Glycogen Breakdown

[@bobhiggins8591]

Why am I paying a university thousands of dollars when this guy offers the same thing but vastly superior for free?

[@faisalal-sammarraie9140]

bob higgins you won't get a degree by watching his videos

[@TheDuvee6]

papers...

[@giorgosgranitsiotis]

For a paper actually...

[@arshdeepkaur4092]

Here we get knowledge, there a piece of paper.

[@AltairKasem]

Not all heroes wear capes. Thanks a lot!

[@Eric-sq4hd]

he should wear a cape tho

[@uronaturopathyclinic]

The interesting thing is that this guy is good at everything , he is an asset for science

[@minagamal7566]

This guy is worth donation we should all at least support by any amount of money we can afford

[@veronikamuller967]

Honestly you couldn’t have explained better. You saved biochemistry in my medicine studies, THANK YOU!

[@ishaannandwani2537]

7 years later and i'm commenting because your videos have been so incredibly helpful for the mcat. thank you so much for these.

[@alyssa-abcde]

Forever grateful to you, sir. Thank you for being a GREAT teacher!

[@naderrefai7083]

Saving medical students once again AK Lectures. Keep it up!!!

[@aanalbhatt2444]

things made so simpler! wayy to go #AKLectures :) thank you!!

[@AKLECTURES]

+Aanal Bhatt you're welcome! :-) glad to hear that

[@nikkyuong6793]

I freaked out earlier today since I could not catch up with the materials... And I found your series.... THANK YOU! THANK YOU SO MUCH!!!

[@immanuelrod1]

Basically, you're lectures will most likely help me become a doctor. When that happens and if you're still around, I'm making a fat donation! You are literally a dream maker!

[@Eric-sq4hd]

this dominates my textbook. didn't understand anything after 30 minutes reading learned it here in 13:25

[@fatimayasin3971]

I’m so so thankful for you You are perfect @Ak LECTURES

[@healthinsuranceguru4633]

i wish he would put his older lectures in a playlist too bc this material is way over my head.

[@Haani36]

Sir!. You are doing a great Job... Your way to teach is outstanding...! I can't imagine my Biochemistry without you.. Stay Blessed ❤️❤️❤️

[@soargamer1437]

Oy my God this guy teaches way better than any lecturer l have. He is a superstar and worth donating to. Keep it up once l am done with my school l must will for sure donate

[@anusha4975]

I just took my biochem final and I could literally see your diagrams in my head when I answered questions. Thank you :)

[@omerabbas745]

your great! would be really good if you get a little into the clinical aspect of things, but I genuinely appreciate it

[@ahmadbilal7724]

Thanks a lot....In few minutes you explain what our Professors explain in hours.

[@stefanastefanova5]

Incredibly helpful! Thank you, Andrey K!✊🙏

[@anastasiavasilopoulou4450]

YOU ARE THE BEST!!I got a 9/10 because of you!!!!

[@tabakhan2330]

He gives lecture a way better than our universities professors

[@sarahhe.5455]

I love your videos!!! It is the most clear explanation of biochem I have ever seen. I have been staring at the book for hours, and went to my prof's office many times and got nothing. I feel it's such a waste of money and time to go a university while better teachers are out there teach for free or with much lower cost. Stupid outdated and rigid education system

[@blackeywhiteyakilaforlife182]

You have made it very much easier to understand!! Detailed and awesome explanation:) Thanks aLot!!

[@OzOz17]

best professor ever

[@victorchimaobi9787]

i dnt complain when i miss some classes because i knw where to get d best explanations.... thanks alot

[@diptibarvadia8797]

this is so helpful i wish u had a video on photosynthesis

[@simchami]

you are the best ever ....thnk you sooooooooooo much ..you always make it so clear and simple for me .....love youuuuuuuuu

[@denrightSN]

these lectures are extremely helpful. thank you.

[@mayazazu7070]

These lectures are fantastic, thank you so much! :)

[@ashokmehta6185]

Wonderfully explained the most difficult and boring subject "BIOCHEMISTRY" in Highly digestible form. Thank you SIR

[@TheTootah2009]

the best explanation 👌thank you 💚

[@mohammadriaz777]

thanks for the video its made the process easier for me Great work! Good luck!

[@219malcolm]

Great job with this video!!! Very informative!! Very simple!!!

[@ridsbutterfly9850]

Awesome lecture. Thank you sir..

[@mubasharali4386]

Rids Butterfly 😍

[@benjamintrammell8541]

Any other medical students here? This guy has literally saved me. I hate biochemistry but he makes it slightly more tolerable.

