. I had an EF of 40% Within 6 months, i went to 50% In a year, it was at 60% I was mostly trying to eat keto/paleo and intermittent fasting(8 hour window) to boost autophagy (self-healing). I also regularly get chiropractic adjustmentandnd take coq10 and magnesium supplements. I'm 35 years old and not overweight.I declined an ICD. As you can see above, I used holistic health methods alongside the medication.

[@daddyo8758]

Thanks for this reply, it has given me some hope. I too, have a RF of 40% and had no other symptoms other than a heart murmur discovered by my PCP several months ago. I'm scheduled for an angiogram next week so I'll know more then.

[@BillyO8828]

I have an EF of 25%. Was diagnosed around 2 years ago after difficulty breathing. My cardiologist had me on Carvedelol, Spironolactone, Lasix, and Lisinipril. I took them for 1 year and they did nothing. I got off all of them because I started to develop diabetes for some strange reason. I fasted for 3 days straight only drinking water...which got my diabetes glucose under 100 by just fasting. This was AGAINST my cardiologist's recommendation. Started taking Cq10, Magnesium, Berberine and Hawthorne for my heart. Took Cinnimon, garlic, Maqui Berry for my blood sugar. I also refused an ICD. Refused Metformin for my diabetes. Never had a heart attack since. Blood sugar at 150, so it's a little high, but not nearly as bad. Never felt better. That said, my EF is still at 25%. So...I wonder how long I have to live. If you're at 40% and have no symtoms, I think you have many years left. But that's just my opinion and I am not a doctor.

[@BillyO8828]

I forgot to add that I intermittant fast every week for 40 hours. I believe this helps, but my cardiologist says he doesn't think it will help me at all. I dunno, but I will take my chances.

[@daddyo8758]

@@BillyO8828 I've been doing intermittent fasting for quite awhile but only 16-20 hours at a time. I've cut carbs to

[@quacker998]

@@BillyO8828 it’s obvious from your post you don’t understand heart failure and what the drugs do - you’d be advised to ask your cardiologist how beta blockers and diuretics work to help your heart in cases of low ef before discarding the therapy. Secondly your t2d is out of control if your bs’s are consistently 150 - you need to get that number down asap with diet and more exercise - how’s your A1c? On the positive fasting will help, a largely plant based diet will help and taking the right drugs for your heart failure will help your long term health and survival - you may feel great not taking the drugs but your life expectancy will be limited as your thyroid pumps stressor hormones into your system. Best of luck

[@damienbell3155]

I started taking this last yr on Halloween 2022 it’s 2023 nov 9 now.

[@_hymnix]

Can these cause head tremors? Ive been experiencing head tremors after taking these esp when im a lilttle nervous 🥺

[@nyacoustics8373]

The study will sound rosy and great because novartis paid for it. They also wrote the papers . Of course it will sound like a game changer because they stand to benefit the most from it financially!

[@tomheartwood7059]

PUT ME IN ICU TWICE IN 40 DAYS

[@embededfabrication4482]

check out what dr vinay prasad yt video on paradigm trial. parallax and life trials show it's no better than valsartan, maybe worse. no fart is has been fined hundreds of millions in the past over valsartan. there are 9 generic arb available. how can any doctor be so sure about it??

[@bighigh69]

Doesn't Entresto interfere with any kind of weight loss?

[@wread1982]

What is your favorite ARB?

[@charlynnLBC]

lol this guy is so funny. thanks for the helpful explanation!

[@embededfabrication4482]

he's a salesman for novartis, entresto is a scam, they just invalidated the patent, it doesn't do anything the generic valsartan can do and it's actually worse than valsartan in some regards, the evidence is right there in the LIFE clinical trial

[@eldarisakovic6085]

can you split it 100%??????????

[@HondaPilotGirl]

*I just want to double-check. Entresto CAN BE SPLIT in half? Also, what do you think about Entresto causing renal failure. I'm so afraid of this med causing me to lose kidney function.*

[@eldarisakovic6085]

HondaPilotGirl i would like to know it too i will spit it

[@jpro1810]

i also would like to know

[@QBeeZzZy]

It could be cut in half to make it easy to swallow. Manufacturer do not guarantee even dose distribution in both halfs. How much dose change and could it affect your health, i leave it to your decision.

[@allensmith9312]

Do these meds lower Vitamin D?

[@JC-lh1pj]

I stopped after 3 days having dizziness and an event were my pulse spiked while BP 88/54. No long term data.

