How do neanderthal genes affect your health? (With Geneticist Laurits Skov)

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How do neanderthal genes affect your health? Today I'm chatting with UC Berkeley geneticist, Laurits Skov about his research in this area. We even get to look at my genome!
Sources:
www.nature.com/articles/srep0...
www.nature.com/articles/s4158...
johnhawks.net/weblog/tracing-...
academic.oup.com/gbe/article/...
/ stefanmilo
Disclaimer: Use my videos as a rough guide to a topic. I am not an expert, I may get things wrong. This is why I always post my sources so you can critique my work and verify things for yourselves. Of course I aim to be as accurate as possible which is why you will only find reputable sources in my videos. Secondly, information is always subject to changes as new information is uncovered by archaeologists.
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[@StefanMilo]

Go to ground.news/stefan to stay fully informed. Subscribe through my link for as little as $1/month or get 40% off unlimited access this month only.

[@Madferreiro]

​@@ansfridaeyowulfsdottir8095dude chill, stef wont awe you on every video. Dude is deep on the dad bod though, need to do some diet and exercises

[@StefanMilo]

@@ansfridaeyowulfsdottir8095 get lost

[@dama3979]

@@Madferreirowhy be a dick he’s not doing fitness channel is he?

[@ElusiveCube]

why is everyone assuming we had the Neanderthal gene through sex? Could it be we have their genes through an evolutionary process??

[@Tompanelli1]

Gerard Depardieu!!! So funny I literally LOL'd

[@EmperorTigerstar]

I'm always happy to find another thing to blame my flaws on!

[@StefanMilo]

Well if you watch to the end you might find a hidden Neanderthal strength

[@dominicfox101]

Oh hey

[@bobert6259]

@@StefanMilonice prostate

[@StefanMilo]

Positively glowing

[@akcarlos]

@@StefanMilo its certainly something you can brag about to a potential mate.... or anybody else that will listen.

[@Cidiuss]

"Stephan Milo, neanderthal prostate" is a phrase that 100% goes on a business card, period

[@AdDewaard-hu3xk]

Shrieking with laughter.

[@DunningKrugerJnr]

Come at me, prostate! 😂

[@brawndothethirstmutilator9848]

AussieMav, That’s what s h e said.

[@TheMosv]

"I think it's easier to explain all the boinking we did if there was a little bit of chat..." You've got a talent for humanizing evolution and making genetic science feel relatable, good job man!

[@mattstevenson1334]

Gotta take me to dinner before you can take me dancing good Neanderthal sir

[@ManuelCampagna]

Note that the bit of chat may have been done in sign language.

[@barbarusbloodshed6347]

Whenever there's talk about our ancestors' boinking I let out a little sigh... as I'm afraid the most likely scenario in most cases was rape. That would need no language and "robbing the other guys of their women" has been a widely used strategy in our species' history. And if we assume that our species was more prone to this behaviour than Neanderthals it would explain both, why hybridization happened and why the number of "pure" Neanderthals got smaller and smaller.

[@apextroll]

I had heard years ago that language came about because hominids began to walk upright and rape was less possible so "chatting her up" became a strategy.

[@pat8988]

@@barbarusbloodshed6347I agree completely. With the basic human intolerance for anyone different (real or imagined), I find it easy to imagine that rape and pillage and slavery were the predominant methods of interspecies reproduction.

[@brun4775]

I only found your channel recently and have binge-watched everything. Please hurry up and make more videos to sate my self-absorbed sense of entitlement.

[@john.premose]

It seems like he's been binge eating.

[@ManuelCampagna]

@@john.premose with all that popcorn, he must be close to bursting...

[@Mettabeshay]

welcome, I am obsessed with this mans videos

[@IReallyLikeTreessmileyface]

Beautiful thumbnail as always Stefan, very memeable, thank you for blessing us on this day

[@AlexFairchild]

Bro, what is UP with that thumbnail 😅😅😅

[@josephd.5524]

@@AlexFairchild the human-neanderthal-potato link is undeniable!

