Making an old pain and fever medication

[@SimonBoshoff]

Love your work! How about doing an "end of the world"-medicines series. You know.. how to make 5 or so of the most basic medicines.

[@NileRed]

Interesting idea. Ill keep it in mind

[@benjaminjernfors]

NileRed I would totally subscribe if you did that

[@SimonBoshoff]

NileRed maybe the antibiotic Augmentin ?

[@bjornlindberg9779]

Yes something like that, medicines you can make at home when everything gone to s**t, the prepper version kind of.

[@SimonBoshoff]

how about a local anesthetic from picric acid, which can be synthesised from asprin, H2SO4 and KNO3

[@kalolord]

Just a heads up for when you make para red: I've made it twice in the lab, and it is a VERY STRONG dye! It stains everything, expect yourself to be scrubbing your equipment for weeks after making it.

[@supercool1312]

Dániel Kalocsai Is there not something you can do to stop it staining (maybe covering the glass in some kind of plastic film?) or weaken it

[@kalolord]

@@supercool1312 Well, it might work, but I've never done such a thing nor have I've seen anyone do that... Plastic labware exists though, so it might be worth a shot. If you don't use glassware that has joints, the stain is manageable too. Glazed ceramics work decent too in my experience (Büchner funnel). Most important: do not use glass filters, they are immediately ruined.

[@nicholashodges201]

What about coating your equipment with water glass? It's actually glass in a solution that forms a fairly impermeable film that can be flaked off later

[@kalolord]

@@nicholashodges201 Never tried it or heard about anyone trying it.

[@nicholashodges201]

@@kalolord it's old, pretty sure nilered has has a video on it. It's was used to created barriers on cloth leather & other materials until plastic coatings became a thing. You can make it w lye & desiccant GEL (it's gotta be the silica based stuff)

[@KnolltopFarms]

You know...half of the enjoyment I receive from your videos comes from the thought that you are really enjoying yourself on screen...or more precisely, on mic. You also have a great tone and syllabic tempo, so it adds to the easy enjoyment, thank you. Your average farmer.

[@NileRed]

+Knolltop Farms thanks, I really appreciate that!

[@NOTZeroBlank]

The other half?

[@ShiNoNaiHasu]

@@NOTZeroBlank learning i guess

[@madkirk7431]

Well, if he didn't like doing this he wouldn't do this.

[@KidPrarchord95]

@@madkirk7431 Is that true, though? It's gotta at least be worth the money.

[@vanhetgoor]

When I see you explaining and showing us how it is done, I get more respect for the chemists from one hundred years ago, who did all this work without modern equipment. Maybe they had a bunsen-burner, a thermometer and a scale. And a good set of brains of course!

[@origamigek]

And the funny part is that after a million hours of work, boiling and roasting a billion gallons of urine, to isolate phosphorus, which is insanely cool, they try to use it to turn base metals into gold.

[@CS_Mango]

Well they actually had a lot of stuff that's used nowadays back then.

[@karvast5726]

Eh,they probably had quite elaborate lab equipement already just not stuff like hot plates and magnetic stirring

[@aayushpaswan2941]

about mpemba effect:- kzbin.info/www/bejne/j3rWZKeeZZaBjJI

[@jordanwitte]

@@karvast5726 Minus NMR, MS, hplc, GC, IR, and every other piece of modern instrumentation that is required for modern drug synthesis

[@Obi-Wan_Kenobi]

I am very thankful for the modern medicine that exists today being both invented and easy to access. Thanks to them, my life is so much safer compared to the billions of humans who lived before me and I am incredibly grateful.

[@polyrhythmnix9723]

It still isn't advanced enough to give Anakin his legs back after you left him to burn on that lava planet, you freakin psychopath.

[@TheGlitch93]

Master kenobi...

[@joschiringeis9863]

Me to 👍

[@Helena-me6mp]

GENERAL KENOBI! *coughs*

[@anakinskinwalker1724]

Say that to Anakin who LIVES off of medicine

[@erikdimitrov8140]

Finally some complicated organic synthesis again. I started getting a little bit bored from these extractions. Please do more videos like this one.

