Sideroblastic Anemia

[@MedicosisPerfectionalis]

💉 📜 50 hematology cases are waiting, as well as the answer to today's question...Go to www.patreon.com/medicosis/ 😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119 👩‍💻Sign up for Dropbox here: db.tt/IIlB8ejxWe 📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis

[@dr.d933]

Mds

[@NimcaanBashiir-d9r]

mds

[@praiseatedhor1414]

In alcoholism, MCV is increased because of macrocytosis Prussian blue(Perl's reaction) is used for staining the sideroblast rings

[@maemai1011]

Thank you

[@MedicosisPerfectionalis]

Do you wanna see more Biochemistry videos?

[@aimannasir3649]

Yes please

[@MedicosisPerfectionalis]

Sure!

[@Roon864]

Yes please

[@kinzaasif7241]

Yesss

[@rathodnehal2869]

yaa

[@romeolhk1008]

By all means you are the very best in this subject, no one makes it simpler and clearer than you! So glad that I met you!

[@MedicosisPerfectionalis]

+Lee Romeo Me too! That’s so kind of you...I don’t deserve all of that! I am just a regular student trying to make something big! Thanks again.

[@michaelhabeeb9957]

I have hematology finals tomorrow and am not even worried as always.After watching your videos,i feel no need to memorize stuffs,just undastnd.!! youre second to none.

[@MedicosisPerfectionalis]

Thanks, bro, good luck!

[@Ll0raa]

a few miles away from Beirut 7 of my professors passed away because of covid-19 including this subject's professor but we still have to move on with our first exam this semester if it was't for this playlist i would've honestly given up and dissociated until the end of finals thank you for the awesome explanation and for your super-human power of simplifying even the most complicated points

[@MedicosisPerfectionalis]

I didn’t do anything! Thank you so much for watching! And I am so sorry to hear what you’ve been through...It must’ve been hard.

[@niharnayak6417]

my heart goes out to you. it is almost humiliating how we bitch and moan about our easier lives really makes me introspect

[@drkaran9183]

Omg!

[@roverzuhaib]

you sometimes feel like a magician who miraculously insert and make every topic so ease as it takes just words that transmit from your mouth to our mind and we became the receptor ... you do are a magician

[@MedicosisPerfectionalis]

Thank you so much ☺️ I am so happy after reading your comment!

[@roverzuhaib]

its a grace of honour aa i am preparing fir plab , i ain’t much worry cuz all the topics are certainly present in your playlist and as i told you , you transfer , we receptor ..... you are a web and we are a hard drive , we download the files which require.... hope i succeed in my attempt ....

[@MedicosisPerfectionalis]

🩸 Hematology Playlist: kzbin.info/aero/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU&si=tomFsUjAgOKhOJVq

[@vishwasarude2494]

8:45 acquired sideroblastic anemia. Prussian blue staining for iron

[@ebrahembenbadis590]

Prussian blue staining (Perls’ reaction)

[@thrilling9279]

Is it really??? As i forget it??

[@jessicaokey7965]

“I know I’m boring” BUT no you aren’t!! I love your videos:)

[@MedicosisPerfectionalis]

Thank you so much 😊

[@simran-em4gl]

Amazing series on anemia..conceptual approach and so simplified..thank you so much🤗 helped a lot in preparation of the topic🤗

[@MedicosisPerfectionalis]

Awesome 👏

[@lairafonner7957]

You are so smart, such a great teacher, and you are very funny. thank you!! I've always thought learning should be fun, and your sense of humor absolutely makes learning fun!

[@romeolhk1008]

Thank you very much! I love the etymology thing very much as well! IMO sidero- means star, -blast means immature cell It is a type of immature cell that look like a starry sky It is not called siderocyte because siderocyte is a mature RBC that looks like a starry sky Please comment if I am wrong :P

[@MedicosisPerfectionalis]

+Lee Romeo I think “Sidero”- here means iron, as we say “hemosiderosis”... blast means: growing, germ, or cell with a nucleus. But thinking of it as a star or constellation helps during studying but I am not sure it’s scientifically accurate. That’s all that I know :)

[@نورسعبدالكريم-م2ط]

lead poisoning is often listed in textbooks as a cause of sideroblastic anemia. It is the author's experience, however, that lead poisoning is not associated with sideroblastic changes [76]. Like sideroblastic anemia, lead poisoning can cause anemia, a low reticulocyte count, and neurologic changes. Like sideroblastic anemia, lead poisoning is associated with disordered heme synthesis. Unlike sideroblastic anemia, lead poisoning typically produces heavy basophilic stippling rather than Pappenheimer bodies in RBCs or ring sideroblasts. Unlike sideroblastic anemia, lead poisoning is associated with elevated blood lead levels.

[@marizacranky]

bless your soul. Saved my grades !

