How Creatine is Disrupting a 2 Billion Dollar Anxiety & Depression Market | Dr. Darren Candow

[@sarahhope6315]

So fun fact.. I suffered a brain injury from septicemia meningitis.. doctors wanted me on big pharma, meds.. I found a study from the Ukraine about treating sever mental illness by using creatine.. needless to say, I went that latter route.. I honestly never felt better and ended up recovering 100% and then some.... Just a thought for someone experiencing brain health illness.

[@cynthiaycamiify]

which one did you use may I ask?

[@sarahhope6315]

I honestly can't remember the exact name. It was just a pure raw creatine, with no additives. A basic blue and white container. I'm sorry I'm not much help for your question.

[@bensugden1586]

​@@cynthiaycamiifymonohydrate is the best and cheapest, no need to get certain types

[@cynthiaycamiify]

Thanks for replying.

[@paulevans2246]

@sarahope6315 how many grams per day did you take and for how long? 🙏

[@whatsyourthing]

After taking SSRI’s for more than 6 years, I began taking 5g of creatine daily. Along with regular exercise I was able to taper off the SSRI’s, thank goodness. The combination of creatine & exercise have transformed my life.

[@whatsyourthing]

@@jaymorrison5895 I did it gradually over 6 weeks but I was only on 50mg. If you’re on a higher dose I suggest doing it over a longer period of time in gradual increments. You might have days where you have a little wobble but trust yourself. Wishing you lots of luck.

[@luismiguel69able]

How do you know it was the creatine vs the excercise?

[@whatsyourthing]

@@luismiguel69able it’s a combination of both. I wouldn’t just give up the exercise and take creatine.

[@julies570]

​@@jaymorrison5895how did zoloft help you?

[@julies570]

@whatsyourthing that's really great, please tell me more ?

[@poetryandhiking]

I had a severe concussion this year. For a month after I stuggled to exercise, even walk, although my body wasn’t injured besides my head. I had trouble concentrating or reading. I would get very dizzy while driving so I had to stop. I read about creatine for people with traumatic brain injury and started taking it. Within 24 hours all of those symptoms disappeared. I started exercising and driving again. It was very dramatic how quickly it worked.

[@untamedwildhorse]

Wow, that is amazing. Thanks for sharing your story.

[@BillyPilgrim70]

Best placebo effect EVER!!!!! It takes weeks to months for creatine to accumulate in the brain. Watch the video.

[@albertadlg]

​@BillyPilgrim70 As per studies yet! My son has ADHD and uses creatine and also showed benefits in a much shorter time span than suggested:)

[@saikatghosh90]

I had 4 brain haemorrhages, after discharge from hospital i started taking creatine and collagen. Then found it may impact kidney. Then the sleeping disorders started , gone back to doctors, they put me on antidepressants. Then it was a disaster. Did some yoga mudras and started collagen and creatine, now feeling somewhat normal.

[@saikatghosh90]

I had 4 brain haemorrhages, after discharge from hospital i started taking creatine and collagen. Then found it may impact kidney. Then the sleeping disorders started , gone back to doctors, they put me on antidepressants. Then it was a disaster. Did some yoga mudras and started collagen and creatine, now feeling somewhat normal. How many haemorrhages you had ?

[@thatrandomgurl5238]

Creatine is the truth!!!!!! Oh my goodness,. I realized the effects of it unintentionally. I was simply taking it for strength benefits and realized my depression and anxiety/ my memory significantly improved. It was so weird! I had no clue what was happening or the reason for this improvement until I stopped taking it and my depression restarted and the light bulb went off! I’m happy it happened in this order because I know for a fact it works!

[@BlackSeedOil20]

Thanks for sharing your experience.

[@vincemarshall8550]

Is there any downside adverse effects?

[@Ndfourlife]

How many grams are you taking?

[@julies570]

@@thatrandomgurl5238 Are you on any anti depressants as well as the creatine? Asking because I am and want to try creatine at the same time

[@Natraj_Chaturvedi]

Its probably very individual like many things in suplementation are. I used to take creatine regularly for hypertrophy and didnt quite notice any mental benefits but later when I was off it, I re felt had more clarity and focus with regards to things like diet, discipline to sleep on time etc when on creatine.

[@HeyCoalCat]

I have taken creatine on occasion on and off for 30 years. I typically take 2 to 3 g a day. When I take it, I notice a cognitive and overall energy improvement.

[@maxinemoo6972]

What kind do you take?

[@lizmona9679]

Could you please tell us what kind of creatine you take? Thank you :)

[@robinbreeds9217]

@@lizmona9679 monohydrate

[@HeyCoalCat]

@@maxinemoo6972 monohydrate

[@HeyCoalCat]

I take it every other day or so

[@lindar8095]

I was misdiagnosed when I spoke with my doc about depression and anxiety! It was just not eating enough healthy foods and all the processed foods in the stores I was thinking it was healthy for me!! I just eat meat fish and vegetables and have completely stopped eating anything else!! Also pineapple everyday ! Fruits are good but I limit the amount of. I have so much clarity and have noticed a complete difference in my mood and energy levels!

[@William.Driscoll]

Thank you.

[@anastasiavila5284]

That's amazing! Makes you wonder how many other people are in your exact same situation, but haven't figured out that diet is at the root of it...

[@yoeyyoey8937]

@@anastasiavila5284probably most

[@yoeyyoey8937]

Diet is king

[@HeyCoalCat]

Get your vitamin D checked, it's responsible for regulating your autonomic nervous system if it's low you'll likely be sympathetic dominant which is fight or flight. You want to be parasympathetic. Low vitamin D can also cause a host of other vitamin and mineral deficiencies that cannot be resolved until the levels of vitamin D are optimal

[@charleslapresse2177]

I have just recently started taking creatine to get to a higher training level. I'm 47 and already in good shape, I train regularly and eat healthy food daily (staying away from refined sugar and alcohol). After a week of taking 5g/day (no loading phase), I have noticed a change in my response towards certain tasks at work. I feel more focused and calm. I also have noticed a significant change/upgrade in my general humour and memory. I was only expecting muscular upgrade, so I'm glad for the extra benefits.

