How Diet Can Treat Depression: The Metabolic Marvel of Bile Acids

[@douglashenson4793]

It is heart breaking that Robin Williams suffered in secret. For all that he gave us, we could not help him. Thank you Nick for your tribute and thank you for having his son speak. I think there is hope now since the shocking loss of Robin Williams which may have helped propel new research into mental illness and how diet, gut biome, and metabolic health are key factors and may be the most important factors.

[@nicknorwitzPhD]

He truely was a remarkable human being

[@Macgee826]

Robin had a heart of gold ,not many in his line of work like him if any!

[@thelairel6664]

My n=1 experience has shown me first hand how much healthier and mentally resilient I am when I am eating a whole food low carb diet. Grew up being treated for bipolar, and spent a lot of my teens depressed, and if I start eating highly processed carbs my moods get incredibly unstable pretty quickly.

[@nicknorwitzPhD]

Sounds like you've had quite the journey. I'm glad you're doing better.

[@PavanMehta]

This has been my journey as well. From teens to early 30s. On and off meds on standard indian vegetarian diet with some dairy in the mix. Switched to low carb in Jun 2024. Slipped again in Aug. Back to it since last few weeks and I feel a lot better.

[@DAMIAN_SVHETS]

what kind of cereal do you eat? As far as I know many cereals are high carbohydrate anyway. How do you keep to a low carbohydrate diet?

[@Mockoland]

​@@PavanMehta I feel you man

[@mmanda515]

​@@DAMIAN_SVHETS Cereal is one of the worst things these days. Filled with ultra processed chemicals, overloaded with sugars & carbs + seed oils. Meats, seafood, butter, bacon, eggs. If you want, low carb veggies & low sugar fruits like berries too. Repeat. After the first few days withdrawing from all the junk, it's easy peasy. NEVER felt better, never had better bloodwork, etc.

[@willemvanriet7160]

Mental health benefits is what will finally make keto go mainstream

[@nicknorwitzPhD]

Hope so!

[@Macgee826]

Dunno mate big pharma will do everything in their power to prevent that.too much money to be lost

[@dreamlife808]

Curing autoimmune disorders is what will make carnivore go mainstream.

[@rossbabcock3790]

Cured bipolar, GAD, T2 diabetes and addiction in me! Get away from the 'death' in processed foods!

[@gratefulagoraphobe]

I was carnivore for 5 mths. I lost 5.5 inches of belly fat. I think I healed my metabolic health. It's like someone dusted my brain. The cobwebs cleared and I have been able to face my severe agoraphobia and ocd. My depression has pretty much gone and I'm positive about my future. It changed my outlook. Although I'm not in ketosis anymore, I think that my body needed the shock of 5 mths ketosis to heal. It's been game changing in a 20yr struggle

[@nicknorwitzPhD]

I love this for you.

[@gratefulagoraphobe]

@nicknorwitzPhD I think ketogenic therapy really need to be researched more. All I get from doctors is meds, more meds and psychologists, therapists just want to rehash the same things over and over. Don't get me wrong, there's a place for both sometimes. But you're wasting your time (and money) if you don't fix your metabolic health. A few weeks or months of ketosis can change your brain

[@Pa-we1lw]

I went carnivore for 4 months out of desperation to heal my gut. It worked and cleared my head, as well. I truly wish I enjoyed the diet.

[@reinotsurugi]

Keto and carnivore are GREAT for head clearing. I'm glad that people can see it now as therapy and not as a mandatory lifestyle. I've tried many things and am still seeking optimal for me. Too much keto amps me up too much. The problem is, we are divorced from the natural cycles that used to force behaviors. We used to eat seasonally. We used to have periods of scarcity. Periodization requires more discipline than most people can muster, but for many, it will be the key to better health.

[@gratefulagoraphobe]

@reinotsurugi I think that the shock of changes from going in and out of ketosis makes me feel great. Like you said, we had periods of scarcity and abundance. I'm trying to find what works best for me and too long on the same cycle isn't optimal for me

[@fiddlerJohn]

6:52 "The late great Robin Williams once said 'people don't fake depression they fake being okay.' Rob Williams' suicide, in 2014, was the moment that I realized that anybody can struggle with mental health issues, and it's often not visible, He was a figure that, in my childhood, was always a symbol of Joy, Humor and vitality the kind of person who could touch your heart without ever having met you."

