Nicotine therapeutics: therapeutic aspects of nicotine stimulation for brain disorders

Nicotine therapeutics: therapeutic aspects of nicotine stimulation for brain disorders
Paul Newhouse (USA)

[@artsiecrafty4164]

I have been on the patch for about a year. I experienced a remarkable improvement in my mood. Also cognitive function is much better. I’m much better organized in general. My house looks better. I went back to painting in my retirement and I’m making wonderful progress. It is a shame that more people don’t benefit due to superstition and stupidity. Sort of like the Middle Ages.

[@robertferraro236]

I'm a 45 year smoker and also recently discovered nicotine pouches. I use the strongest 8 mg type and I use at least 10 per day plus still smoke so I am taking in around 100 mg per day. The truth is that I have never felt better in my entire life than I do now. I feel a general sense of wellbeing 24/7. The additional nicotine from the pouches have a much more significant effect than smoking alone. I have never felt like I do now just based upon smoking alone. As for the blood pressure - went to the Dr for regular checkup the other day. My blood pressure was just 112/76. He was very impressed and had never heard of these pouches before. Unfortunately because of smoking getting a bad rap, the general public is completely mislead about the benefits of nicotine. It is a poison in most people's minds. There had to be a good reason why Native Americans used it and now I know why. It is one of those gifts from nature in the plants around us.

[@RaqibZaman]

I would suggest getting of the ciggs, and going fully on the pouches? You can find stronger ones online if you need that... have you found coffee to help with replacing some of the cigg use?

[@richardrussell4065]

Another thing is nicotine makes your body break down caffeine faster.

[@RaqibZaman]

@@richardrussell4065 The study I know of mentioned that for smokers, I don't know if that's true for nicotine alone.

[@richardrussell4065]

@@RaqibZaman oh I see. Still interesting nonetheless

[@saintessa]

Pouches or patches? The transdermal ones where you put on your skin? I've got 21 mg ones that you can wear 24/7 and I've adhd so I'm gonna try see if it helps. I don't smoke quite as much ad the dosage

[@ronmalloy8504]

I've been vaping for 14 years and feel great vaping saved my life and my doctor agrees with me

[@JohnRBIV]

The blood pressure thing is interesting, I can attest to it anecdotally. I’m athletic and train in jiu jitsu and kickboxing often, my blood pressure is at times 130/70, which isn’t so bad, but when I use nicotine I’ve seen it go as low as 119/58! Maybe that’s just a stress relief aspect of it. I’m interested in seeing more data about that.

[@carlandrews5810]

Neither of those blood pressures is bad. 120/70 is about perfect

[@tictactoedias1908]

And now apparently it’s can prevent covid 19 , true story. Studies In France 🇫🇷 I guess I’ll keep puffing away 👍

[@Unodostres1944]

Da truth! 👌🏼

[@lovellesmith2088]

I have "long Haul" Covid. I have been sick for 3 years. My first piece of gum 2 mg (which is nothing) and I started dreaming again, Im up doing things.. my life is returning.

[@travv88]

You can ingest nicotine through non-smoking methods. Smoke is bad. Look into gum or pouch.

[@sallydroz1413]

The nicotine won't hurt u but the additional 400+ chemicals they put in cig. will kill u.

[@jaime5081]

¿Es la Nicotina Adictiva? Harvard realizó un estudio con animales en 2015 para determinar la adicción a la nicotina. Para su sorpresa no consiguieron que ningún animal se hiciera adicto a la nicotina estricta en el agua. Así que los investigadores solicitaron documentos de las empresas tabacaleras y en los documentos se enteraron de que los fabricantes de productos del tabaco se dieron cuenta en los años 70 de que nadie volvería a comprar «cigarrillos light», así que tuvieron que averiguar cómo hacer que los productos del tabaco fueran adictivos. Harvard se enteró en 2015 de lo que hicieron los gigantes del tabaco para que los productos del tabaco y la NICOTINA fueran adictivos. Añadieron una sustancia química llamada Pirazinas que es altamente adictiva y lo han estado haciendo desde entonces. La nicotina no es la sustancia adictiva en los productos del tabaco, los productos químicos de pirazina hacen que la nicotina sea adictiva. Las pirazinas son sólo uno de los 600 productos químicos aprobados que la FDA permite a los fabricantes de tabaco añadir a sus productos en los EE.UU. Me pregunto cuáles son las otros. Aquí hay un enlace al estudio de Harvard y artículos que discuten sus conclusiones de que la nicotina no es adictiva. Título del estudio de Harvard: Un estudio sobre las pirazinas en los cigarrillos y cómo podrían utilizarse aditivos para potenciar la adicción al tabaco tobaccocontrol.bmj.com/content/25/4/444