[@otterconnor942]

I've been taking creatine every work day for over a year, and I feel better. I feel better hydrated, I feel more awake, and I feel less stressed and depressed.

[@BlackSeedOil20]

Does it help staying hydrated?

[@otterconnor942]

It helps with getting water to where it's needed.

[@hobologna]

i'm a grill cook and work in crazy heat, after a morning at the gym, school, and freelance marketing/photography. I am typically miserable behind the massive grill there, and I pick up the slack because I want to leave that hell as soon as possible. I typically start to resent lazy coworkers and get pissed when anything gets in the way of me doing my job and going home. Now I am coasting through it with a smile on my face, helping out the knuckle draggers, chatting up the servers.. and not so bent on leaving on time. I am taking a few other supps, but Creatine is a game changer for sure.

[@josephberg3155]

This video might be the most important video I’ve heard on KZbin in quite awhile ! I started two weeks ago with 2 grams a day and my anxiety has stopped ! Absolutely grateful to you and your guest ! It’s also helping me in the gym ….

[@TankMAIN877]

has it still stopped and may i ask what brand you are taking ?

[@joesph9748]

Nope, there is no way Creatine for two weeks at 2g did this.

[@luismiguel69able]

Are you excercising too? I am trying to figure out if this correlation ia from creatine or everythjng else that goes along with creatine usually.

[@BlackSeedOil20]

Wow! It is good that testimonials of people who took creatine are coming in.

[@UncleTermite]

I’ve taking creatine for over 30 years I’m 50 now and look at least 20 years younger then my real age ,I’d have to have a real rough night out to remotely look 50 so when you read about studies of it being used as an anti aging therapies for degenerative diseases I can conform it works ,I feel those who never took it long term missed the boat it definitely slows aging down ,don’t have a wrinkle on my either .

[@lotfibouhedjeur]

Thomas's interviewing style is great. He lets his guests actually speak. Love it.

[@luismiguel69able]

totally. Amazing how so many ppl dont let guests speak.

[@rajindarsingh1417]

I tried everything, ketamine infusion , anti depressants ( a few types ) made me worse I started creatine & 3 days later , palpitations stop , crying spells stop , shivers stop .

[@AlexKellogg-pv4qk]

Thanks for sharing

[@balajifitness4746]

Can u share more details

[@rajindarsingh1417]

Pretty much what happened. For almost 5 months I was going through hell gradually. Never had depression before in my life or anxiety etc . My life was perfect but after a retina detachment operation I started developing insomnia, almost 50 days with maximum 2-3 hours of sleep a day. Lose almost 10kg in the time. Tried everything acupuncture, medication, reiki etc . Nothing worked. Stopped eating gluten. When I started taking creatine at end of May , my palpitations & tremors subsided. I thought it was what a therapist told me, right about that time- she told me to stop taking the medication & start riding my motorcycle & have faith that I don’t have depression. It was everything opposite what everyone else told me. So I was told I was ok , maybe psychologically it helped & creatine replaced the medication & 2 weeks after that I went through a spiritual retreat to detox in Vellore / Chennai India . There it was confirmed that I didn’t have depression. Whilst trained doctors claimed I had depression, PTSD etc. it was weird but it been more than a year, I only had a very slight symptom for a day. But I kept telling myself Fuck off & went on with my life. I still sometimes shit in my pants thinking of how I should deal with this if it comes back again but I challenge it daily. Exercising & socialising & drinking with my friends & just not worrying a bit . I NEVER WANT TO EVER GO THROUGH THIS HELL AGAIN.

[@nicholascorliss]

Check out daily essential nutrients - one of the most researched micronutrients supplements of earth for mental health

[@mindpower6089]

That's wonderful. How much did you take a day?

[@NoahNobody]

I had undiagnosed ADHD and suffered terrible depression as a result of underachieving my whole life. I had my blood works done and had very good creatine saturation. I took creatine supplements anyway to see if it helped but it did not. Taking ADHD meds has been a game changer for me.

[@stevenkovler5133]

I used to take a lot of creatine. Especially when I was really working out. I was hit with depression and anxiety in late 2021 as I stopped taking creatine and was not working out as much !

[@DeadDingoDan]

What was happening in 2021? 🤔

[@googull4778]

I take it semi regularly. Especially if I slept poorly or stayed up too late. It helps keep me with it. Not an everyday remedy for bad sleep though, just the one offs.

[@cc1drt]

@@S7Vmvpeople with iqs higher than 80 dont think effects have a singular cause 🤡

[@microfx]

@@googull4778have you found out how long it takes for the water to get out of your muscle tissue?

[@tjvirginia1319]

@@DeadDingoDanthat's where I went

[@Gundog55]

I was diagnosed with Parkinson’s four years ago. I started doing my own research and began taking supplements with creatine being among them. I had just retired and thought that the calmness that I had begun to feel was due to no longer working but the creatine and L-Theanine just might be the reason

[@bensavage6389]

That is l-theanine right there

[@Keithzzzzt]

Do you take high dose thiamine?

[@Gundog55]

@@Keithzzzzt I took 100mg sublingualy for 8 weeks which resolved the neuropathy in my right ankle and foot. I then broke out in a rash across my stomach so I backed off to one every couple of weeks. Which seems to be working for me

[@neomatrix6115]

Do you mind sharing dosages?

[@Gundog55]

@@neomatrix6115 5grams of Creatine and 400mg of the L-Theanine

[@larryseago730]

I am appreciative this came into my video feed. I just had my right Knee replaced, I am sleep deprived, in pain constantly, and had quit creatine pre surgery, and I'm three weeks post surgery now, and I am in distress. So, I grabbed up my creatine, and dosed today, and will from now on daily. Thanks for this info

[@Sky10811]

look into glucosamine and chondroitin as well, for your joints, and collagen

[@PontificusPinion]

Did it work?

[@utdkidswifeITO]

same bro

[@sharonoddlyenough]

How are you feeling?

[@Lucas_Jeffrey]

Thomas is becoming a very humble and self-aware, thoughtful and balanced interviewer. It's clear he's becoming more so over time and it's really respectable. Editor's clickbait titles and thumbnails on the other hand do not match Thomas' genuine growth.

