Dr. Peter Attia on Mastering Longevity - Insights on Cancer Prevention, Heart Disease, and Aging

[@FoundMyFitness]

Download my free Cognitive Enhancement Blueprint - packed with my specific protocols for boosting BDNF with heat stress, omega-3s, and exercise: bdnfprotocols.com/ Dr. Attia's book "Outlive: The Art and Science of Longevity": www.amazon.com/Outlive-Longevity-Peter-Attia-MD/dp/0593236599 CHAPTERS: (00:00:00) In this episode (00:04:29) Defining cardiovascular disease (00:06:36) Coronary plaque and fatality risk (00:08:02) What is cholesterol? (00:10:27) How ApoB predicts heart disease (00:18:27) Factors elevating ApoB (00:22:17) ApoB reference range explained (00:24:16) Does high ApoB cause cardiovascular disease (00:33:54) ApoB thresholds for ASCVD prevention (00:37:20) Dietary factors raising ApoB (00:36:26) Genetics of ApoB and LDL (00:50:17) Does low LDL increase cancer? (00:53:12) Cholesterol-lowering drugs (00:56:52) Statins, uses, and side effects (01:00:05) Are statins toxic to mitochondria? (01:06:49) Ubiquinol for statin-induced muscle soreness (01:08:02) How to train in zone 2 (01:14:02) Statins and neurodegenerative disease risk (01:18:47) Cholesterol synthesis in the brain (desmosterol role) (01:22:51) Statin alternatives - pros and cons (01:24:23) Ezetimibe (01:27:54) Bempedoic acid (01:33:42) Berberine for CVD Risk Reduction? (01:36:29) Muscle as a glucose sink (01:42:51) Chronic glucose toxicity and vascular impact (01:48:31) Hemoglobin A1C Levels and Mortality Data (01:52:28) 80/20 Zone 2/VO2 Max Training Protocol (01:59:05) Insights from VO2 max testing data (02:09:10) How obesity increases cancer risk (02:11:56) Cancer screening benefits and risks (02:17:40) Dr. Attia's recommended cancer screening age (02:25:47) Liquid biopsies for detecting cancer (02:31:41) CT scans, mammograms and radiation concerns (02:37:25) Menopause - hormonal shifts and health effects (02:42:06) Hormone replacement therapy (HRT) (02:55:50) Perimenopause diagnosis with hormone levels (02:58:57) HRT's impact on dementia, cancer, and heart disease risk (03:01:42) Estrogen's role in bone density (03:04:35) Vitamin D (03:13:17) Testosterone replacement for women's sexual function (03:15:40) HRT safety 10 years post-menopause (03:19:58) Treating low testosterone in men (03:26:46) TRT side effects and risks (03:29:26) Ways to reduce blood pressure (03:36:26) How to measure blood pressure (03:42:23) Peter's longevity optimization routines

[@coachsimard8641]

Thanks for this Doc! The Norwegian 4x4s - OMG those are brutal, but gooooooood! Cheers!

[@angielazaro]

I’m fry f

[@jaykish4746]

Question... I'd a person works outside in the heat do they get heat shock protein benefits?

[@Melody-ym4do]

@Dr Patrick - you are so brilliant, amazing, smart, and beautiful. Thank you for sharing your knowledge, suggestions, and insights with all of us. Appreciate you and Dr. Attia, Dr. Huberman, Dr. Walker, and the other ones whose names I can't remember off the top of my head. You're all amazing ❤

[@ptortland]

I’ve been a practicing physician for almost 30 years (Sports Medicine, nonsurgical orthopedics, and Regenerative medicine) Other than the discussion on bio-identical hormones, with which I am well trained and well-versed, this has been one of the most instructional and informative videos that I’ve seen in my entire career.

[@fletcher9328]

Rhonda Patrick x Peter Attia = LEGENDARY! So excited for this!

[@LauraTryUK]

I’m with you!!!

[@chaunceywilliams8405]

These two along with Doctors Panda and Lustig changed my life 10 years ago at 63. Changed what I eat, how I exercise, when I sleep etc. Thank you Rhonda for a life worth living.

[@octavianandron9635]

Lustig loool

[@vinodsharda2553]

Same here , though Attia is new for me and I am 71

[@recuerdos2457]

What have you changed if you don’t mind to share, thanks

[@houndofzoltan]

I only listen to 4 podcasts, so it's fantastic when there are two of them together and then: it's four hours!! I love the long format. Huge thanks to both Doctors for sharing their passion and knowledge.