[@Pinkcouture111]

I have been smoke free my whole life, I am now in my mid 40s and have tried nicotine spray in desperation, because I have been suffering with anxiety and low mood and having trouble being focused, I am shocked at how effective a few sprays have been for me. Now I understand how smoking was so addictive for family with high stress jobs.

[@artsiecrafty4164]

Actually, cigarettes have hundreds of chemicals in them including pyrezines which are highly addictive.

[@living4adrenaline]

People sadly don't want to hear it because they asssociate nicotine with smoking. There are other methods of delivery...

[@icy3004]

Dr. Ardis is doing great work on this!

[@davidkellymitchell4747]

I've used tobacco everyday since I was 15. I'm now 70 and smoking the very finest premium cigars. I'm always dealing with low blood pressure but that's mainly because I only eat once a day. You have to eat to maintain blood pressure. Added nitrates is what skyrockets BP which is the opposite of what we are told. The food industry would go out of business with no nitrates. Nitrates break down into chemicals called nitrosamines. These nitrosamines can increase your risk of cancer. Everyone that I knew that quit tobacco something went terribly wrong with their health and some didn't make it. I think in many cases nicotine acts like chemotherapy which is a poison as well. Cancer can't live in all that poison. However, lungs full of smoke is a death wish. I always dipped snuff, chewing tobacco, and smoked cigars and pipes. Never inhaled. Never been a cigarette user.

[@puzzletherapy4u]

You're lucky you didn't get cancer in your mouth

[@artsiecrafty4164]

I’m 75. I began to use a nicotine patch a few years ago. I think nicotine is very healthy. Nitrates are not harmful either. But regardless, keep doing what you are doing.

[@Peter-dw5xq]

Absolutely fascinating. I chew 24 nicotine gums a day! Have done for over ten years. That's 168 gums per week. 720 per month. 8,760 annually. I am aproaching 120,000 consumed in total. I use it as a stimulate like coffee and as an appetite suppressant. It helps me cope with mild depression. My main concern is it will accelerate atherosclerosis...

[@RaqibZaman]

Coffee is probably healthier in the long run because one of its metabolites is a vasodilator.

[@amifunnymynameisbob]

@@RaqibZaman I have adhd and use both, life quality has been much better for me since I've started having a cup of coffee in the morning + two 4mg nicotine lozenges daily

[@RaqibZaman]

@@amifunnymynameisbob Haha, I also go hard on the nicotine lozenges, and try to make sure to only use them while studying. It's much more effective than coffee for my ADD symptoms, and I agree that coffee pairs well with nicotine. Just trying to moderate my use, which is a little hard. The vasoconstriction it causes isn't healthy though.

[@coryphillips1783]

go on a plant based diet and don't worry about it. Check this out kzbin.info/www/bejne/ooTafWppmtuImqM

[@richardrussell4065]

A bit of exercise and sauna will help that risk

[@randyjohnson5426]

I have never smoked but after hearing Tucker Carlson talk about the positives of nicotine i started chewing nicotine gum.

[@lorraineziegler3605]

Wow

[@bradical7772]

Anything you hear from tucker is toxic.

[@lyntaylor4131]

​@@bradical7772 really? I find him to be refreshingly honest... what has made you come to that conclusion?

[@puzzletherapy4u]

​@@bradical7772tucker speaks truth more than most news media people

[@babycakesweetiepie77]

Man i miss smoking ,everything in my life went down hill when o stopped

[@MMABeijing]

Interesting,. It s been 6 months since ur last comment, how do u feel?

[@carlandrews5810]

​@@MMABeijingthey died

[@HappyLife-wv5ms]

Is there a follow up video on this research?