[@MedicosisPerfectionalis]

Awesome 👏 I am so happy right now 😃

[@miamisalem8706]

You're better than alot of doctors 💕 I screened ur slides.. I'm happy cz I understood them easily

[@MedicosisPerfectionalis]

Great...That’s amazing!

[@shoshannahatwell5225]

I am glad to know the nutritional equivalents to the body's absorption placement to help my acquired symptoms with no general defects. I combine my personal experience with food and your technical instructions. Keep posting! Thanks for helping me save my life!

[@durumutlamonica3856]

Mcv can be high in myelodysplasia. Because MDS is also a cause of non megaloblastic macrocytic anaemia. So MDS may have low mcv or high mcv. Low mcv- if MDS is a cause of sideroblastic anaemia and High mcv- if MDS is a cause of non megaloblastic macrocytic anaemia

[@thisumamarasinghe8171]

what about the alcoholism?It too can cause high MCV

[@medicaleducation8978]

@@thisumamarasinghe8171 it will lead to non megaloblastic anemia

[@favromcomscenes3903]

But the question is when is mcv high in sideroblastic type of anemia and not other type like non megaloblastic macrocytic anemia... The stain is prussian stain.

[@salmaibrahim2928]

@@favromcomscenes3903 ok

[@banaalani7216]

You’re not boring but Great! Thanks a lot for this video so helpful

[@MedicosisPerfectionalis]

Thanks a million!

[@pavansunkara5358]

Chronic alcohol use may lead to macrocytic but sideroblastic anemia. Iron can be visualised with prussian blue stain. Am I right? Thank you for the video

[@mousa205]

I am from Iraq You are amazing Thank you

[@MedicosisPerfectionalis]

Thanks a ton

[@udechukwuemmanuel3113]

MCV is normal in sideroblastic Anaemia that is X-linked. The stain used is Prussian blue stain

[@sabreens8228]

MCV is raised in acquired type .. Perls' prussian blue stian .. Thans ^^

[@hazalsarird1219]

in b6 deficiency then?

[@aashishshah6695]

Are you internist? Dude im amazed by how much information you hold in your brain...love your videos

[@MedicosisPerfectionalis]

Thank you so much 😊 I am not an internist!

[@noorhamed4690]

Your connection to the information is wonderfull

[@MedicosisPerfectionalis]

Thanks, bro

[@emmanueldodoo1699]

mcv is high in MDS, and the stain used for staining iron is prussian blue

[@MedicosisPerfectionalis]

Excellent!

[@madhujagoswami3814]

I am from India. Thank you so much for your explanation☺️

[@MedicosisPerfectionalis]

My pleasure 😇 Can you please help me by sharing?

[@madhujagoswami3814]

@@MedicosisPerfectionalis yes sure!😊

[@خليفةالعماري-ض1غ]

the mcv will be high in sidrobalstic anemia .. in case of MDL .. myeloid leukemia .. and the stain that used to stain iron stores is Perls stain .

[@meitamano1401]

ANSWER: MCV is expected to be high in cases of Myelodysplastic Syndrome. Stain used for sideroblastic anemia are New Methylene Blue and Wright Stain. Correct me if I'm wrong. I'm grateful to you sir, thank you so much. P.S. more info in MDS pls. :)

[@xolamahlaba9859]

I think the stain is Perls Prussia Blue

[@tomcruise9317]

Mcv is high in alcohol chronic

[@langeo.2383]

.... "I know am boring" I just love this crazy genius...

[@MedicosisPerfectionalis]

Thank you ☺️

[@ibrarullah1828]

MCV is high in sideroblastic anemia in myelodysplastic syndrome

[@amjadaldossary3045]

macrocytic in sideroblastic anemia is seen in the acquired form

[@lauracarrillo884]

when it coexist with a megaloblastic anemia?

[@salmakhan11112]

thanks alot Sir.....it's wash off all my difficulties related to it✨

[@bruryrosally]

Actually you're our real professor

[@MedicosisPerfectionalis]

Thanks a ton! I am honored! Can you please help me by sharing?

[@user-Nice-Me]

الحمد لله انى لقيت القناة دي 😊

[@MedicosisPerfectionalis]

🙏

[@kemnana8740]

"I know am boring" Not at all, you are amazing 🌸

[@MedicosisPerfectionalis]

Thank you dear for always encouraging me :)

[@1st.marvelvsdc]

You are shitting me right

[@manal_s1257]

u r not boring!! u r hilarious & i lov ur channel so much!

[@MedicosisPerfectionalis]

❤️❤️

[@مصطفىعرفه-ك8ن]

In acquired ones As Alcoholism, Myelodysplastic syndrome

[@dailymedico3059]

Anemia is microcytic in congenital causes of SA And macrocytic in acquired causes

[@EnchantedBanana101]

Your videos are so helpful! Thank you for making them !