[@aminebi4324]

Thanks for your useful presentations !

[@yogeeta-4477]

You are best✨ You know how to simplify biochemistry Thanks alot 🤗🤩

[@nourhanmoustafa7099]

you made biochemistry an easy interesting science☺ big thank you ..wish you all the best #AkLectures

[@omamashahid3250]

I really appreciate your effort (y)

[@R134able]

thank you so much!!! u explained it way better than my lectuers :D

[@halaissa853]

Thank you very much, that was so helpful :)

[@nuevopurpleplanttissuecult7128]

great video!! Thank you very much for the clear n very digestible information!👌✌

[@ebarolajinefer]

Thank you!! Everything are so clear!

[@krisharivera4935]

Im not sure if my university teaches glycogen breakdown or my mental breakdown

[@MrTurbojet93]

Excellent job this helped so much!

[@alejandrojjimenezquintero2957]

8:58 doesnt hexokinase form glucose-6-phoshate? why does it form directly the glucose-1-P?

[@Cass_i]

Because of the fact that it was just cleaved from the 6th carbon on the linear chain leaving the first carbon open and reactive

[@jenniferlawrencefan8]

hexokinase (so far what ive learned) only plays a part in a specific step in glycolysis. Hexokinase doesnt really form G6P, its just an enzyme that does a job in a particular way, meaning u shouldnt see it as hexokinase forms G6P, its more liek what hexokinase does to glucose forms G6P. There are multiple pathways to creating G6P and degradation of glycogen bypasses the need for hexokinase because another mecanism is used instead- as explained in this video. During glycolysis, hexokinase takes glucose and phosphorylates it into G6P by adding a phosphate group at the 6th carbon on glucose. This reaction seen in this video, however, doesnt start with glucose, it starts with glycogen. So theres no need for hexokinase because theres already a phosphate group on the glucose 1 phosphate sugar, only it is on carbon 1 and not carbon 6, which is why the whole 3rd step in the video transforms G1P into G6P. Basically, this process is different because glucose is a 6-carbon sugar without phosphate group, whereas in this situation *glycogen phosphorylate* will be adding a phosphate group to the glucose that was cleaved from the alpha 1-4 glycosidic bond, creating G1P. Hexokinase cant rlly work with G1P (in this context), only with glucose. hope this helps whoevers having the same question :)

[@esthersim1974]

You were sent from heaven, I am sure of it.

[@lardigmer]

Thank you a lot! I think there should be an H2O in the reaction that is catalyzed by alpha-1,6-glucosidase, when a glucose molecule is released. :) The remaining glycogen + H2O ---(alpha-1,6-glucosidase)--> glucose + The remaining glycogen

[@juliobracamonte9777]

Thanks

[@ReglaRojas]

this was extremely helpful, thank you so much

[@anne8nOtrn]

thank you so much i was desperate with biochemistry :P big thanks you are the best !

[@AymanSmairat]

I swear that you are better than my lecturer 😌

[@jawadjaradat9426]

وحش ايمن :)

[@amounanina8642]

So blessed . tysm for these lectures

[@cecejamesable]

God bless you, sir. God bless you!

[@jelenatubic6488]

Thank you sooooo much, this is very helpful to me,.....Awesome lecture :DDDD

[@mahamraouf5546]

thank u sooooooo muchhh sir excellent video i have ever watched

[@roaahany2779]

Really ur videos care magnificent thx a bunch

[@mujahidjalal6556]

Thank u so much dear sir...!

[@gabrielsanzvillegas1707]

This is amazing. Thank you!

[@jenniferlawrencefan8]

I LOVE YOU. i mean it with all my heart.

[@OzOz17]

Andrey K for president !!!!!

[@TheNatttyJ]

Brilliant!

[@kerolloseskander4035]

Great job thank you

[@nathansteadman2831]

Would the free glucose that was released from it's alpha 1,6- glycobond not just be exported straight out of the liver? Or is this model representative of muscle cells? Thanks for the videos. Very concise and efficient

[@sarahha.4267]

incredibly amazing:') big thanks

[@whiplashdamn5978]

awesome just awesome

[@giorgosgranitsiotis]

Thank you sir

[@zainabali2062]

You are great one😊😊💜

[@francescabaysa1773]

AMAZING THANK YOU

[@rakeshparida8829]

u r the best sir

[@1800gingers]

really helped thank you

[@veronicamoubarek9933]

Awesome videos!

[@tommyle5952]

So in both the glycogenesis and glycogenolysis videos, you said that the phosphoryl group is essentially moved from carbon 1 to carbon 6. Is it because the phosphoryl group always starts at carbon 1 relative to the oxygen?

