Sideroblastic Anemia

[@MedicosisPerfectionalis]

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[@dr.d933]

Mds

[@NimcaanBashiir-d9r]

mds

[@praiseatedhor1414]

In alcoholism, MCV is increased because of macrocytosis Prussian blue(Perl's reaction) is used for staining the sideroblast rings

[@maemai1011]

Thank you

[@MedicosisPerfectionalis]

Do you wanna see more Biochemistry videos?

[@aimannasir3649]

Yes please

[@MedicosisPerfectionalis]

Sure!

[@Roon864]

Yes please

[@kinzaasif7241]

Yesss

[@rathodnehal2869]

yaa

[@durumutlamonica3856]

Mcv can be high in myelodysplasia. Because MDS is also a cause of non megaloblastic macrocytic anaemia. So MDS may have low mcv or high mcv. Low mcv- if MDS is a cause of sideroblastic anaemia and High mcv- if MDS is a cause of non megaloblastic macrocytic anaemia

[@thisumamarasinghe8171]

what about the alcoholism?It too can cause high MCV

[@medicaleducation8978]

@@thisumamarasinghe8171 it will lead to non megaloblastic anemia

[@favromcomscenes3903]

But the question is when is mcv high in sideroblastic type of anemia and not other type like non megaloblastic macrocytic anemia... The stain is prussian stain.

[@salmaibrahim2928]

@@favromcomscenes3903 ok

[@romeolhk1008]

By all means you are the very best in this subject, no one makes it simpler and clearer than you! So glad that I met you!

[@MedicosisPerfectionalis]

+Lee Romeo Me too! That’s so kind of you...I don’t deserve all of that! I am just a regular student trying to make something big! Thanks again.

[@michaelhabeeb9957]

I have hematology finals tomorrow and am not even worried as always.After watching your videos,i feel no need to memorize stuffs,just undastnd.!! youre second to none.

[@MedicosisPerfectionalis]

Thanks, bro, good luck!

[@saraahmadi3939]

The most extraordinary training I've ever seen .sideroblastic anemia was so hard for me to understand Thank you sooo much

[@MedicosisPerfectionalis]

My pleasure 😇

[@vishwasarude2494]

8:45 acquired sideroblastic anemia. Prussian blue staining for iron

[@Ll0raa]

a few miles away from Beirut 7 of my professors passed away because of covid-19 including this subject's professor but we still have to move on with our first exam this semester if it was't for this playlist i would've honestly given up and dissociated until the end of finals thank you for the awesome explanation and for your super-human power of simplifying even the most complicated points

[@MedicosisPerfectionalis]

I didn’t do anything! Thank you so much for watching! And I am so sorry to hear what you’ve been through...It must’ve been hard.

[@niharnayak6417]

my heart goes out to you. it is almost humiliating how we bitch and moan about our easier lives really makes me introspect

[@drkaran9183]

Omg!

[@MedicosisPerfectionalis]

🩸 Hematology Playlist: kzbin.info/aero/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU&si=tomFsUjAgOKhOJVq

[@Chrisanna123]

"I know. I am boring" 😂😂😂😂 Thanks for explaining this topic. Very easy to understand now.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@محمدشريف-و8س]

U r a doctor from another planet

[@MedicosisPerfectionalis]

Thanks 😊

[@mohamedabdalla9495]

You made me like Medicine, the way you simplify the information and the interesting way you conduct the lesson especially when you say "and this is the whole story morning glory" I even started to use it sometimes when I talk 😂 Thanks so much Dr ❤️ All my love from Sudan 🇸🇩

[@MedicosisPerfectionalis]

I appreciate you!

[@ummehafsa4096]

May Allah bless you! Love from Bangladesh 🇧🇩

[@MedicosisPerfectionalis]

Thank you 🙏

[@johnkodhek]

Saving millions of lives with the health professionals you teach👏🏾👏🏾👏🏾👏🏾💐💐💐Thankyou kind sir!

