Heme Synthesis Pathway - Biochemistry and Hematology

Heme synthesis, Hemoglobin, Porphyria, Vitamin B6, Anemia
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►👨‍🏫💊Antibiotics Lectures: www.medicosisp... ... Check out my brand new "Electrolytes" course at www.medicosisp... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Heme synthesis is essential to form hemoglobin, which is responsible for the RBCs ability to carry oxygen.
Iron (ferrous, Fe2+) combines with protoporphyrin to form heme, then, heme combines with globin to form hemoglobin.
If you understand heme synthesis, you are more likely to understand topics like acute intermittent porphyria (AIP) as well as porphyria cutanea tarda (PCT).
This is an introduction to sideroblastic anemia.
Can anyone tell me why do we give dextrose to treat porphyrias?
The answer is in the video...Please let me know in the comments.
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(Disclaimer: The medical information contained herein is intended for educational purposes only, and are not intended for diagnosis of any illness. If you think you may be suffering from any medical condition, you should consult your physician or seek immediate medical attention.)
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If you cannot synthesize heme, you cannot make hemoglobin, and the red blood cells (RBCs) won't be able to carry oxygen "symptoms of anemia and hypoxia" If you like my videos, please consider leaving a tip at www.paypal.me/...
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Medicosis Perfectionalis thanks a lot dear

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My pleasure! Please consider sharing my videos with others! Thanks 🙏

[@themelbeliever]

What's up Medicosis I'm watching this video in 2024, I guess it's one of your early videos I can see you've really come a long way and you've really improved 🤩 Keep up the good work,Doc.

[@MedicosisPerfectionalis]

Thanks!

[@rr.studios]

"Any doctor who diagnosis Acute intermittent Porphyria is a genius..." Me: Write that down...WRITE THAT DOWN!!

[@MedicosisPerfectionalis]

Haha 😂

[@mbbslife3780]

kzbin.info/www/bejne/fJColJSPerZ2hM0❤️loved this video on heme synthesis

[@smooorko]

All Professors should learn from you how to teach, life would be much easier. Thank you good man.

[@MedicosisPerfectionalis]

I am honored!

[@maemai1011]

Indeed I agree

[@sonjalun.a3802]

I´m in school for medical laboratory technicians and we´re getting close to our final exam, these videos are absolutely amazing and contain exactly the amount and depth of information needed :) thank you very much, it helps a lot

[@MedicosisPerfectionalis]

My pleasure 😇 Good luck 🍀

[@SonneDeus]

I used your videos when I was at a pharmacy school now I graduated and use them to recall and teach other students :) just wanted to let you know your video will live along to many generations !! ^^ THANK YOU

[@MedicosisPerfectionalis]

This is amazing! Thank you so much, Sondos!

[@FinesseKicks]

Not a "doctor" well not for humans at least, anyway going to be a Vet, your video really helped me. Thank you

[@MedicosisPerfectionalis]

Thank you 🙏

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Vets are also doctors....

[@wedeyforyou]

@@fatimarehman4900no they aren’t 😂😂😂. They eat their patients

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You're a doctor too :)

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You are a doctor in my heart and acedemically! my pet lived for 8 years thanks to you guys I am so grateful ❤

[@amandasurujnauth9313]

Love your videos! They're helping me prepare for my ASCP Boards for my MLS certification. Much appreciated!

[@MedicosisPerfectionalis]

That’s awesome...thanks for watching!

[@atamgbogogonte9043]

I hope you passed? I'm doing this as well.

[@TajabNasi24]

1:52 played 50 times already😅😂(cute)

[@MedicosisPerfectionalis]

Can anyone tell me why do we give dextrose to treat porphyrias? The answer is in the video...Please let me know in the comments.

[@dakshupadhyay6810]

Because glucose and other compounds like dextrose are inhibitors of delta ala production hence porphobilinogen won't be produced.

[@MedicosisPerfectionalis]

You got it...Excellent!

[@AngelaMoses123]

I believe it slows down the reaction softens the blow. The reaction is still enevitable at some level.

[@06Apeksha]

Glucose inhibits the heme synthesis pathway in 1st itself.

[@niharnayak6417]

glucose inhibits the first step, so there will be no accumulation of porphyrins

[@kristincooper1730]

I completely agree with Amanda Surujnauth from 2 years ago. Your videos are great. They are helping me complete my MLS program and prepare for the ASCP Boards.

[@MedicosisPerfectionalis]

Kristin, you’re the best! Thank you so much for your kind words! And thanks for supporting my channel on KZbin...Thanks for clicking on the “join” button...It means the world to me!

[@lilytruong3500]

literally me LOL.