[@Kentainmb]

erik dimitrov helll yeah. His explanation of how he manipulated the equilibrium through the aniline rxn with acetic anhydride was on point

[@NileRed]

ha thanks

[@K0ester]

Agree, I love these videos.

[@FourTwentyMagic]

Hardly a complicated synthesis, but interesting nonetheless!

[@aayushpaswan2941]

about mpemba effect:- kzbin.info/www/bejne/j3rWZKeeZZaBjJI

[@cbjonsey5785]

when i saw the title i was like “ohhhhh, he’s talking about heroine”

[@jonjordan5871]

I wonder if it is possible to synthesize it completely synthetic without the normal precursors because I know its semi synthetic opioid. Not looking for a recipe just curious lol. (Take it easy on me I dont have extensive chemistry knowledge.)

[@jonjordan5871]

Also if its not possible to make synthetically made opiates an explanation would be pretty cool.

[@baconpantsable]

I thought he was making crack

[@mchagnon7]

@@jonjordan5871 Krokadil is basically exactly that.

[@jonjordan5871]

@@mchagnon7 that uses codeine in the synthesis if I’m not mistaken?

[@bbgallant6257]

Thanks!

[@sussybaka4200]

Damn son

[@carterplasek498]

I love these organic synthesis videos, thank you for the great content!

[@nr1NPC]

"Kalle and CO" So Swedish name lol

[@elitearbor]

Those are absolutely gorgeous crystals. Chemistry can be so aesthetically pleasing at times!

[@pacificcoastpiper3949]

Definitely

[@MetallicAGirl14]

Does anyone else have absolutely no knowledge in chemistry but love watching these videos? Nile could just make something that a child could make but I’d be impressed 😂

[@BrunoDantasS.5655]

Me before knowing NileRed: "And i HATE Chemistry" Me after knowing NileRed: "And i LOVE Chemistry"

[@toxikspeaks689]

Nilered, Thank you for the videos that you make, as someone who started chemistry about a year ago and has been teaching myself as of recent, these videos are very helpful. i find medicines in general to be incredibly interesting and i love how right off the bat i learned something i didnt know. I have some knowledge of old medicines but not near the knowledge it seems you have. Keep up the amazing work, you are an inspiration. don't worry though, im going back to school here soon to finish the degree.

[@the12nina]

If your reaction is carried out in acidic conditions you could purify your aniline with activated charcoal. I find doing vacuum distillations very boring and time demanding. I love your Channel! Please keep it up!!!

[@gavinli1368]

Huh. Acetanilide. I vaguely recognize that from Dr. Stone. It was one of Senku’s intermediary steps into making sulfanilamide to cure pneumonia in a stone age tech world.

[@gonzalobertomeu2938]

I came to the coment section only to see if someone have realized too XD, I've used the ctr+f to find stone and here it is

[@rogvirstormblade9803]

your videos are what made me want to follow a career in chemistry, just finished my first semester of college on the path to becoming a chemical engineer. thank you

[@GreenFanBoy]

How is your path to chemistry doing?

[@AnUnknownPlayer.]

@@GreenFanBoy i suspect they’re probably still in college.

[@puss404]

How you doing bro? Everything is okay?

[@Lostpanda123]

Great video as always! Love that you take your time and go through the mechanisms!!

[@ColinRies]

I think that Doug's Lab Acetic Anhydride method is pretty cool, but really dangerous and requires some specialized apparatus. The classic Acetyl Chloride (can be easily bought here) and Sodium Acetate method is much easier to do. Nice video anyway, I always wonder how you (and NurdRage, ChemPlayer, Doug's Lab,...) come up with such projects. Speaking of Para Red, got any plans to make actual Nile Red? I ask because Nile Red is a really cool dye with very interesting properties.

[@NileRed]

+Colin Ries I will make it. Both para red and Nile red need 2-naphthol, which I just bought

[@ColinRies]

Nice :) Looking forward to the video. Got any literature for me where I could read about the synthesis and maybe try myself? I really want to have some.

[@GogiRegion]

(+Colin Ries) Why would you regulate acetic anhydride but not acetyl chloride?! The reason they regulate acetic anhydride is because of heroin, which can be made just as easily with acetyl chloride. The only difference is that acetyl chloride is more dangerous.

