Epstein Barr Virus (EBV) Serology

Please read and agree to the disclaimer before watching this video.
. Epstein Barr Virus (EBV) Serology
Let’s review the serology of the Epstein Barr Virus (EBV). EBV causes Infectious Mononucleosis. This disease is usually benign and self limiting. However, in some cases it can become chronic, or reactivating. EBV can also cause cancers and other serious complications. Let’s review the serology of the EBV.
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About infectious Mononucleosis
www.ncbi.nlm.nih.gov/pmc/arti...
CDC on EBV Serology
www.cdc.gov/epstein-barr/labo...
Serological diagnosis of Epstein-Barr virus infection: Problems and solutions
www.ncbi.nlm.nih.gov/pmc/arti...
The Relationship Between Environmental Factors and the Profile of Epstein-Barr Virus Antibodies in the Lytic and Latent Infection Periods in Healthy Populations from Endemic and Non-Endemic Nasopharyngeal Carcinoma Areas in China
www.thelancet.com/article/S23...
Epstein-Barr virus (EBV), Infectious Mononucleosis
labpedia.net/epstein-barr-vir...
High level overview of the serology
States of a person:
Susceptible to EBV (never had it before.)
No antibodies
Acute infection
VCA IgM
Acute infection late acute
VCA-IgM and increasing VCA-IgG
Past infection
VCA-IgG and EBNA-1 IgG
Reactivation of the EBV
www.ncbi.nlm.nih.gov/pmc/arti...
High EA (D) IgG
Increasing VCA-IgG
Decreasing EBNA-1 IgG
Even VCA-IgM may reappear during the reactivation
Immunosuppressed may have
Only EBVCA IgG without EBVCA IgM or EBNA-1
In 1.7% of the infected patients may only show EBNA-1 without EBVCA-IgG (this pattern is usually thought to be implausible.)
Antibody patterns and causes from LabPedia
labpedia.net/epstein-barr-vir...
#DrBeen #EBV #InfectiousMononucleosis ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

[@kevineakins5276]

An excellent series of lectures. Top class. I have never heard ebv pathology & characteristics presented so clearly.

[@ZlayaCo6aka]

Another thing that might be helpful: According to several medical articles I've read, backup symptoms of a chronic EBV infection are chronic vitamin-D and vitamin-B12 deficiencies. In my case, vit-D is typically between 10 and 25 even though I took 20,000 IU per day of supplements. I now take 40,000 per day and my vit-D is approaching 30. B12 is barely in the green, and homocysteine is significantly elevated. These test results/conditions have been consistent for more than 15 years. Doctors always dismiss these results with: "Everyone is low."

[@paulette-rose]

Wow! Thank you Dr. Mobeen! You keep my 72 year-old brain active and healthy by all this teaching!!😄 This was wonderful!

[@jonipleau9284]

Me too! Better than doing crossword, especially during this time we are facing.

[@manarsmaan2624]

What a great doctor. This video will help me with my ASCP board exam and i am so thankful to you.

[@jamesmacdonald5556]

Unfortunately the “doctors” who need to hear this information are most likely the doctors that will not hear this information or even worse not allowed to apply this information to there practice.

[@jamesmacdonald5556]

I keep hearing that main line medicine is 10 to 17 years behind what researchers know. We need to really speed this up. Several years ago on the radio the head a very prestigious medical university and two other very prestigious doctors with all the whistles and bells. Their advice? Do not put all your faith in medical experts, do the research for yourself and use common sense. Now that is the opinion of three doctors I do accept .

[@radmilamiljanic5977]

Dr. Been is beaming with joy: he has a mechanism to describe:))) And rightfully so-he is so good at that!!! Respect!!!

[@sachabarlow9483]

I had always wondered about this topic, Many thanks.

[@medico52]

Could share what app /software you use to share your screen and live stream. Excellent for teaching

[@cristinaco7952]

Thank you Dr.Mobeen , learn a lot .God bless you 💖🌹

[@ZlayaCo6aka]

Something that might be helpful, that I hope will be addressed in a follow-up lecture: The sample source for EBV-PCR tests MATTERS, whether whole blood or plasma/serum. In my case, every PCR that used whole blood was positive (in the 1000 to 9999 range,) and every PCR that used plasma/serum was negative. There are articles in the medical journals that explain why, and how the loads and ratios of simultaneous PCR tests correlate with EBV-related illnesses. Basically, when whole blood is processed into plasma/serum, infected cells are removed from the sample before testing. Unless the subject has "cell-free DNA" in the plasma/serum, the PCR will be negative. In my case, every doctor upon receiving a negative PCR result immediately dismissed EBV as the cause of my illnesses. But, in my case it gets worse: VCA-IgG is always over 750, EBNA is always negative, and whenever my misery peaks EA is positive (otherwise it's negative.) So far, every doctor diagnosed "recent infection" even though my history with EBV goes back to 2003 when I had severe mono, complete with the classic rash, for more than 9 months. Also, IgM is positive only when I experience a reactivation, which is evidenced by severe viral syndrome with fever over 101 for up to 16 days. My reactivations have always been diagnosed as primary infections because EBNA is always negative, even though youth is a distant memory. The degree of EBV-ignorance in the medical profession is staggering, at the very least. So, I hope the doctor will address these subjects in a future video!