[@chi-if7kv]

Tibet mentioned!! I am both Tibetan and Sherpa, and it's so interesting to see this. Hopefully, someday I get to do a deep dive in my genes, too.

[@laxman90210]

With that combination, you can live on top of mt Everest easy!

[@LoisoPondohva]

That's cool! My graduate paper was on Denisovan gene influence on Sherpa oxygen metabolism and interstitial lung liquid concentration.

[@yorkshirepudding9860]

We can't blame Gérard Depardieu on the Neanderthals.

[@JKDMan2000]

huh

[@danalasmane6191]

His placement was hilarious 😅

[@JoeyVol]

😂 KZbin changing how our handles are seen to foil scammers must have shocked you, because you're no longer Mary (or whatever it was) you're now Yorkshire Pudding. 😂

[@yorkshirepudding9860]

Pudding by name, Pudding by nature. @@JoeyVol

[@murdockscott]

Let me tell you how refreshing it is to look at the about page for a KZbin channel and actually fine USEFUL information about the presenter and their credentials! Thank you for that, I wish more people gave the information we need to evaluate the information we are viewing.

[@Geeman002]

Very interesting video, as yours always are, Stephan. I get a little tinge of excitement when I see you have put a new video out: always informative, and with a nice touch of humor. I do miss the spoon however 😂

[@-xirx-]

I completely agree about the spoon. I had stopped mentioning it recently as I was getting the feeling that it was annoying Stefan. But I do still come to the comments every video to see how many of the older fans still mention it! 😉 R.I.P *_SpoonMic™_*

[@LuSquared_]

He's too big for the spoon now, he's forgotten his humble start 😂 (just to clarify I'm just joking)

[@AdDewaard-hu3xk]

Yes, the spoon is the brand! Spoon on!

[@julescaru8591]

What a great discussion with a very personable,and knowledgeable, guest! Loved it! All the best Jules 💕👍

[@tunneloflight]

Excellent. The largest obvious impact from Neanderthal genes is in the immune system with the HLA-B27 gene. It codes for a robust immune system. However, it has a problem. Bacteria evolved along with Neanderthals to cause a susceptibility to severe arthitis (reactive arthritis, anklyosing spondylitis and others). It doesn't cause the diseases. It does lead to a susceptibility if infected by the offending organisms. More interesting is the huge variation in vision, and in CYP enzymes. Whether these are of Neaderthal or simply ancient human origin from the north of Europe is as yet unknown. The CYP enzymes can with the right mix lead to vastly higher levels of pregnenolone (and sex hormones in general). And this leads to more robust nerve sheaths and vastly faster nerve speed, higher IQ, and quicker responses. This appears to be related to improved night vision in low light. Other genetics leads to vastly better night color vision, much increased blue vision (and sensitivity), and more. It also leads to much faster repsonse to motion in the visual field and differences in repsonse to flicker. And no - none of this is in the science literature - yet. The Neanderthals had huge changes in brain structure related to vision, and hundreds of thousands of years to adapt to the far north and low light for long periods which strongly favored adaptation to those conditions. The high altitude genes come from three (maybe four) separate populations. Denisovan for the Tibetan version. Ethiopia for a Sapien version. And the Andes (e.g. Peru) for a different Sapien descendant version. Clearly Neaderthals had hugely advanced technologies for the time (evidenced by the pitch they used to cement their weapons), which require high temperatures to produce - that we have yet to reproduce today. Passing this on (along with nmany other things) required language. Erectus which preceeded Neaderthals, Denisovans and Sapiens had advanced tech as well. They had to have sailed to get to some places they went. That moves sailing and the tech for that back to a million years ago. That kind of tech all but requires language. Though there is a sapien bias toward the idea that Neaderthals, and Denisovans went extinct and there was limited breeding and interaction, the amount of their genes in us argues that rather than limited interaction, what really happened was that the severe events from major volcanic eruptions impact on climate 74,000 years ago, 39,000 years ago, and up to 12,000 years ago severely stressed and nearly killed off all of the homo lineages. They then all simply merged. And the result is sapiens sapiens made up of the sapiens from before, some remaining erectus, neaderthal, at least three different denisovan species, an unknown other speices from europe, as many as seven distinct strains from Africa, and possibly others. We never were truly seperate species in the gneetic sense. And we weren't all that genetically different. We were in some cases culturally and tribally quite different and adapated to very different climates. But when push came to shove, that geographic speciation fell by the wayside.