[@MarcoPolux]

definitively. The best interviewer in his topic 👍

[@torturedsoul8066]

simp much

[@garychristopher5480]

Great point and very true

[@peterpan31000]

@@torturedsoul8066 triggered much snowflake

[@AZ-kr6ff]

​@@torturedsoul8066 Go polish your helmet.

[@Pinhead650]

My autistic daughter has had only a single meltdown in a year and a half since we started giving her creatine. The one meltdown she had was after two days of being lax with supplementation. Before supplementation she was having two or three meltdowns a day... However, when you mentioned that it's a slow process for creatine supplementation to effect cognition, and that it can't be used as a "nootropic," that is definitely NOT our experience. When we started supplementation it only took a minute or two for the creatine to effect her behavior. We could also tell when she had a hard day at school and gave her "extra" in the evening to replenish her supplies. When we know she is going to have an extra stressful day (when she will be forced to socialize with a large number of people, for example) we give her extra beforehand and have absolutely seen cognitive improvements with supplementation vs without on an acute basis.

[@indierabbit13]

Can you do blood tests to see if the levels are low?

[@DenseEpiphany]

Placebo? Did she know that you gave it to her or something? Like is she realizing that you 'medicate' her?

[@Pinhead650]

It's blinded by necessity; she won't touch her drink if she knows we mixed something into it. When we started giving it to her it was an accidental double-blind test. My wife added it to her morning milk without telling me about it. That morning was the first time in her life that I didn't have to take her out of Sunday Mass. When I asked my wife if she had done something different she replied that she had finally remembered to add the creatine.

[@Pinhead650]

​@@indierabbit13 Possibly. But I've not had good luck finding a doctor who gives a damn about diet in relation to autism. I've had to figure it all out on my own.

[@kikilynn1167]

​@Pinhead650 Thanks for sharing how Creatine helps your daughter. isn't the casein in milk a trigger for autistic kids? It is for my daughter.

[@dafreakingusername]

Creatine drastically reduces my sleep requirements. Also helped with the jet lag. Latety it seems to help with mental wear from excessive load (new job + language)

[@savvyroca]

I had a concussion recently. I highly recommend creatinine to recover!! Also recommend Malama Mushrooms “brain gains” instead of coffee to help with focus. For better sleep magnesium threonate or malama mushrooms “chill bruh” does the trick. And most importantly aerobic exercise a simple walk boosts brain functioning.

[@freepressright]

I am positive for the MTHFR gene and COMT. As a result I am always very low in dopamine. Anything that elevates serotonin kills my sex drive, because I am serotonin dominant. I've found creatine brings my libido above normal baseline better than DLPA, Tyrosine or B6 alone. Much better, in fact. I always feel great on creatine.

[@AlexKellogg-pv4qk]

Thanks for sharing

[@JacobBailey-yq1kg]

Very cool.

[@---rg1gb]

Interesting

[@marcinpiorko2808]

Can I ask where did u do a gene test and how much was it?

[@eivindfskjellum]

I have been taking creatine regularly for many months now, but this inspired me to up my dosage. Creatine has been a real gamechanger for me and this additional information as to why is gold. Thank you!

[@thatrandomgurl5238]

Thanks!

[@Pastorius23]

Correlation/Causation ... you gotta separate out three things: 1) meds, 2) Creatine, 3) exercise ... if the reason someone starts using Creatine is because they are beginning a weight training/body building regimen, then that itself could be the reason for the decrease in anxiety, not the Creatine. That being said, I would not be surprised if Creatine helped. I'm a big believer in ARGININE myself.

[@zoni36]

Tons of human studies that show creatine, even without exercise, helps. Google Scholar is a great place to search this

[@kidkong637]

The energy that Creatine provides is the reason.

[@schmalzilla1985]

Exercise being the main contributor is my assumption as well. I do feel more relaxed afterwards, and usually it'll set the tone for my day. We already have studies that suggest that exercising increases higher levels of dopamine, and plenty of people who report a that their quality of life is better with exercising.

[@schmalzilla1985]

​@@kidkong637sugar, fats, and carbohydrates increase the the energy of the body, and yet they aren't talked about as great for mental health. Why would creatine, adding more energy be the reason that it is special to mental health?

[@kidkong637]

@@schmalzilla1985 It deserves more attention and recognition I think. Sure, sugars, fats, carbs are mostly wasted calories and the energy they provide often comes at a cost.

[@kirbyaugustine761]

Been a long term creatine user for over 35 years now. It’s the one supplement I’ve used consistently throughout my life more than any other aside from maybe whey protein. I take 5g religiously everyday although I’ll cycle off for about 30 days every few months but will have to up my dose to 10g.

[@denisebrand8536]

I can attest to the very noticeable effect on my mood and my partners anxiety taking 10g a day.

[@skittles2055]

Thank you for sharing!

[@tpoeatvon]

That is way too much wtf

[@DamonsMetalCasting]

@@tpoeatvon I agree with you I was taking creatine for lifting and my doctor could detect it in my blood indicating kidney failure. I stopped to get retested and it wasn't kidney failure it was just the high levels of creatinine in my blood. I was only on 1-2grams a day and that was well enough to saturate my body to give a false reading of kidney failure. I am not a doctor but 10g a day would seem like alot to me for a daily continued dose.

[@bobbykoller2003]

@@tpoeatvonmost recommended dose is 10g for loading and 5g for maintenance.

[@LivingGrey]

​@@tpoeatvon he literally recommends that amount in this very video...

[@jeffrysantiago8497]

I am diagnosed with MDD And anxiety and I been taking creatine monohydrate for the past two months and I can definitely conclude.. that it has helped me significantly with my diagnosis.

[@CrispyCircuits]

I take powerful anti-seizure medications and opioids for pain. I started creatine for fitness usage and it totally lifted the brutal brain fog from the medications. I also take collagen which is rich in glycine. I wonder if the combo makes a big difference?

[@HawaiiLimey]

Add methylene blue and alpha lipoic acid. To take to the next level Ubiquinol, PQQ and NAC.

[@kris4786]

For pain I use a lot of ginger and turmeric in my tea. Both are anti-inflammatory. It's what I used for my knees as I couldn't tie my shoes and needed orthopedic knee braces. I can exercise again and fully functioning, no braces. Doing squats and kettle bell work outs now. Best anti-inflammatory is Noni juice, about 2 tbs a day. Used it for my friends pancreatitis, couldn't produce insulin because of it. After a few days on the juice he was fine, Alive to this day and started the juice 9 years ago. Give those a try and good luck.