[@Ptemi_vlogs]

Yeahhhh. Me toooo

[@MedicosisPerfectionalis]

🩸 Hematology Playlist: kzbin.info/aero/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU&si=tomFsUjAgOKhOJVq

[@amitsaklani1207]

Levodopa. Thanks a lot doctor. Best medicine videos on youtube.

[@MedicosisPerfectionalis]

Thank you 🙏

[@juliabrown5379]

You are incredibly helpful for PA school as well not just medical school. We go so fast!

[@MedicosisPerfectionalis]

I am glad to hear that my videos are helpful:)

[@vicentecuba3707]

Why I love his voice so much 😍

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@hnurtanic]

You called me doctor and got my heart 😂❤

[@MedicosisPerfectionalis]

📝 Download my handwritten notes: www.medicosisperfectionalis.com/

[@cherryvlogs6361]

The drug used is L-dopa.Thanks a ton! Love from India😊

[@MedicosisPerfectionalis]

Thank you!

[@ilaydamahmutoglu5942]

you ARE THE BEST IN KZbin, sir, THANKS A LOT!!!!

[@MedicosisPerfectionalis]

Thank you 😊

[@ketevankhujadze9322]

Hey, thank you very much for these videos ❤️ But where is the video about acute intermittent porphyria? I'm asking, cause you promised us and word is word, sir 🤠 ❤️

[@sirranhaal3099]

Thanks mate, also didn't know that about carbidopa and b6 so I got two for the price of one.

[@MedicosisPerfectionalis]

Great :)

[@Allaboutmed]

Carbidopa which is oftenly combined with levodopa, inhibits the conversion of B6 to PLP which is a cofactor of delta-ALA synthase.

[@arwinraj861]

Is it levodopa?

[@MedicosisPerfectionalis]

You got it...Excellent

[@mrsamandabernier]

That was what I thought too. I was reading the comments to confirm lol

[@sanahameed4205]

my best teacher ever❤

[@healingmiles]

Sir your big fan from India! Your videos are amazing! As always

[@MedicosisPerfectionalis]

Thank you so much!

[@sarahmasri4534]

Nursing students watching too not only drs😌😌 helpful info thx 🙃

[@MedicosisPerfectionalis]

Thank you so much for watching 😊

[@mustafaerdemonal6686]

I think there is a little mistake.ALA dehydratase is found in the cytosol. Love your lectures!

[@aimz_med]

Ur right

[@etsehiwotabebe3417]

Yup

[@xogud8293]

my exams is a week away and i completely forgot all about this. thank you for refreshing my memory !

[@dorin20016]

Awww that word you couldn't spell for second was so cute ascent

[@MedicosisPerfectionalis]

:)

[@unasikivou]

Levodopa...Great help thank you so much!!

[@onellafernandes6748]

I am in LOVE with your voice...

[@MedicosisPerfectionalis]

Thank you so much 😊

[@mbbslife3780]

Loved this video on heme synthesis ❤️❤️kzbin.info/www/bejne/fJColJSPerZ2hM0

[@MsMadamadamada]

awesome vid, again ;) binge watching all of them. NO WAY LIONEL HAS A BIOCHEM BOOK. (but is it sufficient without his videos to understand well enough?) I love you way more now.

[@MedicosisPerfectionalis]

Lionel’s books are great...Videos with the book are better...The trick in biochemistry is to take out a piece of paper and try to write down all the pathway from scratch...Then try to focus on the rate limiting steps, and the enzymes that will cause diseases when deficient! Good luck!

[@MsMadamadamada]

do we need to know all the pathways by heart? :/

[@MedicosisPerfectionalis]

No, but the more you know the better...I will first start by memorizing the rate limiting step and the steps that have a disease associated with their deficiency, then I will try to add more to my memory!

[@DTalisMan]

Thank you so much for this.. nice voice and straight to the point

[@MedicosisPerfectionalis]

Thank you so much 😊

[@chandanidas4600]

Thanks bro your voice is willing to give sleep to insomaniac patient Gb

[@MedicosisPerfectionalis]

Happy to help!

[@alizaiour4438]

Thank you very much, you are such an amazing professor

[@DrMG-yw9ff]

Loved the way you started😍

[@MedicosisPerfectionalis]

Thanks 🙏

[@aroojfatima558]

You're great Sir 💜

[@MedicosisPerfectionalis]

Thank you so much 😊

[@aroojfatima558]

@@MedicosisPerfectionalis my pleasure 💜

[@DrSteve666]

*Thank you so much... you explained so simply* ❤❤

[@yuvaldemayo0]

Clear and to the point. Thank you!

