How Biologic Medicines Are Made | How It's Made

Unlike traditional drugs synthesized from chemicals, biologic medicines are proteins made from living cells.
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[@breannaraub5647]

I love the narrator's voice, it makes it so easy for me to watch episode after episode

[@mov2937]

Damn, this looks so professional and clean. I love humanity.

[@SofaKingTouge]

I'm starting humera soon. I was joking around with friend saying "it's probably alien semen. NOPE hamster ovaries.

[@Polite_Cat]

I could be wrong but I believe not all biologic medicines are made with hamster cells, sometimes it's other mammals, and I believe Humira actually is made with human cells and no animals, hence the name "HUMira". I think this apparently might lower the chance of allergic reactions. Don't quote me on that though.

[@julianj8609]

@@Polite_Cat It is also made in CHO cells. The medicine doesn’t retain any part of the animal, they are just really good at making proteins.

[@titassiaulys3849]

the HUMira part indicates a fully humanised monoclonal antibody type

[@ajdajenkole5002]

Could have used this last year for my bio assignment....

[@bellabroadhurst2763]

Ajda Jenkole I feel ya

[@SeanPGribbons]

Still no idea how they’re made

[@bmsmedicaltech]

Looks great!

[@jrstation4775]

Fascinating

[@marshmallowpill]

This is the most clean factory I've ever seen

[@angryjoe98]

Thats the idea i work in sterile, manufacturing the pharmaceutical injectable drugs, and we have to sanitize our rooms daily sometimes as many as 6 times a day

[@Tunishasharmaforever.]

You should see factory where microchip processors are made,its like 3x more cleaner than this😅.

[@lancepursuit7055]

Wow that is amazing

[@natural9721]

These comments remind me of my young age as a student in high school with bored students asking so many questions and commenting about the science stuff just to annoy the science teacher. Good times...

[@nesseihtgnay9419]

Now can you tell me how these chemical bonds work?

[@markarca6360]

This hits home when vaccines say, "Vero-Cell".

[@Tunishasharmaforever.]

Science is so amazing🥰🥰🥰.

[@user-in8bz3kd7d]

Bro, have you ever made oxytocin? I'm very curious about this. How is it extracted from the ergot fungus? I really want to extract it myself. Can you teach me?

[@brianrigsby7900]

Incredible what we’re capable of

[@1inchpunisher715]

Facts, human mind is amazing 🙏

[@asyncasync]

Too bad we can't figure out how to actually fix these health issues but we patch them up with things like this.

[@nyannaaung2544]

Everything looks so clean.

[@davidkippy101]

Kinda looks like a futuristic movie

[@aidenk7047]

It’s a biology lab, they all look like this. Plus, it goes in your body so I’d hope so.

[@smellypatel5272]

It has to be sterile. This stuff is ingested and has to serve its purpose. Don't want nasty cellular contamination that might complicate treatments.

[@Quincy8Boy]

Hence, it is made in a "clean room." EU Grade A, B, or C.

[@ronaldsuarez6012]

I will be joining you, Mr.Suarez.

[@jeremywvarietyofviewpoints3104]

This is a very informative video. My only complaint is that the music isn't good.

[@Quincy8Boy]

It's never good. For Canadians, anything above the sound of moose mating is beautiful.

[@kimjuticus]

Ok, since no one else is asking, and google is giving me nothing.... What the heck is Urdaeaneme? I was fascinated by the process, but was left curious about the actual use/application and to what ends.... Couldn't find anything though.

[@kimjuticus]

Just noticed the Lorem Ipsum.....

[@user-vc9ig3pf5y]

I have Just become a Blood donor and IAM still learning more about the ues Of plasmer there are 18 products made from plasmer

[@DiepSpartan119]

I got vaccine for traveling but they costs $98 until the doctor gave me the shot

[@monishsundrani2078]

have been on different biologics since 2013...