[@gralaw1965]

This is slightly off topic but worth mentioning I have arthritis in my hips and shoulders it was affecting my sleep and every day life. I started taking Collagen after 3 months my pain was almost gone and now 9 months later no pain.

[@JL-fx5cm]

I am also epileptic. I'm assuming you get a blood panel check every 4 to 6 months. Have you noticed a rise in your Kidneys.

[@JL-fx5cm]

@@HawaiiLimey I have just come across this supplement. Can you tell me the benefits? Thank you in advance.

[@JaboodyEnthusiast]

I felt it in my prefrontal cortex when I started taking it regularly a few years ago. To this day I've never missed a day.

[@afrog2666]

Even if you`re not injured or sick, taking creatine is just awesome, 2-3 weeks and you`ll have more energy and feel quicker, maybe it a little bloated (very individual), but for me that passes in a short while. I`m actually OUT of creatine right now, AND protein, AND PWO, rough month :/ Still have coffee though, ☕😁 gotta value the little things 😇

[@Alacrity01]

A 2 lb steak only has about 5 grams of creatine. A loading dose of creatine is up to 20 grams per day for 7 days with 2-10 grams daily for long term maintenance. That’s 8 lbs of steak per day for loading and 4 lbs per day for maintenance. Or 4 teaspoons creatine monohydrate loading, 2 teaspoons maintenance.

[@stringlarson1247]

Ha. I love good grass-fed beef. I can't imagine eating 8lbs then 4lbs/day, much less afford it. It reminds me of the Simpson's with Homer eating the giant steak.

[@jamomeara1894]

What if you just start with 5g/day without the high loading dose?

[@Denussy]

@@jamomeara1894 loading dose is totally unnecessary to anyone not suffering from ADHD or FOMO or OCD or any other neurotic disorder that compels them to overdo things. 5g/day is perfect.

[@nmlss-r9]

​@@stringlarson1247And unless you ate it very rare, most of the creatine would degrade into carcinogens through heat. www.cancer.gov/about-cancer/causes-prevention/risk/diet/cooked-meats-fact-sheet

[@dawnofthedelts]

​@@jamomeara1894research has concluded that the loading phase protocol is not a necessity. Steadily dosing at 5g per day will accumulate in the muscles and tissues, and excess will be excreted.

[@ethanhunter6195]

Wonderful information! Especially in treating and reducing brain inflammation and improving sleep. Thank you!!

[@rolandsilver7742]

Your content is just getting better and better man. well done!

[@APOLLINAIREBARTHOLOMIEU]

Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.

[@steceymorgan814]

Can you help with the reliable source I would really appreciate it. Many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Australia. Really need!

[@elizabethwilliams6651]

Yes, dr.larks I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.

[@patriaciasmith3499]

Anxiety happens when you think you have to figure out everything all at once. Breathe. You're strong. You got this Take it day by day.

[@steceymorgan814]

Is he on instagram?

[@elizabethwilliams6651]

Yes he is. dr.larks

[@MrJkosta]

I've been taking creatine for 25 yrs with brief breaks here and there.

[@SuperFacecloth]

For me personally, creatine 100% helped with my mental health. It actually made it easier for me to come off medication I was taking for nerve pain.

[@jrman413]

What dose of Creatine?

[@ccaselli7]

On another video about creatine, several people in the comments were talking about their side effects fro using creatine, like oedema, gallbladderstones, etc. But also someone said that it's the mono hydrate type that can cause that, and so it's best use the hcl form instead, as it absorbs better..

[@ItsMeChillTyme]

Thanks for letting us know. Often time I impulsively jump to try supposedly harmless recommended stuff by fitness channels but I've had gall bladder issues in the past so I'll be skipping on the whole 10g creatine per day thing for now.

[@imkvn4681]

only took 50+ years to figure out something we knew. Still thing lions main and walking 3-4 times in nature will relieve most of anxiety and depression.

[@jcrider392]

I've considered lions mane. How much and how do you take?

[@swirlingchi]

Psilocybin and walks in nature 🤯

[@CherylBerryl]

Ashwaganda too

[@oshea2300]

​@@CherylBerrylashwagandha tends to make it worse after a while. It can be a short-term help but in the long run it makes things worse

[@marklopez4762]

Have a source that shows Ashwagonhda is bad long term?

[@FLmetalhead]

I’ve only been taking 3-5 grams a day for a month and I feel it right away after drinking. Within 5 minutes I have more energy. I would take more but it dries my stool and makes it harder to poop.

[@baddmint]

I have been using Creatine I joined the gym a number of months can honestly say I am happier and more confident phisicaly stronger it has completely dulled my anxiety I ride a motorcycle and it has made for more confident as a rider I lane filter more and do my lifesaving checks automaticly without thinking it was made some of my actions instinctive and intuitive. I hate doing quick calculations it used to give me a headache thinking of doing it that no longer have that and can concentrate better. I sleep and wake better I'm a Baker so I get up early and I wake up faster everyone should try it it has completely changed my life.

[@Melissaanne1271]

Thank you for sharing your experience! 🙏🏼

[@brianmcnary3960]

I’m taking 5 grams a day for a week so far and I feel the benefits in my brain already.

[@DIGITALSCREAMS]

I use creatine to combat the effects of Long Covid. Fatigue, dizziness etc. Allows me to be more physically and mentally active, allows me to reduce the likelihood of crashes and if they do occur - their severity. I take 3.4g per day. When I need an extra boost I take 6.8g per day for 3 - 5 days. In my experience, the more creatine I take, the more my brain and body works. Its worth trying....

[@NinaKatharinaWeber]

I am having the same experience on Long Covid. I upped VitC, VitD (very low stores in the body with LC despite 4000 iU per day) and started taking Creatine. I suddenly improved after 4 years of LC. I am cautiously optimistic for the first time. Still scared of crashing again.

[@naturesbest7977]

Started going to the gym, my trainer recommended Creatine. Idk if the combo of working out 5-6 days a week and Creatine. But, I feel like little things do t bother me anymore.

