Hemoglobin | Human anatomy and physiology | Health & Medicine | Khan Academy

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Hemoglobin and its role in the circulatory system. Created by Sal Khan.
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I was ten years old when I first found khan academy and I first learnt about the lungs and pulmonary system from there videos and my science teacher was so impressed and now I'm his favourite student after watching more videos

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+And Pearl Why is that of any importance to you?

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U lair

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Thats great

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@sagarkapur9006 helllo how old r u?

[@texkokes1]

Thanks for keeping the "why" at the forefront! I have watched at least 10 videos on this subject and this one is by far the best. thank you thank you!

[@MRBOQORE]

Thank you. I love you. As said before: "You deserve a noble prize"

[@BryhanEspinosa]

2,3-Bisphosphoglycerate lowers Hemoglobin's binding affinity for O2- molecules which allows O2- molecules to travel to tissue requiring oxygen for anyone wondering why oxygen is removed.

[@JacobMD1000]

great video! i studied hemoglobin a lot at a very high level and then watching this video helped connect it all. maybe post a video on hemoglobin and its interaction 2,3- BPG in the blood.

[@corey5454]

I'm am addicted to these videos, I just love to learn!

[@fleshcookie]

9:06- " give or take, ive never sat down and counted them" Lol Sal kills me.

[@AabbbbA]

Killed me there 😂😂😂😂

[@splatitup6862]

God bless your amazing soul I get biochemistry now

[@caesarguerrero6314]

Thank you so much!!! You are the best teacher ever. Your enthusiasm and joy in teaching has no parallel. I am a teacher myself taking the Boards and I have nothing but good words for you. Thanks a million you are the best

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he makes me understand concepts I always tried to understand but never do............best teacher in the whole universe!!!!! 2 thumbs up!!!!! :)

[@qais84able]

I should say you are one of the best lecturer ever.... if you have a published book about hematology, would you post its name please. I usually get distracted when I sit in a lecture but your lecture is amazing.. I just love it... Thank you for this incredible video.

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The Creator is indeed an intelligent being!!! I have never seen a mechanism so accurate and well-coordinated as this one!

[@apocalypticskepticus3299]

Tefelo Mathibane creator is also so brilliant that he created Hemoglobinopathies as well... Simply wonderful group of diseases.

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relax. poeing is acceptable

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We are fearfully and wonderfully made.... ps. 139

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He's beyond an intelligent being He made us talk and made it so we could create cities with the first Jews (Adam and Eve).

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It happend to me that ... I've seen this video entirely too... I just wanted to see a little, but it's fully addictive the way this man explain things easily and loving it. It's contagious!

[@naturelover3548]

omg ! This video deserves a million thumbs up for the clarity, organization, timing, and I love that I could just hear an audio with a clear deep voice and while listening to the voice I am focus on watching all what was written in front of me. I like just hearing an audio with all the step by step instructions or lectures than watching someone visually and them trying to explain everything. This is a well done video and it is perfect for me to watch without distructions what is in front of me but able to learn what this lectures all about! Wow !!! I am so impressed with the voice (calm, confident, knowledgeable , very specific or direct to the point). I could watch or listen your video over and over and over again without getting tired hearing your voice while learning a lot of stuff, because of how you explain things ! Very well done !!! Love it !!!! Thank you !!!! This helps a lot for me !

[@serotonin9218]

“I have never sat down and counted them” Amateur I have spent three decades counting all my cells and I have a number of 54,134 trillion cells.

[@bslaozora]

That means you still have to count more than 10,000,000 cells per second.

[@clairens]

well...I watched your kidney function video first. This has been the 5th in a row, and honestly, it was better to watch in terms of excitement, brain engagement, and fun than any series or cartoons. :) thanks for these past 1,5 hours!!

[@brandoncashin8317]

Missed my Biochem lecture yesterday and this helped me get back on track, thanks!!!!

[@hollytom1]

This is excellent! I wish the title were more descriptive, because maybe I would have watched it when I needed to! Still a great lesson on the oxygen-hemoglobin dissociation curve and what drives it. Thanks!

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This is the stuff!!!!! I wish you were my teacher! Im sure alot of educational institutions would absolutely love to have you. Alot of of would benefit having you around...Fantastic!

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Thank you so much for this educational video. It just helped me pass my exam with an A+, so feel no less than eternally grateful to you. I'll watch all of your stuff closely from now on. Thank you, thank you, thank you.

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Still one of the best videos ever .. straight forward and easy to understand

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More people need to like his videos, seriously we get what we want and give nothing in return so the least thing we could do is like the videos.

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I love your enthusiasm! The human body is truly beautiful and wonderful :)

[@Remorse_Horse]

Haemoglobin and hemoglobin (and heme + haem) are both right, one's the US and and the other is the UK, I forget which way around but that's not the point :)

[@redstrawberries85]

Ok. Out of all the lectures ive listened on youtube. you have the best voice. Thank you for the lecture!

