Folic acid (Vitamin B9)- One carbon metabolism, Megaloblastic anemia and Case discussion

Folic acid (Vitamin B9)
One carbon metabolism,
Folate trap
chemistry
RDA
Dietary sources
Biochemical functions
Deficiency symptoms
1. Megaloblastic anemia,
2. Homocysteinemia,
3. NTD
Deficiency causes
Laboratory investigations
Antagonists

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Thank you sir. Now i understand the folic acid and one carbon metabolism.

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Case discussion is very Helpfulll......

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Sir how increased homocystiene level leads to CVS manifestation....pls explain 🙏

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Could you explain panthothenic acid too

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What will be diagnosis

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[@purabiadharmik1213]

Sir but rbcs do not contain nucleus then how nucleus size will decrease in megaloblastic anemia 😅

[@phantomgamer992]

Bro they are talking about the devlopment stage,cell division occurs in erythropoisis

[@farheenathhaermohd6394]

Deficiency manifestation of vit B9 is macrocytic amemia sir..ur vdeos r awesome sir

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[@shahbaz9231]

Respected Sir, folic acid deficiency impairs Nucleic Acids maturation. The nucleus of RBCs does not condense it appears Large :- Megaloblastic. It has no affect on cytoplasm. on the contrary Iron is used for cytoplasm maturation. You said deficiency of folate causes Increase in size of cytoplasm & decrease in size of Nucleic acid that's confusing. please correct me if I'm wrong.

[@ankushrathee6607]

U r wrong As when a cell divides two thing occurs concomitantly that is cytokinesis and karyokinesis but due to folic acid deficiency karyokinesis do not occur but cytokinesis occurs. This leads to formation of a big cell having cytoplasm doubled but have single nucleus

[@Basementdwelling139]

@@ankushrathee6607 what ? Megaloblastic anemia is when there is persistence of nucleus, rbcs are enucleate, they are not supposed to have a nucleus.

[@saphjpg]

Can you explain why some side defects occur when you take folic acid tablets? Why do some people get nausea and flatulence?

[@Sachin-tu7tq]

Well explained sir

[@rizwanrizwanulislam8130]

But there is no nucleus in rbc ....so how can it decrease in size in megaloblastic anemia

[@Rajesh_Jambhulkar]

It is in the precursor cells

[@vinayshukla5038]

Sir during pregnancy rda of b9 is 400 micrograms and why Dr prescribe 5 mg tablet to pregnant lady

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Because mcg and mg is different 5 mg describes 5000mcg.

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Counseling with fetal medicine/ Gynaecologist will be helpful.

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RBC is Anucleated ?

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Bro they are talking about the devlopment stage,cell division occurs in erythropoisis

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[@medicalbiochemistrybyprof.1644]

Why methionine is essential amino acid if it is produced from homocysteine in the body?

[@hrudyalakshmibose5684]

homocysteine is actually formed from methionine. then it undergoes reconversion back into methionine

[@medicalbiochemistrybyprof.1644]

@@hrudyalakshmibose5684 Thank you Yes you are right So, it is actually regenerated

[@uttamjain9421]

Can anyone tell me.. Which anaemia is caused due to Vit B9 deficiency and Vit B12 deficiency?? And Pernicious anaemia is due to which vitamin or Megaloblastic aneamia is due to which vitamin?

[@Rajesh_Jambhulkar]

pernicious anemia is due to vitamin B12 deficiency due to a lack of intrinsic factor. These two vitamins (FA and B12) are interlinked. Deficiency of B12 causes folate trap and megaloblastic anemia.

[@uttamjain9421]

You mean to say that pernicious and megaloblastic is due to deficiency of vit B12?

[@uttamjain9421]

@@Rajesh_Jambhulkar and which anaemia is due to deficiency of vit B9

[@akshaygupta8058]

@@uttamjain9421 Vita B9 deficiency cause Megaloblastic anemia, Every type of B12 deficiency cause Megaloblastic anemia but whenever it is autoimmune(antibody againest parietal cells),than it cause Pernicious anemia.So All Pernicious anemias are megaloblastic anemia but all megaloblastic anemias are not pernicious anemia

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