GLP-1 Showdown. Ozempic vs. Trulicity!

It’s the showdown of the decade! Ozempic vs. Trulicity: two GLP-1 RAs used for managing blood sugar and weight management control.
What did this rare head-to-head drug trial reveal?
In this video, I'm going to examine the results of the SUSTAIN-7 clinical trial and find out which came out on top.
For more about weight-loss via habit mastery, visit www.healthcareevolve.ca.
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What weight-loss medications comparisons would you love to see? Let me know in the comments.

[@brendanquinn6894]

You have a sense of humour like me ! We are so under appreciated !

[@xxxfanandstrangerthingsfan6774]

Great unbiased review! Like how you did the blood sugar comparisons first and even mentioned there was possibility of biases in favor of ozempic. But you definitely stayed clear of showing favor towards any one drug and stuck with the facts.

[@theofficialdrdan]

Thank you :)

[@lisampb8178]

Perfect explanation. Thank you!!!

[@theofficialdrdan]

Glad it was helpful!

[@SoundBlackRecordings]

I wish I could take Ozempic but it caused me so many digestive issues. I had to go to the hospital. It caused me to develop gastroparesis. I do notice I'm less hungry with Trulicity and I don't have severe constipation which leads to diarrhea and vomiting.

[@belindavokes2857]

It's such a shame we don't have someone like you Dr Dan in Western Australia, I have PCOS and am overweight , have been trying to get on Ozempic for the past 18months but our Australian Goverment restricts how much is in the country so for weight loss patients it's almost impossible to get hold off , it makes me just want to give up as I find you are penalised and looked down upon for being overweight, even though I try to eat healthy and exercise . Love your videos on Ozempic etc and hope one day maybe we have it more available in Australia but wouldn't hold my breath. Disheartening to say the least. Thanks and keep up the good work. 👍

[@wendyrosario]

Thank you!! This is exactly the information I was looking for. I started Ozempic 2 weeks ago and I am already down 9 pounds.

[@krmccarrell]

Ŕeally? 9 pounds in 2 weeks? I'm just starting today. Did you eat any different or exercise?

[@TL....]

@@krmccarrell 1 pound of bodyfat is 3500 calories she probably lost 8 pounds of water weight and 1 pound of fat - if that

[@krmccarrell]

@@TL.... Thanks! You must be taking it as well? Would you mind telling me how it's going (or went!) for you? Are you exercising?

[@TL....]

@@krmccarrell i don't take it, but my girlfriend does i am on adderall and it is much cheaper as an appetite suppressant plus it makes me have laser focus at work and i can work all day nonstop with zero breaks

[@TL....]

@@krmccarrell i've never taken it i take cytomel and clenbuterol

[@ignaciodominguez3214]

Ozempic was horrible and expensive. Switched to Trulicity because of insurance and had ZERO side affects.

[@theofficialdrdan]

Glad that worked for you friend.

[@sabrinaferris9672]

Trulicity is excellent. Tried Saxenda too and no way near as affective as Trulicity.. Super GL1 receptor drug by far..!

[@AhmedAdel-dk6on]

Thank you for the video. I have been using Trulicity 1.5 mg over a year right now, but at the moment there is a temporary shortage of Trulicity in the Egyptian market, so I am going to shift to Ozempic. Should I start with graded dose as advised (0.25, 0.5 then 1 mg) or go directly to the 1 mg dose as I am familiar with Trulicity?

[@SalBTV1914]

What can you tell me about these two drugs for people on Dialysis?

[@jeffchastain2977]

I have been on Trulicity for 2 years, after 20 years of type 2 diabetes that I had tremendous difficulty controlling, and then got completely out of control during the Covid lockdown and put on a lot more weight and I was taking oral meds, and tons of insulin both basal and short acting. Trulicity has helped me not only get control of my diabetes, and it has helped me lose weight, and helped me partially reverse my diabetes, but now I can't get my Trulicity because so many doctors are prescribing this drug to non-diabetic patients so that can look good at the beach this summer. I am terrified that as soon as I can no longer get my prescription refilled for this medicine, that I will start gaining weight and my a1c that has been normal for the last year, will start going back up.