[@zoranvujovic998]

Out of the curiosity, what are the other 2? Because l follow these 2 as well.

[@houndofzoltan]

@@zoranvujovic998 Sam Harris and Sean Carroll. Not the same area, though Dr Attia and Sam Harris have been on each others' podcasts.

[@benpierce2202]

We're lucky to have a Dr. Attia who is able and willing to spend 4 hours educating us on how we can increase our lifespan and healthspan. What a brilliant guy.

[@syafiqramli658]

Truly admirable, unlike other famous doctors or physician recommending certain diet or supplements. Dr Attia really explain almost all his finding of scientific paper to backup any recommendations... As a Healthcare provider myself, i really admire his ability to cite papers left and right like it was nothing. Amazing stuff.

[@ItspronouncedAaron]

I need to master longevity to make it through this episode.

[@nathanc777]

lol

[@anna.m8]

😭😭

[@hans471]

Rip 😢

[@SusanaXpeace2u]

I know, it'd be a bit sedentary to watch it all! Have you got through it yet? I'm going to watch it at work today, and tomorrow.

[@astromob1]

At work? How do you have time?

[@GiovanniT]

Is this the start of the longevity Avengers!? I had to do a triple take on my feed when I saw these two faces side by side. ❤

[@AnalyticalSentient]

Roundtable with Rhonda Patrick, Peter Attia, Thomas Seyfried, Caldwell Esselstyn, Andrew Huberman, and Thomas Delauer would be good

[@NicholasOdinson]

I’d add Matt Kaeberlean to the table!

[@FoeverDirt]

​@@AnalyticalSentientmaybe with a side of David Sinclair?

[@AnalyticalSentient]

@FoeverDirt I mean sure I suppose but I think Huberman, Delauer and Patrick (also perhaps Attia) would probably already have most bases covered from what he might have to add other than something that isn't a low- or no-cost supplement, practice or protocol but yes of course longevity is his specialization no question

[@chinchila0hotmama]

Real life super hero’s for sure 👏

[@YourUpstairsNeighbor]

Dr. Patrick, you were my gateway into a healthier and more deliberate lifestyle. Thank you! I also bought Dr. Attia's book for my mother and she loves it!

[@vantarpon6849]

These two are the Gold Standard! Thanks Rhonda and Peter.

[@kend1964]

Thanks! Very helpful, thorough discussion.

[@drironmom6815]

I am 68. I’ve been on estrogen and testosterone natural pellets and oral progesterone since my mid forties and I have no intention of stopping, ever. I’m still working and I feel as good as I did in my 30’s.

[@rls4072]

Do these have to be prescribed? Thank You for Sharing!🎉

[@DanDascalescu-dandv]

Are you male or female?

[@kellyfj]

Damn I love the "in video" references with the highlights - just amazing!

[@natalievanhouten8809]

I'm that "one" person, 5' 7" 145 lbs (recently gained 20 lbs), sauna and cold plunge 4 x/week. Saw GYN 9/28/23, "normal" pelvic exam, normal PAP, I did c/o overactive bladder and 20 lb weight gain. 12/6/23 diagnosed with stage 4 cancer. Would love to see better screening for ovarian cancer. Also, would be nice if physicians actually listened to your symptom complaints. Just received first chemo tx and down 20 lbs, hoping it's all cancer weight I lost.

[@sazennonumber]

❤ Wishing you great health.

[@RoyalPurpleStar]

I’m sorry, hope you’ll make a full recovery. Is it stage 4 ovarian cancer?

[@natalievanhouten8809]

@@RoyalPurpleStar thank you! It is ovarian cancer. I understand a healthy lifestyle doesn't make you immune to disease, I'm just really frustrated my gyn blew off my complaints.

[@natalievanhouten8809]

@@sazennonumber thank you!

[@elizabeth4689]

That’s ridiculous that they missed that. Wishing you a speedy recovery.

[@Activ80]

I've watched most of Dr. Attia's videos from way back & read his writings over a long time & not to be too critical but most of the information overload is difficult to follow for the average non medically educated person. I am 81 years of age, physically very fit & still reasonably mentally alert. If I was to worry about all the information Peter expounds I would probably lose my focus on just simply keeping active & eating well which enables me to remain "healthy". I listen to the advice from people like Peter because I am now vitally concened with longevity but in reality the "science" seems to be never ending in comlpexity & still there is no clear cut simple direction.