[@MedicosisPerfectionalis]

Thank you so much! I am honored and humbled!

[@marizacranky]

bless your soul. Saved my grades !

[@MedicosisPerfectionalis]

Awesome 👏 I am so happy right now 😃

[@jessicaokey7965]

“I know I’m boring” BUT no you aren’t!! I love your videos:)

[@MedicosisPerfectionalis]

Thank you so much 😊

[@نورسعبدالكريم-م2ط]

lead poisoning is often listed in textbooks as a cause of sideroblastic anemia. It is the author's experience, however, that lead poisoning is not associated with sideroblastic changes [76]. Like sideroblastic anemia, lead poisoning can cause anemia, a low reticulocyte count, and neurologic changes. Like sideroblastic anemia, lead poisoning is associated with disordered heme synthesis. Unlike sideroblastic anemia, lead poisoning typically produces heavy basophilic stippling rather than Pappenheimer bodies in RBCs or ring sideroblasts. Unlike sideroblastic anemia, lead poisoning is associated with elevated blood lead levels.

[@ebrahembenbadis590]

Prussian blue staining (Perls’ reaction)

[@thrilling9279]

Is it really??? As i forget it??

[@user-qr4te5pv7e]

Prussian Blue- Fe stain

[@MedicosisPerfectionalis]

+x Correct

[@drabhishekorthpaedics]

Prussian blue iron stain

[@MedicosisPerfectionalis]

Right!

[@mousa205]

I am from Iraq You are amazing Thank you

[@MedicosisPerfectionalis]

Thanks a ton

[@rozhnazabdoul937]

Acquired sideroblastic anaemia is frequently associated with myelodysplastic syndrome (macrocytic anaemia). high MCV.

[@noorhamed4690]

Your connection to the information is wonderfull

[@MedicosisPerfectionalis]

Thanks, bro

[@justcheckit5034]

You just maked me professionalis

[@MedicosisPerfectionalis]

Yay 😁

[@lynaberr2704]

Much thanks and love 💕 A pharmacist from 🇩🇿 is saying Hi

[@user-Nice-Me]

الحمد لله انى لقيت القناة دي 😊

[@MedicosisPerfectionalis]

🙏

[@langeo.2383]

.... "I know am boring" I just love this crazy genius...

[@MedicosisPerfectionalis]

Thank you ☺️

[@banaalani7216]

You’re not boring but Great! Thanks a lot for this video so helpful

[@MedicosisPerfectionalis]

Thanks a million!

[@lairafonner7957]

You are so smart, such a great teacher, and you are very funny. thank you!! I've always thought learning should be fun, and your sense of humor absolutely makes learning fun!

[@simplepeacelover]

Congenital forms often present with normocytic or microcytic anemia while acquired forms of sideroblastic anemia are often normocytic or macrocytic. Congenital forms including X-linked SA, autosomal recessive SA, genetic syndromes Acquired forms including acquired clonal SA (which fall under the broader category of myelodysplastic syndromes (MDS)), acquired reversible SA (alcoholism, pyridoxine deficiency, lead poisoning, copper deficiency, excess zinc) Prussian blue stains iron

[@madhujagoswami3814]

I am from India. Thank you so much for your explanation☺️

[@MedicosisPerfectionalis]

My pleasure 😇 Can you please help me by sharing?

[@madhujagoswami3814]

@@MedicosisPerfectionalis yes sure!😊

[@bruryrosally]

Actually you're our real professor

[@MedicosisPerfectionalis]

Thanks a ton! I am honored! Can you please help me by sharing?