[@RockyMountainBlades]

It’s just interesting how the first people to come up with involved reactions like this one were just like “woah i created some crazy chemical looking thing, i wonder if i can use it as a pain medication?”

[@TheNerogarden]

"Bob? Are you okay? Damn... This one is also poisonous... oh well, next"

[@RockyMountainBlades]

@@TheNerogarden lol

[@BLODSWIPER]

Would be cool to see you try and make medicine made out of raw herbs / plants.

[@Mark_nobody3]

To do that, you have to extract the herbs compound by drying and crushing it into powder then mixing it with other components that gives the effects you need for a medicine, also another option is freeze drying and making it into a pill

[@skinwalker69420]

That's alchemy, which is an outdated method of pseudoscience.

[@BLODSWIPER]

@@skinwalker69420 Yeah but it would be cool to see him extract certain properties from plants and make medicine/vitamin supplement out of it.

[@MsPegasus1001]

@@skinwalker69420 outdated medicine is still medicine and it is not pseudoscience its original science. Big pharma coined everything they couldn't profit from as pseudo to monopolize on medicine, Dandelions still treat stomach problems, appendicitis, and breast problems, such as inflammation or lack of milk flow, fever, boils, eye problems, diabetes, and diarrhea. Then they demonized dandelions because there was no way to compete with such a versatile plant so they said it was a noxious weed that was useless when in fact it is a wonderful plant to keep. Stop spreading bs about things you have no clue about!

[@MsPegasus1001]

You can make your own medicine at home. Elderberry cough syrup 1lb ripe Elderberries washed. Then into a metal saucepan, add 1/4 cup water quick boil, then simmer add 3 to 4 aniseeds, two or three large Apple peels just the peels, 1/4 cup mint leaves and stems and reduce to half. Strain out liquid make sure no Elderberry seeds remain. Return to clean sauce pan and continue to simmer; add 1 cup honey, keep the heat low, and stir. Add honey or sugar until syrup consistency. Put into mason jars and refrigerate will keep for 3 to 4 months in the fridge during the winter. 1 tablespoon for adults 1 teaspoon for children under 5 Elderberries are to never be eaten raw but cooked with no seeds is delicious. The elderberry juice will stain anything it touches, and find a nursery that carries elderberries if you don't know how to identify them. My children prefer this over store-bought, and it kicks the butt of everything from a common cold to the flu.

[@gigglysamentz2021]

Waaah, you even rinse the glass rod, that's dedication to yield XD

[@renanocsso]

wow, next couple of months? This must be really a lot of work, and lots of studies. Great videos, you really teaches stuff. I can't wait to see the next one. Good work!!

[@nicholi8933]

I love precipitate crashes. They are a lot of fun when it works correctly.

[@Reth_Hard]

Still waiting for this LSD synthesis video...

[@AhmetOzdemir-om3bj]

Reth Tard Not really possible in his lab.He would need more specilised equipment.

[@humr2346]

Good luck with purchasing lysergic acid :D

[@icedawggg]

@@humr2346 it's easy I do it all the time 🤪

[@mediahighlights-r1w]

@@AhmetOzdemir-om3bj Equipment is easy, precursors aren't. Unless you're talking total synthesis, which would be a massive pain in the ass...

[@melzkunlod8380]

@@mediahighlights-r1w even meth precursor is only a cough medicine.

[@manyshnooks]

Acetic anhydride is restricted as it's the final step in diamorph (aka heroin) manufacture - acetylation. However by restricting the chemical clan chemists switched to using glacial and the MAM produced so called "black tar" heroin, which while less refined, was actually higher potency (and worse for users that didn't use wheel filters or check pH)

[@cellogirl11rw55]

That's very interesting. I am severely allergic to sulfa drugs, but not to acetaminophen, which is also based on acetaldehyde.

[@cromowarrior7308]

Hey! FIrst of all, know that I'm going to watch every one of your videos, and have already seen many of them! I love them and thank you for all the nice reaction you show us :D Just wanted to add a little tought here, you could have made a saturated solution with acetanilide and dump in the best looking ones like you made with the lead sugar one :) I wonder how could they look like! p.s.(Lately I've always chosen your videos as my multimedial substrate to relay on when I smoke a good bong it somehow resembles your glassware) Ciao!

