Excitation-Contraction Coupling 🐧🧠💪

[@tonyalan3070]

You don't know How much thankful I am to you

[@lesliemiller7917]

Thank you for sounding so happy and excited, it really makes a difference in the learning experience. It makes learning these difficult details so much more pleasant. Thank you for cheering up science nerds everywhere :)

[@Penguinprof]

+Leslie Miller Thank you for appreciating that - it's subtle, but SO important! Science IS fun and wonderful! I love my profession and my students, so I'm so glad to hear it comes across. :)

[@khaledsaleh2468]

Med school professors could not explain this easy concept and you did it in ten minutes. Great researcher does not mean great teacher. Learned that the hard way.

[@utubebrah]

Amazing!!! Grad student, you explained in 10 mins what takes most profs hours. Thank you so much for posting. I love your format.

[@habblebabble70]

Your clarity and optimism is greatly appreciated.

[@JuanPablo-it1ll]

Your voice is so sweet I could be hearing you all day, uh, and very clear explained.

[@marthamendoza7080]

you are an amazing professor, I love your tone of voice but what I love the most is how well you explained this. I wish my professor loved to teach as much as you do!! My respects for you ma'am.

[@Penguinprof]

Wow, thank you! Thanks for watching!!!

[@ellarafati5241]

LOVE THIS EXPLANATION - YOU ARE GREAT - PLEASE KEEP CREATING CONTENT MEDICAL STUDENTS NEED YOU!

[@Penguinprof]

OK I WILL - THANK YOU FOR WATCHING!!! Good luck in med school!!!

[@sabelomayapi7672]

WOOOOOW!!, this is beautiful!!. I have been reading this in my text book, my lecturer`s slides and my tutor`s notes but it made no sense!, I just couldn`t distinguish between excitation-contraction coupling, sliding filament theory and cross bridge cycling but now I get it, all thanks to you Prof!!, your work is much appreciated!.

[@Penguinprof]

I am SOOO glad you found this helpful! Thanks for letting me know!

[@hamdasn7291]

Thank you. this is very clear to me, especially your easy words and sentences make it easy to understand.

[@Penguinprof]

Glad to hear that!

[@chientranly4506]

very thankful to your exciting video, it is really informative. It provides more knowledges about DHP receptor and RyR that in my textbook doesn't exist, hope you can release more such interesting video.

[@Penguinprof]

So happy to hear that!

[@mirandahurley7697]

Hello I was wondering if STAC3 could make its way onto this video. This was great!

[@umerkhan7545]

What os STAC 3

[@umerkhan7545]

WhT is STAC 3

[@mirandahurley7697]

A skeletal muscle specific protein that is crucial for DHPR/RyR coupling

[@connnayy01]

I'M SO HAPPY I FOUND YOUR CHANNEL

[@tammyhjlpere6714]

What a great teacher! Could you possibly tell me what a STAC3 defect affects the Ca+ and the muscle contraction?

[@Penguinprof]

I've read recently that STAC3 has been identified as a (possible) fourth essential EC coupling protein and it may couple CaV1.1 with RyR1 for calcium release in skeletal muscle. This would explain observed myopathies in patients with STAC3 defects. Some good info here: www.pnas.org/content/114/2/E228

[@cherylwalter8693]

Thank you sooooo much. The animation and dialog were exactly what I needed to get my head around this concept! Your videos are great!

[@caaawny]

This video helped me out so much! I'm in a one month physiology course and it's so hard to learn all of the material before an exam in 4 days. One question - does this also happen in cardiac muscle cells?

[@randomman2588]

Wow! I had completely misunderstood the entire thing when my professor explained it, but now I get it. Thanks a lot!

[@raskolnikovii1191]

Finally i understand the mechanism. Thanks !!!

[@Penguinprof]

I'm so glad to hear it! You are most welcome!!!

[@astethoscope6468]

Thank you so much !! I couldn't find a video or textbook explaining the sequence in chronological order - thank you :)

[@yasersalah8977]

finally someone explain the mechanism of DHP simply and professionally :)

[@ajaiarora4711]

Excellent explanation ! 👌👌

[@Penguinprof]

Thank you 🙂

[@ClaireAbdulAzeez]

Thanks for the heads up on Open Stax.... I was able to get a couple of useful textbooks...thankss :)

[@ibbyibra]

THANKS SO MUCH YOU'VE LITERALLY SAVED MY LIFE!

[@JKwiatkowski94]

This is the best physiology video I've ever seen...

[@djcb91]

Wonderful lecture hope that there are more professors like you,keep up the good work.

[@Penguinprof]

Thank you so much! Thanks for watching!

[@SquatFull]

That was very interesting. I appreciate understanding whats going on at the molecule level with muscle contractions. It adds to the mind muscle connection when weight training.

[@MariaRosa-bi4wb]

You make it sound so easy , i marvel your way of explaining thank you

[@Penguinprof]

You are welcome! So glad you find my videos helpful!

[@esraaalnaqeeb4811]

Thank you soo much for your helpful explanation!!!

[@Penguinprof]

Glad it was helpful!

[@TheHighrollaa]

short sweet and to the point. very helpful keep them coming!

[@salun7820]

Adipoli mole ushaar ayikunnu 👍👍👍

[@pandakabob8013]

Love your channel. Really helpful and easy to understand. Keep up your great work, I and many others really appreciate it!