[@نورسعبدالكريم-م2ط]

Erythrocyte protoporphyrin - The erythrocyte protoporphyrin (PP) measurement has not been systematically examined in the majority of sideroblastic anemia types and has limited value in diagnosis. RBC PP values have been established in a few forms: ●In X-linked sideroblastic anemia (XLSA) and with defects in SLC25A38, the erythrocyte PP level is uniformly low because heme synthesis and hence protoporphyrin production are reduced ●In XLSA with ataxia (XLSA/A), erythrocyte PP is increased (mainly as zinc protoporphyrin) [9,10] ●In MDS disorders with ring sideroblasts, erythrocyte PP is characteristically increased up to 300 mcg/dL (normal: 20 to 80 mcg/dL)

[@sarah8844]

Because of yours other videos I was able to answer our demonstrator's question which other students were unable to answer!!

[@MedicosisPerfectionalis]

I am so glad 😃

[@simran-em4gl]

Amazing series on anemia..conceptual approach and so simplified..thank you so much🤗 helped a lot in preparation of the topic🤗

[@MedicosisPerfectionalis]

Awesome 👏

[@mohamedabdalla9495]

You made me like Medicine, the way you simplify the information and the interesting way you conduct the lesson especially when you say "and this is the whole story morning glory" I even started to use it sometimes when I talk 😂 Thanks so much Dr ❤️

[@MedicosisPerfectionalis]

Haha 😂 You’re very welcome, Sir!

[@favromcomscenes3903]

Now let us know the answer doc ☺️

[@emmanueldodoo1699]

mcv is high in MDS, and the stain used for staining iron is prussian blue

[@MedicosisPerfectionalis]

Excellent!

[@pavansunkara5358]

Chronic alcohol use may lead to macrocytic but sideroblastic anemia. Iron can be visualised with prussian blue stain. Am I right? Thank you for the video

[@rayayalmaz9403]

It's MDS, because in this condition there is JAK 2 gene mutation, this gene codes for a protein called Juan kinase, it's a protein that transmit stimulations from hormones like EPO and thyroxine to the nucleus helping in cell differentiation, thus the cell will get the ability to have new functions like Hb synthesis. Each time the cell gets a new function, it's work-list increases so it will be less interrested by division instead of maturation. In the mutation of Jak2, the cell keeps it's ability of division but lose it's ability for maturattion,this mutation happens so early in the pathway before even pro-erythroblastic state. This mutation can alse affect others blasts from # lineage not only erythroblasts, so the divisions increase and they consume vit B12 so the cells becomes macrocytic instead of being blastic ( having big size). And because there is no maturation of RBC's, there will be no synthesis of Hb components cause there will be no EPO and other hormone stimulus cause there in no jak2. And then the mitochondria surrounding the nucleus charges with Fe and wait for it's clue (enzymes) essential for Hb synthesis, that will never come. So we will have macrocytic sideroblasts. In the case of alcohol yes we can have vit B12 deffeciency (causing macrocytosis) but in opposition we may have sideroblastosis and decrease in Hb synthesis (microcytosis), if both of them meets they can lead to normocytosis.

[@luffy101n2]

Woahh amazing 👏

[@luffy101n2]

What does "they become macrocytic and not blastic"mean? Is it Because if the vit b12 gets over due to excess usage even the blasts won't be produced and whatever cells are already in circulation would be macrocytic.bcz now even the blasts can't be made

[@rayayalmaz9403]

@@luffy101n2 No myelodysplasia is different from aplasia, the first one there will be blasts but few ones cause there is a lack of vit B12 not total absence, so there will be divisions that give big cells and those cells because they are big they remain few this is why we have anemia but in the case of Aplasia there is no Blasts at all. 0 bone marrow.

[@manal_s1257]

u r not boring!! u r hilarious & i lov ur channel so much!

[@MedicosisPerfectionalis]

❤️❤️

[@aqdashassan545]

You are the legend in this topic ❤️

[@MedicosisPerfectionalis]

Thank you 🙏

[@Alaa-cv8pj]

Thank you 🤩

[@MedicosisPerfectionalis]

You’re welcome!