[@godbork]

he drops so much biotechnical information to give you the impression he knows what he is talking about. Still, most of what he says about cardiovascular health and the cholesterol-saturated fat myth is sheer nonsense. He spreads the Ancel Keys disinformation and ignores the findings and insights of Joseph Kraft. Watch the interview with Joseph Kraft, the father of the insulin assay (kzbin.info/www/bejne/rWHRh2CVmcmLpcU), and you will be surprised about the level of nonsense he waffles about...

[@laza6141]

Just stay very active , don't smoke , don't drink too much , get enough sleep and try to avoid processed foods.

[@orenelbaum1487]

This is a 4 hour podcast, I think it's aimed more at the people who want a deep dive.

[@robynhope219]

That's true...use common sense!

[@CreativityNow]

Active 80: My method is including multiple teas as a hot or cold soup daily and a avoiding pills. I did the pills for a decade and did NOT like the results. I don't do well with pills. I am fine with a half dozen teas. So far, I have the second longest life so far among my ancestors.

[@cridsy]

My two favourite podcasters together, what a treat and as always so informative and educative. I love how you both freely share your learning and knowledge and will happily say when you don't know the answer to something, or outline that you've changed your previous thoughts/position on topics. You are both shining examples. Thank you for continuing to share how we can live longer and healthier lives. Rhonda you should seriously consider writing a book! Peter Attia's book sits on my study desk as a constant reference and the audio version I find very consumable. Thank you Rhonda and Peter.

[@chrisyoung9550]

Wow. I can so relate to this. My daughter was born 6 years ago and I'm in my mid 40s. My dad had 5 strokes and a heart attack starting at age 50. As a result I got into exercise at a very young age and even went on to get my degree in exercise physiology. I too am so fascinated by the topic of longevity and I love Dr. Attia. He really inspires me to keep digging though all of this and learning more and training smarter and eating better.

[@zork325]

did you dad have high lpa?

[@joeyfunk4327]

I remember she interviewed him years ago while he was working I’m pretty sure given he was wearing scrubs. Epic to see how far this has came

[@me-zn5dz]

Thanks Dr Rhonda, I have watched this numerous times and really appreciate the chapter headings. 🎉😊

[@sheryl3268]

I was wondering when she would have him on her show too, again. He had her on his episode 252, I think. Great to see both of these people discuss health together anytime, anywhere!

[@chrisbusby4395]

A friend was being tested for MS amongst other things because she couldn’t grip properly etc ,it turned out her vit d levels were extremely low. She was given short term very high doses and after a few weeks everything returned to normal,she was due an MRI scan shortly before one clever doctor suggested to test for vit d.

[@f.h.4038]

It is normal that MS patients have bursts of symptoms and than pauses in between. She should take real medicine if it is real MS. Vit D is down regulated during disease. Therefore it seems to play a role in many diseases but is only downregulated by default during disease. Measure it when you are not in an active disease state.

[@RandyMiller-oo5tq]

I really like the pace of Dr. Attias talking. He talks slow enough a layman like myself can process and mostly understand what he's saying even on complex topics.

[@MrMandrew7]

Thank you so much for your investment into the sports science and associated factors. You have become my favourite go to source of information as well as inspiration to motivate alternative fitness pathways. Once again, thank you

[@stevenwilson2292]

I wish this was a regular thing. Like regular short 30 minute quick dives into topics.

[@auricauric8150]

Love the long form interview and annotations. Great job all around and thankyou for sharing your knowledge.

[@agingdoc]

I've never seen vid annotations as robust as Rhondas. How suitable she joined with Peter who himself has remarkable strength in his shownotes (great for both).

[@ryancolson1212]

I'm so glad I discovered these legends. So much great content in these four hours. I'll be sure to listen in to the podcasts, very excited

[@cherieservello4891]

Such incredible information What an IMPACTFUL PODCAST!! Thank you!!❤

[@FoundMyFitness]

Glad you enjoyed it!

[@gregmaurer1]

Incredible episode - he is flat out amazing - and the information is so helpful - busted many mistaken beliefs I have had - facts beat chest pounding every time.

[@bardsamok9221]

Indeed, these two are beacons of sanity in the precarious seas of KZbin information.

[@JHyrick]

Thanks!

[@jshan853]

One of the most informative, excellent podcasts of them all- thank you, you two are phenomenal!!

