Gene Regulation and the Operon

[@AmoebaSisters]

UPDATE: 1. Isn't it fascinating that, as mentioned, ALL of your DNA is found in your body cells, but genes can be turned "on" or "off?" We just want to to note: there are a few body cells that do not have *any* DNA though. Mature red blood cells or cornified epidermal cells for example. Always some fascinating exceptions in biology. 2. If you're studying the lac operon, we want to remind you that our video looks at basic concepts with the goal of inspiring to explore more. For example, we don't talk about the conversion of lactose to allolactose, the cAMP-CAP conversion that stimulates the RNA polymerase, or the names of the different genes and their individual functions. We also don't mention that there are other factors that can affect the activation of this operon (such as glucose levels). Check out the further reading details to explore more! Also, did you know we have a gene regulation GIF? Find it and more of our science GIFs here www.amoebasisters.com/gifs

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Great that you pinned this message! As this is not sufficient for biochemistry at the university I was going to comment on what you mentioned here. But otherwise, great video! It's great as an introduction to the topic.

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84updown We love to hear this---we wish you great success! :D

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I just graduated college and am preparing for my MCAT and this explained operons better than anything I have studied in the past 4 years. You're a godsend.

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[@Tomathorsten]

you are litlerally the sweetest things on earth and honestly your way of explaining is far easier to understand than the way we learn about this in class. that being said, i am completly lost

[@amaranwar3051]

This is the best video I have ever seen. Period. Thankyou so much for introducing me to the basics of gene regulation, was just about to start the topic when I found your amazing video. Keep up the amazing work!

[@AmoebaSisters]

Thanks so much! :D

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Periodt *

[@iveshatmyself7568]

This was the most funny and easiest way to learn about lac operons. I tried to watch my professors video about it, but nothing was making sense and it was hard to focus. But this? This was absolutely chefs kiss. Thank you Amoeba Sisters, you now have a new fan and subscriber. I knew science could be fun and easy to learn.

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I've read this (lac operon) in my textbook at least 5 times and never understood it until just now in a short 6 minute video. Thank you so much for existing.

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I was having a hard time understanding the lac operon from either my cell bio or genetics classes. You simplified it so well that I can understand the material with confidence! Thank you Amoeba Sisters!!!

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I am 20 Years old And this is The First Video i've watched from this Channel And i have to say it was absolutely lovely! I genuinely laughed about the lactose regretting thing! And it's even very good to learn with! Keep the good work up!

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Thank you so much!! :)

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I was about to cry because my test is tomorrow and I didn't understand anything before. This was so useful!! Thank you so much :))

[@Sxitz]

is this the same thing as gene expression?

[@minniemay-]

its about the expression of a certain gene (enzymes that break down lactose) in a bacteria, its not really the same as a the genes expression in a human being ​@Sxitz

[@Sxitz]

@@minniemay- ight thanks, I’m also studying for a test tmr lol

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This video explained a very confusing concept in a simple way . I really appreciate the efforts that were put in to carefully build up the concept .

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I have been glaring at my lecture note to understand what operons are for almost an hour or so, but this piece explains it in six minutes. Thank you!

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+mscaroline4097 Thanks so much---we hope you rock that SAT II Biology test! :D

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Hello, Amoeba Sisters. I just want to thank you for this great educational content. I am a graduated theoretical physics student from Germany and I was told to perform a so called genetic toggle switch experiment in the lab. Since my biology wisdom was very poor I could perform the experiment and take conclusions about the physical quantities in the experiment BUT I was not able to understand *why* this phenomena was happening! (I had 2 populations of E.Coli which are red light or green light fluorescent). Thanks to your videos I started to find out about the "different players" acting in the bacteria!!! This was the first video I watched and now its also the last because after watching it for the first time I started to get so interested in all this topics that I ended watching them all. Thank you very much! In Germany we have a saying which fits wonderfully to my situation that says "You saved my butt."... because next week I have an oral exam with a biology professor at my university and he might ask me about this... also now I am so curious about all this stuff that I cant understand why nobody told me about all this before!!! Who hided all this information from me!?!?! hahahaha THANKS

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[@bilaltanvir832]

this is probably the best explanation of gene regulation ive come across so far! Ive got exams tomorrow and found this really really awesome!

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Helped me on my A'LEVELS exams! Thank you so much! Do you have a video on trp operon?

[@AmoebaSisters]

Not yet but hoping to someday! :)

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You're awesome. I'm in a molecular genetics class now (as an engineering student, so very little biology background) and this honestly cleared up quite a few things for me!

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[@AmoebaSisters]

We hope you rocked your exam!! Thanks so much for the great feedback!

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Indeed I kind of rock it! Thank you so much again :3

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Best biology video I've seen to make such a complicated topic into basic principles.

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Thank you for making these types of videos!!!!! Your video makes gene regulation sooo much easier to understand...I am also a college student who needed help understanding this material for my biology final, and now because of this video I understand! Keep on making these videos, great job!!!:)

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This is the best video ever, literally amazing visuals and understood the process in 6 minutes.

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You seriously deserve more views. Im a visual learner so this was extremely helpful. THANK YOU!!

[@iamacomment3999]

I FINALLY UNDERSTAND THE BASICS OF THIS MODEL ...well...now i have to learn the details but I finally understand it at all 😭😭✌ thank youuu~ (kinda funny that I understand an english video but i don't understand this model by videos in german/my native languages)

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You explain science in the cutest way with the knowledge that is needed for us to learn. Thank you

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THANK YOU SO MUCH!!! It’s the night before a big biology test and I just couldn’t wrap my head around the lac operon process. This video helped me so much!!!

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You make things so much easier to understand! You are definitely a great teacher and a great person because you upload these videos for free just to help other people. Amazing. Thank you very much. Keep on sharing the knowledge you have. Best wishes xx

[@mikeo.4203]

The video does what It needs to, but I think an update would be nice as the audio in later videos improved immensely.

[@antoniojesus8513]

I can't believe how easy to learn, detailed and fun this was! Thank you!

[@thatsnotme3235]

Thanks so much! The level of detail is perfect tbh. Most of the channels I find go into very shallow depth about different topics. This was just enough depth, talking about the way the repressor actually works and can get configured when a lactose molecule binds to it, without simply glossing over it !

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If I have kids, I'm going to have them watch all your videos. You guys make this so fun! THANKKKK YOOOUUUU

[@nienke0222]

5:26 “NOOOO! I should have let you block the thing!” I’m wheezing😂😂😂😂😂😂

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my biology teacher brought me here. Thanks Ms.Farber and thank you amoeba sisters!

[@abiraj2578]

I love your videos ! They always help me understand stuff like this better in biology! Plus, you make it interesting and funny to watch. :P Can you do a video on trp operon and the 4 controls of gene control in eukaryotes? Thank you :)

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I've been struggling with this concept for a couple days. I've got a big test coming up soon. Thank you so much for helping me!

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YOOOOOOO, Ameoba Sisters out here getting me an "A" in Microbiology! Keep On Keepin On!