[@evasartorius9528]

Wow, that was worth reading twice. I do believe that the found Neanderthal DNA in fossilized crap found in California that were dated at 250K old. So these people where all getting around by boat or on foot for a very long time. Have you seen any research about Neanderthal hearing? Finally, I always did see the possibility of a Neanderthal family or individual being the last of it's tribe joining the Human's that were passing through. Sort of a 'why don't you come with us' thing.

[@rogerogrant]

FASCINATING! According to 23&me I have a very high number of Neanderthal markers (>87% of their database). I also have a semi-mysterious autoimmune disease that has resulted in much arthritic damage that started when I was about 25. Anecdotally I think I have faster than average response to visual stimuli as well, and something about the shape and size of my optic nerves has freaked eye doctors out for my whole life. They think I’m about to go blind or something, but I’ve never had any problems except for age related presbyopia (I’m 50).

[@evasartorius9528]

I have never done the 23 and Me thing but I Hear you. I was in amazing shape until my fifties. I didn't have any meds, no glasses never had a broken bone...But then the rot set in. I can still get by without glasses if I squint, but the arthritis - OMFG! They have known since 1960 that the stronger your bones are the more osteoarthritis you will have. I have a lot. I also have a long boody and short legs, I am bow legged, My eyesight was 20/60 when I was young. I could read at 60M what others could read at 20. and I didn't need reading glasses. My driver examiner was dumbfounded. I developed Sjogrens and it didn't go away it can cause arthritis in the hands and I have that. My question is do your feet get cold often? Do you get frostbite.@@rogerogrant

[@voodooranger1]

@@rogerogrant The “autoimmune disease” you mentioned, and related to what was mentioned above about organism related arthritis; could the mysterious autoimmune disease be related to bacterial microbiome bias, like an overpopulation of a certain triggering gut bacteria. Have you had stomach ulcers? Or if you've had full spectrum anti-biotic's without a post good bacterial intake, it's possible that bad bacteria have populated and hold back the good populations.

[@dumbvedeoz]

plus Neanderthals hunted and ate humans by night! And rape was widely practiced by both groups! The idea is humans invent the bow and arrow to fight off the Neanderthals. The first arms race!

[@stonehengemaca]

Thank you so much for not using click baiting titles. It's great to know what I'm getting from the title. Instead of, "There's something strange about Neanderthal DNA" etc..

[@abjectnihilism...]

Excellent video, as always. Your dedication to academic integrity and your hilarious sense of humor are a breath of fresh air. Appreciation for Mr. Skov's expertise, as well. Thank you for posting.

[@llabronco]

I always eagerly await content from you, just yesterday I checked your channel to see if you had posted anything new, but then, to open KZbin today and see this stunning thumbnail... GLORIOUS.

[@heftymoreganic4158]

Fantastic video this, great shout getting a geneticist in and making the video call flow really well (i imagine there must have been quite a hit of editing required on your part there)

[@Grace-gw8rs]

Keep up the great work man! Absolutely love your channel.

[@galeocean4182]

another stellar episode - hope to see you again real soon!

[@John-qo9hw]

I thought this was like a 6-7 minute video when it finished. Amazing job( as always )stefan

[@josephjanitorius797]

Stefan could've done an hour on this topic and it would've still seemed like 6 minutes.

[@whyttestar]

Love this channel. Great to be early to an upload

[@CM-ju2ti]

Been waiting for new Stefan Milo content 🙌🙌🙌👌👌 it's a Christmas miracle

[@MarkVrem]

yup always a nice watch, even if it all went in one ear and out the other

[@keithklassen5320]

It's November.

