Extravascular Hemolysis

[@MedicosisPerfectionalis]

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[@deryasimsek3786]

I have a question mark about haptoglobin . the reason why it decreases is actually caused by the binding of free hemoglobin which increased in the serum bc of hemolytic anemia. not because they are attacked by the neutrophils . so actually free haptoglobin number changes there is no harm to its structure

[@margotalvey491]

Yes. Haptoglobin only binds free hemoglobin in the plasma (not inside the RBC or macrophage). With extravascular hemolysis, the macrophage degrades the hemoglobin, and no free hemoglobin is released into the blood. So haptoglobin levels remain constant in extravascular hemolysis. But they bind to free hemoglobin released by increased intravascular hemolysis, meaning they're used up, so then in intravascular the haptoglobin value is decreased.

[@MedicosisPerfectionalis]

MISTAKE: there is a mistake in this video...PLEASE read the description below the video! My appologies!

[@ramaanouz1607]

I think even in the caption there is a mistake . You said the complex is in the rbcs not the plasma So no one gets confused

[@elaineluther1799]

Medicosis perfectionalis, you asked us to explain the difference between macrophage, monocyte, and histiocyte. This was a very good question because these terms are confusing. But there is not a perfect answer, because these terms are confusing. Ideally, the macrophage is the umbrella term for any phagocytic agranulocyte. This can be divided into two major categories: 1) The histotiocyte is the macrophage of solid tissue. 2) The monocyte is the macrophage of blood. However, there is a lot of misuse/confusion/disagreement on how these terms are used. I had to look at dozens of definitions before I figured this out. Did I get it right? Thanks for making me investigate this. I had been lost in the confusion up to now. It's starting to become clear now.

[@MedicosisPerfectionalis]

You’re excellent 👏👏

[@lina9122]

Thanks, you're helping medical students from all over the world! best wishes from Spain.

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@user-qr4te5pv7e]

Monocyte in the blood. when in tissues, monocyte becomes Mo. Histiocyte is a macrophage found in connective tissue.,

[@MedicosisPerfectionalis]

You got it!

[@egidefiska]

this video is super helping me to solve the learning objectives that i need to be coping with right away tomorrow and easy to understand. big shout out to the owner of this channel tho. BIG LOVE😍

[@MedicosisPerfectionalis]

Thanks a million! I wish you the best of luck! Please consider sharing these videos with others, if you can! Thanks again!

[@RR-we7iz]

I can't describe how much your vedio benefits me thank you so much

[@MedicosisPerfectionalis]

And I can't describe how much I am thankful to you...Best wishes!

[@godslove7301]

''the liver can't handle this insanity'' lol I don't know why I find this funny :-)

[@MedicosisPerfectionalis]

😂😂

[@adham0makki]

according the Pathoma and Medscape : decreased serum haptoglobin is more likely in intravascular hemolysis.

[@MedicosisPerfectionalis]

Watch this video to understand the whole picture: Intravascular Vs Extravascular Hemolytic Anemia kzbin.info/www/bejne/iHqkkKlqhbGco8U

[@swathis198]

Thank u so much sir...i clearly understood d concepts..it was really awesome🤗

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@asmamohammedkhairy1121]

Put the speed on 1.25x it will be way better🙄

[@chamikaishara3778]

For me 1.75× is better ✌️

[@MedicosisPerfectionalis]

🩸 Hematology Playlist: kzbin.info/aero/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU&si=tomFsUjAgOKhOJVq

[@zahraamohammed4206]

amazing!!! 🔥🔥🔥🔥🔥

[@MedicosisPerfectionalis]

Thank you 😊

[@lhthree5629]

Thank you. I love every video you post. Keep it up!!!

[@MedicosisPerfectionalis]

Thanks a million for your kind words! My pleasure!

[@patient3841]

I think u should review the pathophysiology of decrease haptoglobin

[@MedicosisPerfectionalis]

True. I've corrected my mistake and made a whole video titled “Haptoglobin”. Thank you 🙏

[@himanshujha9567]

You said sickle cell rbc undergoes extravascular hemolysis but in robbins its clearly mentioned that it undergoes intravascular hemolysis

[@MedicosisPerfectionalis]

It's both!