[@JoseChavez-tu8ne]

Same but w a rig

[@ancient7716]

Awesome! I would love to see more pharmacology related videos like this

[@TheLuluTV]

Hey, i know this Video is kinda old but i am currently binge watching all your Videos. And i just found that the Antifebrin canister you showed was produced by kalle & co in biebrich, germany. Which is in my direkt neighborhood and still exists to this Date! When it was produced biebrich was still a separate City but has been integrated as a suburb of Wiesbaden. Best wishes from germany. Keep up your awesome work and stay healthy and safe!

[@lukegamerdonkey6663]

what an awesome comment! cant believe he didn't even reply to you 🤷‍♂️👍

[@Capibapi1]

Am

[@mariogiunta1989]

@@lukegamerdonkey6663 it's a 4 year old video, it wouldn't surprise me if he hasn't opened this video up in years.

[@MLife1000]

This channel is so interesting and the videos and explanations help make it easy to understand. I’m glad I subscribed to this channel a few years ago.

[@brittneyknopp2473]

I would love to see a “how fast can I say” or “how to pronounce” video about methemoglobinemia and other long science and chemical names :)

[@GreenFanBoy]

*looks at Titin *

[@RAM-jg7ez]

Isn't it just fitting ,that youtube gave me an ad about a medicine against pain and fever, in a video about making a medicine against pain and fever...

[@MrCat-fy7bz]

I don't understand any chemistry but i still find your videos so interesting

[@clarsach29]

Three-way cow adapter. Never was there a gadget so well-named and yet so tragically under-used. It should take pride of place in your videos on lactose degradation and casein isolation.

[@manyshnooks]

Chloral hydrate would be a good one. I know it's available dirt cheap from Aldrich by the kilogram, but it's an easy and interesting synthesis.

[@faisalhamid1421]

This has brings out my school nostalgia ,we used to go our chemistry lab for preparation of parectamol ...

[@holdinmcgroin8639]

What medicine do you suggest for someone who is tired of the pains of life?

[@cdawson198600]

Holdin McGroin a dose of get over it works for those willing to take it.

[@truephysics2835]

*NaCN*

[@flapdrol4771]

C2H5OH

[@GraydonTreude]

a 9mm applied directly to the head

[@ryderlancewilson760]

Holdin McGroin 1 kg of C17H21NO4

[@grugg3108]

Looking up the restriction of Acetic Anhydride, I found two main reason for it's restriction. The largest of the two is that it is used to manufacture heroin. The more minor, yet still somewhat prevelant reason is that it could also be used to manufacture explosives.

[@StefanNoack]

I am watching this while suffering from pain and fever.

[@tyrellrivera]

😂😂😂😂

[@shawnorthrop2009]

Second bullet, second word of Phenacetin's side-effects. Once you see it, you can't unsee it. Love the vids

[@fetusenchilada]

can you please do a video of either producing or extracting of Safranal. Safranal is contained in saffron,fig leafs,wolf berry,cumin seed, elderberry and lemon. but i would much the see the synthesis of Safranal.

[@UC235]

Aniline (crude or otherwise) is conveniently and effectively dried by allowing it to stand over solid KOH.

[@ryderlancewilson760]

Hi, can you make some menthol crystals? For house perfume

[@trychan959]

Uvuvwevwevwe Onyetenyevwe Ugwemubwem Ossas its osas ffs

[@dascorncakes1151]

yes please do this, I thought menthol was a dumb name for meth but no, it's actually a cool smelling minty crystal thing that you can buy online easily.

[@ryderlancewilson760]

Joshua Sorrenti Yes, i put 2-3 crystals on a hot coal and they makes a lot of smoke, the smoke smells so good and the house smells like mint for hours! :) (sorry for my bad english but i'm italian)

[@patuszodi7532]

i just read on wiki the other day that the vast majority of menthol used in our tobacco and foodstuffs is chemically synthesized (rather than extracted from naturally occurring sources). it's cheaper economically and environmentally to just make the stuff. i'd like to watch a video of its synthesis.

[@gigglysamentz2021]

Menthol is chiral (as in 8 different forms chiral...), so I assume it would be pretty difficult to make in an amateur lab.