[@babycakesweetiepie77]

I stopped smoking and became so depressed like never before . I wonder if i started again it would save my life ?

[@chatwithagunowner8645]

Try vaping. It's WAY safer than inhaling carcinogenic smoke. I wish you the best!

[@lovetodocoolstuff9309]

Have you considered using a patch, gum, or nicotine pouches? Then you would get the benefits of the nicotine without the drawbacks of smoking. I’m so sorry that you’re depressed. Counseling can help a lot. I love BetterHelp, it’s so easy to talk to my therapist regularly… Well, sending love from Alaska ❤

[@babycakesweetiepie77]

@@lovetodocoolstuff9309 thanks i will give it a try

[@Morrie-queens]

Buy an inhalator,just nicotine and menthol,no other nasty additives.

[@rajinevin7273]

They are not talking about smoking! Tobacco in typical mainstream cigarettes are TOXIC! They add all kinds of chemicals to them - including addictive chemicals. He is talking about PURE NICOTINE - which is NOT toxic. Completely different! Better watch the video again and do some more research.

[@Tech_Duster]

Why don’t you start putting nicotine pouches on Alzheimer’s patients.

[@matthewarnspiger632]

This guy's organization actually does that, and it has good results. kzbin.info/www/bejne/roLYdWxnpa9_psU

[@AOTS123]

Probably the negative connotation with the word itself. Flexibility, people. Drugs aren’t “good” and “bad”. They are compounds.

[@rgw5991]

The government isnt here to saves lives, just make money.

[@rgw5991]

Thats why any cheap/simple/free solutions they won't give you.

[@JohnRBIV]

They actually are in some cases, and it seems from early trials to help.

[@vickielemonis9528]

Does anyone know if there is a detox die off from nicotine use - especially for new to nicotine users? Any information would be greatly appreciated. Thank you

[@saintessa]

Was seriously just wondering this. How nicotine patches could effect adhd being a stimulant

[@phero9]

In my experience nicotine patches can be extremely helpful as a stimulant medication at ADHD. It can give you a clear mind, it helps you focus amazingly, and treats the depression and anxiety that comes with ADHD. So it’s a real miracle treatment in my opinion. You just have to find your dose, because if the dose is too low, it won’t work, and if it’s too high, it won’t work either. So you must take your time and find the best dose for you, which can be differ individually in my opinion.

[@JohnRBIV]

I have a positive personal anecdote on that. I’ve struggled with ADHD and anxiety my whole life, and even dropped out of school despite testing highly. I’m an author and artist, but I’ve had severe trouble focusing and getting work done. But when I smoke or chew the gum when working? Man, it really helps. I’ve tested it many times over.

[@Lisa-ep5bw]

Would you mind telling me what patch amount you started with? I have never smoked but have been thinking about trying this for adhd@@phero9

[@benpracht2655]

How does nicotene compare to coffee or other stimulants?

[@smorgan125]

Nicotine seems to raise my heart rate and make me dehydrated. Seems to be the only downside I can think of

[@RobertWarren-h9o]

"Depression " interesting studies on nicotine treatment effects .

[@Morrie-queens]

It also stimulates ones bowels (Dump) a few puffs on my inhalator really gets the juices flowing. 👍🏻

[@MADSCIENTISTGONESANE6166]

That's one of the main reasons I enjoy and consume nicotine. It helps loosen and allow for a good bowel movement. It might not always happen right away yet it helps ease the digestive system therefore when you do go, it's much easier.

[@benf101]

I appreciate your parenthetical clarification

[@pastamandjinka]

@@benf101 😆

[@lindadillonduncan6149]

My son, who used to chew and then vape, is now using Zyn nicotine pouches. He's still addicted. What is in these that keep him addicted?

[@jeanninecathcart627]

Is it true that nicotine helps Chrone's disease?

[@idaUnchained]

I’d love to know the answer to this, too.

