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The past 35 years of Dr. Apkarian’s life have been devoted to unravelling brain mechanisms that underlie acute and chronic pain, and more generally how the brain dynamically processes information that gives rise to perception. Over the last 20 years, he has used brain imaging technology to delineate brain biomarkers of chronic pain, with an emphasis on brain mechanisms of chronic back pain (CBP).
These efforts have been quite successful and his work has resulted in many significant advances in the field of pain research: the first identification of grey matter atrophy related to chronic pain, the first account of brain activity unique to spontaneous fluctuations of chronic pain, the first characterization of resting state brain network abnormalities in chronic pain populations, the first determination of mesocorticolimbic biomarkers predicting future pain chronification, the first parallel human-rodent neuroimaging of the transition to chronic pain, the first demonstration that hippocampal synaptic plasticity and neurogenesis are critical for neuropathic pain, the first identification of brain biomarkers for placebo response propensity, and more.
These observations have been replicated across multiple international laboratories. With over 30,000 citations, his h index is 81 (Google Scholar) and his work has been continuously funded by NIH for three decades from six different institutes within the NIH. This work would not have been possible without the enthusiasm, creativity, and persistence of a large number of graduate students and post-doctoral fellows whom he has trained, as well as the talent and inspiration of his colleagues.
Learn more at aivohealth.com and aivohealth.com/campaign/research-study.
To learn more about complex regional pain syndrome (CRPS) and reflex sympathetic dystrophy (RSD), visit Reflex Sympathetic Dystrophy Syndrome Association (RSDSA)’s website at rsds.org.
#RSDSA #CRPS #RSD