[@romeolhk1008]

Thank you very much! I love the etymology thing very much as well! IMO sidero- means star, -blast means immature cell It is a type of immature cell that look like a starry sky It is not called siderocyte because siderocyte is a mature RBC that looks like a starry sky Please comment if I am wrong :P

[@MedicosisPerfectionalis]

+Lee Romeo I think “Sidero”- here means iron, as we say “hemosiderosis”... blast means: growing, germ, or cell with a nucleus. But thinking of it as a star or constellation helps during studying but I am not sure it’s scientifically accurate. That’s all that I know :)

[@miamisalem8706]

You're better than alot of doctors 💕 I screened ur slides.. I'm happy cz I understood them easily

[@MedicosisPerfectionalis]

Great...That’s amazing!

[@shoshannahatwell5225]

I am glad to know the nutritional equivalents to the body's absorption placement to help my acquired symptoms with no general defects. I combine my personal experience with food and your technical instructions. Keep posting! Thanks for helping me save my life!

[@dr.md.imrulkaes9793]

Iron stain is prussian blue. In acquired type MCV is high Ex. MDS ......... AND I HAVE A QUESTION TOO, WHY YOU DONOT COMMENT ON RETICULOCYTE? IN SIDEROBLASTIC ANAEMIA THERE IS INEFFECTIVE ERYTHOPOIESIS SO THERE WILL BE RETICULOCYTOPENIA IN RELATIONS TO ANAEMIA.

[@salmakhan11112]

thanks alot Sir.....it's wash off all my difficulties related to it✨

[@kemnana8740]

"I know am boring" Not at all, you are amazing 🌸

[@MedicosisPerfectionalis]

Thank you dear for always encouraging me :)

[@1st.marvelvsdc]

You are shitting me right

[@MSadamgasm]

I absolute love your lectures, it’s concise and I like your humour 😂 makes it fun so I don’t fall asleep half way through!

[@MedicosisPerfectionalis]

Thank you 🙏

[@reachtt]

I love your teaching very much. Thanks, I learn a lot. :)

[@MedicosisPerfectionalis]

+reachtt That’s why Medicosis exists! Thanks for your great words! My pleasure!

[@biohack3077]

...The moment I found myself shouting "Perl's stain" to my screen.

[@aashishshah6695]

Are you internist? Dude im amazed by how much information you hold in your brain...love your videos

[@MedicosisPerfectionalis]

Thank you so much 😊 I am not an internist!

[@hagermera1533]

Thank you very much ..an amaaazing series

[@MedicosisPerfectionalis]

My pleasure 😇

[@vinaykumaravvenkatesha9598]

Awesome presentation... Will never forget sideroblastic anemia.. thank you.

[@MedicosisPerfectionalis]

My pleasure 😇

[@solomon4671]

Your fantastic! Stop saying your boring.

[@MedicosisPerfectionalis]

Thanks 🙏

[@sabreens8228]

MCV is raised in acquired type .. Perls' prussian blue stian .. Thans ^^

[@hazalsarird1219]

in b6 deficiency then?

[@EnchantedBanana101]

Your videos are so helpful! Thank you for making them !

[@MedicosisPerfectionalis]

+EnchantedBanana101 Wow! Thank you for watching them. I really appreciate you taking time and writing me a great comment. Wish you all the best!

[@ramandeeprai9330]

Mcv often raised in acquired type.

[@MedicosisPerfectionalis]

Excellent! Also in MDS.

[@marinaishak1609]

you are amazing .. thank u for making it easy .

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@marif4654]

Man, this looks so easy when i am on your videos I felt like i am hematologist lol🥰

[@MedicosisPerfectionalis]

Thank you 😊

[@zohalwali2747]

Purrsion blue bundle of thanks from Afghanistan 🙂

[@MedicosisPerfectionalis]

You’re welcome 😊

[@hakeemahali8813]

NO, you are not boring❤️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@meitamano1401]

ANSWER: MCV is expected to be high in cases of Myelodysplastic Syndrome. Stain used for sideroblastic anemia are New Methylene Blue and Wright Stain. Correct me if I'm wrong. I'm grateful to you sir, thank you so much. P.S. more info in MDS pls. :)

[@xolamahlaba9859]

I think the stain is Perls Prussia Blue

[@tomcruise9317]

Mcv is high in alcohol chronic

[@sami4144]

Nucleus persistence > mRNA > protein > inc cytoplasm > Inc cell size > High MCV

[@خليفةالعماري-ض1غ]

the mcv will be high in sidrobalstic anemia .. in case of MDL .. myeloid leukemia .. and the stain that used to stain iron stores is Perls stain .