[@damiandamiano3651]

yup i am crohns and it did helped me

[@jerrybarno7757]

I have Ulcerative Colitis I know it helps for that but ive heard and read that it makes Chrones worse. Reddit is packed with those answers

[@Morrie-queens]

I also have IBD.High dose vitamin D3 helps along with vitamin K2. It has powerful anti inflammatory properties. You have to take 20+ thousand IU's daily. I started off with 50.000iu along with 300iu K2 daily for 2 weeks then cut down to 30.000 for 200iu K2 for another 2 weeks then went down to 20.000iu D3 200iu K2 Daily as a maintenance dose. Never felt better! A good Bcomplex is good along with extra benfotiamine B1 start low with the Benfotiamine,they come in 150mg capsules usually,take half a capsule daily for a week or 2 then increase to a full capsule,then repeat untill you've found the dose that helps you,you can eventually take up to 600mg daily.

[@CIRSlab]

It may help! One way in which it might is by stimulating a peptide hormone called Melanocyte Stimulating Hormone (MSH), which is produced in the pituitary/hypothalamic regions. MSH has a large number of regulating functions in the body, and one of them is gut permeability (a deficiency in MSH results in leaky gut, which results in dysbiosis, IBS, and so on). There are studies showing a strong relation between MSH and IBD. It turns out that nicotine is a potent stimulant of MSH in the brain, so I wouldn't be surprised if it's beneficial in patients with an abnormal digestive problems, particularly when the underlying cause is a deficiency in MSH. We've been able to test this hypothesis in a patient population with something called Chronic Inflammatory Response Syndrome (CIRS).

[@lumberpilot]

I would like to offer myself as a test subject for a scientific study as I am the only person I know who cannot effectively start a smoking habit even though I have the ability to fully enjoy and appreciate a good, fresh cigarette rolled with quality organic tobacco. They claim nicotine is one of the most highly addictive substances know to man and yet it hold no sway over me.

[@marcosburgos8415]

It's not the nicotine itself that becomes so highly addictive but it's the chemical cocktail big tobacco companies use in them.

[@SoulAustin]

That’s really interesting! I would like to see people explore some of the anomalies brain chemistry. I found my mood underwent positive change with small doses of nicotine - whereas with antidepressants I just felt completely numb

[@wutangclaney]

Same boat.

[@rajinevin7273]

It is NOT the cigarettes they are talking about. The "addiction" comes from the CHEMICALS that they put in MOST mainstream cigarettes - not in the kind you say you smoked - which is why you easily gave them out without feeling addicted. Nicotine on it's own is NOT addictive! But it is important to purchase clean, pure form of nicotine if you purchase the patches.

[@bryang949]

I have actually read that nicotine itself is NOT addictive at all and that when the heads of the tobacco giants declared in 1994 under oath to the US Congress that it was not addictive they were in fact telling the truth!!! However, the addiction was created by other elements of the products they were making to create the addiction. The truth of the matter is that there are many health benefits of nicotine that "the system" does not want you to know about and hence its demonization

[@saintessa]

Are nicotine pouches the same as patches? (where it's absorbed through one's skin/transdermal)

[@erinmariebaker712]

Patches are used on the skin & the pouches are used in the mouth.

[@saintessa]

@@erinmariebaker712 I had just never heard of the pouches before

[@smorgan125]

Patches don’t work very well IME

[@Wds__99]

@@smorgan125 put them in your mouth for 5 mins. It’ll work lol.

[@rajinevin7273]

They are not saying pouches - they re saying patches.

[@tylermears2671]

What about the affect nicotine has on blood glucose levels? I’m concerned that using lozenges will cause my blood sugar to spike, and continuous use will increase my risk of type 2 diabetes.

[@sigikah3916]

Actually it is said to increase insulin sensitivity. So it should be beneficial for blood sugar levels.

[@MRT-co1sd]

@@sigikah3916That’s what I heard too, better insulin activity, better I.e. lower blood sugar level.

[@lindadillonduncan6149]

They taste terrible! Can you dissolve them in a better tasting drink?

[@damiandamiano3651]

thank you to give me 1000 reasons to continue smoking

[@eshwkar7868]

🤣

[@oscar6832]

I'm so happy to have quit smoking. Good luck to all who wants to quit. 😊👍

[@kea484]

Really, you're going to continue smoking?! Smoking is life threatening, nicotine is not. Why do it?

[@damiandamiano3651]

@@kea484 easy way to inject nicotine into system, small dose per day, wont harm me less than fast food

[@pastamandjinka]

pls don't, its about nicotine not cigarettes, smoke is still bad..