[@dibagabbary2066]

thank you so much

[@hyderali692]

Can you make a video on "Breakdown of starch" ? Please @AK lectures

[@saadrashidusmani832]

bravo from Pakistan

[@musa4060]

Thank you!

[@agent475816]

Why does hexokinase form glucose-1-phosphate just so phophoglucomutase can convert it to glucose-6-phosphate from the α(1-->6) cleaved glucose by α(1-->6) glucosidase? Wouldn't it be more efficient if hexokinase just forms the glucose-6-phosphate just like it does in glycolysis?

[@victorwainaina2584]

I was wondering the same thing. Hopefully some magical person comes and explains. If you have an idea why since you made this comment 3months ago, I'd appreciate the answer...though when I come to think of it I'll probably not need the info once today's exam is done, hahaha.

[@wajihaaldabbas5418]

enzymes and substrate have absolute specificity...one enzyme can not catalayse another substrate

[@محمودالرحبي-و9ت]

they have different function dear ….. hexokinase is convert glucose to glucose -6-phosphate by using ATP but the function of phosphoglucomutase just transfer p group fromone side to another in the same molecule و الله أعلم

[@korenpollak8344]

Thank you !!

[@ritupriyadebnath]

Thank you so much 💓

[@ehsanhumayun689]

Hi your way of teaching is excellent but in this lecture i have 2 questions 1st is that is the degradation of glycogen is started only at the alpha 1-6 chain or it is also occured at alpha 1-4 chain at same time? 2nd glucose is converted to glucose 6 phosphate by any cell to capture it inside cell and to prevent from escaping. in third step glucose 6 phosphate is synthesised now can u explain me that how it is transported to other cells from liver. How could it escaped out from liver cell when in form of glucose 6 phosphate

[@metaworldpeacetoday]

Fabulous lectures thank u, btw... are u Ukranian?

[@AKLECTURES]

Nope.

[@alialhilo2289]

Thank you!!!!! Just a simple Q: Step 3 is it reversible?

[@lanana939]

Great video!! thank you! :)

[@AmyStylinson]

Why does hexokinase form glucose-6-phosphate in glycolysis but it forms glucose-1-phosphate in this situation?

[@dustinsatti2086]

dude you are awesome

[@ملاك-خ8و]

At the first I will thank you so much for this encrideble explanation and for your time which u spend to explain these lectures❤❤❤ but I have a question is the transferase and alpha1,4-glucosidase the same thing with the debranching enzyme??? #aklectures

[@inezchong3000]

it's alpha-1,6-glucosidase; and yes, they're both debranching enzymes! :D

[@nanaminoz8159]

Awesome *-*

[@Sara-wt4hh]

Thanks 💙💙💙💙💙💙

[@ritupriyadebnath]

Love it

[@arshisheik9980]

Thanku sir ☺☺☺

[@ayeshaumer1315]

what primay first product formed by glycogen decomposition????

[@frankienoel9937]

what is the name of the enzyme in eukaryotes that replaces transferase and alpha 1-6 glucosidase? is it hexokinase? +Ak Lectures

[@jose7777777777777777]

at about 4:28 you said Glucose and I think you meant glycogen

[@tun6006]

Is the remaining residual core not broken down further?

[@lulu-wp3hr]

I LOVE YOU

[@rakeshparida8829]

can y give some notes in your video in pdf from

[@dr.danishraja497]

Take screenshot at 10:31

[@ehsanhumayun689]

And also glycogen is broken down to provide glucose so if we produce glucose 6 phosphate in third step how it converted in to glucose as we mention conversion of glucose to glucose 6 phosphate as irreversible reaction

[@saunyboy123]

+Ehsan Humayun Glucose to G6P is a reversible reaction catalysed by Hexokinase

[@protosist]

Ehsan Humayun There is a glucose-6-phosphatase in the liver that cleaves the phosphate off if there is any need to rise the blood sugar level.

[@ehsanhumayun689]

Andrei Munteanu if glucose 6 P is in muscle cells how could glucose 6 phosphatase of liver will reverse it as glucose 6 P form is only present inside cells so they can't escape out

[@protosist]

Ehsan Humayun Yes, there is no g-6-phosphatase in the muscle cell, and in fact muscle cells don't have the ability to rise the blood sugar level unless g-6-p undergoes anerobic glycolysis, gets transformed into lactate that travels to the liver or the kidneys where it becomes glucose by GNG.

[@ritwikmandal1928]

do u follow stryer for this references?