G1 Phase Checkpoint of Cell Cycle

The g1 phase, gap 1 phase, or growth 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division. In this part of interphase, the cell synthesizes mRNA and proteins in preparation for subsequent steps leading to mitosis. G1 phase ends when the cell moves into the S phase of interphase. It takes 30-40 percentage time of a cell cycle
The G1/S checkpoint is the point between G1 phase and the S phase in which the cell is cleared for progression into the S phase. Reasons the cell would not move into the S phase include insufficient cell growth, damaged DNA, or other preparations have not been completed.
At the G1/S checkpoint, formation of the G1/S cyclin with Cdk to form a complex commits the cell to a new division cycle.[2] These complexes then activate S-Cdk complexes that move forward with DNA replication in the S phase. Concurrently, anaphase-promoting complex (APC) activity decreases significantly, allowing S and M cyclins to become activated.
If a cell does not clear to pass through to the S phase, it enters the dormant G0 phase in which there is no cellular growth or division.

[@GameScenesHQ9748]

How easy it becomes with diagrams, thanks to u my man

[@monalisapal9238]

Does the ATM mediated pathway & p53 mediated pathway work at the same time or does it work for different kind of cell ?

[@mdsanaullah8206]

Could you please make a video on role of cdks in regulation of cell cycle, it is confusing me a lot.

[@Kaur_2343]

Thnku sir...u made this concpt vry easy...salute to ur hard wrk😊🙏👏👏

[@manjusamyuktha2013]

Thank you sir.... A understandable explanation thank you sir

[@gebrellmosquera8306]

What is the duration for each checkpoint?

[@parth-x-gaminng5913]

Thnx sir for this explanation 👍

[@knowfactsbyaditya]

Sir your explanation style is very best, thankyou sir for helping the students

[@hussainbiology]

thanks for appreciation..Glad it helps....✌️

[@michaeleisenberg7867]

Shabir, Packed 💼 📦 with info 📚. The animations 🎨 are great!! Plenty of proteasomes ✂️ running in the background. Please keep up the great work! 👏👏💖💖

[@hussainbiology]

Hey Doc... Thanks for appreciation.... Keep supporting ✌️✌️

[@michaeleisenberg7867]

@@hussainbiologyShabir, You're welcome! I am trying to come up (in my mind) with a simple explanation of quantum mechanics and thermodynamics. Is what I decided was quantum mechanics is used to explain the construction of atoms and thermodynamics is used to explain the movements and actions of molecules such as these big proteins.

[@nothingbutdope5316]

helpful asf

[@shwethakrishna3716]

Nice sir.. thanks a lot

[@hussainbiology]

Thanks for appreciation..Glad to know that it helps ✌️

[@kimberlywilliams1166]

amazing content. so helpful. THANK YOU

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@shwethakrishna3716]

Thanks sir ji

[@hussainbiology]

thanks Shwetha for appreciation

[@the_encephalonaire]

Sir please tell me that in which field you did your bachelor's and master's degree?

[@hussainbiology]

B.Sc with CBZ Masters in Zoology

[@the_encephalonaire]

Sir How can i get into an md phd program after my MSC in biochemistry?

[@nagarajsavitha3840]

Sir I wouldn't find ur G2 checkpoint video

[@nagarajsavitha3840]

Can anyone reply

[@barnalisinha4705]

Thank you for all ur hardwork....keep it up sir😊 ... nicely explained

[@hussainbiology]

thanks for appreciation 😊

[@porselvikumar6965]

Sir please upload the G- protein coupled receptor

[@hussainbiology]

kzbin.info/www/bejne/jmjUiKmbhbCoebM

[@hussainbiology]

This is GTPase Switch mechanism , The GPCR video will be made soon

[@porselvikumar6965]

@@hussainbiology ok sir