[@user-go2on3vb6o]

Hi i had heart attack last month after stent my FR is 35 my dr put me on entresto 50 one aday to see my reaction to it along with Brilinta 90 and acetylsLicylic acide 100 Telling me this might increase the FE i hope so 2 question pls I forgot that i have to wait 36 hours I took it after 28 hours is this goning to make damage to my The second question my daily life routine i have work not very hard but carrying loads something like 15 to 20 kg and walk very fast But i feel good I don't feel tired or something. Should i stop that

[@orni99]

Were you able to increase your heart function with Entresto?

[@orni99]

??

[@ewelinaniesporek6605]

Mój synek ma 16 miesięcy i ma ciężko niewydolność serca jego frakcja wynosiła 7 procent obecnie zażywać entresto i jest poprawa na 40 procent wspaniały lek dziekuje lekarzom za ten lek dla mojego synka wiara w Boga czyni cuda

[@embededfabrication4482]

ostatnie badania kliniczne wskazują, że nie jest lepszy niż generyczny walsartan

[@ewelinaniesporek6605]

Co mam rozumieć że nie jest dobrym lekiem proszę o odpowiedź

[@whitegoth98]

Hi my girlfriend is 22 years old and she had a heart failure last year. Her EF was at 10%. I believe it was caused by untreated PCOS. She is currently using a paraguard copper IUD. My question is, do you think that the progestins in hormonal iuds (like mirena) will have a negative interaction with Entresto?

[@loveshmunnee4833]

how is your gf now sir?

[@orni99]

I'm sorry .. I hope your girlfriend's heart function has improved🙏

[@shanlynnskinner8477]

Great information. I'm currently suffering from the heart failure you described as a result of a bad case of covid delta pneumonia. There is NO WAY I can afford this drug so I'll have to see what the company can do and talk to my cardiologist. I sure didn't like the fact that the drug study was sponsored by the maker and that there is a 17% risk of dying!! Scary things to think about. I still think of myself as being young but I'm 63 so I guess I'm middle-aged! Thanks for sharing the information.

[@tomheartwood7059]

THIS PRODUCT NEARLY KILLED ME DRUG SLINGING MURDERER REPEATEFDLY

[@embededfabrication4482]

recent clinical trials indicate it's no better than generic valsartan. they company has been fined hundreds of millions in the past for illegally pushing their products on doctors.

[@HabibaPlayz]

I dont think tablet can be cut, its a complex and not simply a combination, if u cut it then equal amount cant be achieved leading to destroy the cyrstalline structure

[@nathanaelcarmona36]

Just started Entresto I'm at 15% let's see how we do. Blessings!!

[@PretzelKid]

Hey, any change yet? Have you noticed any difference?

[@jacobstravail]

Any update?

[@bornjamerican52]

Thank you so much doctor! I have heart disease, my heart is very weak. I’m on many medication 💊 and today I’m on this. I take it twice a day

[@EukellDiniz]

Melhorou?

[@jhovansantos9340]

Been taking this for almost a year and I feel great about it. I tried stopping it occasionally but conditions gets back so i think i need to accept the fact that Entresto will now be part of my budget forever. I had this cardiomyopathy after i had covid

[@ernestsmothers8355]

did it improve your injection fraction?

[@littleme3597]

The same.

[@asrelbartley5906]

I am going through the same thing after I took the vaccine

[@mixc8]

I did the same as well I stopped using it to see what would happen I was ok for about a week. Then I felt I had to go back on it. I don't like the sides and found I tolerate it better with food.

[@Mr.Thenula2011]

I've put 2 stents after vaccine and my EF was below 30%

[@dmana3172]

Where can I buy without a prescription???

[@KznnyL]

Go to Canada.

[@ppg19782]

Hi Dr. I was diagnosed with a weak heart due to my left ventricle was not pumping properly. I was hospitalized and at the hospital I was in code blue...I was gone from this earth. They shocked me and CPR then I was resucitated. Had an angiogram done and nothing was found in clogged arteries whatsoever. Due to arythmia in my heart an ICD was implanted. I got shocked once already not a nice feeling. I felt like someone was beating my heart with a bat....ouch... The recommendation due to the arythmia was that for a heart transplant. I am taking Entresto 49-51, Spironolactone 25 mg, Carvedilol 12.5 mg, Furosemide (Lasix) 40 mg,... I need your advice and guidance in this situation. I dont want a heart transplant, but doctors said that if I keep getting shock from the ICD what kind of living would that be?? Honestly the unknown terrifies my thoughts....please advice. Be safe and much blessings 🙏

[@michigancrownmolding]

I’m with you, I totally understand, have faith in God.. you will be saved , please be in peace, have faith, God bless you

[@orni99]

hello, was Entresto able to increase your FE?