[@MsMadamadamada]

I love how you integrate biochemistry in pathophysiology! Can you please tell me, if you were to start from the very beginning, is reading Goljan the best initial step? haha or biochemistry? I just started studying for step 1 and I'm so lost from where to start. WAY past pre-clinical years in md school, forgot it all

[@MedicosisPerfectionalis]

Start with pathoma, then do biochemistry followed by Goljan!

[@rallydriver5160]

I think hemolysis causes normoblastic macrocytic anemia. As there is increased demand the immature red cells having bigger mcv will be released into the circulation resulting in macrocytic anemia. As there is no B12,folate deficiency there will be no dna maturation lag and normoblastic anemia (not megaloblastic). Am i right ?

[@conniezikou7612]

Very helpful and to the point video!Thank you!!May I ask....G6PD deficiency causes both intravascular and extravascular hemolysis?Have I understand right ??

[@abhishekr987]

Does haptoglobin decrease in both types of hemolysis?

[@jafarsaif182]

Thanks so much

[@user-eq8lu6ob5d]

Very nice video, thanks alot

[@MedicosisPerfectionalis]

My pleasure!

[@mduduzinkabinde6222]

Very helpful. Thanks. Final year B.Pharmacy (South Africa)

[@MedicosisPerfectionalis]

Thank you so much 😊 Good luck!

[@AsimAli-vk6oz]

Is that heptoglobin decrease in intravascular hemolysis too?

[@MedicosisPerfectionalis]

Yes

[@Lailaa.h]

Sickle cell disease, sperocytosis g6pd are intravascular but you said extravascular

[@aboud99911]

were you recording this video in the bathroom?

[@elizabethstofko93]

Thx...wonderful

[@meryamlazrak1329]

Thank you Dr

[@MedicosisPerfectionalis]

My pleasure 😇

[@fredababe]

You mentioned G6PD AS Extravascular and you mentioned it as INTRAVASCULAR as well????

[@MedicosisPerfectionalis]

Sorry 😐 It's intravascular.

[@mjd8139]

g6pd deficency is intravascular hemolysis not extravascular

[@ibrahimtorifi8530]

Agree

[@ashishtoppo4172]

What all are intravascular?

[@elfassimariam250]

These celles are the same cells the difference is in their localisation ,when they are in blood circulation we call them monocytes , in pulmonary tissue we call them macrophages ans in other tissues we call them histiocytes ... i know something is missing in my explenation 😅😅😅

[@MedicosisPerfectionalis]

That’s very good actually 👍👍

[@elfassimariam250]

I can add : in the liver they r named kupfër cells 😊

[@MedicosisPerfectionalis]

Absolutely 👏

[@shirinsh2002]

What treatment this is extravascular hemolysis??pleas tell me??

[@MedicosisPerfectionalis]

It depends on the cause

[@shirinsh2002]

@@MedicosisPerfectionalis Cause of death if not treatment

[@MedicosisPerfectionalis]

I am not sure I understand

[@ErnieLooCZ]

G6PD causes intravascular hemolysis instead of extravascular hemolysis

[@abdelatifsaou6981]

false information the heptoglobin is a plasma protein not rbc

[@MedicosisPerfectionalis]

Thank you so much for correcting me..You’re absolutely right...I will write a correction in the description of the video...thanks again!

[@apexpredator99]

You are awesome! You know that.?

[@MedicosisPerfectionalis]

Oh, Yeah...Haha...Thanks a ton!

[@omarsahel986]

Hemolysis effect in laboratory result at least two example

[@MedicosisPerfectionalis]

What do you mean?

[@omarsahel986]

@@MedicosisPerfectionalis how does the effect of hemolysis in a laboratory result (two example)

[@romeolhk1008]

Have you even played a video game called Portal? Am I the only one who think you sound like GLados in the game lol??

[@romeolhk1008]

Btw very nice video as usual, thank you!

[@MedicosisPerfectionalis]

Thanks a lot

[@MedicosisPerfectionalis]

I have checked that game...and LOL! That’s true!

[@gail7347]

😍

[@user-gz1xf5ny1x]

you are so كيوت

[@sarahbrandao6028]

Cheer up, man! It looks like you're anemic.

[@MedicosisPerfectionalis]

:)