[@MrLorenzo190]

Mmm now supporting my favourite KZbinr. A proud moment

[@TheChemicalWorkshop]

we can't get acetic anhydride in Germany...making it is quite dangerous but we will do it... also i'm wondering whatever Dough's Lab ist still alive? we haven't seen videos from hin for a looong time...

[@196Stefan2]

I know! But you can either buy acetylchloride and anhydrous sodium acetate, or (for another way), glacial acetic acid and phosphorous tribromide (and sodium acetate). Unfortunately acetylchloride and PBr3 are quite expensive.

[@tobinator680]

Another very OTC way albeit a very dangerous one would be a ketene lamp like in Dougs video. Although I would use a second scrubber with acetic acid and would burn the Methane and with the it any leftover ketene.

[@SS-ut6zm]

"Today I am making an old pain and fever medication. Heroin."

[@liamdertinger5705]

Here is a google mini series idea, try to synthesis all of the main sugars found in human life, (glucose, fructose, lactose, cellulose, ect). Try them and compare their flavours and sweetness levels.

[@GoTurbo]

Cellulose is a polysaccharide so will be absolutely tasteless. The other ones would be interesting though.

[@realityshotgun]

@@GoTurbo cellulose is actually very slightly sweet. I have tasted it.

[@GoTurbo]

Cellulose is completely tasteless, but would be theoretically sweet if in contact with cellulases which hydrolyse glycosidic bonds, releasing the individual monomers. Or, there could be contamination with other sugars.

[@klauskarlkraus]

Sugar is sugar. Your body don't care 🤷‍♂️

[@karygreene471]

One of the coolest things I have ever watched.

[@kaviaari]

Nice work. There's a missing curved arrow in the 1,2-attack at 8:13

[@NileRed]

+kaviaari oh no :(

[@manueldeubler1127]

Yout get the like for the crystallization. So satisfying.

[@poppyrendall847]

I did not know paracetamol can effect asthma, that would have been good to know o_O

[@NileRed]

+Poppy Rendall I think it's mostly in kids though.

[@poppyrendall847]

Ahh ok, I'm only 19 so that would explain a bit xD

[@ger128]

I was excited to see you use the "cow adapter" you had previously mentioned in your benzaldehyde from almond oil video

[@LaraSchilling]

NileRed! I got into uni for Medicinal Chemistry, actually going to be an educated drug cook!

[@amodernalchemist432]

Lemme know when I can place an order.....hehehehe

[@LaraSchilling]

@@amodernalchemist432 oh damn, bad news, yo. I dropped out :(

[@saintt9044]

Lara Schilling what a twist lmao. I just happened upon this comment thread

[@LaraSchilling]

@@saintt9044 Yeah, it was a hard decision, but I couldn't keep up with the academic rat race. If I had actually stayed enrolled at the start of lockdown, I'd have been able to attend classes from home, but they couldn't offer that when I needed them because nobody cares about disabled students having access until a pandemic hits and affects the ableds. LOL.

[@monkebrainedfish3130]

Plot twist:He was hired by Gus Fring to produce some nice crystals for research porpuses of course and this video is just Nile flexing

[@TheTaylorhorton]

Sulfanilamide from acetanilide? Getting some Doctor Stone vibes.

[@gavinli1368]

I was looking for one of these comments. I knew I couldn’t be the only Dr. Stone fan watching this video.

[@kevinbyrne4538]

Sulfanilamide ! A dream come true ! I've been waiting soooo long for some KZbinr to make it. P.S. We should collect contributions to buy you one of those gadgets for measuring melting points.

[@Adam-wl8wn]

This never got made.

[@normalhuman9878]

Honestly I was kinda expecting something illegal

[@stevetobias4890]

Very cool video. You inspire me to study chemistry and improve my understanding of different substances.

[@SWTH71]

Next video how to isolate THC please?

[@blixtm.]

Weird how youtube recommended me this as soon I get a cold

[@theramblingbrit4431]

This is probably a stupid question, but if you're adding it to water anyway, why can't you use the Aniline that was distilled with some water?

[@NileRed]

+The Rambling Brit I definitely could have. It's more to not taint my aniline supply. I probably should hav just used the wet aniline and then added whatever the difference I was to make it up to 20g. Oh well, I already have more than I'll probably ever use

[@thesemenwar5008]

The Rambling Brit If you know the initial concentrations you can calculate the theorical yield more accurately. He dosen't know how much water was in there, so maybe is because of that.