[@UncleTermite]

Creatine definitely helps prevent injuries and makes bones stronger I’m 50 now and still lift like I’m in my 20”s in fact I’m stronger now and have been using Creatine since 1991 .

[@NateDohDoubleGee]

Time to double my creatine intake. Thank you!

[@michellecoloma369]

Just thought the same thing!

[@Lucas_Jeffrey]

I have been seeing people say 10 grams everywhere for ages and I have just scoffed at how it seems excessive lol Understanding more how creatine is produced in the brain and the blood brain barrier prevents uptake, it makes a lot more sense that dosing high enough so that your body is no longer using up arginine and glycine, allowing it to stay in the blood and be used in the brain. I will be increasing as well.

[@michellecoloma369]

My only concern is that it already makes me pee more, so I drink more water and then I have to pee more 😩

[@NateDohDoubleGee]

@@michellecoloma369 I know everyone recommends "more water," but I just drink when I'm thirsty. Never had an issue.

[@saintjabroni]

@@michellecoloma369😂😂😂😂

[@victorcs_]

Fantastic interview. Thanks Thomas.

[@joe-zp7ge]

Started creatine after watching this video. taking one gram a day to start and my mind has been calm and focused. im hoping this also translates into the gym for more endurance and strenght. will increase dose as needed. its definitely effective for anxiousness. appreciate this video !!! 65 and going strong

[@julies570]

That's great.

[@victoriakleeberg2806]

So glycine is required for the 3 step process to produce creatine. Glyphosate is a glycine molecule and as such it substitutes for the real amino acid glycine and makes the subseqent protien ineffective . See Stephanie Senef's extensive work on glyphosate . Thus a non organic plant based diet especially, would significanyly compromise creatine proxuction.

[@boostinggtirtime]

vitamin D is also a Mao oxidase inhibitor.

[@Macfromwales]

😂

[@Patron714]

mono-amine oxidase oxidase inhibitor

[@chasvonplatten1298]

​@@Patron714So it does nothing.

[@bobbypukes605]

Sounds terrible. Thanks for sharing.

[@blisterbill8477]

Oh, those communist dictator inhibitors.

[@quasarhi]

no matter how Ive tried to take Creatine, I get major gut issues, & headaches, nausea....some people just cannot tolerate it.

[@jaygib105]

Try transparent labs own..see if it works for you

[@pamelaj76]

Try PE Science!

[@jackieruiz3645]

Can you just eat herring?

[@justing888]

Have you tried it in HCL form? I don't get bloated using this form

[@JimBobMcGeee]

Look for a better quality creatine might have to pay extra

[@MrQuadcity]

Here are the key takeaways from the discussion with Dr. Darren Candow on the potential effects of creatine on mood disorders and brain health: 1. **Emerging Research on Mood Disorders**: - Creatine supplementation is being explored for its potential to alleviate symptoms of depression, anxiety, and PTSD. - These mood disorders may reduce brain creatine stores, which are crucial for brain bioenergetics. 2. **Mechanism of Action**: - Creatine helps reduce oxidative stress and improves mitochondrial health in the brain. - This process could translate into better cognitive function and mood stabilization. 3. **Current Evidence and Studies**: - Most studies have involved participants who are also on medication for mood disorders. - There is promising evidence from rodent models, but human studies are still emerging. 4. **Dietary Impact**: - While vegans and vegetarians have lower muscle creatine levels, their brain creatine levels remain similar to those of omnivores. - The brain can produce its own creatine, independently of dietary intake. 5. **Dosage Recommendations**: - Higher doses of creatine (around 10 grams daily) over extended periods (weeks to months) are recommended to see significant benefits in brain health. - Lower doses might benefit muscle creatine levels but are less likely to impact brain creatine stores significantly. 6. **Anti-Inflammatory Effects**: - Creatine may reduce neuroinflammation and oxidative stress, linking muscle, bone, and brain health. 7. **Sleep Deprivation and Cognitive Performance**: - Creatine seems to benefit cognitive performance more than physical performance under sleep-deprived conditions. - It helps mitigate the cognitive decline associated with sleep deprivation. 8. **Creatine Synthesis in the Body**: - The body produces creatine through a process involving the amino acids arginine, glycine, and methionine. - This synthesis occurs in the brain similarly to how it happens in the liver and kidneys. 9. **Use as a Nootropic**: - Creatine is not effective as an acute nootropic for immediate cognitive boosts. - It should be taken consistently over time for cumulative benefits. 10. **Overall Health Benefits**: - Creatine is not just an ergogenic aid for physical performance but also offers recovery and overall health benefits. - Its benefits extend across various age groups, from children to older adults. 11. **Practical Application**: - For those considering creatine supplementation, a whole-body perspective is recommended, with patience for long-term results in brain health.

[@DouglasReed-hh7jh]

Thanks!

[@outcastfpv7655]

💪

[@kirbyaugustine761]

Thank you

[@plumbthumbs9584]

Appreciate you!

[@LooseNut099]

Thank you!

[@monicamerlucci7100]

I have been diagnosed with an autoimmune disease that causes hair loss. I’ve heard creatine can help with autoimmune but on the flip side I’ve heard it can also cause hair loss. I really want to start taking it considering I work in a fire department as a medic and sleep deprivation is a real thing too

[@everywherenowhere6901]

Maybe search about how bicarbonate can switch off inflammation in auto-immune conditions?

[@artmanjohn2]

Early in the conversation you guys mentioned Creatine Phosphate. I remember around 1995 when Creatine supplements first came on the Market my first Creatine I bought was Creatine Phosphate, not monohydrate. This Creatine Phosphate was amazing in it results, far superior the the Creatine Monohydrate that was put out later. It also made me feel amazing! Why can't I find the pure Phosphate form of Creatine today! Why isn't it still available? Was it banned?

[@LilithCain]

Interesting question..... I had forgotten about that. I remember buying it at the old GNC when they were in the malls 😁

[@AB1B1]

​@@LilithCain Is that the creatine that was in tablet form? It was kinda chalky but they flavored it which tastes pretty good?

[@LilithCain]

@AB1B1 the one I had back in the 80s 😬 I think, was powder? Don't hold me to that 😆

[@00dfm00]

CP breaks down too quick and isn't great for storage. You body actually creates and uses CP from CM anyways.