[@nicknorwitzPhD]

I guess you’re saying you liked this quote?

[@fiddlerJohn]

9:31 "Remember mental health is holistic it's not just in your head it's in every part of your body. By taking care of your Metabolic Health you're also taking care of your Mental health."

[@fiddlerJohn]

@@nicknorwitzPhD Yes. Love Robin's quote, but I connect to your " the moment that I realized that anybody can struggle with mental health." That's it. Well said. Thank you.

[@rm6857]

most actors are abused by their parents, mostly actors. And they are broken since childhood and have problems with alcohol, drugs, have psyhoterapist since young age.

I'm still low carb because my depression and anxiety remission is highly corelated to what I eat. My hypothesis is that some foods increase or reduce inflammation in my brain and that's where my focus is, so I'm usually avoiding ultra-processed foods like seed oils. I also noticed that inflammation in my gut and mood instability usually go hand to hand. However exercise, good sleep, healthy relationships and a healthy mindset have also made wonders for my mental health and my life in general.

[@nicknorwitzPhD]

Love to hear it. Go you!!

[@karenohanlon4183]

I would also add life remains very stressful for those who are disadvantaged. Being lower class has a drastic affect on health outcomes. Interesting to see that since Covid the top 1% became even more wealthy. Thank you Nick for all you do to help educate and inform the people who most need your knowledge.

[@IndubitableBabble]

That was addressed in the rat study

[@helenahandkart1857]

I'm sure many would love to hear about this regarding people who have no gall bladder. I know I certainly would. Kind regards.

[@anthonycoyer7186]

I had my gallbladder removed a few years ago, 260 days on carnivore diet and I feel like a new man, no worries.

[@nicknorwitzPhD]

You still make bile acids without a gallbladder. I don’t think it has much bearing on these data tbh

[@mitunknowngirl]

I have searched. There's relevance here. Gallbladder removal increases risk of major depressive disorder and mental health issues. However, you can still train your body to produce more bile acids at the right time. Gradual increasing fatty meat and animal fat intake and supplementing tudca or bile salts at the very beginning would help.

[@ThePowerofRandomKnowledge]

​@@mitunknowngirlso interesting

[@clinhart]

@@mitunknowngirl Interesting. Matches my experience with gallbladder removal more than 20 years ago. Now I am on an almost carnivore diet for more than 8 months, no issue with fat digestion, I don't need bile salts. Mood and energy is also good - essentially reversed long-Covid by now.

[@Dr_Boult]

Excellent video and while I'll be one of (likely few) to go read the paper It would have been nice to see your videos. And +1 for the reach out to Williams, that was a nice surprise and good addition!.

[@nicknorwitzPhD]

Thanks! Glad you appreciate it. Hope you like the paper

[@slaterider]

Gut microbiome and specifically "Lactobacillus Reuteri" plays an important role in the bile acid deconjugation and up regulation of TGR5 receptors. I have personally found supplementing Lactobacillus Reuteri has dramatically helped my mental health. Research has also found that L. Reuteri has diminished in human biome in the last 40 yrs. along with an increase in mental health issues.

[@nicknorwitzPhD]

Very happy you've found something that works. Perhaps you want to share your research and strain/supplement for fellow viewers?

[@itzakpoelzig330]

Pottengers Human has some valuable videos about this.

[@ThePowerofRandomKnowledge]

I just took some very strong antibiotics because of sibo and I have been feeling really bad mentally

[@DAMIAN_SVHETS]

What strain are you taking and how much yoghurt do you eat each day ? Thank you.

[@slaterider]

@@DAMIAN_SVHETS I follow Dr. Davis's yogurt recipe with the Bio Gaia Gastrus chewable tablets. I eat at least a 1/2 cup a day.

[@willemvanriet7160]

So another reason to not just remove your gal bladder. Rather change your diet. Can clear the ducts in a month but doctors always knee jerk to surgery…

[@nicknorwitzPhD]

You still make BA without a gallbladder

[@itzakpoelzig330]

Yeah, but my understanding is that the gallbladder is there to modulate its release. There is no such thing as a throwaway organ.