[@annerutherfordroll7684]

Thanks so much for sharing this.

[@ItsAV2023]

Great lecture. Thank you so much! I had no idea about the connection between latent EBV and various cancers. Do you have an informational lecture like this on the other herpetic virus strains? I’m looking to study up on CMV and Shingles? Thank you!

[@ZlayaCo6aka]

I've had several severe reactivations but have NEVER been EBNA positive.

[@MV-uh7kr]

Good to know all this info about Mono.

[@weloveourkittens]

Thank you so much for clarifying the tests, chronic versus reactivation and the great helper you said at the end to use in reactivated state. I am in reactivated state taking numerous supplements but will add the ivm also.

[@marijean282]

Thank you, Dr. Mobeen!

[@crystalmckinney3151]

Do you believe during the reactivate phase that fibromyalgia is developing and getting magnified each time?

[@amberlyonferguson8604]

I was hoping to find answers to why my tests have shown "primary new infection" for 15 years based on Pos VCAIGM, Pos VCAIGG Neg EA and Neg EBNA. I have never seen this combination on any chart from any lab. The fact that I have never made antibiodies to this virus is mind boggling. I don't fit the Chronic or Reactivated definition because I keep a positive IGM. I have been tested yearly or even twice a year for 15 years with consistent results. I would think I have Chronic Active that just will not go dormant which is why I never get a neg EBNA, but having a positive IGM constantly really confuses me. Great video!

[@kmook76]

Perhaps you should enroll in one of the vaccine trials. Are you on suppressive antivirals? High dose AV over time can reduce permanent viral load at least for those with sufficent immune response

[@jimgraham6722]

It took me 9 years to fully clear EBV

[@poppylove3673]

How did you fully clear EBV? That’s great! Thank you, very interested and would appreciate knowing what you did to help.

[@jimgraham6722]

@@poppylove3673My main problem was recurrences short sharp fevers usually lasting 6-8 hours often as night sweats. These occurred every four months or so for nine years. Then suddenly stopped. There was no treatment, just effluxion of time.

[@irenemacdonald4955]

I can see a link here with chronic relapsing multiple sclerosis and it’s cycles too ~ and how the immune system goes into inflammatory mode at times as these B cells may well attack our own tissue. I too take IVM monthly and find it helpful. You have a wonderful brain and an amazingly big heart Dr Been. Can you use that big brain of yours to look at EBV and MS?

[@nataliem8954]

Hello Irene, he’s very un-orthodox, but Anthony William has lots to say about Epstein Barr and it’s link to MS.

[@barbarasmith4560]

I'm taking IVM and low dose naltrexone and supplements for inflammation too

[@barbarasmith4560]

Do you take ivm everyday?

[@MoparGiRLiE_]

My EBV reactive are high I’m now trying LDN

[@barbarasmith4560]

What are symptoms of chronic ebv

[@charmainemeissenheimer3850]

This is extremely informative, and I would like to just tickle the idea that Acyclovir may be effective in treating the presence of reactivated EBV in Hashimotos??? Cystic ovaries in a woman diagnosed with polycystic ovarian syndrome??? Could there be a connection??? And are there past studies on this matter???

[@VikingVikingKobenhavn]

I have antibodies to ebv showing past infection. I have classic flu like symptoms daily unless I completely rest and some blood tests came back showing reactivation at the time of blood test. I had swine flu 10 years ago and diagnosed 7 years ago with chronic fatigue syndrome. M. E. I read a research paper stated possible protection against covid if you have had swine flu. I had never felt so poorly in my life with swine flu went back to work and have never felt the same person since. Has anybody out there had similar. Interesting about ivermectin. I'm in the UK

[@poppylove3673]

About 10 years ago, a good friend of mine didn’t know what was going on, at first, but suddenly it seemed couldn’t even walk from one room to the other, and said it felt like they could just lay down wherever they were, even in a store, it was weird and not like anything they had ever experienced before. She went to the doctor and the blood tests came back saying, she had a resolving case of ebv. Since then, she’s never felt like herself. She’s been to a lot of doctors and since then, over the past ten years, she was told she had fibromyalgia, then arthritis and nerve issues. She is in pain a lot, and seems to have trouble talking and mid sentence forgets what she was thinking and saying, she says it’s brain fog. I feel so bad for her because she hasn’t been helped by doctors and is trying to find out what she can do on her own, because doctors haven’t helped. Any ideas I can pass on to her would be much appreciated. Thanks

[@FrenchCocoa369]

@@poppylove3673 tell your friend to see a Naturopathic Doctor.