[@MedicosisPerfectionalis]

+EnchantedBanana101 Wow! Thank you for watching them. I really appreciate you taking time and writing me a great comment. Wish you all the best!

[@Alaa-cv8pj]

Thank you 🤩

[@MedicosisPerfectionalis]

You’re welcome!

[@masumaabduljabbar7305]

It could be myelodysplastic anemic or alcohol excess which can cause macrocytic without megaloblastic anemia

[@biohack3077]

...The moment I found myself shouting "Perl's stain" to my screen.

[@bomhayhay]

, As always excellent and well presented information. Thank you.

[@MedicosisPerfectionalis]

+Basheer Oudah Thank you for watching

[@abdalgaderyounis9332]

MCV high when is the siderobastic anemia was acquired type

[@michaelhabeeb9957]

for the question of the day answer,is it going to be megaloblastic anemia? due to B12 deficiency?

[@adnanbaloch3452]

In alcoholism mcv can be raised

[@sarahhabloog1383]

Your videos are sooo helpul thanx Cause alcohol cause it's associaed with B12 deficiency

[@MedicosisPerfectionalis]

Thanks a lot, but I didn’t understand the second half of your comment. Can you elaborate?

[@Mazzawak]

I finally know what the heck Sideroblastic anemia is, thank you! Also MCV would be high in MDS And a personal request, can you make a video for MDS vs Aplastic Anemia, I know you have one video for each but it would be very helpful to make a comparison video to highlight the differences and similarities between the two conditions.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@MuhammadAli-ml9bt]

very nice so easy, wow i wish college professors can teach the same way

[@zohalwali2747]

Purrsion blue bundle of thanks from Afghanistan 🙂

[@MedicosisPerfectionalis]

You’re welcome 😊

[@yannychiou282]

In MDS, MCV increases!

[@MedicosisPerfectionalis]

Excellent!

[@marinaishak1609]

you are amazing .. thank u for making it easy .

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@evilcandy1017]

I actually have sideroblastic anemia :) I go to the hospital all the time for blood transfusions

[@mty6391]

what is the cause

[@evilcandy1017]

@@mty6391 Im not actually sure, I'll have to get back to you

[@evilcandy1017]

@@mty6391 Sorry its been nine 9 months but I dont really know what caused it sorry. i've had it since I was born and I cannot remember an actual reason for it. Im sorry

[@porbarialawa8316]

MCV is high in acquired sideroblastic anemia

[@khastneeaggarwal2074]

Why TIBC is low???

[@solomon4671]

Your fantastic! Stop saying your boring.

[@MedicosisPerfectionalis]

Thanks 🙏

[@em1765]

Herdetiry have low MCV Perl's Stain for Bone .M

[@osaidbashar3388]

Prussian blue stain

[@samikshasharma1276]

Mcv will be high in MDS

[@aleehyder5798]

Please also make video on thalassaemia intermedia classification??

[@khastneeaggarwal2074]

Why TIBC increases when ferritin increases??

[@MedicosisPerfectionalis]

I think you meant it the other way around...right?

[@mahboobshah6239]

What is heme synthesis enlist some cruical anzyme which deficiency lead to sideroblastic anemia

[@shuvoislam8104]

In acquired case and also in MDS.....bt my question is why??

[@safilotra]

Purssian blue stain Sideroblastic anemia with MDS would give a high MCV

[@MedicosisPerfectionalis]

Excellent

[@safilotra]

@@MedicosisPerfectionalis thank you for your videos!

[@sami4144]

Nucleus persistence > mRNA > protein > inc cytoplasm > Inc cell size > High MCV

[@Abdulrazaqmamoonaldoory]

i think when the underlying cause is alcohol

[@user-qr4te5pv7e]

MCV can be high in MDS but I am not sure how.

[@MedicosisPerfectionalis]

You're correct

[@chintanpatil1727]

Because of immature cell stages are there in MDS .

[@MedicosisPerfectionalis]

You’re absolutely correct!

[@julialysiak587]

@@chintanpatil1727 do you know why only in acquired anemia and not in congenital?

[@marko_atanaskovic]

Can MCV be high in chronic alcoholism also? Due to both, direct alcohol toxicity on bone marrow, and B12 and/or folate deficiency secondary to poor nutrition.

[@fidelisshonhiwa1232]

MCV is high in alcolism.....

[@madhukardeshpande563]

Nice explanation

[@MedicosisPerfectionalis]

Thanks 🙏

[@srinivasaraosirasapalli5104]

excellent description

[@MedicosisPerfectionalis]

Thanks a lot!