[@joeberrouard3743]

@@itzakpoelzig330what about the appendix?

[@SkedgySky]

​@@itzakpoelzig330unless it's filled with gigantic stones

[@ernesthader1109]

Low carb and ketogenic diets was being used to treat mental disorders as far back as 1930's. Why is this information not being tackled and researched extensively.

[@nicknorwitzPhD]

Incentive structure 💰

[@A_Dome_Dream]

Depression can be caused by so many things relating to diet so it's great to see that we are starting to understand it more. I know that the mainstream understanding right now is that depression is caused by chemical Imbalances due to genetics, but I don't buy it. Some maybe, but why do we have such a rise in depression in the last few decades? Our diets have changed, we are bombarded with forever chemicals that disrupt our microbiome and digestion, we can't go more than 5 minutes without being sold or advertised some super processed foods, etc.

[@canileaveitblank1476]

Fun fact: there’s absolutely no test to show “chemical imbalance” in the human body. It’s just a term that started being used, but never, ever proven. ❤️🍀

[@iss8504]

Depression has many causes. Menopause and perimenopause can cause it too. I was on keto and it didn't help my mood until hrt was added.

[@johnswitzer6566]

Of all the seasoned comedians, and I’ve met a few, more than a few,I’ve made this one observation. Though paradoxical,you have only to scratch the surface to find pathos. Continued success, Chef John

[@nicknorwitzPhD]

Robin was something special

[@johnswitzer6566]

@@nicknorwitzPhD -just like a comet in the canyon in the morning..

[@AnimalFarm341]

Interesting. Tudca, a bile acid, shows promise in Parkinson’s.

[@nicknorwitzPhD]

Really? Have a citation?

[@AnimalFarm341]

@@nicknorwitzPhD www.ncbi.nlm.nih.gov/pmc/articles/PMC9166453/

[@kevinroelofs739]

I dont have a citation, but you have my personal anecdotal evidence. I'm a Veteran with severe PTSD and Depression ​and the combination of TUDCA and Myo-Inositol has done wonders for me. I dont sit with anxiety all day anymore and my outlook on life has changed considerably @nicknorwitzPhD

[@arnoldfrackenmeyer8157]

I'm on the Federal Inflation Diet. Food prices go up, my waistline goes down.

[@nicknorwitzPhD]

Lol

[@Julia29853]

😂

[@IsakTougaard9]

Anecdote: Flushing out my bile repeatedly has made my depression worse. I was doing shankaprakshalana (basically drinking 4L isotonic salt water combined with dynamic stretches to wash out the intestinal tract) to clear out inflammatory food remnants. Yogic recommendations said to do it with months in between. Me being reckless, I thought what's the harm in losing a bit of bile? Well, now I know. Thanks for teaching us about this.

[@nicknorwitzPhD]

That’s an interesting anecdote. Thanks for sharing

[@austinswift1602]

awesome Nick! Thank you for educating us on this important discovery!

[@nicknorwitzPhD]

Very welcome :)

[@mattamiller]

Nice video. Need a follow-up video on how to optimize and increase bile production

[@nicknorwitzPhD]

Didn’t I hit that in the video?

[@jackiedelvalle]

​@@nicknorwitzPhDMaybe it needs to be put in simpler language - I missed that too.

[@Julia29853]

I didnt see it either. You can take Tudca as a supplement, but I dont think he explained if there is a way to encourage your body to make more on its own.

[@mattamiller]

@@nicknorwitzPhD I guess I missed it. What's the time stamp?

[@eagsalazar]

@nicknorwitzPhD, I was also curious if you felt supplementing with Tudca had value here.

[@jeep-australia]

I've experienced it firsthand. My emotions were all over the place to the point where I was actually asking myself, 'Who am I?' I was feeling super happy or super sad, like I was on a rollercoaster. I was, this isnt me why any i feeling this way Just from watching sad or happy movies. Since switching to carnivore, I haven’t had this at all. I've been more balanced, and the emotional highs and lows are much more stable. Bile type matters

[@nicknorwitzPhD]

Love this for you

[@TemoteControl]

Can speak from experience - anytime I fall of keto/carnivore - my mental health deteriorates.. diagnose bipolar and have found so many benefits with ketosis… working to heal my addiction to carbs and sugar…

[@ProdicleSon.]