[@irnistarfirix]

As part of our pharmacy course we made acetanilide in the lab along with aspirin, benzanilide and a lot of other drugs

[@DeltaMezzo]

Making Minecraft potion in real life

[@AtlasReburdened]

Awww maaaan. Doug's Lab... That hit me right in the feels. I miss his videos. Chem Player too. KZbin is such a bastard for kicking Chem Player.

[@lenagaaa]

This is so spooky KZbin recommended after this was my unknown in Orgo lab 🤔

[@ameftowriter1319]

You probably don't know, but your experiment reminds me a manga series called Dr. Stone where the main character has actually made that and even Sulfanilimide in its early chapters.

[@Hellcommander245]

Do a video on how to make lysergic acid diethylamide.

[@deplorableamerican9451]

Mr. Krabs That's illegal.

[@justinpatterson7700]

And? it'll probably get a few views before taken down and nile arrested.

[@ballboys607]

Mr. Krabs he's explicitly stated he won't ever do that in his methylamine video... this is just obnoxious.

[@BeepingSheep]

Social stigma and legality issues aside, a full synthesis of something as difficult as a lysergamide would be incredibly educational.

[@Hopee667]

you are so amazingly brilliant your videos always blow my mind 🤯 thank you for doing everything safely too ♥️

[@bjornlindberg9779]

Hello Nile, thanks for another awesome video. I have a question, I see that you use stir bars a lot. I assume that a stir bar must be highly nonreactive with almost everything it comes in contact with. So what are they made of? Could you make some of that stuff? Also, what, if anything, would break it down? Thanks / Björn

[@qwertyTRiG]

Björn Lindberg He describes it as a glass rod.

[@KallePihlajasaari]

The magnetic stir-bars are usually coated with high grade PTFE (Teflon). The the stirring rods are usually glass rods with flame rounded ends, PTFE rods or sometimes chemically resistant polypropylene (Nalgene) rods.

[@josecqneto]

This is so much more efficient than the one that I did in the lab!! Thanks for doing awesome videos!

[@Flor2Easy]

Can you do my exams please?

[@NileRed]

Sure. Ill fail anything you want me to

[@CAoffRoading]

NileRed nice... totally Savage.

[@Flor2Easy]

^_^

[@DavidGreybeard]

Thanks for bumping Doug's Lab. He hasn't uploaded in a hot minute.

[@ashleyferris5749]

hey I love your videos and want to know if in the future you can do a kids friendly chemistry video, like how to grow your own Crystals. I always like doing home science things with my niece and nephew and would like to get them into basic chemistry.

[@JonathanKayne]

I would love to see you make sulfanilamide since it's referenced in anime like Dr stone.

[@Sauce787]

I wish there was a chemistry channel like this that would focus on the chemistry behind psychoactive molecules, and would do demonstrations making tryptamines and phenethylamines.

[@NileRed]

+Sauce Boy i would do it if it weren't illegal

[@Sauce787]

NileRed I understand that, and will work use as much research and information as I can get from reliable sources such as PIHKAL, TIHKAL and online forums. Keep up the good work though.

[@HidekiShinichi]

NileRed texhnically you could do that as long as your ingridients would be legal. you would need to make it, film it, destroy the results somehow so that you wont have illegal substance, post fil and say that you make it on a boat in a piece of ocean that does not belong to anyone/ is part of country that does not ban those stuff

[@Sauce787]

Hideki Shinichi Lol, it's easier just to make legal analogs or pro drugs for the illegal compounds. That way you can demonstrate the general chemistry without breaking the laws. Main problem however is that to do that you would still need to obtain many watched and regulated chemicals and precursors.

[@HidekiShinichi]

Sauce Boy yeah but its not the same

[@clayrush5576]

I work at a museum and we have cough syrup that is made from alcohol, Cannabis Indica, chloroform and Morphia, sulf. It also says "skillfully combined with a number of other ingredients

[@jumpierwolf]

Acetic anhydride is restricted due to its use in converting morphine to heroin

[@AsmodeusMictian]

The answer to the question I didn't want to ask! Thank you!