[@Wes-Tyler]

I don't see any videos on your channel about this topic, so I was wondering if you could do a review of blood pressure and how to lower it with lifestyle intervention. The reason I ask is because I feel like I do everything right, yet my blood pressure readings are always very high. - Gym 3x a week - HIIT 2x a week - Sauna use 3x a week - Diet high in nitrate-rich vegetables - Diet low in sodium, alcohol, and fried foods And I've been doing this for about 10 years now, and my blood pressure is still extremely high.

[@ashdgee]

Always illuminating listening to these two. Key point for me on diet. Lower saturated fat to reduce apo-b. Tryglecerides are a proxy for insulin resistance.

[@benseal3072]

great guest

[@CorvusCorps]

Thank you guys for sharing your knowledge with us!

[@davidwhite4547]

Go for it Rhonda! Write that book!

[@goji8430]

Great discussion! I respect and admire Dr. Ronda Patrick’s and Dr. Peter Attia’s work. I told my doctor about you. Could you please elaborate more about mitochondrial biogenesis, metabolic flexibility and how to optimize mitochondrial health? Thank you.

[@rmjauregui]

Love that final part :” Yeah Peter! Tell her, tell her” You are so smart Ronda, give it a thought 💭💕

[@MusixPro4u]

Would've been nice if you'd pushed him on Berberine being a PCSK9 inhibitor and whether this would outweigh it being a Metformin analogue in regards to overall health.

[@ShowMeWhatINeedToKnow]

I was a bit disappointed as well, but considering that he talks so highly of statins, which are some of the worst drugs you could possibly take -- it's pretty apparent he's pushing big pharma's agenda.

[@stephanienewton6618]

@@ShowMeWhatINeedToKnowthis disappoints me, too. My mom just started a statin and now has lower back pain and other side effects. Her LDL is 100, not even really out of range. I’m so frustrated with her doctor. My brother and I talk her out of taking it and then her doctor gets upset and talks her into taking it again. Each time she gets side effects.

[@ShowMeWhatINeedToKnow]

@@stephanienewton6618 - Check out pantetheine -- I've been using it for sleep but apparently it is VERY GOOD at lowering cholesterol. Also red yeast rice is supposed to be very good too.

[@ShowMeWhatINeedToKnow]

@@stephanienewton6618 - Check out pantethine and red yeast rice. Seriously.

[@ShowMeWhatINeedToKnow]

@@stephanienewton6618 Look into red yeast rice and pantethine.

[@djrandlev2864]

Fascinating… this is what podcasts are all about. Thank you

[@agingdoc]

+1

[@rateller]

Great podcast with Dr. Attia and great questions from Dr. Patrick!!

[@LauraTryUK]

WHAT A DUO! 🙌🤩

[@johnbrown2030]

FINALLY !! ... This has been the first time I've heard Peter talk about Maffetone heart rate numbers and associate them with lactate based Z2 heart rate numbers .. this clarified a lot ! Great podcast !!!

[@bardsamok9221]

Check out his podcast, there's lots about it on there

[@itayshorek6872]

peter is just the best. thanks rhonda!

[@thomasstitch1708]

I recommend having Dr. Michael Greger on the podcast. His new book "How Not To Age" offers a different view point from Attia, but is well researched and science based. I think your viewers would appreciate his work on the subject of longevity. It would be interesting to hear Rhonda question him on the research he cites in the book.

[@stellarblur]

Actually Dr. Attia recommends low protein

[@stellarblur]

Sorry spell fixer

[@stellarblur]

I believe Dr attia discovered rampamycin

[@stellarblur]

More importantly mTor

[@PedroNord]

Actually, Attia recommends 2 grams of protein per kilogram of body weight per day. That’s a very high protein diet.

[@ferminromero2602]

Great to see Rhonda on this show! Excellent discussion with two powerhouses!

[@KidSaleen]

What a podcast, thanks to you both.

[@jeffdeneui3681]

Yes ! please write a book !!! (just please make it much more layman friendly with practical suggestions and big picture of what is most important)

[@brittanyg6796]

I've been listening to your podcast for years (maybe since 2015?) and I would absolutely be the first in line to buy your book!! I hope you consider writing one! ❤

[@agingdoc]

Me too. She makes science accessible to the general public. Too many science communicators talk down or go into dogma to separate themselves. Rhonda just gives her opinion. That and a science communicator that reads the literature herself (my niche) makes her in the remarkable few in this space.

[@ortizma13]

I don’t say this often enough about certain lecturers on podcasts, but the fact that he hasn’t referred to Notes I’m almost 3 hours into this just shows how smart he is, even though he does still believe in calories and calories out

[@marcsantamaria4097]

So insightful. Thank you both.