[@DODens1984]

Really great video, thanks! Made this physiology chapter super easy.

[@ambidexmed]

I think it is important to note that there is a graded/local potential started by the nicotinic-AchR by Na influx. This in turn, propagates to activate V-gated Na channels that make a new AP. The new AP travels down the T-tuble etc.

[@ChanetNiicole]

Thank you, now I understand how excitation-coupling works.

[@Penguinprof]

You're welcome! Thanks for watching!

[@ChanetNiicole]

ThePenguinProf I shared with my class!

[@TheRock2live]

Thanks a TON! You explained so perfect and simple. I have never understood it better than now!

[@drewandersen6625]

Thank you for your help!

[@Penguinprof]

I'm so glad it was helpful!

[@cherryroseshott4805]

No skipping ad😁 Love the of fairy penguin 😁😁

[@Penguinprof]

Fairy penguins ALWAYS.

[@hadeelalshangiti2675]

The best explanation better than my professor

[@messchief]

I love this channel!! Keep it up!

[@akhilannam4628]

always coudn't imagine DHPR and RyR .....made it a bit clear...thanks.......please keep making more heplful videos like this....

[@PaperlessX]

please do for cardiac muscle...

[@f.m.a7184]

what an amazing explanation!

[@rubensbrazilianbrothers]

very nice explanation!!!! thanks a lot

[@sarajohn1215]

Thank uuuuu so much you are seriously a life saverrrr!!!

[@margretsmit3560]

So helpful. Thank you so much.

[@sarithjinasena6600]

This was super helpful

[@Penguinprof]

I'm so glad!

[@corchua]

Great drawing! Thank you!

[@montrellcurvey3081]

This was amazing! Thank you so much!

[@yuvarathana7027]

I am watching this vedio in 2022 😊 I don't know fluent english but this vedio make me feel good 🤗

[@Penguinprof]

I'm so glad to hear it! Best of luck to you!

[@MegaBev]

thank you so much. this was the most helpful explanation.

[@nicholaslegacy8677]

I love your work!

[@dpatulea]

[@evanzrmt0639]

Great video 💕

[@wraithdefilerjj1039]

Thank you!

[@Penguinprof]

You're welcome!

[@amityar100]

Thank you, you helped me a lot!!

[@drsamuelk]

You have such a lovely voice

[@Penguinprof]

I'll let my vocal couch know you said so! Thanks!

[@drsamuelk]

@@Penguinprof I meant voice modulation 😀

[@sudhis555]

Beautiful ❤️

[@Penguinprof]

Thank you! 😊

[@kimmietay9611]

dis shit helpful dawg

[@marebearzzz027]

this is amazing, thank you penguin prof!

[@bkkcarts]

Loved it!

[@CristianoRaashid77]

I love you thank you sooo much!!!

[@tasadayl]

This video is very awesome. However, I do have a question about the dihydropyridine receptor. Currently, have researchers been able to better understand the DHP-R (a voltage-gated L-type calcium channel) and know that it opens the ryanodine receptor by releasing calcium into the cytoplasm which binds to the RyR to open it and release calcium within the sarcoplasmic reticulum? I'm trying to piece everything together between KZbin videos and my textbook.

[@swinxfee]

Thank you thank you thank you thank you thank you!!!

[@Rashedov]

Fantastic

[@Penguinprof]

Thank you so much 😀

[@Hamd1513]

thanks !!! really helpful

[@phonglan2551]

thank you. your video is awesome

[@gagnon124]

What happens when nicotine binds to those receptors ? It does not cause muscle contraction ?

[@xinbush8756]

Thank you so much!

[@AmirAbuleil92]

Extra Thank for the link

[@watchout658]

So sweet voice!

[@user-tl4jl7bg3i]

wow amazing! thank you so much! much better then my prof aha

[@brahmachemitikanti4849]

Good. Thank you

[@Penguinprof]

You are welcome!!!

[@Spiritedaway94]

thank u so much! u saved me!

[@Stjc7]

amazing really thx

[@ommar3654]

Only worthwhile video on excitation-contraction coupling on KZbin.

[@pharmastudents7800]

woòooooow ...... very helpful. .... hundreds thanks

[@Penguinprof]

+Manal Kanouaa You are so welcome! Thanks for watching!

[@kidcyber008]

So how is the excitation-contraction coupling related to the sliding filament theory?

[@thatsitdotcom]

wow. just wow. i can learn how to build a rocket ship with this professor.

[@ketulpatel2201]

very helpful thanks thanks thanks

[@vickypanjari3678]

it's good🤗

[@promisemwase2770]

Wooooow

[@Penguinprof]

SOOOOO glad you like it...

[@sukalyanpanja1558]

Thanku mammmmmmm

[@Penguinprof]

You are soooooo welcome!!!

[@seva00793]

how muscles grow???

[@wycliffenyandika9017]

❤

[@Penguinprof]

❤️🐧❤️

[@hussain55019]

I love you

[@Penguinprof]

Awww... thanks!!!

[@Textbook000]

Da best

[@BobEisenbergRSE]

Too FAST Too MUCH ....from a pro who has studied this stuff for a long long time

[@jenniebun]

thank you!!!

[@zoereynolds3610]

Thank you so much!

[@passengerprincesspodcast]

thank you so much!