[@artmanjohn2]

@@AB1B1 What I bought was a green powder the tasted like lime.

[@SDG51]

Thomas, I really appreciate your work. You are always learning and willing to reposition based on what you learn.

[@Petunia-fl9lu]

we've known it helps elderly brains since about 2010?

[@Arpin_Lusene]

Huh. I didn't knew that before. I was very depressed during period before I took creatine. Now that I consume it, I do feel getting less depressed comparatively. It doesn't completely remove it but it's not as bad as it was before. Now that I heard it, it makes sense now.

[@harrisonmcdaniels6019]

I have a hearty red meat diet so perhaps the effect of supplementing creatine was muted, but in my experience, creatine's effects are significantly smaller than any prescribed stimulant I've taken as well as any SSRI or SNRI.

[@bobbypukes605]

Yeah, very few people notoce anything at all from it. I was hoping that with chronic use, I'd at least notice a better ability with my lifts at the gym but truth be told, since I've stopped taking it completely (now 100% natural), I am basically the strongest I've ever been

[@dynamitedmoney]

It’s amazing to me that you can go to the doctors and they can prescribe you all sorts of big Pharma pharmaceuticals, but start asking questions about creatine, supplementation, collagen, beef liver, and it’s like they’ve gone stupid! Have nothing to offer on Ross roots and dairy organic free range meats, eliminating refined sugars and seed oil raw dairy kefir, and the list goes on 🤫 for me creatinine has the opposite affect and makes me tired and anxious.

[@michaelrandazzo3959]

I like creatine but I was a little afraid that taking it would reduce the body’s ability to produce it. Any studies on that?

[@mark100177]

You ask so many good questions that I know I would have eventually had. Thanks for the great interview and info.

[@devorahacts]

It seems like it's been recommended for everything one can think of, I'm not a big believer although I've taken it for months at a time several times. **shrug**

[@zoffwolfgung2933]

People using a ssri to treat depression and taking creatine is that safe?

[@thesuicidewalrus415]

Love your videos , keep em coming brother!

[@christophermullins3127]

So beef has creatine in it, and big pharma has beef with creatine! Go figure 🤣

[@cdiarra]

This needs to be pinned 😂 😂

[@IFYOUWANTITGOGETIT]

Clever

[@cmasailor]

As a bonefied dad, I approve of this joke.

[@ceciliapreziose3783]

can you put this in English

[@MoSec9]

Where did you think scientists got the idea of creatine? It’s like saying, so fish have omega 3s. I didn’t know maybe ten years ago but I wasn’t surprised. Why are you surprised, just curious where you thought it came from 😂

[@aaroninfante-levy3612]

Thank you for this great interview! N of 1 example here, but I began taking Creatine for training benefits a few years ago. I noticed it had a subtle mitigating effect on my depressive symptoms, especially when I had poor sleep due to insomnia or graduate school. Similar to the mood-buffering effects when I’m on my standard ketogenic diet. I also noticed that the loading 10 mg dose seemed to occasionally trigger very minor gout flareups - still researching what that mechanism is. So I’ve tried to keep myself around 2.5 mg Creatine (half scoop) most days, sometimes 5 mg when I train hard, and that seems to be sweet spot for me.

[@romari2706]

Creatine has been shown to improve cognition at 2.5 grams a day

[@Macfromwales]

It's great for memory friend it said....errrr, something or other

[@CrispyCircuits]

Sources, please. I've had a positive experience, but I am not in the average healthy person status.

[@Alan_Page]

So when I was younger and lifting weights a lot, I took creatine but was told I was supposed to cycle it because if I kept supplementing with it my body’s natural production would decline. This was the 1990s so I don’t know if this is valid, and a Google search of this question has mixed results.

[@sheridansherr8974]

I cut carbs and it helped too. :-) I guess I'll add more creatine now. Thank you for informing us!! 💖💖💖

[@AlexKellogg-pv4qk]

Seems like too many carbs could be devastating to us all It’s just as bad or worse than many drugs. In some ways it might be worse and it’s certainly super addicting

[@DissonantCat]

@@AlexKellogg-pv4qk Doesn't seem to affect Sardinians (from the island off of Italy) who live healthier and longer lives on average. The traditional Sardinian diet is characterized by a high consumption of whole grains, fruits, and vegetables, as well as moderate wine consumption. Could it be the quality of the carbs?

[@jasonstallworth]

Thank you Thomas, as always. Is there a particular brand that you recommend, or are most creatine products sourced from the same manufacturer (just slapping a different label on it)? And is creatine monohydrate supreme to the other types that are more pricey?

[@bobpx]

Best is any brand that is 'crea-pure'

[@carl8568]

Yes, look for Creapure, it's manufactured in Germany.

[@theaouch4749]

Creatine has the power to increase water retention, water strength, water load, mass builder, memory retention, decrease dementia, cognitive function, increase strength .

[@tomg5405]

And make loose hair.. That is shit

[@Corey-iw4ot]

Holding on to water is deadly

[@theaouch4749]

@@Corey-iw4ot been on it 15 years.

[@theaouch4749]

@@Corey-iw4ot 75% your body made of water.

[@sfguzmani]

@@Corey-iw4ot It's not holding or retaining water the way you think it is.

[@bobbyk1023]

First time subscriber. Ty for what you do.

[@cgrass4035]

I grew up near London, Ontario in Canada. I hear a strong accent from Dr. Candow and none from Thomas. I find that interesting.

[@elyerrey7750]

Accent sounds like Ilderton or possible Birr😉

[@dmac9300]

Funny I thought something similar - I related it to down east a bit.

[@stevep2430]

It would be interesting if they studied if dementia patience also had low Creatine levels in the brain and what was their dietary habits before they were diagnosed with the condition. Did they eat heavily processed foods, lead vegan or vegetarian life styles or maybe lacked other types of amino acids that is required by the body/brain to make Creatine?

[@andredaedone7732]

Being a 68 year old Carnivore, I consume only Fatty Beef, Fatty Lamb, salt and water but do omega 3's, creatine, D3,K2 regularly. Keeping it simple.