[@nouranfarag1228]

In sideroblastic anemia: Low MCV in congenital type High MCV in acquired type

[@drmzi9693]

Hey

[@HussainH1999]

my professor asked a question to the students after teaching us about microcytic anaemias: he said "if a patient only eats Spanish what type of anaemia would he get?" assuming he has normal levels of iron and folate. what do you think the answer is? I think the answer is sideroblastic & thalassemia but thalassemia is only caused by genetic disorders so do you think it's sideroblastic? I also thought of anaemia caused by vitamin b12 deficiency but I'm not sure if spinach provides the essential needs of it or not.

[@MedicosisPerfectionalis]

Is “assuming he has normal levels of iron and folate” part of the question? Or is this your answer?

[@HussainH1999]

Medicosis Perfectionalis it is a part of the question. The patient has normal levels of iron and folate. My bad lol i didnt type it well

[@MedicosisPerfectionalis]

No worries. Then I think the answer is B12 deficiency. It’s a hypothetical question as you know.

[@HussainH1999]

Medicosis Perfectionalis can the answer be sideroblastic anemia?

[@MedicosisPerfectionalis]

Why?

[@drmaher6466]

Idiopathic sideroblastic anemia (MDS)or secondary sideroblastic anemia ,we can see mcv high

[@haiderrida2353]

I know I am boring 😅

[@eslamsultanovic8842]

you are very awesome -from Egypt

[@MedicosisPerfectionalis]

Thank you 🙏

[@MsMadamadamada]

just a side question,are you that perfect with all Medicine, or is heme-onc your fave?

[@MedicosisPerfectionalis]

Hey! This is the best comment...I am not perfect, but I aim Hi...With sufficient reading I can do all medicine, even better than heme-onc! Teaching is my passion...Stay tuned! I can’t thank you enough!

[@MsMadamadamada]

Well then, where are other massive playlists then tho? I wanna be Dr House and I can't do this without you. Unless you do tutoring, or something.;p

[@MedicosisPerfectionalis]

The other playlists are coming...We will have a vote shortly where you can choose what subjects should be next!

[@نسمهالساحلي]

Iwill answer i just see the video.. Stain is prussian blue Stain MCV is high in aquired form ALCOHOLISM..

[@MsMadamadamada]

Why target cells? What makes them look this way? I saw them in your thalassemia vid too :P

[@MedicosisPerfectionalis]

Great question...Please watch my video on target cells: kzbin.info/www/bejne/fKuZfn6vlM9nlcU

[@charishmareddy4781]

Acquierd type of sideroblastic anaemia and perls stain is used

[@hakeemahali8813]

NO, you are not boring❤️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@أيمنرسولكاظمعباس]

Yor are amazing MCV ⬆️ in B6 deficiency

[@MedicosisPerfectionalis]

MCV is high in MDS. Thank you 🙏

[@mybabymxx2944]

i have term paper to write on sideroblastic... can you recommend any books, online journals, references? thanks so much:)

[@MedicosisPerfectionalis]

Harrison’s internal medicine, Davidson’s internal medicine, Goldmann-Cecil internal medicine, Robbin’s Pathology.

[@thecordialcorner6634]

Thnkuuuuu

[@MedicosisPerfectionalis]

My pleasure 😇

[@bisan7823]

as always.. you are the best , 💙

[@MedicosisPerfectionalis]

Thank you 😊

[@katiebennett7172]

MDS; Prussian blue

[@MedicosisPerfectionalis]

Super!

[@venkybly]

Tq 👍🏼

[@MedicosisPerfectionalis]

My pleasure 😇

[@lindimomo8536]

you amazing ..thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@mariyajacob4107]

Perfect lectures

[@MedicosisPerfectionalis]

Thank you 🙏

[@TheDod00]

sideroblastic anemia may show High MCV in the setting of Alcoholism

[@MedicosisPerfectionalis]

Yes, or in MDS.

[@hammadahmed2353]

Love from Pakistan.. ♥️

[@MedicosisPerfectionalis]

Thanks 😊

[@hosseinafshari2405]

YOU ARE BEST😍😍😍😍😍😍😍

[@MedicosisPerfectionalis]

Thank you 🙏

[@nha8909]

MCV is high in MDS ..... right??

[@khaledalharony227]

Thank you 😊

[@MedicosisPerfectionalis]

My pleasure 😇

[@kimanhchung8372]

Thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@commonsense472]

1. megaloblastic anamia 2. prussian blue stain

[@Kismatlabtech]

perls prussian blue staining it was discovered by max perls grman pathologiat

[@MedicosisPerfectionalis]

Cool 😎

[@louiskhoo3507]

why ferritin is high then TIBC is low?

[@MedicosisPerfectionalis]

Great question! I have explained it in my video on iron: kzbin.info/www/bejne/fKrUqJuYpqydirs

[@Nafeesdoc]

Prussian Blue MDS