[@eatingcleaner]

And I am over 10 year post menopause and still on HRT. And could not feel better.

[@wellthi]

HRT is not safe (cancer, CVD, stroke) there are more natural approches. Dr Greger have plenty of vid about it on his channel nutritionfacts

[@menemismix]

Just found your channel. Love it already. I’ve watched your JRE appearances and I’m glad to see you’re doing your thing here

[@string8888]

My breast cancer was NOT found on the mammogram, but was found on the Ultrasound

[@wellthi]

type breast cancer in nutritionfacts YT channel or website

[@malsiecolouraddict2189]

Mine too, alerted by pain, which is not the norm for breast cancer, but luckily for me was the case. No obvious lump and well hidden. The ultrasound looked suspicious and needle aspirations were needed. Early stage, and 6 years on, all good!

[@CoachJB1981]

I listened, can’t say I understood any of this podcast on a science basis, but to summarize: lots of zone 2 mixed with HIIT, lower glucose by eating cleaner, no smoking, cancer screening regularly, live love….LIFE!

[@socrates1818]

What’s Zone 2? Way too complex and I read Kierkegaard for fun!

[@redhen689]

@@socrates1818I think it’s referring to perceived exertion. You should be working out a level that you feel a little difficulty speaking in complete sentences.

[@SamShank175]

I think Peter is right about so many things. The use of pharmaceuticals over nutrition is one area that I think he's wrong.

[@ananavarrete7218]

Yes agree and unapologetic about it

[@randeepwalia1507]

One of you has the data on their side. Besides, I think his position is more accurately characterized as pharmaceuticals AND nutrition

[@VanillaAttila]

He finally realized metformin was not good for him and stopped taking it. Also takes regenerative food more seriously

[@houndofzoltan]

Except ... he's doing constant bloodwork to see what's working and I'm assuming you're not. I suspect you're falling for the "natural is better" fallacy.

[@SamShank175]

@@houndofzoltan Bruce Lipton's book The Biology of Belief tells the history of the study of human biology. Every time we thought we had it figured out and then OOPS. Every time we thought a body part was vestigial, because we didn't understand what it did, only to discover it was actually doing something important. All the diet drugs that have been prescribed by Drs, only to be banned once the bodies started piling up. I think the GLP-1 drugs will be the same, the evidence is just now starting to come to light. Antibiotics? They save lives, right? Oh, except now we have super bugs and we know about the microbiome. Peter himself has changed his mind on various things over the years, any good scientist does.

[@evelynramos445]

Thank you Doctors

[@gabyfridman7475]

Excellent. Thank You !!!

[@michelle4688]

Strong open, Dr P!

[@missymason2377]

Listening from new Zealand 🇳🇿. Totally educational

[@claudiofossati338]

Thank you, no other words worth

[@greyhnd001]

Please mention the whole food plant diet

[@laza6141]

Attia doesn't really care about diets as long as you are getting enough protein and are in control of your calories ( not fat or too skinny ) because loss of muscle mass is increasing as we age , and is terrible for both health span and lifespan.

[@1002CK]

Love the deeper detail that is in this episode

[@SonnyDarvish]

1:44:50 I'm now curious what this means for building capillary system with exercise if elevated blood glucose is detrimental to small blood vessels. Does he mean chronically elevated, or at any point that would be damaging? Getting to the point (crudely), do we gain more benefit for increasing blood vessels by exercising on keto / low carb?

[@jakeliefer]

At 03:37:00, Peter mentions the SPRINT trial and the blood pressure testing protocol being 5 minute rest periods between blood pressure checks, resulting in 15 minutes. However, this is incorrect, the SPRINT trial protocol was 5 minutes rest, followed by 1 minute intervals between each blood pressure measurement, resulting in a total of 7 minutes of measurement, not 15.

[@alfonso1455]

Please, please get into the detail of sauna and HRT patches. Does excessive sweating like a 70 min sauna yoga session nullify the benefits of the patch thereafter?

[@suzannestruble]

I would also love to please hear more about HRT patches and sauna!! Also, Dr Patrick, do you have an opinion about whether sauna during a cold or flu is contraindicated?

[@PatrickMC]

42:20 love the little shot at Paul Saladino 😉

[@alfonso1455]

Thanks so much. I'm in early onset menopause doing well on HRT. Can I keep going on it till I die? Battling to find info on that....