I’ve been carnivore/keto for the last year after suffering for 8 years with mental health issues caused by poor lifestyle choices such as eating junk food, drinking too much and not getting enough sleep. My body and mind had enough and I physically could not function anymore. I tried different antidepressants and exercise but it was like putting a band aid over a massive gash. It didn’t work. My last try was to give the carnivore diet a go and after that first steak I had my life has changed in ways I could never imagine. I could feel my brain turning on again. I could laugh and be present like I once could when I was younger. I dove deep into this issue of how diet has such a profound impact on our mental health and try to spread this information. It’s only a matter of time until this becomes mainstream and people can finally start to heal themselves without using all these pharmaceuticals that don’t even address the issue. The issue being our habits and lifestyle choices.

[@g-forcefundamentals2912]

From a new subscriber... The science is great and the presentation length of about 10 min is just right.

[@nicknorwitzPhD]

Appreciate it! Welcome welcome!

[@Djynni]

I loved Robin Williams and was deeply touched by his death. I think it's great that you included his son in this video.

[@nicknorwitzPhD]

Thanks! Was so happy Zac was willing 😊

[@brcage]

This makes so much sense.. i was hit with debilitating OCD/Instrusive thoughts which has ruined my life, after being forced to take anti-acid long term due to a hiatal hernia i developed...

[@davidgrimes4726]

Amazing video! Also very interesting that bile acid have direct effects on HPA! I would have assumed secondary effects in terms of nutrient absorption or shaping the microbiome.

[@nicknorwitzPhD]

I found it very cool too :)… evidently

[@greglemon57]

Fix your diet= Fix your health!

[@nicknorwitzPhD]

👍👍

[@dacisky]

This was a profound video,thank you Nick.

[@sarahjarrett2155]

Well done, Nick!

[@nicknorwitzPhD]

Thanks

[@oldguy5458]

Nick, Thanks for all you do..Best Regards

[@nicknorwitzPhD]

Thank you. Funny handle btw

[@clinhart]

Interesting. Can this explain why after having my gallbladder removed, I felt like I somehow lost my mental grit? I felt more limp. This was a pretty significant mental shift after that surgery, and I never had an explanation for it. I can imagine that removing the gallbladder alters the levels and timing of bile acids in the bloodstream. Also I had a 1 1/2 year depression after that surgery, but that's not that clear cut to have been caused by that surgery because I had a burnout before, and I also had pancreatitis which only slowly healed. So that may also have contributed.

[@ThePowerofRandomKnowledge]

There is a connection indeed www.ncbi.nlm.nih.gov/pmc/articles/PMC4460135/#:~:text=Among%20patients%20with%20gallstones%2C%20those,cholecystectomy%20%5B25%E2%80%9327%5D.

[@nicknorwitzPhD]

Sorry to hear about all that. Sounds like there was a lot going on. Hope you’re doing better now

[@clinhart]

@@nicknorwitzPhD Thank you, and yes, I do better now. It was more than 20 years ago.

[@mr8966]

Not being glib - but following on the Oreo Cookies and 720 Eggs videos - perhaps you should consider a one month 100% animal fat carnivore diet?? I would hazard a guess that it would draw more than the first two videos combined and put to bed the ‘saturated-fat-bad’ dogmatists.

[@nicknorwitzPhD]

Will consider

[@karenohanlon4183]

Go for it Nick.

[@mmanda515]

Love this & agree. I also think for those following keto or carnivore, cutting out all the ultra processed chemicals & garbage in 'foods' these days helps tremendously too. Otherwise, it's like putting diesel in a gas engine. Worse & worse over time, the entire car will fail.

[@nicknorwitzPhD]

Absolutely

[@kinpatu]

Takeda is the name of one of the original researchers. The etymology has no relationship to the biological function.

[@nicknorwitzPhD]

I like warrior rice paddy more 😒

[@1timbarrett]

Yes! Takeda is a common surname in Japan…! 🇯🇵

[@Robin318-r9p]

O' Captain, My Captain! Thanks Nick...keep helping all of us!