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you deserve a nobel prize. I love you!!! best teacher ever

[@lindasoto8280]

Thanks so much! i comprehend this concept so much more clearer now :D

[@sugarchowchow]

You're such a life-saver. This is a great lecture for my incoming Prelim exam on Hematology :) You explained it way better than my book.

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I enjoy learning and studying about human body as that reminds me how amazing creator is my God 💙

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please come to new york city to teach!!! so clear , simple, fast, easy to understand!!

[@robg938]

Once Hb dumps the O2, there is no oxygen present in the porphyrin moiety. The Hb is now a gun with no "bullets" and needs more bullets. As the empty gun Hb gets into the lung (specifically the alveoli), those empty guns deprived of O2 are now in a zone where there is an overwhelming ABUNDANCE of O2. The empty Hb gun gets reloaded with new bullets.

[@sicarios92]

u did not mention 3rd allosteric inhibitor - bpg and carring on how a fetous gets oxygen from mummy i find it super intresting ;) but to conclude i love the video

[@kimmymanco1]

I feel stupid asking this but I need to ask to finalize and confirm my understanding...My book states..."As cells metabolize glucose and use O2, they release CO2, which increases the PO2 and H+ levels in the capillary blood. Now I think this is what you had talked about when you mentioned that when we are in an acidic environment (high H+ levels), or in the presence of a lot of CO2 then hemoglobin will "dump" its O2. Am I correct on this?

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How amazing human body works ! Who created this creature.

[@snackbob100]

your an inspiration, and your passion is infectious.

[@JanePelcher]

It makes sense now, thank you! So much better than the textbook. :D

[@crvasser]

having a hard time following because it keeps buffering and dont know how to make it stop. Information is exactly what I need to prepare for my exam

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You really are an absolutely remarkable lecturer. Wouldn't you write a book of teaching principles to share with professors and teachers around the world? I think i would fit well with your social goals, too... because you could (a) use the proceeds to add to Khan Academy or (b) give the proceeds to another agency working towards the equitable distribution of knowledge using technology, etc...

[@tbh_thebrand]

I'm here because I want to educate myself because my son has a rare case of korle bu and I want to understand how the blood works and yeah I'm confused as crap but your video was a ton of help.. thanks

[@kimmymanco1]

It goes on to say, "Both declining blood pH (acidosis) and increasing PCO2 weaken the Hb-O2 bond. As a result, oxygen unloading is enhanced where it is most needed."So, my question is, is this because hemoglobin cannot pick-up O2 and CO2 at the same time? It's either one or the other and not both? In other words, if an RBC is dumping O2 than is it picking up CO2? And or if it's picking up O2 then is it's dumping CO2?

[@uniquelyjasminec]

Thanks! Currently studying for a big biology exam and your videos are helping me.

[@imdadullah8691]

Outstanding lecture for biologists and football match commentary for non biologists.

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Y'know, his criticisms of the typical classroom setting are even deeper than mine.

[@sexynica88]

are u a techer>? u should be coz ur very good. ive learned more in ur vids than in class

[@RyanGenX2]

Allosteric Inhibition effect of the acidic enviroment is called "Bohr"-effect and it works the other way around too, meaning alkalic enviroment supports the O2-Binding of Haem(Heme). Anyway, great video as always Sal. You really know how to simplify all these complex knowledge and make it easier to understand without leaving any vital information out. Great Job!

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excellent teacher. thank you for taking time out of your day to better others futures. I think we need more people like you.

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I am currently using your tutorial videos to study for the MCAT. I just want to say thank you for making all this information accessible for all learners out there. You make learning exciting again, just as when we were young.

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hows it goin 10 years later?

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YEAH HOW"S IT GOING DID YOU GRADUATE BRO ARE YOU WORKING AS AN ENGINEER BRO!? TUNE INTO GENZ DUDE!

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PLEASE BE MY TEACHER lol!! No but seriously thank you so much for this! Makes total sense now :)

[@mazitazana1975]

this is soo helpful! THANKS! You know, I've been studying those facts, but this helps to connect the information, to truly understand the mechanism... and not to lose the overview.

[@ELUNE8888]

All I can say after each video is a big THANK YOU !

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still this video is EXTREMELY helpful for us idiots who aren't that good at chemistry

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If you could add languages you'd be the perfect one man school.

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definitely!!!

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excellent excellent , i couldnt understand these concepts with such a clarity in my entire life

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Really... This man is something else❤❤🎉

[@MaH80gd]

Sal Khan, you explain it so well! Thank you.

[@naveenkumartangudu5838]

really a nice talk about hemoglobin,, its a nice way to explain about things.. best explanation i have ever heard before.. thnks... :)

[@edwardhaughney9665]

This is most impressive. It is not just the great info but the great speaking voice that makes watching this video great. Here's to more of the same.