[@kite6864]

wonder if the same case will be with mournjaro vs ozempic ... mounjaro is said to be the stronger one but so far feels like Wegvy was stronger with controlling hunger

[@kellymulligan2157]

Really enjoyed and appreciate your content. Been on ozempic 6 months, not finding a great deal of weight loss but I am 168 now down to 160. A bit queezy tummy wise, blood sugar down from day to day but A1C still almost 8. Not sure how I feel about ozempic for the cost $476...a month good thing I have insurance. I'm taking 1mg now was .5 how long should I hope to see weight loss? I'm very active, eat amazing watch macros carbs and no sugar. Thanks again for your channel.

[@theofficialdrdan]

It is tough to say. You need to still obtain a consistent calorie deficit in order to lose weight! A simple formula of 12 x your goal body weight can help.

[@brassy49er37]

If you’ve only lost 8 lbs in 6 mos, and Bsgr not dropped much, I’d be quitting it. It’s obviously not for you.

[@moniquerobertson2854]

I'm on week two of Ozempic .25 and aside from mild sour stomach and occasional sulfur burps, I've been doing very well. I don't obsess over food and am frankly worried about going up to .5 as I'm rarely hungry. I make myself eat small portions of balanced, nutritious food (lots of veggies) but any advice on this would be helpful. Thank you!

[@theofficialdrdan]

That is fantastic here! It does help to create freedom around food. I would keep doing what you are doing. Slowly increase your portions - focus on protein and veggies. Eventually it will get easier to eat more to ensure you are properly feeding your body. Don't feel like you need to rush on increasing the dose you can stay at 0.25mg once weekly for longer!

[@kellymulligan2157]

Try to stay .25 until you see weight loss, I didn't see any so my dr went from .5 to now 1mg to up my weight-loss, your sugars will go down. If you aren't eating enough please may I suggest chia seed pudding or protein shake as a meal or protein substitute I find it fills me and I know I'm getting my macro nutrition.

[@ondrej1893]

Hi, can I ask which drug leads to more weight loss and which would you recommend: Ozempic 1mg or Saxenda 3mg? It seems that our GP could also prescribe Ozempic to my dad even if he’s not full blown diabetic. His BMI is 40 so I assume it’s too late for something like Mysimba. And from what I googled it could be much cheaper, maybe 3x cheaper to be on Ozempic 1mg vs. Saxenda 3mg. In my own (possibly flawed) search the weight loss seemed roughly the same. Also, in my mind I’m thinking future switch to Wegovy would be smooth. (not yet approved in EU). But officially the adverts you see here etc. are for Saxenda, which makes sense as it is still the latest “official” weight loss medication. Are there other considerations I’m missing except the daily vs weekly application? Thanks.

[@theofficialdrdan]

Yes you are correct. Ozempic 1mg is more potent than Saxenda 3mg daily. Not only based on the literature but also based on clinical experience. The 1mg once weekly of Ozempic is cheaper. However, when Wegovy comes out and the dose increased to 2.4mg once weekly the price will likely be similar to what Saxenda is now.

[@ondrej1893]

@@theofficialdrdan That’s actually great given the 15+% weight loss on Wegovy. Maybe I’ll try the “off-label” Ozempic for dad. I don’t have high hopes for him following basic healthy lifestyle😀 but I see people losing on these medications anyway. I’m not even sure “diet” is necessary. It surely helps but it kind of seems like a moral position from the past. Doesn’t it kind of happen automatically with fulness and other central effects or side effects after dietary mistakes? I see youtubers on ozempic/wegovy admitting they really didn’t change their diet or were lazy for a gym and the weight still comes off. In the past dad did keto and actually went from 128 to 107 kg and then yoyoed back to 132 kg, so he was able to stick to a regime.

[@jmsiapno]

it suxs i was taking ozempic and having very good results, but this year my insurance bluecross stopped covering ozempic. only 1 they are covering is trulicity.