[@nicknorwitzPhD]

Dead Poet’s Society… amazing movie

[@3buzzy]

Keep going Nick! You’re doing great 👍

[@nicknorwitzPhD]

Thank you! Will do!

[@shelleyhodgkinson1341]

So interesting! Keep it coming!

[@nicknorwitzPhD]

Thank you! Will do!

[@cynthiagilbreth1352]

Luckily, I have never had mental health issues. That being said I am amazed at how much my mental well being has improved since I’ve been on keto way of eating.

[@nicknorwitzPhD]

There's good ... and there's great! If you can have the latter, take it!

[@cynthiafasulo3828]

One of my own special people. Poignant video. Sure hit home. Metabolic truth is finally emerging. How can we thank you?!

[@nicknorwitzPhD]

Thanks. Just keep engaging with me here and on other platforms. That's the greatest thank you.

[@EMP469]

If you look up Nutrition Detective he came up with Toxic Bile Theory, many ppl on his program are recovering from things like acutane use, decades of thyroid issues w/ meds, and much more. Nutrition Detective episode 71 on youtube, he explains it. God bless you all.

[@nicknorwitzPhD]

Thanks for the suggestion

[@itzakpoelzig330]

Thanks, I'll definitely give him a gander!

[@lewynld]

I am completely confounded by Nick's caloric intake during his experiments and how he can fail to gain weight. Could you please consider sharing metabolic labs in a future video?

[@nicknorwitzPhD]

Re the 6000 Cal expt? What do you want to know?

[@lewynld]

@@nicknorwitzPhD Did you do fasting insulin pre and post experiment? Ldl, triglycerides, apo b, any of those markers?

[@StrasserRocker]

Fascinating. What implications does this have for those of us who don't have a gallbladder? As I understand it, our bile never gets very concentrated.

[@BCResilience]

Great one! Too bad people won't know about the tribute without actually watching the video.

[@nicknorwitzPhD]

Ya, well the idea of a KZbin is for people to watch the video afterall

[@maidomaidonaidekka]

武田(Takeda) is the last name of the person... I assume it was named after someone like Aloysius "Alois" Alzheimer of Alzheimer's disease. ☺

[@nicknorwitzPhD]

So a guy name Takeda discovered TGR5? That’s boring 🥱

[@arifaahamed7239]

Takeda is a common family name in Japan ; I guess someone named Takeda found the gene and named in his name 😊

[@nicknorwitzPhD]

I wish the story were more interesting 🧐

[@faylouise8169]

Little talked-about topic, 'Bile Brain' LOL "Bile acids (BA) activate receptors and ion channels. Nuclear receptors activated by BA include the farnesoid X receptor (FXR), pregnane X receptor (PXR), vitamin D receptor (VDR), liver X receptor (LXR), and glucocorticoid receptor (GR). Unconjugated BA might be able to cross the plasma membrane, and conjugated BA might cross the plasma membrane using transporters." Looking at bile in the brain, gut, liver, vitamin D, a healthy bile entrohepatic system means a healthy brain bile system, the two are of course connected. The Biosynthesis, Signaling, and Neurological Functions of Bile Acids: Bile acid receptors and signaling crosstalk in the liver, gut and brain: Insulin and Bile Acids in Cholesterol Homeostasis: New Players in Diabetes-Associated Atherosclerosis:

[@janbeck7989]

Well done!

[@nicknorwitzPhD]

Thanks

[@eagsalazar]

Hi Nick, thanks for this great content! Have you made a video that summarizes what I should *do*? Like "Check these 3 things", if a,b,c, then do Keto, focus on exercise of type X, sometimes consume carbs using strategy Y, and take supplements m,n,o..."? As interesting as your videos are, I'm struggling to make sense of it all and translate your content into a coherent plan (beyond "do keto").

[@hannahattermann5249]

Please do a video about the Rotterdam study. It associates insulin levels and plaque in the arteries. Thank you.

[@andrewrivera4029]

I weird side effect I get from a carb cheat is I feel a little more emotional!?!? When I’m back on 0 carb that tends to go.