[@briancarter3704]

Their both alright as long as they got legs

[@alexeysaranchev6118]

"Old fever and pain medication" I thought my boy was about to make some heroin

[@FrugalGarden]

Please make caffeine with coffee and carbon dioxide

[@AlldaylongRock]

i guess he doesnt have the equipment to do that, he will make it from theobromine maybe( since we have the theobromine extract vid) and he has Me-I on stock, maybe that is a way

[@DrakkarCalethiel]

Jorge M I think he even said he will synthesise the caffeine from scratch. (I think it was in the caffeine extraction from greentea) The theobromine and methyl-iodine reaction is the most simple and the good thing is he has everything.

[@origamigek]

KZbin: Applied Science - Extracting caffeine with supercritical CO2

[@polyjohn3425]

+ᴠᴧᴨᴛᴧᴃᴌᴧcᴋ Wow, that's a lot simpler than I would've expected.

[@mhxybeats653]

Nile calling back to his college days with the way he was cutting that powder

[@goodfeller2]

Where in the hell did you get that acetic anhydride?

[@GogiRegion]

(+Mitchell G) Make acetyl chloride if you really want to (it’s more reactive and dangerous, but that also means it works just as well if not better).

[@DrGreerIsRight]

Hey @Nilered . You're my favorite KZbin person. Your videos are amazing. Love ya. Bye

[@Moritz_X50-4]

Can you do some Uranium chemistry?

[@BFGUITAR]

Cool video! But there is a problem with your mechanism at 8:30. Never propose an oxygen with a negative charge under acidic conditions! The acetic anhydride is likely activated by the acid.

[@vidi00]

do you know how to make xans and lsd?

[@hatednyc]

12:35 looks so familiar 😵‍💫

[@silentassassins47]

be careful man, if u start teaching ppl to make medicine free.. ur gonna have a hard time...

[@ethelv3]

Finally gonna watch this video after it’s been in my KZbin suggested for a week

[@reeven1721]

"I don't have much to say about this, I just thought the close-up was kind of cool".

[@Nikioko]

Acetanilide is a prodrug of paracetamol which is formed by p-hydroxylation. Likewise, phenacetin is also a prodrug, forming paracetamol by ether splitting.

[@jackrabbit8255]

I wish you conducted a melting point test to verify the recrystallized product’s purity.

[@elnombre91]

According to the laboratory chemical purification bible that no synthetic chemist should be without, the colouration of aged aniline samples is due to sulfur-containing impurities, which can be removed by stirring over SnCl2. Never tried it though, I've always just used distillation.

[@NileRed]

+Rob Newland hmm I never heard that before

[@elnombre91]

Yeah, can't say I've tried it. I guess it makes sense as nitrobenzene isn't strongly coloured and I'd hope a large amount of diazobenzene compounds wouldn't be formed. Reference: books.google.co.uk

[@supercool1312]

do a series where you turn 1 basic household substance into another

[@5tarr_zer0]

not me watching this while crying madly in the dark bc my relationship with my parents has fallen apart again and my meds arent working anymore lmao

[@bouncydachon]

Ah yes a youtube video on making drugs! My favorite!

[@em-eois3228]

this was pretty interesting even if i couldn't understand a lot of it. im not even in a class or anything, it just was on my fyp

[@tijlaerts]

10:20 why do you add an extra 100ml of water? thought you should only add as much as needed to dissolve all to get the highest yield possible

[@FarhanAmin1994]

If he didn't add that extra 100 mL, the rate of precipitation would be very high and that way one can end up with impure precipitates. With a slower rate of precipitation, one ends up with fine crystals, which are purer and easier to dry.

[@rileylaveck8017]

I thank you for helping me fall asleep

[@ignilc]

this guys got some serious ass GLASSWARE

[@drmoss_ca]

I know, it's splitting hairs, but penicillin was the first antibiotic as it is a substance produced naturally by an organism (penicillium mold). Sulfonamides are not technically antibiotics because they are man-made and not produced by a micro-organism. And yes, to muddy the waters, the vast majority of modern antibiotics are semi-synthetic, in which a naturally occurring penicillin or cephalosporin, for example, is modified to give it new properties.