Vittorio Sebastiano | Epigenetic Reprogramming of Aging

[@p101pana9]

Come on lets do it. This guy seems to be a the next most positive thinking guy after Aubrey. ❤️❤️

[@anthonydavinci7985]

Prioritize your time...Here is a worthy Goal for Humanity , to eliminate diseases of ageing..THANK YOU

[@royzlatanestevez9843]

Unfortunately impossible... until 4000AD or so. AGING is too strong. But I am glad people are trying.

[@kirillkulygin8799]

@@royzlatanestevez9843 are u a scientist to claim stuff like this?

[@royzlatanestevez9843]

@@kirillkulygin8799 No sir... I am a SCHOLAR of HISTORY sir.

[@kirillkulygin8799]

@@royzlatanestevez9843 history doesn’t have to do a lot with that sir. It’s like the same as saying 30 years ago that internet is impossible because no one has done it in the history of humankind. You have to realize sir, humans are basically meant to break biological boundaries

[@royzlatanestevez9843]

@@kirillkulygin8799 I respectsfully disagree sir. For example... many people will say we have tried Communism many times and the outcome always the same. But humans don't learn from history and try Communism again. So many people will say why do it again - are you (humans) stupid? This is what I am doing. Looking at history. Thousands of years. For me... I say... Okay... no problem... we only tried for about 100 years. Maybe we can try communism again and figure it out. We don't have a long history of failed communism. And we have a VERY LONG history of failed attempts to cure aging. Now this is just a statistic... but it's a perfectly legitimate hypothesis. I am taking the historical series and forming my statistics and expectation from that (goose fat in ancient egypt... mercury in china... some mysterious herb from the ocean floor in ancient Babylon... the philosopher's stone in medieval times europe... you get the idea). You have a different SERIES you extrapolate from (humanity always progressed the boundaries) - perfectly legitimate too. We both have the legitimate statistics. Only the future will tell who is right. I hope you are but i don't expect so. Thank you.

[@ramakrishna5480]

Extremely positive news , also he looks and talks like an research scientist

[@milkdud3427]

yes, vittorio!! Let's do this!

[@hevnervals]

I hope these treatments will be available to the general public at one point. Governments should prepare systems to deal with it.

[@IzabellaRequiem]

you can buy fisetin

[@svegritet]

❤❤❤

[@Rafas216]

vão estar disponíveis a todos. Você somente vai votar em quem se comprometer com isso. Atualmente infelizmente poucas pessoas se interessam pelo assunto. Em 5 ou 10 anos todas as pessoas vão saber do potencial dessas pesquisas e os Governos vão ter que se adaptar.

[@joeschmoe5583]

This video was surprisingly good! Thank you!

[@chanpol321]

Like the graph of human growth.

[@jp12x]

Thank you!

[@haroldkatcher1369]

We have reversed aging in rats and human skin - in rats, by 54%. Changing cells in culture is easy, in whole organisms, well that's another question; one we have answered. We're much closer to clinical application than you might think. Teratomas result from that same application of the Yamanaka factors in living animals. The truth is that aging is a progression of life stages, each with its own cell-type-specific and organ-specific transcriptional, translational, and splicing changes. At least we agree that aging is programmed at the systemic level, but has its effect at the cellular level.

[@dantes4729]

and now where are we at

[@Retrochronus]

Fantastic

[@andrewwalker8985]

These presentations are always amazing, but given how promising it all looks I keep wondering why we see such little data? If they know the factors and they can manufacture the mRNA, why aren't we overflowing with data about this being applied thousands of times across every kind of human cell for differing periods? Is it just that expensive to do and analyse or is it because those results are being seen but are confidential/proprietary?

[@squamish4244]

Yes in the first case. Good science is very expensive, and Vittorio works for Stanford, so he has limited funds. That's why the billion-dollar biotech companies are offering $1 million salaries to people like him to lure them away from universities, to do basically unlimited research. Also, this research _was_ slow, and protein folding technologies just started drastically accelerating this kind of research in the past year or so. For instance, AlphaFold 2 only became open software exactly two years ago. Since then, the 60x faster ESM Metagenomic Atlas debuted in November 2022, and the even faster RGN2 debuted at the same time. All of this and other programs have vastly accelerated the speed of protein folding prediction, which AlphaFold had already vastly accelerated from years to days. This is all according to my rudimentary understanding. As for proprietary, since he works for a university, it should not be proprietary. So I don't know the answer to that.

[@andrewwalker8985]

@@squamish4244 he works for Stanford but the ERA tech is licensed to Turn Bio. That’s interesting feedback on the productisation of AlphaFold. It always sounded amazing but it wasn’t concrete for me how it may be affecting the research. Amazing if it’s having that kind of acceleration effect!

[@archive807]

Have not had a chance to watch the whole hour long presentation. Did he talk about the dermatology pipeline (including hair growth) at all?

[@surfreadjumpsleep]

no he only talked about the potential for immortality. too bad because we might end up immortal with a bald head. /s

[@janmiedza6607]

@@surfreadjumpsleep yes, but as an immortals we can wait 1000 years for a head full of hair:P

[@surfreadjumpsleep]

@@janmiedza6607 I would rather die if I didn't have a full head of hair. Lately also the hair on my back has been falling out. I'm very concerned!

[@janmiedza6607]

@@surfreadjumpsleep of course you have the right to your own opinion, but I believe that you overestimate the role of hair, the most valuable is simply life

[@richardnunziata3221]

How can someone set up their own rejuvenation program (Yamanaka factors). There are people who would take the risk ... think of them as astronauts (1960s), test pilots ....let take one small step for an individual a giant leap for humankind

[@emittfuller6348]

anyone in an old folks hospice bed would take the leap but there are a few kinks to work out before it will do anything but fill you with tumors

[@richardnunziata3221]

@@emittfuller6348 works for mice

[@emittfuller6348]

@@richardnunziata3221 yes it does and it also for human cells in vitro the real struggle is uncoupling cell differentiation from the reprogramming and figuring out the way to send it throught the body in vivo when different cell types need different amount of reprogramming time if you could just shoot the body full with the yamanaka factors it would cause some cells to reguvinate but others will become ipsc and teratomas more is needed

[@richardnunziata3221]

@@emittfuller6348 doesn't mean we that we can not try....treatments can be isolated to organs ... you just have to make the effort. The issue is risk money and regulations that punish failure. When the first gene treatment was tried and a patient died they shut down the whole field for years....that kind of fear and conservative mind set is what is holding investment and progress. We can do it with vaccines we can do it with this. We can send people to space , many have died we dont talk about them but they lead the way.

[@th3r3canb3only1]

You might want to look into Liz Parrish and her efforts. She didn't use the Yamanaka factors, but she did some self-experimentation with gene therapies.

[@jeagr209]

Where are the slides mentioned at the beginning and in your text description? I can’t find them on Vittorio’s linked page.

[@woloabel]

(On Thursday April 20, 2023). On the Matter of Gerontology....Heil!

[@jakobw135]

Since most of your audience is layman, why don't you explain exactly what you mean by methylation instead of having for us to rely on previous knowledge previous lectures etc.?