[@udechukwuemmanuel3113]

MCV is normal in sideroblastic Anaemia that is X-linked. The stain used is Prussian blue stain

[@lauracarrillo884]

when it coexist with a megaloblastic anemia?

[@leavinoneday]

In alcohol maybe google says alcohol causes multi vitamin difiecencies like folate,pyridoxine and thiamin difiecency

[@bisan7823]

as always.. you are the best , 💙

[@MedicosisPerfectionalis]

Thank you 😊

[@Chrisanna123]

7:50 Prussian blue stain

[@MedicosisPerfectionalis]

Excellent!

[@Chrisanna123]

@@MedicosisPerfectionalis 😊

[@prathmeshahirwar11]

Ferritin is storage form of iron in liver and bone marrow .. and tibc is total iron binding capacity( max is 6 ) .. but I cannot understand why they are inversely proportional .. I'm asking a stupid question but I don't know . Help ?

[@dragospop202]

a little late, but i think that the answer is intuitive. When the iron storage (ferritin) is high, you dont need the means of transportation to the deposits to be that eficient any more. you need the means of transportation to be very efficient only when the storage is empty.

[@bomhayhay]

, As always excellent and well presented information. Thank you.

[@MedicosisPerfectionalis]

+Basheer Oudah Thank you for watching

[@eslamsultanovic8842]

you are very awesome -from Egypt

[@MedicosisPerfectionalis]

Thank you 🙏

[@mohamadaly]

very helpful

[@MedicosisPerfectionalis]

Thanks 🙏

[@hosseinafshari2405]

YOU ARE BEST😍😍😍😍😍😍😍

[@MedicosisPerfectionalis]

Thank you 🙏

[@msopauline2340]

MCV can be high ie macrocytic in acquired forms eg MDS, medication s eg isoniazid, chemotherapy etc, and also in alcohol abuse. Stain with Prussian blue

[@evilcandy1017]

I actually have sideroblastic anemia :) I go to the hospital all the time for blood transfusions

[@mty6391]

what is the cause

[@evilcandy1017]

@@mty6391 Im not actually sure, I'll have to get back to you

[@evilcandy1017]

@@mty6391 Sorry its been nine 9 months but I dont really know what caused it sorry. i've had it since I was born and I cannot remember an actual reason for it. Im sorry

[@MuhammadAli-ml9bt]

very nice so easy, wow i wish college professors can teach the same way

[@zobreannbrown631]

Is it that the MCV would be high in the sideroblastic anemias caused by a myelodysplastic syndrome, having an underlying megaloblastic process as well? You can see stainable bone marrow iron by staining with the Prussian Blue stain.

[@madhukardeshpande563]

Nice explanation

[@MedicosisPerfectionalis]

Thanks:)

[@user-qr4te5pv7e]

MCV can be high in MDS but I am not sure how.

[@MedicosisPerfectionalis]

You're correct

[@URVCHIT]

Because of immature cell stages are there in MDS .

[@MedicosisPerfectionalis]

You’re absolutely correct!

[@julialysiak587]

@@URVCHIT do you know why only in acquired anemia and not in congenital?

[@marko_atanaskovic]

Can MCV be high in chronic alcoholism also? Due to both, direct alcohol toxicity on bone marrow, and B12 and/or folate deficiency secondary to poor nutrition.