[@Tara-zq3il]

what about Glynac.Good results for older adults

[@BeatrizHatfield-vc4ig]

Same here. Lion diet, creatine. Hyperbolic tapering off psych drugs.

[@everywherenowhere6901]

You might want to add some heart and liver to that for adequate amounts of important nutrients like taurine, copper, magnesium and Vitamin A etc.

[@janeslater8004]

D3 is rat poison google it. Unbelievable how brainwashed people are.

[@janeslater8004]

​@@everywherenowhere6901heat destroys taurine you wont increase levels that way

[@NaanFungibull]

The main problems I have with creatine is it interferes with sleep because I wake up to pee more often, and it also makes my face look puffy/fat despite having low body fat. If anyone knows how to get around these issues please let me know.

[@msSAN300]

I would say the Holy Trinity for mental health is Exercise, Nutrition and Meditation. I´ve been working out at the gym for the past 20 years, on and off (due to injuries) and it sure helps to manage depression and anxiety. However I started taking creatine (combined with matcha powder and BCAAs) a while back and whenever I take this as a pre workout I feel I have physical and mental strength to train for hours! Recovery is so much better as well!

[@operatorblack]

This was a really fascinating discussion thanks

[@petergoodman7805]

Creatine caused me to have kidney pain. And yes I did drink plenty of water

[@bobbypukes605]

It also increases creatinine levels (or gives a false reading). I can't remember which. But it definitely seems to affect the kidney.

[@Digital_Kyle]

Is there any information on vertigo as a side effect when dosing 10+ grams a day. I just started taking creatine about 2 weeks ago and when I take around 10 or more grams in a day, I experience fairly significant vertigo. What is going on with that? Only thing I have found is a reddit forum where a few other people said they experienced the same thing.

[@DarkoFitCoach]

Stop taking it and see of it improves. If not then its bot creatine. If it does then it is

[@jayrichardson221]

Dehydration, as creatine causes the muscles to uptake way more water, you may need to hydrate a little more if taking upwards of 5g-10g

[@Kylbigel]

Too much water retention. Your middle ear is not adjusting well to that much fluid.

[@Digital_Kyle]

@@Kylbigel I think that is what it was. I ended up lowering my intake and then just slow-loading over a few weeks. Worked for me much better that way. No vertigo that way.

[@anastasiavila5284]

This is incredible........now, how we do we reverse the insomnia that always accompanies it? Like, 10 grams sounds like an awesome way to kickstart all that sleep deprivation you guys discussed. I've come across hundreds of complaints about creatine causing insomnia.

[@LilMacMcMo]

A heavy hitting Indica will clear that insomnia up really quick 😎

[@tylerwill5250]

People are SO misinformed. Creatine IS natural, IS NOT going to affect sleep or hormones or hair loss.

[@ManusCamus]

To me Matt and Dr Berg are the nicest guys on YT!

[@charliewhon6548]

I have a modest college education in veterinary science, and I am very passionate about horse health and nutrition, but this subject has opened some questions as I help my adult daughter who has some health issues that I have been considering using creatine for. Here is my question. If creatine is formed from argenine, glycine, and methionine, then humans would definitely have to make sure they have enough lysine, threonine and leucine, before an over the counter product called creatine would be as effective as it could be? The reason being, that lysine is the first limiting amino acid in the human. Then threonine and leucine. If an individual doesn’t have enough of the more limiting amino acids, then utilization of creatine would not be as helpful. If the limiting amino acids are being taken in, and the argenine, glycine and methionine are being added, the body can make its own creatine. I wonder which would be most beneficial, and less expensive; taking all the proper aminos in the proper proportions, or taking just the creatine supplement?

[@lorarooni]

Which creatine is best? Mono hydrate or HCI ?

[@nos145]

try both and see. some people are allergic to one or other

[@man94xxBIG]

Check out PR supps Creatine..

[@yourenotwrong3511]

Mono

[@kennethpoole5354]

​@@yourenotwrong3511 I bought a creatine called bucked up and the label showed they have a few different creatines mixed in

[@Thunderstick-y8h]

My stomach prefers HCI

[@Farambul76]

So when is the optimal time to take creatine?

[@seanknox7321]

Every day at the time you’ll actually take it. 5mg a day. (One scoop)

[@walterblack3651]

@@seanknox7321i think you meant 5g, not 5mg

[@danielsamraj5503]

@@seanknox7321 5 mg???

[@matth1139]

5 grams.. not milligrams

[@Macfromwales]

It doesn't matter friend. It will build up in your muscles, 5g a day is enough for muscle benefit but if you want the brain stuff do a loading phase of 20g a day and then drop to 10g but 5g daily is usually plenty. It doesn't even matter missing days, just take more on the other days. You basically can't od on it and apparently it helps absolutely everything

[@ro6384]

when i tried starting creatine supplements, i could not sleep. wide awake almost the entire night for days until associated with starting creatine. i stopped taking it and in a few days my sleep went back to normal.

[@vcash1112]

Take it in the morning and exercise.

[@LagMasterSam]

Creatine does seem to give some people insomnia. For me it's the opposite. I sleep much better while taking creatine.

[@One_Pun]

I see John Malkovich on the thumbnail, I click.

[@muffinsmuffins8074]

1:19 was he censored here?

[@Omar.Banuelos]

Yup

[@crucifixgym]

Can’t say the C word

[@Darkstorm666]

​@@crucifixgymlmao. Clown World

[@cephascephas8308]

Have there been any studies on creatine causing anger and anxiousness in people? I’ve seen some threads of anecdotes that it can make people very angry. I only heard of it when one of my friends, who is older and on a couple pysch meds, and a med that keeps his urges for opioids lower. I did not believe him at first when he told me. But he got very defensive when he opened up about it and said that he use to be able to take it and feel great when he was younger (many years ago). But after trying it this time it gave him very dark thoughts, little things made him very angry, and as soon as he stopped taking it (after 3 days) the anger went away. I’m sure it has to do with combining it with certain meds and his current state of mind. So I just wanted to see if anyone else had heard of this or seen it in studies??

[@totallynotpaul6211]

Yeah, I've heard of it in people with bipolar. There's good anecdotal evidence that it induces manic episodes. Does this man have bipolar? Is that what his meds are for?