[@fahsannnnnn]

cool

[@AddyW8800]

Im not a paranoid person but i get the feeling there was alot left out of this video

[@MooooonDemon]

yep.

[@paigeturner7513]

Freyja you're not the only one.😒Trust me😑

[@jaycowijaya4058]

I believe it is so

[@BIGCATGT1]

They left out the 6 other stages that are known as down stream production. It's mainly filtering out impurities and sanitizing for human use. The process would probably take an hour or more to explain

[@user-ld3tm9mu6u]

Yeah. A whole lot left out

[@HandsupLX]

What are the "other dry ingredients" ?

[@niblet8308]

I'm not exactly sure but I'm assuming it's just other minerals like sodium and stuff

[@azruleinibrahim5692]

For that 'dry ingredients" part, mostly Sodium hydroxide and even that will be use for cleaning and conditioning.

[@jaisonjoseph6540]

Dextrose, acetates etc. There are a lot of solutions necessary for purification.

[@Quincy8Boy]

Buffers for one. Phosphate buffer solution, PBS, is used a lot.

[@angryjoe98]

Im a compounding technician and usually its a buffer solution and other chemicals, used for titration and getting the pH level, correct as well as WFI, which stands for water for injection and API or active pharmaceutical ingredient as well as possibly a preservative of some kind.

[@jnguyen8788]

So they saying I have hamster cells in my body now . Thank you 🐹 hamsters

[@bmc5075]

Has it helped u

[@jnguyen8788]

@@bmc5075 yess 80 percent the loading doses help

[@C1schecter101]

Lol wtf this is just gross …and who’s not to say are body won’t attack such cells 🤦🏻‍♂️🤦🏻‍♂️🤦🏻‍♂️

[@devashishgole4722]

Not the hamster cells but the protein end result which they were designed to synthesis in their cells. Even human insulin is mass produced in similar fashion. But understand that human insulin isn't antigenic to us. Pork or bovine insulin was and hence it was phased out as we learned to make the safer form of insulin.

[@devashishgole4722]

@@C1schecter101 Science is a lot more complex that what you're making it seem like in your head. Understand clearly first rather than making erroneous judgements about anything which involves highly advanced science. Be it biologics or electronics. Thank God we have people around who're invested into studying & researching applied sciences which benefits every human beings who refuse to budge on the science that run their lives

[@bmc5075]

Is this like cimzia

[@ceeaitch11]

Why do they always skip the first step? I wanna fucking see some natural stuff growing in the wild get tweaked and altered into something synthetic

[@gussferretti9665]

It doesn't work like that. That's what they exaggerate on 3d rendering, in reality they use microscopes to play around with a cell and multiply it. They do not know if it works or not. They test on people.

[@gussferretti9665]

Anybody with the right equipment and training can do it.

[@digestiveissue7710]

@@gussferretti9665 I wanna do it, sounds fun

[@ranian7]

Where are the living cells from? Like even generally? Plants? Animals? Humans?

[@mistermr2147]

It really depends, most common is bacteria because they're really cheap, fast and easy to grow (don't need growth factors), but they can struggle to adequately produce large/complex proteins. Yeast are generally similar, lower yields but better able to produce human proteins because they're eukaryotes too, but not perfect. Depending on the drug and conditions it could be something else (like in this video, where they use ovarian hamster cells). Some processes use immortalized human cells (HEK cells are what I'm familiar with if you'd like to google it), which are harder to work with, and potentially be contaminated with human viruses, but are the best for producing complex molecules and have the lowest allergy risk.

[@ellekay1721]

Chinese hamsters ovaries. They purposely left out that process.

[@jiangyongguo]

Hello my friend, may I ask if your company needs anti-cancer drugs- (Including formula, raw materials, semi-finished products)? I am from China.

[@lazydoctorr]

Yes, our company could benefit from such beneficial medical samples. Will this be from your government, or a privatized company? If bulk is available, ready, and consistent then please let us know so we can prepare the necessary documents for you. Thanks, and we look forward to working with you to ensure a better tomorrow for the world!