[@antonscottgoustin]

I learned the concept of allostery from my prof at UC Berkeley, the late Dan Koshland, Sr. Unforgettable, clear, and very intriguing concepts!

[@hun7a]

thank you very much... you have help me prepare for my exam your good teacher...

[@greasyclean]

incredible explanation. and ur handwriting is out of this world. thank you so much for this!!

[@erikao517]

you should do a liver video/breakdown of homoglobin :)

[@marinapisaruka8772]

Thank you very much. You are brilliant teacher in the whole world. ..

[@TheSashalea]

Thank you You are really a wonderful Professor. My professor doesn't teach as closed as you do.

[@woodyguthriefan1]

@thie2009 i would say biology but i guess it is also chemistry so biochem would be right. However keep in mind that t is under the playlist or 'subheading' of biology.

[@jcfs123]

You make a difficult topic sound incredibly clear! Thank you.

[@tonfa17]

thank you so much for this. its helped me alot with my bio also there are 54-81 quintillion hemoglobin in our bodies quintillion: a digit with 18 zeros behind it

[@justbored9233]

Oh my gosh!!! *mind blown*😮

[@VampireBloke]

Wow...I feel as if I've just watched some super movie trailer, except that this was hundred times better! Bravo :D

[@daniel32o]

HEMOGLOBIN!!!! Anyone agree it should be a heavy-metal band name?

[@kathleencraigie4703]

I love your videos on LUB DUB and HEART SOUNDS..... I have learned so much from those also... I love everything connected with the heart, blood, and immunity............ Your videos are so interesting and enjoyable... Thank you!!!!

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molto utile, riassuntivo ma esauriente, grazie ancora

[@n2zs2]

Very interesting!

[@helpmefinddewaeallhailtheq3290]

Im 9 i have no idea what hes saying but i love learning

[@osamamaq4971]

on another side, lack of hemoglobin causes anemia which affects 1.62 billion individuals all over the world.

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i love khan... i really do... thank you so much.

[@YersiniaPestisNPO]

too bad my professors can't get off their high horses to explain concepts like you do. Thanks.

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Simple, complete, clear, amazing!

[@sNtheU]

awesome vid I'm M1 student & it really helped me, thanks

[@rem1736]

Is it possible to make these videos play 1.5x? I can do it on most KZbin videos, but not on Khanacademy ones. It would be great for reviewing.

[@christinarodriguez297]

Thank you very much!

[@unchanging-gf8tj]

Let's get it moving. Where there is movement, there is oxygen...

[@trishmaggieful1]

I LOVE all your videos, I owe you my LIFE! lol:) You are amazing, and you have a way of taking really complicated material and breaking it down to be understandable. Wish all teachers knew how to do this:) Keep up the good work and appreciate all videos!!! Ive never seen the "interactive transcript" before that is freakin awesome Im always like, what did he say...and replay it 15 times (which I still do) but that is SO cool. Whenever I have a topic I always look to see if you have a vid on it.

[@MartialBachoffner]

Really cool! More I learn, more I want learn more and more and more...

[@imegatrone]

Nice Video That You Share , So Very Nice Thanks You Hemoglobin and its role in the circulatory system

[@usmansharifmicky]

i found it brilliant, and you are very brilliant as well.

[@TaurielleThe]

you're such a cool, fun teacher. very hard to find

[@ashishmohankhare]

brilliant..brilliant explaination sir..,thank u so much for the video

[@marisolgarcia6580]

Thank you for this Video.!! I was confused on this section but from watching this video I actually love the subject on how Hemoglobin works.. :D yay!! thanks again..

[@flexxking]

Thank you zoo much! You will help me pass my exam at Adelaide University.... Human Bio 1B :D

[@jeremiah160]

BRILLIANT

[@AabbbbA]

Same i find it actually more than brilliant 🤣. Thank you for your video

[@aishafatima8906]

Thanks sal it was really helpful

[@aishluvzme]

hi.This was wonderful!! I totally get it now!!!!! and btw, I was wondering, do you have any lessons on proteins? Meaning, their structure and stuff? Thanks a lot :D

[@riseredeos]

Great Videos. you have certainly found a great calling.

[@AishKurade]

@XshirayukiX Haemoglobin- British Hemoglobin- American :)

[@nouraelzein96]

You make studying really fun!

[@jackbluemusic5417]

This video is simply excellent

[@batumanav]

Just saved my life

[@jintapatchi09]

i think the CO2 bind to the amine group of the amino acids of the Hb. It forms carbaminohemoglobin which has a lower oxygen affinity. Is that what you meant by "unsure of where CO2 binds"?

[@Exploretheexperiece]

Amazing explanation.May Almighty bless you.