Diuretics Part-2 | Loop diuretic

[@uvaissiddiqui3806]

Your lecture are awesome👏👏

[@sanjupaladia824]

Beautifully explained 👍👍thanks a lot to make it so easy , god bless you

[@Himanshu49912]

Superb ma'am maine lije aur subs5 bhi kr di diya ❤❤

[@rohitpandey2838]

Mam you are the best teacher of whole universr

[@HEMASELIYA]

Thank you!

[@fkhankhan7698]

Nice leature

[@williamlam2986]

Thank you Ma'am. good explanation.

[@HEMASELIYA]

You're welcome! Thank you!

[@MHAMMAD16]

How these effect lipid profile, could you plz explain

[@tushardhiman3975]

Potassium frr kese baad me blood mai jayea ? Kya woo loop of henle mai hi pdha rhega

[@kaustubhrege969]

Thank you, ma'am, for the guidance.

[@HEMASELIYA]

You're welcome!

[@Bhupendra_rawat47]

Tysm mam 🙂👌

[@sumitrathour1235]

Mam make video on thiazide diuretics please.

[@HEMASELIYA]

Please visit www.pharmedicosolutions.services/

[@sumitrathour1235]

@@HEMASELIYA mam some of the videos are private how to enable it. mam membershp leni padegi kya

[@sumitrathour1235]

Mam please bata dijiyega private videos ko kaise access kr skte hain please,

[@HEMASELIYA]

Haan

[@jyotijyoti1378]

Thanks mam

[@Danger-vloger1]

Thanku ma'am dCT per bhi video bnaye maam

[@HEMASELIYA]

You're welcome! I will try my best!

[@mubashirafghan8977]

mam what is the cause that some of the videos cant play are they for chenal subscribers

[@HEMASELIYA]

All the videos are not publicly accessible!

[@manmohansinghrao8200]

Ma'am your way of teaching is similar to Dr. Najeeb Sir. Have you had ever visited to his channel. 🤔

[@indrasisdasgupta592]

Mam why loop diuretics cause metabolic alkalosis?

[@HEMASELIYA]

Loop diuretics, such as furosemide, cause an increase in the excretion of chloride (Cl-) ions in the urine, which leads to an increased loss of hydrogen (H+) ions. This results in a decrease in the hydrogen ion concentration in the body, causing the pH of the blood to increase, or the blood to become more alkaline, a condition known as metabolic alkalosis. Additionally, loop diuretics can also cause an increase in the excretion of bicarbonate (HCO3-), which can contribute to the development of metabolic alkalosis. The decrease in chloride ions and increase in bicarbonate ions can lead to a decrease in the activity of the enzyme carbonic anhydrase, which is responsible for the removal of carbon dioxide from the body, this can also lead to the development of metabolic alkalosis. It is important to note that loop diuretics can cause other electrolyte imbalances as well, such as hypokalemia and hypomagnesemia, which can further contribute to the development of metabolic alkalosis. It's important to monitor electrolytes levels of patient who are on loop diuretics.

[@indrasisdasgupta592]

@@HEMASELIYA Mam how loop diuretics can alter positive and negative free water clearance?

[@HEMASELIYA]

@@indrasisdasgupta592 Loop diuretics can alter positive and negative free water clearance by increasing the excretion of electrolytes and water in the urine, leading to changes in fluid and electrolyte balance. Positive free water clearance: refers to the amount of water that is being excreted in excess of solute (electrolyte) excretion. Loop diuretics increase the excretion of both water and electrolytes, leading to an increase in positive free water clearance. Negative free water clearance: refers to the retention of water in excess of solute (electrolyte) retention. Loop diuretics increase the excretion of electrolytes, leading to a decrease in negative free water clearance, which can contribute to dehydration and other electrolyte imbalances. It is important to monitor fluid and electrolyte levels in patients on loop diuretics to ensure proper fluid balance and to prevent adverse effects such as dehydration and electrolyte imbalances.

[@indrasisdasgupta592]

@@HEMASELIYA thank you mam.

[@mattiqurrahman9685]

Q1 We know what maximum reabsorption of electrolytes occur in PCT but why doctor give loop diuretics like furosemide. Q2 Due to give of diuretics to patients Hyperuricemia occur , how to decrease level of uricemia in blood.

[@rohitpandey2838]

Q. 2- i think as I know colchicine is a best drug to decrease the level of uric acid but here i am not sure because it is a drug of anti gout but it also inhibit uricacid formation so we can use that drug in this condition

[@HEMASELIYA]

Unfortunately drug that may act on PCT has not been designed yet that's why loop diuretics are the best option among all diuretics. Although Carbonic anhydrase inhibitors work on PCT & affect Na+ reabsorption in indirect manner, leads to mild diuresis.

[@HEMASELIYA]

Diuretic induced hypercemia can be managed by following healthy diet & if required allopurinol can be prescribed as urate lowering drug.

[@rohitpandey2838]

That's a reason because maximum amount of electrolytes are reabsorb from pct, if the drug which block the reabsorption of 65% of electrolytes from the pct can cause bradycardia and severe electrolytes imbalance. I think that's a basic reason

[@HEMASELIYA]

@@rohitpandey2838 Yes, blocking the reabsorption of electrolytes in the proximal convoluted tubule (PCT) of the kidney can lead to an imbalance in electrolytes and result in bradycardia and other complications. The PCT plays a crucial role in the reabsorption of electrolytes and other molecules from the filtrate back into the bloodstream, and any disruption to this process can lead to imbalances in electrolyte levels, which can affect the normal functioning of the heart and other organs.

[@kpPrajapati-nm5fb]

Thanks mam