[@ondrej1893]

Given the GLP1 positive effect on markers of metabolic syndrome, is it often necessary to modify blood pressure, lipid or other medication, or is the effect rather mild?🙂

[@theofficialdrdan]

It really varies person to person how much those conditions are affected by the individuals weight. Some people their comorbid condition can resolve almost entirely with weightloss via GLP1 therapy and for other people there is no change as their condition is more driven by genetics or some other factor - I would say this is the minority though.

[@numah12]

In my case, Ozempic has helped me lose almost 30 lbs, A1C has dropped 1.5 pts. BG is now in the lower 100s, down from the 200s and even 300s... I have managed to cut 2 doses of hypertension medication. About to cut a third dose. Very few and mild side effects only. Started in May on the Ozempic. Up to 1 mg dosage currently. Next A1C check is next month

[@less8941]

I take trulicity 4.5 and I haven’t noticed any weight loss. I have type 2 diabetes it has brought down my a1c though

[@ja5207]

Ozempic worked great,but after 9months I developed a terrible tiredness,I was really tragiclly exhausted.Does other GLP1 have this side effect?

[@theofficialdrdan]

Most likely due to malnutrition vs. the drug at that point.

[@jennyblackburn2007]

I have great success with ozampic with loss of 22 kilos , now I can’t get ozampic in Australia, I’m worried about having long qt syndrome and trulicity had recorded deaths caused by heart issues. I’m type 2 diabetes as well .

[@theofficialdrdan]

Not sure where you are getting your data from Trulicity similar to Ozempic reduces risk of heart disease. Neither cause QT prolongation.

[@jennyblackburn2007]

Thank you I now feel confident to use Trulicity. Great news . I’m so close to goal weight only 5k to go . It’s a miracle after being obese all my life , I’m now slim .

[@moazmaraja]

What about the person who don’t want to lose weight

[@firstladi5457]

Can you do virtual appointments and give a prescription?

[@theofficialdrdan]

I cannot no.

[@firstladi5457]

@@theofficialdrdan ok thanks.

[@rpuneeth4014]

Hi I tried semaglutide oral supplement for weight loss but it didn’t work…. Now doctor suggested trulicity injections so I hope this works…. I just took my first dose 2 days back….

[@Lady_Leo8577]

Any updates

[@allkindsamusicchick]

I've remained on the lowest dose of Trulicity. Ozempic...was...not covered. Maybe, I'm just super sensitive to drugs, but on the lowest dose of Trulicity...I do experience some nausea, and potty issues for a day or three. Nothing that is unbearable...but still.....the side effects. Show me a drug without side effects. C'mon...I dare ya...

[@aditadiablita]

I had 0 side effects. Its not the med is your body

[@cwdgoff]

Question, I was on Trulicity .75mg dose for three months. My Dr was moving me up to the 1.5 dose but with the the trulicity shortage right now we can not get it. I was able to get insurance to cover the Ozempic. My starting dose on the Ozempic is going to be 1mg, is that normal becuase I was already on Trulicity so I can have a higher starting doese of the Ozempic then normal? Just going form truclicity to ozempic without missing any dosages.

[@theofficialdrdan]

I would definitely recommend starting at 0.5mg once weekly max. Ozempic is substantially more potent than Trulicity.

[@cwdgoff]

THank you for the fast reply. I will contact my Dr. to see if he has to put in a new Rx for the lower dosage or if I will be able to dial it down to .5mg. I thought the starting 1mg was high but didn't know if it was because I have been on Trulicity. Thank you@@theofficialdrdan

[@Concordeagle]

Thanks,great video. So is Ozempic still king for weight loss?

[@theofficialdrdan]

Thus far! There is some drugs in the pipeline that will give it a run for its money though!

[@Concordeagle]

@@theofficialdrdan which ones? Like Wegovy? Looking forward to hearing more about it on your channel.

[@theofficialdrdan]

@@Concordeagle Possibly even better than Wegovy! Stay tuned.