[@nicknorwitzPhD]

You’re not alone there.

[@qyoinqyuri]

Mr. Norwitz, have you explained your thoughts on coffee and/or caffeine consumption? Would love to know what you think about the subject. I've been struggling with my health and caffeine addiction is one of the most glaring issues I have in my diet.

[@craftycalley]

My brain is exploding. Any chance of a simplified version?

[@nicknorwitzPhD]

Studies are showing that certain diets can treat cases of depression. I review a study speaking to one mechanism that might be involved.

[@polibm6510]

Isn't Takeda also a pharmaceutical company?

[@nicknorwitzPhD]

I didn't know that.

[@mattlevault5140]

Takeda Pharmaceutical Company Limited Global Headquarters 1-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo 103-8668, Japan

[@1timbarrett]

Yes, it is Japan’s largest pharmaceutical company. 🇯🇵 💊

[@meatdog]

I sure hope you had Robin Williams family's permission to exploit this man's misery. He did not want to disappear into the madness of ALZHEIMERS and severe depression and did what he needed to do with his own destiny.

[@nicknorwitzPhD]

Yes, his oldest son and members of his foundation’s approved this video and thumbnail. His oldest son also spoke in it. And he had Lewy Body disease, not Alzheimer’s.

[@peterfaber7124]

Another great video,.. but to spice things up a little, Nick,.... It's not "these data".... The correct way is to say "this data set". ChatGPT agrees with me: "The focus on language precision, like using "these data," can sometimes overshadow the more important aspect-what the data is actually referring to. By being overly rigid with language, there's a risk of losing clarity about the substance or context, which is more critical in conveying the point. Precision in the content itself is what truly matters, not just in the words used to describe it." 🙃

[@nicknorwitzPhD]

“These data” is perfectly correct ✅

[@kevinroelofs739]

TUDCA has helped me with depression. It's bile salts.

[@nicknorwitzPhD]

Pretty amazing. I haven't heard of it having that clinical use case. Tell us more.

[@anthonysalvato3]

Does this mean an increase in cortisol always leads to a decrease in TGR5? Or is it primarily chronically elevated cortisol that has this effect? I know there's research about leptin suppressing hunger via the HPA axis, so maybe the link to obesity and depression is related to chronically elevated cortisol due to impaired leptin signaling, which would both impair hunger suppression and chronically decrease TGR5. I want to link a study but I don't know if youtube treats links from comments as spam.

[@nicknorwitzPhD]

You should be able to link a study. And I think chronically elevated cortisol would be the problem. You do need cortisol. It has a purpose. If you didn't have any, that would be a problem. IDK what role leptin could play in all this... it may associate and be an epiphenomenon. If you want more on leptin signaling, see a prior video I did on leptin resistance in the brain. Cool stuff.

[@Deanriley]

I see a Nobel Prize in your future.

[@nicknorwitzPhD]

I wouldn’t count on it… but I would say no if offered… I’m in my 20s so I have time 🤣

[@gstlynx]

Thanks Doc. Great presentation.

[@nicknorwitzPhD]

Glad you liked it!

[@jenlambie14]

Two questions.. Does metabolic health have an impact regarding dementia ? Also does stress and/or trauma affect our DNA & can metabolic health change that ?

[@vad1kanaita]

It would be great if you could dig deeper into familial hypercholesterolemia. Would be interesteding in mechanism of this and what people can do to solve elevated cholesterol....

[@jackiedelvalle]

'Solve'? 🤔

[@jackoverton8343]

I think it's just the same? Eat healthy(0 processed foods) so there is no inflammation. You just have to adhere more consistently than others without hypercholestrolemia. No different from someone that ate to the point of diabetes. They have follow keto/low carb more strictly than the average person to avoid accelerated decline.

[@jackiedelvalle]

R Williams seemed a lovely soul 🥺

[@nicknorwitzPhD]

Certainly… remarkable human

[@gwpainter4606]

Nick, what does this mean if I'm on a bile acid sequestrant to reduce cholesterol? What unintended consequences should I watch out for?