[@jamesscott1711]

Awesome information! Keep up the good work Rhonda and Peter 👍👍👍

[@fsalam]

She did bring up berberine and he brought up the fact that it a metformin analog. However, there is no conclusion. Is it good or bad?

[@sheryl3268]

I wondered same thing

[@agingdoc]

She has spoken of it favorably before. What the conversation missed for lack of time is that we have good hard endpoint data (favorable) for diabetics but very limited data on berberine.

[@cindypina4944]

Berberine has helped lower my numbers. I don’t want to take statins. Everyone I know on statins have body aches.

[@nichtsistkostenlos6565]

I think the point is that they don't know for sure, but if you're concerned about things like mitochondrial inhibition and/or insulin resistance, then you should be just as worried about berberine as you would be about statins.

[@fsalam]

@@nichtsistkostenlos6565 I think you miss the point here. Berberine and metformin are used as treatments for type 2 diabetes and insulin resistance. It cannot cause insulin resistance. If berberine has CVD protective effect on top of analog effect like metformin, considering how popular metformin is, then berberine is a shoo in, unless there are other drawbacks with berberine and hence the interest in getting a more nuanced opinion from them

[@NickSchweitzer]

I found the comments regarding Metformin on Lactate to be really interesting. I've been taking Berberine to help with insulin sensitivity and gut health for the past year (I'm not diabetic, but have a family history). This along with other changes last year helped me to drop 40 lbs along with a lot of other benefits. I'm a very active cyclist, and so the lactate threshold comments were interesting to me. I don't feel like I've noticed issues for myself, but I also am not measuring it. Does anyone know if Berberine has similar issues with Lactate production as Metformin?

[@hcrone]

40 to 50 grams of protein 4 times per day, Pete? I can't eat 8 cans of sardines in a day. I just cannot. How does anyone do this?

[@karlpk3907]

Whey protein in a shake

[@margomoore4527]

Don’t eat any carbs. Eat protein until you aren’t hungry anymore. Does it have to be sardines?

[@coachsimard8641]

Dbl up on JOCKO MÖLK (2 scoops) blended w/a cup of unsweetened vanilla almond milk! 44grams of protein and a bunch of other good stuff! I keep Molk in the freezer, put the blender jar w/the almond milk in the freezer for 15 mins before blending and it's basically a vanilla milkshake!

[@alterego157]

There's no need for that much protein. Do some more research on the subject. He's just stuck in some old bs narratives.

[@jvm-tv]

- Morning shake 40g - Lunch meat + yoghurt 40g - Dinner chicken or fish 40g - A snack during day of nuts + yoghurt + beef jerky 40g

[@zermelo1]

1:58:06 VO2 max is best with 1-1 on and off. Eg, 3m on, 3m off

[@stevenkates4876]

So good to see the evolution of Peter Attia. He is fantastic but no one is aways perfect. Watch that first episode with Rhonda. Compare his personae. His was angry with his own humanity and perfection in those days. He’s a genius and a great academic.

[@ejboczar]

Great update as usual. I have been reading about colchicine and its new therapeutic use in CAD. Any comments?

[@d2row96]

You can't get most doctors to test for insulin resistance so how would you know if the statin is causing insulin resistance.

[@porkpie2884]

There is no test for insulin resistance

[@cindypina4944]

There is a test for how much insulin you have. Mine was 14 which is considered high. However my A1C and glucose were good levels.

[@porkpie2884]

That test for how mush insulin your pancreas is creating doesn't measure insulin resistance though @@cindypina4944

[@nichtsistkostenlos6565]

​@@porkpie2884 There are ways to estimate insulin resistance pretty accurately. HOMA-IR and LP-IR are probably the most practical. To the OP, you can calculate HOMA-IR yourself if you have your fasting glucose and fasting insulin from a basic blood test.

[@godbork]

@@porkpie2884 have a look at the Kraft test...

[@chris4814b]

Hi rhonda. Been trying to find an answer to something i saw you cover, years ago... on rogan i think. You mentioned that you don't like... i forget if it was either butcher's broom or horse chestnut? as a vascular supplement and recommended something else instead. What was the alternative? Do you have a video link for the topic?

[@a.Mulligan]

Dear Dr The was amazing: so clearThank you so much

[@welanduzfullo8496]

3:33:04 why not l-citrulline or PDE-5 inhibitors?

[@janereinhardt4715]

That was my mom- sudden death, age 70, back in 2003. My dad went to get his haircut, he came home, and found her dead. She mowed the front & back yard the day before she died, no known health problems and on no meds. She seemed to be exceptionally healthy & full of vigor.