[@ppg19782]

@@orni99 FE???

[@orni99]

@@ppg19782 Has your heart function increased with Entresto? my father has had two heart attacks and his function is at 35% hopefully increases with Entresto

[@ppg19782]

@@orni99 yes it has....Entresto is helping.

[@josemirabal1918]

Wonderful medication. Only for millioners.

[@Mr.Thenula2011]

I was using it for last 2 month it gives me diaherria and dizziness, cannot continue daily tasks when I take it. I was taking 50mg then asked the doctor switch for something else I wish I could take it. If anyone had similar effects like to here how to cope with it.

[@joshpembers]

What about just taking Valsartan alone? Does the combo of Valsartan with Sacubitril work that much better than just taking Valsartan?

[@itsjustvalsartan7844]

the answer to that can be easily found by going to klinical trials doooot gov and searching for it's reg# LCZ696, then search for the two trials where it's compared to valsaarrtan. in short......generic valsartaaan is actually better than pateneted entresstoo. (cmnts r delted by AI, thus mispelt)

[@joshpembers]

@@itsjustvalsartan7844 I was taking Lisinopril (10mg once a day) for years before being switched to Entresto. Daily I wonder if I felt better with the Lisinopril or now with the Entresto. ((or maybe I should "switch to just Valsartan and try that")). I currently have a supply of all 3 of these drugs and I know about the 36 hour wash-out period if switching. **But I don't know equivalence of how much Valsartan to take to match the current lowest dose of 24/26 that I'm taking now with Entresto** Does anyone know what dose of Valsartan would be appropriate to start for someone currently taking Entresto 24/26?

[@itsjustvalsartan7844]

@@joshpembers do you live in a country where they give such meds without a prescription? You should have a doctor set your meds, not good to try and do it yourself. My only goal is to inform people about Big Pharma. But....to answer your question, the amount of valsartan in your entresto is clearly indicated on the label. in this case it's 26 mg. it looks like the lowest dose of valsartan is 40mg, you could cut one in half maybe. Let your doctor set your meds, just tell them you have doubts about entresto, there are 9 different generic ARB available, actually losartan is more common I think.

[@joshpembers]

@@itsjustvalsartan7844 My "Primary" and "Cardiologist" both advise me that I can go back to taking Lisinopril if I feel that made me feel better and have fewer side effects than now while taking Entresto. ((They advised me that Entresto-24/26 is equivalent to Lisinopril-10.)) Now I understand your point and I agree with you that I should work with an MD to advise before going to Valsartan, especially since I have no history or experience having taken that drug in the past. Thanks for your response. ((note: I live in USA, however I also have access to most BP meds without a prescription...but I also do not like dealing with Cardiologists.)).

[@itsjustvalsartan7844]

@@joshpembers I've got a hunch that the ARB just works better for people who also have COPD, and CHF, which is a lot. The enzyme ACE is found in the lungs, maybe stands to reason that people with lung problems would benefit from ARB over ACEi in this case. I dunno. There are a lot of doctors skeptical of the big campaign comparing ARB to ACEi. Check out what vinay prasad md has to say. kzbin.info/www/bejne/fpynfqGVhrVji80

[@Submersed24]

I took 2 teaspoons of tumeric with valsartan and I just found out about side effects

[@jasonwaldrop9626]

My ejection fraction has went from 25% back up to 55-60% using Valsartan 320 and diltiazem 240 once a day and colonadine 0.2 3 times a day and carvedilol 3.125 twice a day. Im 28 years old

[@robarbour3982]

Hi. How long were you at the lower level of ejection fraction ? I think it’s because your so your that’s why your recovered so well? Do you mind me asking you what way you felt when it was at 25% ? I’m at 35% my energy level is up and down some days some not so good

[@jasonwaldrop9626]

@@robarbour3982 my ef was down for more than a year. My energy level was horrible when it was low, however when it was lower my main symptoms was shortness of breath. My energy levels are still up and down. Some days I just don't feel good at all even tho my ej is back up to normal.