[@nicknorwitzPhD]

I don’t think I can answer this personal question in a KZbin comment. Sorry

[@ninapoe]

Does fasting produce the same amount of bile acids as eating a calorie-neutral keto diet? Just wondering, because I can get to the same ketone levels either way but I'd like to know if one might have more of an antidepressant effect than the other.

[@nicknorwitzPhD]

I suspect fasting and ketogenic diets have different effects on bile acids.

[@kimberlyf4888]

Nick, do you think there is connection between the lower levels of deuterium in the foods that typically make up a keto (and especially carnivore) diet and the effects those diets have on both metabolic and mental health?

[@nicknorwitzPhD]

I rarely say never but I think it’s unlikely that is a main driving factor

[@skip2820]

Cortisol spikes glucose - which leads to Insulin Resistant brain - low brain energy

[@nicknorwitzPhD]

May be more complicated than that…

[@themasculinismmovement]

Just tell me what I have to eat to not feel bad. Do I have to eat a wombat? A platypus? A porpoise? Whatever I have to eat I'll eat it.

[@nicknorwitzPhD]

I hear unicorn and hippogriff stew is supposed to work wonders

[@johnswitzer6566]

Posterior cortical, hot zone lighting up like an arcade pinball machine. He is zeroing in on my beloved potatoes.

[@johnswitzer6566]

Doc,yet Another record broken. Note to self, revisit Cool Hand Luke

[@nicknorwitzPhD]

I said nothing about potatoes 🥔 … I don’t think potatoes are bad… but there are definitely healthier forms… quite a versatile root

[@johnswitzer6566]

@@nicknorwitzPhD spuds,the Uber tuber. Do I have egg on my face? Pondering a cogent observation of your egg extravaganza. It’s in the embryonic stage. Boxing above my weight here. LMHR, an enviable phenotype…

[@johnswitzer6566]

@@nicknorwitzPhD I’m boxing Below my weight.

[@JackieUnfilteredASMR]

❤thank you

[@nicknorwitzPhD]

Thank you back

[@ilariabertini968]

powerful!

[@nicknorwitzPhD]

I know! And Robin ❤️

[@ilariabertini968]

@@nicknorwitzPhD 🥰

[@jaymcn]

What are your thoughts on ray peat?

[@nicknorwitzPhD]

I like coconuts 🥥 … how’s that? Tbh, no I don’t think the dietary approach has much legitimacy IMHO, based on what I’ve seen. Just one opinion

[@tomnoyb8301]

Thought Bile was alkaline, not acid?

[@KoiRun50]

Gallstones. Do they serve a purpose?

[@nicknorwitzPhD]

Purpose? I don’t think so.

[@edrozenrozen9600]

Possibly Divine punishment. 😉

[@jackoverton8343]

Yes, to deter you from continuing an unhealthy diet/lifestyle. 😂 Obesity is one of risk factors. Ultra processed foods also implicated.

[@naturallawhealth9272]

Thank you for apologizing to the mice.

[@nicknorwitzPhD]

😂😂😂

[@altruisticscoundrel]

Sweet surprise!

[@nicknorwitzPhD]

Thanks 😊

[@maggiehuff9661]

What you don't address is that Robin Williams had LEWY BODY DEMENTIA. LBD presents in paranoid delusions, depression, hallucinations and suicidal thoughts. It is often misdiagnosed if it's diagnosed at all. Robin was diagnosed postmortem. LBD is a variant of Parkinsons.

[@nicknorwitzPhD]

I know… I’ve seen Robin’s Wish. Excellent doc. Have you seen it? (Incidentally, a large part of my PhD was on Parkinsons… I’m well acquainted with these diagnoses.)

[@maggiehuff9661]

​@@nicknorwitzPhD I did see it. I lost my husband 6 years ago to LBD. By the time we got a diagnosis he was hallucinating and having suicidal thoughts. There is so little known about LBD. I pray that someday nutrition will find it's proper place in health care.

[@matt_staton]

What happens if someone has a sludgy gallbladder or no gallbladder

[@nicknorwitzPhD]

You can make bile without a gallbladder just fine

[@matt_staton]

@@nicknorwitzPhD good to know. Love your content man. Keep it up.

[@loewenberg11]

Is this why you need fat so the bile is secreted?

[@nicknorwitzPhD]

Bile acids do help digest fat, yes.