[@jiangyongguo]

@@lazydoctorr My friend, only our Chinese company has this anti-cancer drug in the world.

[@lazydoctorr]

@@jiangyongguo Yes, I understand, sorry the confusion. I'm saying we'd like to buy. Thanks

[@jiangyongguo]

@@lazydoctorr 祝你新年快乐，龙舞祥云瑞气盈，新春佳节喜相迎。岁月悠悠情更浓，共度时光乐无穷。愿你在新的一年里，事业龙腾虎跃，家庭和睦美满，身体健康长寿，天天开心笑哈哈！

[@lazydoctorr]

@@jiangyongguo can you translate for me on Google, please? Thanks

[@evilflippy753]

Love you Hamsters❤ Thanks for your sacriface im sorry you had to die:(

[@Quincy8Boy]

Only one hamster had to die. The rest of the cells grow on their own ;-)

[@Andrei_Suckoffsky]

These are cell lines. The original hamster is long dead

[@StevenOsburnHollywood]

Two shots cost my insurance just over $7,500 a month.

[@minhaj9802]

Its unbelievables expensive.

[@patrickharris5917]

I think you might want to look into your assurance company man that sounds like they are committing fraud

[@asyncasync]

​@patrickharris5917 or perhaps they are just lucky and dont live in the states

[@ellekay1721]

Didn't exactly start from the beginning. Let's start with the hamster.

[@danishh1385]

Pray for me to take over the world before I die

[@dixiecup6668]

I take humira every week

[@putraadventuras1]

Can you make icecream from it?

[@Nice-xc1yl]

Nro😂😂

[@northenddon]

Would you look at those chemicals lol

[@cheekyoziechick]

Are labs safe these days since the modRNA

[@ElJetzFoo]

17 dislikes are anti-vax moms

[@MistakenMystery]

Yah because giving your new born baby 89 different vaccines straight out of the womb is great! Then these idiots wonder why their baby is allergic to water and hits puberty at age 7. Idiots...

[@scoutadventureshorts572]

Hi

[@spacedust9548]

SUP

[@diegohernandez7258]

Hey how was your day

[@LatabaiKdam-tj3mz]

1 n omsairam omsairam omsairam omsairam omsairam omsairam omsairam omsairam

[@potatomajesty5255]

You guys post so late at noght

[@decentdude1086]

Potato Majesty move to America

[@infomovids2990]

Noght?

[@LiveYourLifeWithJoy]

If this was 12h ago, then it was lunch time in my country

[@Mr3344555]

@potato majesty, we're just 7 billion degenerates who are here to inconvenience you. It's not like time zones are a thing ;)

[@edgarcardenas837]

$#nasa harcode

[@seandonovan8915]

Well looks whos not as smart as they thought!These people are very smart

[@pasteur_datualijameelpinag2853]

Hello

[@infomovids2990]

Hi fatty

[@rteyuertutwtryhwhuwtghswxz5890]

@@infomovids2990 GOT EM

[@doniyorrustamov996]

Biiiiiiigggg Monopoly

[@chrovos4959]

3

[@sanamchauhan]

First tell where is your full episode on Ram Setu ??? Or you just posted the trailer for more Indian Subscribers ??

[@TheRBW62]

I want my bios grown on Weed Dudes...then I know its OK. Peace

[@SKRUBL0RD]

so that's how covid was made

[@shubhammittal3561]

Practical knowledge.. Self practical training done is must.... Be real be practical..... Sports games fun enjoyment love sex lust etc are must always.. Self work self interests self style are must always...

[@samataroy9636]

bad

[@C1schecter101]

Made in china from hampered lofl the irony 🤦🏻‍♂️😂😂😂 seriously not tryin be a hamster in your weird experiment 🧪

[@rexsexson5349]

Wow😮