[@jenreynol1581]

can trulicity be prescribed or taken off label, for purely weight loss, nondiabetic individual? your opinion?:) thanks dr!!:) :)

[@numah12]

Team Ozempic here!~

[@Kikiana510]

Sad Ozempic worked so good for me I was about to go up to 1 and my insurance wouldn’t cover it so now I’m switching to trulicity

[@theofficialdrdan]

It is still an effective medication

[@BeiluvTV]

Same here

[@Bruce991]

How did it work out for you?

[@Kikiana510]

@@Bruce991 Not good I was allergic to it

[@ob6396]

In terms of heart protection, which one would be better? Ozempic or Trulicity?

[@theofficialdrdan]

Ozempic has the best evidence in those with diabetes. The SELECT trial should be published soon which showed significant benefit in those with no diabetes and on wegovy as well.

[@ob6396]

@@theofficialdrdan Thank you so much! Could you kindly send me the link to this information? I took to my Mum who’s diabetic to the endocrinologist last week. I asked her to give her Ozempic due to its benefits with weight loss and blood sugar. She said she would give her trulicity because it protects the heart better than Ozempic. I had my doubts. And I’m glad that you clarified this for me. I’d love to get hold of this information so I can go back to her and ask her that she gives her Ozempic instead. Thank you!

[@theofficialdrdan]

@@ob6396 www.goodrx.com/classes/glp-1-agonists/ozempic-vs-trulicity Search SELECT trial

[@ob6396]

@@theofficialdrdanthank you! Much appreciated

[@elizabethowen7205]

He summarizes at mInute 9:46

[@tabbiemuench1982]

Ok so in lbs how much did the average on trulicity loose

[@theofficialdrdan]

Everyone lost variable amounts of weight in pounds. That is why they use percentages.

[@traderman6681]

Hi , I’m a a 58 year old guy and I went from 165 to 132 lbs after 6 months. My A1c is at 6.5 and I’m pleased with ozempic.

[@carissamartinez2872]

I like ozepic...I went from 225 to 196..in 6 months...but insurance says no...and after 2 months off if it...im trying trulicity to see if it works better

[@theofficialdrdan]

Good luck!

[@anuksunamun0494]

Can i use any of these products without being diabetic? For waightloss?

[@mkaysmith59]

Ozempic made my blood pressure go really high . My doctor switched me to trulicity.

[@jaebeablessings1005]

How is it working??

[@ashleya3495]

When you switched did you start at the lowest dose of trulicity or go straight to the same dose you were on with ozempic?

[@mkaysmith59]

@@ashleya3495 I think the same dose . I’m going to try Ozempic again as soon as my doctor approves me . I really couldn’t tell anything with Trulicity .

[@ashleya3495]

@@mkaysmith59 thank you so much! I love ozempic but there’s none where I live. So instead of losing the dose I’ve made my way up to I’m going to switch to trulicity. Just a pain. Thank you for responding! And good luck

[@unclephd6190]

simply it is coca cola vs pepsi.. pepsi gets the job done..

[@plockacherrys5765]

I know why it was a big difference. Not structure or whatever. It's the dose. Are they equal? Take a look. It's like saying effect in pain for paracetamol on 400mg vs ibuprofen 400mg, doesn't make sense

[@theofficialdrdan]

That isn't true. And if it was trulicity 1.5mg weekly would be more potent them ozempic 1mg weekly. And that isn't the case. The amount of drug in a dose (mg in this case) can't be used to compare potency or effectiveness between drugs. It comes down to how the drug acts and is metabolized in the body - the pharmacokinetic and dynamic properties of it.

[@plockacherrys5765]

@@theofficialdrdan hey so what I meant is trulicity should be compared at 4.5mg vs ozempic 1mg

[@abepetrow]

The difference between 8.3 and 6.5 is not 1.8%. Get out the calculator.

[@milkcocoa718]

I think you need to get the calculator for yourself

[@lisalachapelle1716]

Dr Dan…. The medication bottle on your bookcase behind you is a bit concerning. Please move it

[@theofficialdrdan]

It's a shot glass...

[@neekqvp8152]

Lol this is funny 😄

[@MWORLD333]

😂 Dr. I’ll take a shot of whatever goes in that glass 😅