[@jasonwaldrop9626]

@@robarbour3982 my ej was down to 16% at one point but I dont know how long it was that low. When I found out it was that low I gave up and was just going to let it run its course because I was tired of doctors and hospitals and all that. I know it sounds bad. I ended up going to the one hospital that I hadn't already been to and they are the ones who got my bp down and thats when my ej started going back up

[@mmafanatic-tz5or]

@@jasonwaldrop9626 so sorry. My EF is 30 to 35%. I feel energetic and have no issues but I'm scared to take this medication

[@StatueKing123]

Hey there, awesome to see how much your ejection fraction has increased! About how long did it take for it to go from 25% to 55%?

[@jacobstravail]

My Dr recommended this, I'm afraid because I have Kidney transplant

[@ritesmakgekgenene2707]

Accepted understanď

[@laurenbailey3858]

Hi @CardioGauge. I (27 Female) had my daughter six weeks ago and just days after labor I developed PPCM with an EF of 45%. My PROBNP level was 4,913 with elevated D’Dimer. My chest filled with fluid. I have been taking Entresto 24/26 twice daily, Carvedilol 3.125 mg twice daily, and Spironolactone 12.5 mg once daily since it happened (in addition to my maintenance meds, like Levothyroxine 50 mcg and Valtrex 1000 mg). Up until developing PPCM, I had a history of angina, HSV2, hypothyroidism, gestational diabetes, HR non-16/18 HPV, and diet controlled high blood pressure. My first few weeks taking these medicines I had new onset memory problems, new angina, new headaches, new onset heart palpitations, new sleep apnea, low BP, and bouts of extreme* confusion that got progressively harder to deal with in following weeks. I visited a different cardiologist that told me to cease Entresto (so I did) and much of the confusion and fogginess has abated, as well as most of the heart palpitations and feeling like my heart would stop. There is still a bit of dizziness and low BP. I am still on Spironolactone and Carvedilol, but I want to know what I need to look out for. I am getting BP readings (still) like 100/56 and fogginess. I was wondering, 1.) what BP do you, yourself, consider too low in your patients? 2.) How long do you typically keep your PPCM patients on HF medicines? 3.) Have you seen adverse reactions like these in Entresto patients? 4.) What has been your experience with PPCM patients and their recovery? I understand you can’t give out medical advice and that only my doctor can direct me in what I should be doing. I apologize this comment is so long. This has just been a really stressful time and I’m trying to be more informed about my condition.

[@rockit5288]

My mom has heart failure and she's on entresto. Her pump EF is 25% on the last test before she was on Daflon and vitamin D3. She takes Daflon which contains Diosmin and Hesperidin and she's able to get out of bed in the morning instead of the midday again. She also feels much more energetic and the edema in her face has disappeared whenever she's taking Daflon daily. She also has had high blood pressure for years. She also takes 6000 IU vitamin D3 daily and that made her feel great too. Because she has a dark skin tone (her family is partially Indonesian) she is more at risk for vitamin D deficiency and vitamin D was shown to repair damaged hearts and improve EF in heart failure. She lives in Holland and so do I. Hope this helps.

[@EukellDiniz]

Oi tudo bem como vc está hoje ?

[@alainleger8973]

this combination nearly destroyed me as I could no longer manage with the resulting blood pressure of 70, had to give up within a month.

[@vitorcarvalho316]

WHAT DOES EJECTION FRACTION CONSIST OF?

[@lonniecole1435]

It's the percentage of blood pumped out of the left ventricle with each beat of the heart. Not all blood is pumped out. 55 to 75% is normal. Below 50% might be considered heart failure in some people.The lower the ejection fraction, the worse the heart failure.

[@jacobstravail]

​@@lonniecole1435your numbers are exacerbated. That's not what studies show

[@vitorcarvalho316]

WHAT DOES EF STAND FOR?

[@lonniecole1435]

See your earlier question about EJECTION FRACTION.

[@ritesmakgekgenene2707]

Pleasent

[@adelinematusiak693]

Unfortunately I’m allergic to Entresto. Though my EF WAS 40-45 at that time now it’s at 52. So I refuse to go on it.

[@losinghair-notheartsarah3703]

What symptoms? I've been on it a few days and just now have had issues swallowing

[@adelinematusiak693]

@@losinghair-notheartsarah3703 I had very low Blood Pressure and Almost passed out. I also was dizzy and extremely tired.

[@BigSamHH]

what did you do to get your EF back up?