[@Dancestar1981]

I wonder if it could help me get off long term SSRI antidepressants

[@LagMasterSam]

I would take 5HTP instead of SSRIs. Just don't take both at the same time.

[@Dancestar1981]

@@LagMasterSam been on the SSRIs for over 20 years and can’t get off them even though I never wanted to go on antidepressants in the first place

[@Dreamopticsredlightglasses]

Very interesting, thank you very much

[@mrlafayette1964]

If you have these problems and you're on the sugar wagon that's the first thing you need to address.

[@jonmueller2117]

And cut the alcohol.

[@michael_gaio]

yes, cutting sugar is the #1 best thing for health

[@ItsMeChillTyme]

I used to get shivers down my spine. Went to the spine doc and got some exercises but also went keto around the same time. I think that contributed greatly to me rapidly getting rid of the spasms to a great extent. Also, my skin improved I feel like but looking around online, that's not a universal experience about skin and keto.

[@AlexKellogg-pv4qk]

I fully agree and this is a huge problem worldwide

[@philodox7599]

I hate to brake it to everyone but the most likely reason for creatine improving depression anxiety and other mood disorders is probably that the people who started taking it ALSO started working out and or becoming more healthy and eating better and sleeping better.

[@alankislowitz9590]

There is no medication or supplement that works better to relieve depression and anxiety than vigorous exercise. A healthy mix of aerobic ( cycling in my case) and resistance works great for me.

[@Manbrotomato95]

Although I agree that exercise is the best habit someone can implement to imporve mood and energy. I hate to brake it to you that to give reliable conclusions from a scientific study, the participants are not allowed to change more then 1 element in their life. Else the researchers can't definitively know if the conclusions where the results of that 1 element or any of the other the participants changed.

[@philodox7599]

@@Manbrotomato95 So what element of their life did they change?

[@Pentacost2033]

​@@philodox7599it has been shown to significantly improve the cognition of elderly people who definitely were not doing rigourous exercise. 20g a day for 7 days improved their memory and other cognitive factors significantly versus placebo. Some people who have mental health issues may be suffering from depleted creative stores and for these people it would help with or without exercise but in healthy people who have sufficient creatine it will have little cognitive effect.

[@LagMasterSam]

@@philodox7599 Taking creatine.

[@artelina]

I tolerate only 500mg creatine /day. It effects extreamly negativly on sleep. I sleep only 4-5 h/night if I take any creatine early in the morning like 5.30am. I love the effect on it during the day, it really uplifts the mood and gives muscle strength but sleep becomes so poor. I have a long histrory of chronic stress, burn outs and some years on plant based diet. I wish I could increase the intake of creatine but I just don't fall a sleep in the evening. I take tryptophan and GABA to fall a sleep if I take any creatine in the morning. Does the body get use to it sometime? Been taking it for about 4-6 months now. I eat approx. 300g red meat/day. I can't do white meat more than 1-2 days in row.

[@LilithCain]

Thank you for posting this. I was considering taking this, but my primary concern was sleep disruption.

[@artelina]

@@LilithCain You're welcome ! I've also taken vitamin Bs and that can also effect sleep nagtivly. I didn't take them yesterday and I slept better last night so I'm observing what's happening. I really would like to take higher doses of creatine but I need to exclude the vit B first to see what works and how. Sugar is also very bad for sleep. Can tolerate a very small amount of coffee. Very sensitive to all stimulants.Creatine feels so good for the brain, focus, uplifting, energy, I accomplish so much more effortlessly everything but 10g/day sounds unbelievably high dose. I took about 1g today so lets see how the night goes.

[@LilithCain]

@artelina I don't eat any sugar at all, but I find that Bs dramatically help my sleep. It shuts down all the brain chatter . I take 3 GRAMS of niacin for my anxiety daily as well as a dropper full of B1 and D3 right at bedtime . If I wake up for any reason, I repeat the drops and go right back to sleep. 😊

[@LilithCain]

@artelina for focus I'm really liking aswaganda and methylene blue, no sleep interactions whatsoever

[@raiseyourfaith3162]

I also have history off chronic stress,i have recently started watching Andrew huberman and Thomas,i am experimentng with some of the supplements,this week i started taking 3gm creatine monohydrate on first day result was good,but from second day it upset my stomach badly nd i was too much in my mind and then i have to calm my mind with streching,now i reduced the dosage to 1gm,now i am fine,i will try it early in the morning.

[@laurenbarr9134]

Is whey protein okay as an alternate? Or does it have to be creatine?

[@R1pp3d]

They are two completely different things. Neither one is a substitute for the other.

[@william1863]

Thank you fellows and may the Lord our God bless you all in Christ I pray 🙏✝️👍💖✌️ AMEN

[@antoniaarai166]

Any recommendations on what creatine to take?

[@sonixwellness1536]

Sonic Wave Whole Body Vibration and stacking with music and/or frequencies is very effective in modulating the nervous system. Combine the aural/tactile aspects is very powerful in creating neuroplasticity, not just a temporary fix. Music engages the entire brain simultaneously. Will now incorporate creatine to this to consciously notice any effect?

[@julies570]

What is that? Son8c wave vibration,?

[@cancan2416]

Excellent and practical questions TdL

[@Brutuscomedy]

Also keep in mind, "includes paid promotion"

[@czerwonapigula]

Great episode and tips!

[@kennethpoole5354]

Im wondering how creatine reacts to like a warm beverage like tea coffe or hot chocolate

[@Matt_Maverick]

Been mixing my creatine with my coffee every morning for years lol

[@mikepapadopoulos5968]

@@Matt_Maverickthat’s so cheap of you

[@sokyoutdoors588]

Heat breaks creatine down from what I understand, that’s why even though it’s in meat products we are generally deficient.

[@walterblack3651]

@@sokyoutdoors588 creatine is an incredibly stable substance and won't be affected by heat at all. Creatine even dissolves much easier and quicker in warm liquid than cold too, so it's a win-win.

[@Matt_Maverick]

@@mikepapadopoulos5968 you mean consistent!

[@fractalofgod6324]

I've suffered severe anxiety and panic disorder for over 30 years and i take creatine on a daily basis continuously and it does absolutely nothing to help the anxiety.

[@David-s6e4q]

Then stop taking it