[@pureabsolute4618]

Fats are also building blocks for growth and hormones. They are also a source of energy that are not carbs. And for those of us in poverty, they are a cheap and dense form of energy.

[@Finn959]

Diet has never helped with my mental health. Neither has exercise 😔

[@AI-vs7sm]

But, are you incorporating enough fats into your diet to trigger the bile, or is your bile levels low? Can you eat fat or does it upset your stomach? You don't say if you have any symptoms.

[@francescaerreia8859]

What’s diets have you tried and for how long? And what else was your environment and lifestyle like?

[@nicknorwitzPhD]

Sorry to hear that. Hope you find something that helps.

[@chrismaclean1755]

I've been keto/Carnivore for nearly 10 years and still struggle so I get it completely. I now believe there are other factors involved which I am still looking for but I strongly believe what Nick says is true and we must address our metabolic health while searching for the final answer.

[@nicknorwitzPhD]

@@chrismaclean1755 Thanks for sharing Chris. Of course, I don't mean to imply there is a silver bullet... but learning about the role of metabolism in mental health can - I think - translate to real world benefits.

[@andrejg3086]

It's very interesting. I wonder how much animal research translates to humans.

[@nicknorwitzPhD]

There are practical limitations on the sorts of studies you can do in humans. We turn to animal models to dissect mechanisms and gain understanding into the biology that may underly clinically observed phenomenon. That said, I think there is every reason to believe this mechanism is conserved. What I can't say is what % of the picture it is for any given individual. What we can do is ask questions, remain curious, and innovate.

[@helencooney1363]

Suspect that epigenetic control sequences in non-coding DNA could differ significantly more than the genes involved in metabolic pathways and its control, both within species and between species, cumulatively causing quite significant differences. Not aware if this has been quantified yet.

[@mistahtom]

Like, comment, share, subscribe

[@nicknorwitzPhD]

Thank you 🙏🏻

[@AndreasFroehlich1985]

💯

[@nicknorwitzPhD]

101 ;)

[@edrozenrozen9600]

How can we trust these schools after the Harvard study?

[@nicknorwitzPhD]

Elaborate on your position? What is “the” Harvard study

[@edrozenrozen9600]

@@nicknorwitzPhD there was a study released about 8 months ago that attempted to prove that red meat leads to diabetes.

[@HerimusDarimedi]

@@nicknorwitzPhD это то исследование, которое они скрыли много лет назад. Но хватило бы одной "Гарвардской тарелки", чтобы ВСЁ понять о них. Из них мне понравился только доктор Бервелл, декан Гарвардской медицинской школы, который сказал своим студентам: "Половина того, чему мы собираемся вас научить, ошибочна. Наша проблема в том, что мы не знаем, какая именно половина.".

[@KarsonsChannel]

He had Lewy body dementia didnt he?

[@nicknorwitzPhD]

Yes. High recommendation to see Robin’s Wish documentary

[@gjahncke]

You can do it. Just eat meat

[@nicknorwitzPhD]

Pretty sure you’ll release bile for non-meat foods too… just sayin

[@DCGreenZone]

👍👍👍👍👍

[@nicknorwitzPhD]

👍👍👍👍👍

[@DCGreenZone]

@@nicknorwitzPhD I'm thinking less gun violence for one thing.

[@fleshtonegolem]

ya don't use Robin Williams in your thumbnails. That is really poor taste

[@nicknorwitzPhD]

Members of his foundation approved it and his son consented to the thumbnails and gave his two cents in the video. So I feel very comfortable with my decision

[@lorimckay2704]

whole food vegan diet does same for Depression if that helps you narrow down best study, unless you are being keto industry funded, it is great place to look.

[@nicknorwitzPhD]

Citations? There are quite a few studies not on keto for depression and other mental health disorders. Can you provide me similar for vegan diets because based on my reading of the literature veganism is associated with higher rates of depression, if anything.

[@uvaid3914]

May I get your mail sir...from India just want to show something

[@nicknorwitzPhD]

Sorry, not going to give out my personal info here.

[@HealthHaven998]

Mental health benefits is what will finally make keto go mainstream

[@nicknorwitzPhD]

Would be great