[@adelinematusiak693]

@@BigSamHH I had to change my eating habits. I drank Super Beets in AM. Fish oil pills. …1280mg. Meditated in AM. Salmon 2x a week at least. Sardines are really good also. Find the right vitamins for you. K2 is great for the heart. Vitamin D3 is essential. I threw out many vitamins because they were Toxic to me for some reason. So I try to eat salads at least 2x a week. Excercise…..I only did walking and light weights…as I also have Osteo. Monitor your BP. I’m on a low dose of Lorsartan. Had Thyroid surgery….getting the med dose correct took over 2 years. Thyroid messes with every part of your body and most especially your heart. So if you have heart palpitations have them check your thyroid also.. just had Echo done….heart has improved …a little… I do limit my carbs…..it’s called Garbage Keto as I love Veggies. Try and limit sweets. There is no quick fix. It took me years since my body rejected so many meds including Statins. Good Luck. I wish the Best in finding what right for you. Remember your Cardiologist is your friend not your enemy. Find the right Dr. For you…it took me years also. There are homeopathic Drs out there.

[@brendaandrandyking4126]

My ejection fraction is 55.....my dr put me on entresto i think simply because my bp was too high .....176/90....214/89.....199/82.....

[@embededfabrication4482]

courts just invalidated the patent so what does that tell you?

[@LemonLimes99]

really?!

[@embededfabrication4482]

@@LemonLimes99 the effects of this stuff is just that of generic valsartan, many people cried foul over it from the beginning, check out dr vinay prasads vid about paradigm hf trial and also dr poses review at Brown (Foundation for integrity and responsibility in medicine)

[@wallybingbang4350]

I am on full dose of Entresto plus Eplerenone Beta blocker Dapaglifloxin Apixaban French Maritime Pine Bark (Pycnogenol) Coenzyme-Q10 Exercise - boxing 3 times a week Never Give Up 🥊

[@bigcartoonyIIV]

can entresot cause bubbly urine?

[@jacobstravail]

That's usually kidney issues depending

[@LymanDuggan]

#ENTRESTO

[@jamesotisjr2322]

add vivid dreams to the side effects.

[@jitterbugg6824]

I'm on it , I get it free , the twice a day doseage gives me a migraine .

[@debbieanne7962]

Wow medication is expensive in your country. I was getting a months supply for $6.80. The Australian government has recently changed this to 2 months supply of medication for $6.80 if on pension and up to the maximum $30 for people working full time. Depends on medication. My son works and pays $7 for his meds. Helps that we have universal healthcare

[@lianecornils8733]

Me dr. Me smart Meanwhile, you just wait

[@scunyboy]

My friend is working as a doctor in America , me I am stuck here in F....ing England

[@jaysonsajonas3427]

well as for that i let god decides for my death.. as for now d entresto keep me alive for sure and its really effective and really expensive

[@lianecornils8733]

Looks like im a miracle. I dont require you, until you get your name with mine.

[@2504bella]

My god the price is unbelievable $ 9.00 per pill thank god for Medicare 76 cents here

[@embededfabrication4482]

entresto is just generic valsartan, it's a scam, Novartis is under US DOJ investigations over marketing and kickbacks for it, if your doctor is pushing it he's a crook

[@paulao7022]

My insurance pays, $1,442.00 per month, for a script of Entresto and it's the lowest dose at 2 times per day. Why such a high price?

[@robarbour3982]

I’m living in Ireland and I get my months supply of entresto 24/26 for approximately €90 . You being ripped off in USA

[@vanlifeguy4816]

Greed!

[@sylviafkiss1544]

Just remember to take your pills.

[@dmsaddam1838]

EF = 30 ℅

[@jacobstravail]

How is it now?

[@ibrahimelgendy1688]

Why the price is too high? ! More precised informations are required away from propaganda

[@marguitvaldez4792]

Is very high because Novartis can hold the formula patent for about 3 more years before it can turn into a generic drug. Once this happens, price will drop to a tenth of what it is now.

[@atenistaako9672]

Deaths: Entresto 17% - Enalapril 19.8%. 17% is still a lot of deaths. 2.8% is not a dramatic improvement. This drug does not deserve the hype, nor the "miracle drug" label.

[@stevetrevor8859]

Are you mocking your brother? Lol.

[@CardioGauge]

No, he’s awesome, the lower half of his face was so swollen up, and so was his tongue. It was super disturbing, it was before I went to medical school, so I was clueless about what to do.

[@lianecornils8733]

Ain't nothing worth all that. 😅🤣🤣🤣🤣🐕