[@MedicosisPerfectionalis]

My pleasure 😇

[@shalomngbala-okpabi7084]

Can't wait for "doctor" to be official.

[@MedicosisPerfectionalis]

I wish you success!

[@kemnana8740]

Isoniazid, cyclosporine

[@MedicosisPerfectionalis]

These are not anti-parkinson drugs

[@jjjjjj999]

"Hey doctors" makes me cry i given up my dream , now im following bio medical science but I can't forget my dream😢

[@karishmasingh10]

L dopa is given N to control the action of L dopa.. we also need to give carbidopa

[@jeremiahbaker6396]

to inactivate comt, so happy i know these things now

[@user-up4eg4uh7i]

شكراً جزيلاً

[@mehaksharma6100]

Thanks a lot... Your videos are quite helpful... Please continue the good work 👍

[@MedicosisPerfectionalis]

Thank you 🙏

[@GRAOUIA]

Not a doctor but a lab tech for the hospital, but thank you a lot anyway !

[@MedicosisPerfectionalis]

Thank you 🙏 I appreciate you!

[@johnkevin1104]

so when we say in acute intermittent porphyria there is an increase in urine porphyrins... which exactly are the "porphyrins" in this figure?

[@bomhayhay]

Excellent as always Thank you for all the effort

[@MedicosisPerfectionalis]

+Basheer Oudah You made my day!

[@piyushsamadhanpaithane4012]

I make my digital notes by screenshotting your videos and writing down your explanation

[@91.stutijha]

Can you please send it to me

[@mortadhaqasim959]

Why the captions in Dutch !?

[@slenkaluna7804]

Thank you very much, completely well explain.

[@MedicosisPerfectionalis]

Thanks for your kind words...Good luck!

[@jewelahmed9957]

Jewel from Bangladesh, taking preparation for ASCP MLT exam. Thanks 💕 for your helpful materials. Can you please make dedicated video related to ASCP MLT/MLS exam?

[@MedicosisPerfectionalis]

I have 2 full playlists on “hematology” and “bleeding& coagulation” with tons of videos!

[@georgeiribar8412]

I have this doubt in head for year, have my own hypothesis but not sure, why in lead poisoning we have increase levels of ALA and protoporphyrin 9 if we inhibited 2 enzymes, I mean if we inhibited ALA dehydratase the pathway should stop here, how come it continues until protoporphyrin 9 ?

[@somakamaran2600]

I loved you explanation well done Keep on 🌼

[@MedicosisPerfectionalis]

+Soma Kamaran Thanks a lot! Keep studying!

[@issamadam9352]

Excllent presentation. Carbidopa causes B6 deficiency

[@MedicosisPerfectionalis]

Thanks for your comment! Carbidopa is correct...and Levodopa is even more correct. Because when we give Levodopa and Carbidopa together, we minimize the bad effect on vitamin B6 But anyways, thanks a million! 👍

[@TheiWildWest]

Can you explain why B12? Or did you mean B6 please :) If you meant B6 that's fine you dont need to explain it. -> Video -> Amazing!

[@MedicosisPerfectionalis]

Yeah...I meant B6...Sorry 😊

[@aboodawss1104]

Such a hero

[@MedicosisPerfectionalis]

Thank you 🙏

[@cattymed4419]

Thanks Thanks Cleared the topic....

[@MedicosisPerfectionalis]

You’re welcome!

[@madamalwayshungry8218]

just subscribed​!! such a helpful series :)

[@MedicosisPerfectionalis]

Glad to have you here!

[@JabaanTube]

Always u are te best

[@MedicosisPerfectionalis]

Thank you 🙏

[@SublimeInfidel]

Isoniazid will also inhibit B6 (pyridoxine).

[@MedicosisPerfectionalis]

Yup

[@maryamrahmannia4812]

Wow , really nice , Thanks alot

[@MedicosisPerfectionalis]

My pleasure 😇

[@med8615]

Just discovered your channel, Good videos for medical students. Are you a doctor?

[@MedicosisPerfectionalis]

Thanks for your comment, no,​ I am not a doctor!

[@med8615]

what's your field if you don't mind me asking?

[@MedicosisPerfectionalis]

Just graduated, but I am not treating patients.

[@charliejagger]

The drug for Parkinson is carbidopa and levodopa.

[@amitchandmanne7584]

Levodopa drug used to treat Parkinson disease

[@mohammedmurad1464]

carbidopa/levodopa inhibit vit b6

[@termostat363]

Levodopa will lead to protoporphyrin deficiency?