[@beachnap]

I loved this episode, but I'm still left feeling confused honestly. So much advice out there on cholesterol is for the age 50+ crowd. I am a 33 year old woman, healthy height and very physically active (marathon runner as well as surfing, mtn biking, lift weights 3x/wk, etc). I had an ideal lipid profile for years, but after I experienced an unplanned pregnancy followed by a miscarriage I became very anemic. I got two iron infusions which brought my levels back up but the doctor said I need to increase consumption of heme iron, such as red meat and shellfish. Now my cholesterol has skyrocketed shockingly fast and I can't get it to come down. I feel so much better eating more meat but I am considering changing things up and cutting out red meat and most dairy - eating only fish, chicken, tofu, nonfat yogurt, etc. for protein and taking an iron supplement. Should I even be eating eggs? They are recommended for fertility but I worry they will keep my lipids high. I'm trying to conceive again and I'm just so confused as to what I should be eating! I need to support my fertility but I also don't want to go into a pregnancy with dangerously elevated cholesterol.

[@bobdec6665]

cholesterol myth. Read it

[@saltybaelv]

So many unanswered questions around women’s hormones 😭 I’m 29 and am experiencing jawline acne only around my cycle, otherwise my skin is wonderful. I have severe mood swings two days before I start my period (I swing from super angry and irritable one day to literally crying and suicidal the next day). My cycles are regular, meaning in time every month. I can’t sleep at all when I’m ovulating. I took 5mg melatonin, 400mg mag glyc and ashwagandha with rhidiola and doesn’t do shit during ovulation but I tried progesterone cream and that gave me the best night of sleep I’ve ever had AND I didn’t have any mood swings or breast tenderness this last period. What gives?! Aren’t I too young to be having to apply progesterone cream? I don’t want to give myself breast cancer but I can’t keep living like that every single month 😭 also my obgyn says my hormones are fine. This is such BS. Only think blood work says is that I have low vitamin D but I take 5,000IU Vit D + K2 consistently so none of this make sense lol I hate it

[@Valoric]

Getting enough molecular iodine (not iodide from food and salt) has been shown to be important regarding cyclic mastalgia. Progesterone probably helped because your hormones are dysregulated by insufficient iodine/selenium along with maybe a pathogenic environment/diet/mold exposure. Not gonna say it is 100% this because it's pretty common because of flame retardants like bromide blocking iodine from being used in the body. It's really worth looking into. 400mg of Magnesium Glycinate equals about 60mg of elemental magnesium (RDI is 400mg). It's not much if you actually need it. I take 1g of it morning then 1g night (total 290mg elemental Mg). I was deficient from taking Vitamin D for too long and initially got an ironic excitatory reaction from magnesium at night. I tried metatonin for years. Unless you're old or have some genetic disorder where you can't produce metatonin, it's useless and might actually keep you up at night through a couple different processes. Most melatonin supplements are too much and absorbed too fast. Hormones like that have a very delicate balance and supplements are like a sledgehammer. Only good for changing timezones. We need very little of it. Ashwagandha gave me a hyperthyroid experience (takes a month to fully breakdown ashwagandha). Thyroid is something to think about with that one. IMHO herbal supplements need to be avoided because they can just make it worse since they do way too many things we don't understand and are often contaminated with pesticides and heavy metals. Focus on molecular iodine, your adrenals and thyroid. Which would need to be worked on by mindfulness/acceptance, diet (eat enough fat) and relaxation (only easy exercise). Insomnia is hell and it took me years to realize that the desire for sleep is a catch-22. Unfortunately the more you want it, the less you get. Mindset is half of everything. idk if any of this helps or not. Hope you get some relief soon

[@zeusireog]

Maybe try eating and exercising according to your cycle. Women have 3 hormones to support during different phases of her cycle. Estrogen, Testosterone, Progestrone. (start count from first day of bleeding) Day 1 - 10 - Estrogen (able to withstand lots of HIIT cardio, Intermittent fasting, low carbs diet, keeping blood sugar levels low) Day 11 - 15 - Testosterone will peak during ovulation (suitable for heavy lifting, resistance training, prolonged water fasts) Day 16 - 18 - Hormones will take a big dip or "crash" transitioning into Progestrone (start to introduce good carbs, needs higher blood sugar levels to prepare to shed your lining) Day 19 - 28 - Progestrone (stop fasting, higher carb diet, taper off cardio and do lighter workouts like pilates, yoga, zone 2, long walks, light weights, keeping cortisol low) Hope that helps!