[@charmainemeissenheimer3850]

Hence the fact that some people are allergic to pork...and meat. In some butchers, maybe the beef gets contaminated with sheep meat blood too, or cut by the same blades, etc. So these may be people with latent EBV...

[@upserrudy]

good morning Dr Been. I had a question about some titers. my IGG levels have always been over >600 or >1200 My wife and everyone I know has levels within normal range. All the docs I have seen say they don't know why my levels stay like this. Can u shed some light on why my IGG levels made so much more than normal levels?

[@brookebutcher3225]

I’m the exact same. I really want answers. I feel terrible everyday.

[@brookebutcher3225]

I have a question that no dr can seem to answer. I am praying you can help. Does the value of antibodies made matter? My igg is 750 and my Ebna is 540. I have been sick for about five years. Recently tested positive for ANA. I am miserable and can’t help but believe these numbers matter. My IGM was negative. I would love some help. Thanks so much for these videos. You have no idea how much it helped me understand things. I appreciate you

[@wendylpa]

Hi - I know your post is 10 months old now...just curious if you're feeling any better? I went through about 20+ years of what you describe, very similar labs as well, ANA etc. Since no MD knew how to assist, since it was impacting nearly every body function after 20 years of damage. I had to take functional medicine classes on my own/as well perform extensive medical research to determine root cause of my ongoing fatigue. Thankfully I was able to return myself to somewhat functional - or as functional as I can hope to be after decades of damage where allopathic healthcare was worthless. I'm happy to share the basic protocol that helped me...everyone is different though! For me - my mitochondria needed the most help. EBV clobbered them...and without mito health, we have very little quality of life. Hope you're back to normal by now!

[@steelersgrl2772]

Would chronic EBV cause Panctopenia?

[@annamartin5826]

I have hoshimotos and then in July felt something hit me like a ton of bricks one morning and I kept feeling like I was getting sick for two months. I went to er and they did a mono spot and I tested positive for mono which made sense as to why I was feeling so poorly but then a month later still feeling sick and broke down to my mom on the phone and said I couldn’t handle feeling this way anymore and said I just wanted to sleep forever and ended up in the er psych ward this time in October. Psych dr saw my meds were too low doses. But I’ve increased them as recommended and nothing is happening and with hoshimotos your depressed and meds don’t work so it becomes an immune issue. Both hoshimotos and ebv do I went to an immunologist he said that I probably didn’t have mono ?? He said he would have tested the same oy now I’m so mixed up. He took a bunch of test on my immune system they are not all back yet. This is so ridiculous I have to listen to the rest of the video but just wanted to share a bit of my current experiences

[@bethyelvertonbaker6373]

What about ebv AB VCA igg

[@garrettsmelosky5008]

Could alpha gal syndrome theoretically cause the immune system to attack these glyco proteins?

[@yolandasullivan9713]

Ivermectin and Epstein barr

[@andreaallen5867]

Thank you for this detailed explanation. I have high labs for early antigen, nuclear and vca igg. This is the only source of information I’ve found to give me an answer as to why. I had mono 30 years ago and I’m assuming a few rounds with covid over the last few years has reactivated the virus. Going on 9 months now of feeling awful with no reprieve.

[@barbarasmith4560]

If you got symptoms that's means it's active??

[@karinm2440]

What is EB virus? I was recently told that I have the antibodies. Does this virus cause an issue in getting the covid vaccine?

[@OlderWomenRock]

Many adults have been exposed to it at some stage . Was once called the kissing virus common in teens.

[@repentfast7793]

Epstein-Barr 98% of the world has it it's like a herpetic grandfather

[@vwbustube]

My wife was just diagnosed (tested positive) for EBV. She has been “chronic” for over 50 years, but her main symptom is only complete lack of energy. Any ideas how to treat (medicate) or adjust (lifestyle) that may help? Most days she can’t get out of bed until 2-4pm in the afternoon.

[@MichaelMerritt]

I recently read a recent study where red panax ginseng taken for 90 days, those ebv infected people on average had much less fatigue. Something worth trying beyond the normal antivirals. A-EB/H6 tincture is another specific EBV formulation that many ebv practitioners use. ME/CFS is tricky if that’s what it is, hard to undo.

[@gerardbiddle1808]

Name of this virus suggests it’s somewhat like a Trump Administration pathogen unfortunately. A very informative and complex lecture Dr King Been. Thank you for all the insights that you provide.

[@vwbustube]

I believe you meant “Clinton, not Trump.”