[@laartje24]

"Hey, doctors and future doctors" Me a biologist: Hi

[@MedicosisPerfectionalis]

Haha 😂

[@user-qr4te5pv7e]

carbidopa --> B6 deficiency

[@MedicosisPerfectionalis]

+x What if the patient is treated for TB instead of Parkinson’s?

[@user-qr4te5pv7e]

INH

[@MedicosisPerfectionalis]

+x You got both correct! You are today’s winner! Thanks a lot for participating!

[@MedicosisPerfectionalis]

+x But, I think Levodopa is a better answer for the first one! When we give carbidopa plus levodopa together, we minimize the effect on vitamin B6! Thanks!

[@user-qr4te5pv7e]

thank you for making these videos. i greatly appreciate this.

[@Ranjitapoudel]

Thanks a million!😊😊💕

[@MedicosisPerfectionalis]

My pleasure 😇

[@pranavrana2589]

Hey doctors and future doctors AND FUTURE BIOMEDICAL ENGINEERS 😒

[@MedicosisPerfectionalis]

Welcome 🤗

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that's what the future pharmacist in me thought aswell haha

[@MedicosisPerfectionalis]

😂😂

[@haileym8073]

and future nurses

[@MedicosisPerfectionalis]

Yay! 😃 Welcome Welcome 🙏

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Thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇

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Thank you so much. You are the best ❤️

[@MedicosisPerfectionalis]

My pleasure 😇

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Front flu volume left right cut pain.

[@starrysky1588]

I can't thank you enough!

[@MedicosisPerfectionalis]

Of course!

[@saiprakashm2065]

well explained

[@MedicosisPerfectionalis]

Thank You!

[@antonyshigin4977]

Answer to your quest : Monoamine oxidase B ( MAO B) inhibitors Edit : I am even confused with levodopa. Please answer your quest.

[@yushinchen4547]

Could i ask a question? Why XLSA cause sideroblast anemia but other porphyria don't, they all cause decrease protoporphyrin

[@MedicosisPerfectionalis]

What’s XLSA?

[@yushinchen4547]

@@MedicosisPerfectionalis X-link sideroblastic anemia~~

[@laartje24]

It was usefull to have some of the names for further research but it was a bit of a shame that the process of how, and not only under what influence the substances come to be was left out.

[@niamalkubi406]

Very helpful , much thanks

[@jojo.mahdikareem3116]

Thank u so much ,that was really helpful and easy way to explain this topic ❤️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@shimaakhamis8358]

💜💜💜wonderful 💜

[@MedicosisPerfectionalis]

Thanks ❤️

[@uohstoryline]

Very nice sir

[@Yohohohohoooo]

Thank you so much, you did help me so much🤍🤍

[@MedicosisPerfectionalis]

I am honored!

[@dunkdoc745]

Please which drug inhibits vit 6

[@naral3038]

Thank u bro Keep going

[@MedicosisPerfectionalis]

I will, thanks 🙏 Can you please help me by sharing?

[@zahraamouzegar6919]

Thanks alot

[@MedicosisPerfectionalis]

You’re always welcome :)

[@Lina-np2io]

Thankyouuuu🥰

[@MedicosisPerfectionalis]

My pleasure 😇

[@marinaishak1609]

thank u so much for ur great effort .. can i ask u if u made a video for porphyria ?

[@MedicosisPerfectionalis]

Not yet.

[@GH-ks1qi]

Thank you! 😊

[@MedicosisPerfectionalis]

That’s my pleasure! Don’t mention it! Good luck with everything!

[@meleciamapuanadefreitas7606]

Genius! Subd and shared!!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@hemasree5506]

Thanks a lot!

[@MedicosisPerfectionalis]

My pleasure 😇 Can you please help me by sharing?

[@osafanmenighodaro6789]

The answer to your question, is it carbidopa and levodopa?

[@osayamenogiugo3864]

Levodopa 🌚

[@khizarhayat2937]

At which stage of a Rbc age is heme synthesized ?.As mature Rbc's lack mitochondria how is then some part of heme synthesized in the mitochondria?.

[@annchacko7044]

All these steps occur in erythroblast.

[@RB-rl3lo]

THANK YOUUU

[@kavish1109]

Levodopa??

[@Ayhamyacoub]

very hard question, whats the answer ?pls

[@lsuchik93]

anyone know the answer to the question of the day? i can't find it in the following videos?

[@MedicosisPerfectionalis]

Kindly send me an email: www.medicosisperfectionalis.com/contact/ Thank you 🙏

[@sandalrafiq9648]

its the best

[@MedicosisPerfectionalis]

Thanks 🙏

[@Kanyovu]

The drug is carbidopa. 🤝

[@euniceowusu-antwi832]

7:22 Carbidopa?🤔