[@llkoolbean4935]

Please talk about estrogen positive breast cancer and the hesitation to use hrt in survivors of triple positive BC when they reach menopause. Please.....

[@sperizer]

Recommend seeing a functional doctor.

[@GKerski]

You might be interested in the work of Ray Peat PhD to find answers to all those questions.

[@sirwalksoftly]

3:35:32 Fascinating point for us men!

[@josephacolletti]

summary of "how ApoB predicts heart disease" section total cholesterol (worst); LDL cholesterol via Friedewald Formula (good): LDL-C = (TC) - (HDL-C) - (TG/5); LDL-C "direct" (better); LDL particles (best) via NMR, or ion motility ApoB (king)

[@Angelicnorth]

You make such a lovely couple both with great minds x

[@Itsme-e5j]

Great podcast!

[@lauraon]

Can. you do an episode on oxalates? I'm getting concerned about all I'm hearing about them, but I want to hear your opinion. Love your channel!

[@alec3972]

Totally agree - first symptom was a ‘widow maker’. Life pivot done - eek

[@Outliveathletics]

Thank you so much for this episode! You two are awesome 🎉 your work is GREATLY appreciated 😎💯

[@pardogg]

Dr Attia makes it sound like insulin resistance is a main driver of ApoB formation, and that saturated fat intake is less important - I was under the impression that saturated fat intake is more relevant from what research I've seen. Anyone else have research to show me on this?

[@TheFarmacySeedsNetwork]

Oh man a guide besides! Rhonda! You are so on point! Peter! You too! Love you guys. Thank you!

[@Hiljaruth]

Vitamin D serum levels of 80 ng/mL put my autoimmune diseease into remission. 10 years of suffering gone (I also took vit. D co-factors such as magnesium, zinc, B vitamins, boron). Psst, best-kept secret

[@mannyP7227]

What were the symptoms of your autoimmune disease? I'm just asking because I've been wondering if I developed an autoimmune disease

[@joyshuman2727]

google lyme disease and check out the symptoms.@@mannyP7227Advice to send your blood to Igenex Labs in California and get checked for it. Your body does not fight itself. It fights an unknown to you.

[@nellab5314]

@@mannyP7227take a blood test and find out what your ANA no’s are. ( anti nuclear antibodies are). Then take those results to a rheumatologist.

[@CreativityNow]

Last winter I had an echosonogram at GW University hospital, and all the staff expressed shock that st my age I have no plaque in my veins and no plaque in my arteries. They asked me why. I daid I had no idea, but I researched online what the foods are that clean the veins and the srteries. The only food on that list that I consume in any quantity is chamomile tea. I have been drinking chamomile tea daily for over a dozen years -- one teabag a day. I started drinking chamomile tea by sccident one October when I experimented by buying one box to see what the taste was to flavor water and whether the glavor covered the chlorine in urban tap water. It was okay for that purpose, and I got no colds that winter, so I continued drinking chamomile tea, which at that time eas $1/box of 20 teabags. After a year of 1 teabag/day, my shoe size dropped 1 1/2 sizes and without weight loss. After 3 years, chamomile had reduced the inflamation in my injured arm do well that hge psin stopped. I stopped taking a cholesterol pill over 8 years ago.

[@drironmom6815]

It is my understanding that the “progesterone coated IUD’s” actually contain synthetic progestin - with the same risks as oral synthetic progestins.

[@kylecablay]

Dr Attia and Dr Patrick, I have an Arteriovenous Malformation (AVM) and experienced a recent aneurysm rupture. At the moment, while I am extremely lucky to not have any significant symptoms after the internal bleed, I now am only able to walk or lightly run for exercise. Exertion and strenuous workouts are not available options. For those in similar limiting situations, do you have any recommendations to stay fit and healthy?

[@erwinrogers9470]

Great interview👍

[@paddy3622]

better than any college class.... by far.

[@stormwalker321]

than ylu both very much...

[@LanceMillerPhD]

Which L-methylfolate supplement (brand) and dose do you recommend?

[@nicolasbonnet3495]

What happens to all the high older ApoB carriers who don’t suffer CVD events or show arterial plaques via imaging vs youngsters with comparatively little exposure to ApoB but who die from atherosclerosis? Vascular inflammation caused by smoking or high glycemia is surely a better predictor than ApoB…