[@hammadahmed2353]

Love from Pakistan.. ♥️

[@MedicosisPerfectionalis]

Thanks 😊

[@HussainH1999]

my professor asked a question to the students after teaching us about microcytic anaemias: he said "if a patient only eats Spanish what type of anaemia would he get?" assuming he has normal levels of iron and folate. what do you think the answer is? I think the answer is sideroblastic & thalassemia but thalassemia is only caused by genetic disorders so do you think it's sideroblastic? I also thought of anaemia caused by vitamin b12 deficiency but I'm not sure if spinach provides the essential needs of it or not.

[@MedicosisPerfectionalis]

Is “assuming he has normal levels of iron and folate” part of the question? Or is this your answer?

[@HussainH1999]

Medicosis Perfectionalis it is a part of the question. The patient has normal levels of iron and folate. My bad lol i didnt type it well

[@MedicosisPerfectionalis]

No worries. Then I think the answer is B12 deficiency. It’s a hypothetical question as you know.

[@HussainH1999]

Medicosis Perfectionalis can the answer be sideroblastic anemia?

[@MedicosisPerfectionalis]

Why?

[@khaledalharony227]

Thank you 😊

[@MedicosisPerfectionalis]

My pleasure 😇

[@areejali9657]

love your videos ammazing thanks for all the effort I'm MLT

[@Saffajiha]

MLT students heree

[@srinivasaraosirasapalli5104]

excellent description

[@MedicosisPerfectionalis]

Thanks a lot!

[@amjadaldossary3045]

macrocytic in sideroblastic anemia is seen in the acquired form

[@khastneeaggarwal2074]

Why TIBC is low???

[@dailymedico3059]

Anemia is microcytic in congenital causes of SA And macrocytic in acquired causes

[@TheYAGOBI]

Thank you a lot

[@MedicosisPerfectionalis]

My pleasure 😇

[@TheYAGOBI]

@@MedicosisPerfectionalis I’m IM resident , and I found your videos very useful to me clinically and for Exams , I feel gratefully when I see some persons love to make other people learn like them and make the complex things easier, ALLAH love this people, Thank you again🙏

[@ibrarullah1828]

MCV is high in sideroblastic anemia in myelodysplastic syndrome

[@mariyajacob4107]

Perfect lectures

[@MedicosisPerfectionalis]

Thank you 🙏

[@saraashraf4011]

Thank you

[@michaelhabeeb9957]

for the question of the day answer,is it going to be megaloblastic anemia? due to B12 deficiency?

[@davegilmour2250]

In acquired form of sideroblastic anemia MCV might goes up or normal. In MDS it goes high.

[@abdalgaderyounis9332]

MCV high when is the siderobastic anemia was acquired type

[@mybabymxx2944]

i have term paper to write on sideroblastic... can you recommend any books, online journals, references? thanks so much:)

[@MedicosisPerfectionalis]

Harrison’s internal medicine, Davidson’s internal medicine, Goldmann-Cecil internal medicine, Robbin’s Pathology.

[@porbarialawa8316]

MCV is high in acquired sideroblastic anemia

[@heartydireh506]

Mcv is going to be high if it’s an acquired clonal cause in Myelodysplastic syndrome

[@MedicosisPerfectionalis]

Excellent

[@MsMadamadamada]

just a side question,are you that perfect with all Medicine, or is heme-onc your fave?

[@MedicosisPerfectionalis]

Hey! This is the best comment...I am not perfect, but I aim Hi...With sufficient reading I can do all medicine, even better than heme-onc! Teaching is my passion...Stay tuned! I can’t thank you enough!

[@MsMadamadamada]

Well then, where are other massive playlists then tho? I wanna be Dr House and I can't do this without you. Unless you do tutoring, or something.;p

[@MedicosisPerfectionalis]

The other playlists are coming...We will have a vote shortly where you can choose what subjects should be next!

[@yannychiou282]

In MDS, MCV increases!

[@MedicosisPerfectionalis]

Excellent!

[@مصطفىعرفه-ك8ن]

In acquired ones As Alcoholism, Myelodysplastic syndrome