[@user-ol2mr4bx7c]

You're my favourite thing to watch these days Stefan ❤

[@speed_elf]

he's the coolest thing

[@hitest8925]

Stephan, nice to see you come out of your shell. Always informative and getting more and more entertaining. I trust you won't let the show get between you and you. Cheers.

[@Me-ei8yd]

Thank you!! Excellent work- watched all your work. Really coming into your own style. Thank you editor! ♥️🇨🇦♥️

[@DreaOnzagle]

I think this is my first time commenting on one of your videos! This was fascinating & makes me want to go down a proper genetics rabbit hole.

[@jesterssketchbook]

im really proud to have Neanderthal DNA - they were an amazing species - strong bones, bigger brains than cro-magnons - whats not to love?

[@marionetteproject508]

I may not be neanderthal, but im proud of having denisovan dna- resistance of certain diseases, adaptation of high altitudes, increased immune response.

[@gregoryl.levitre9759]

Pride is a sin.

[@jesterssketchbook]

exactly bro - they arent "lesser" because theyre an ancient group - theyre adapted and strong. @@marionetteproject508

[@Nepetita69696]

​@@gregoryl.levitre9759Ok? Then I'm sinful.😂

[@voodooranger1]

And sin-ful of Denisovan DNA!

[@ralphditchburn1456]

Hi stefan. Love your presentations. Bot your book. Keep truckin'

[@northwall9243]

An incredible video as always. Fascinating stuff Stefan!

[@kurtoogle4576]

This is neat! Thanks Stefan & Laurits Skov!

[@jameswright4640]

I've long suspected you had a more neandertalish prostate. I think it was the plastic spoon that gave it away. Definitely a marker. Great video as always! Thank you so much for this. I learn a ton from your videos.

[@evodevo420]

The internet people say a lot of strange things about neanderthal genetics in humans, so thank you for setting the record straight!! you are doing the lord's work

[@davidec.4021]

Best thumbnail on the channel Thank you Stefan

[@DakiniDream]

Thanks very much for this upload ! Very interesting like all your docus, and still lot of fun to watch.

[@Fushione]

The photo of Gerard Depardieu when mentioning Neanderthal was priceless

[@stuhough5130]

I’m so early Australopithecus would be giving me a high five.

[@elihinze3161]

You always have the best videos. Thanks for this fascinating content!

[@rjdbdbdbhxsb4422]

my favorite youtuber is back!!!!! love ur vids

[@kmalkiee1760]

Thank you for your videos. I always love seeing something new from you, constantly learning so much about where we came from. PS I am very much looking for to your Whitesands video! Edit after actually finishing this video... I watched another history video recently discussing a genetic resistance in some Europeans to the black plague. This was also connected to people who seem to be resistant to contracting HIV. They also made a loose connection to resistance to COVID. Could this be all connected to Neanderthal DNA? I can't wait to see wait DNA tells us next.

[@warmist8197]

I hope im not the ONLY person to laugh hysterically at the thumb upon reading the title...im sorry im only human....but i laughed till i hurt.

[@pacoparigi2163]

Fresh as always... love your style 😊

[@SuperMrHiggins]

Love your vids, Stefan. Keep on keeping on.

[@SuperMrHiggins]

Glad someone found a way for an income from their degree. 😅

[@johnl5316]

my jeans are usually tight

[@braydeny]

My jeans are loose fitting, I work in construction

[@Mob135]

Buy new ones

[@Stoitism]

Super interesting. My 23&me says I have more neanderthal DNA than 85% of their customer base.

[@josephjanitorius797]

Then you must have a remarkable prostate!

[@Mommyof4AAAB]

I'm more Neanderthal than 97% of their customers 😅

[@Stoitism]

@@Mommyof4AAAB Haha congratulations!

[@laxman90210]

@@Mommyof4AAABGerard depardieu is your father!

[@Mommyof4AAAB]

@@laxman90210 I don't know who that is

[@frankhudson5985]

Another fascinating and entertaining video. Stefan, these are my favorites! Kudos too to Mr Skov -- who may have the fastest speech I've ever heard (outside of those rapid-fire tv commercials from some years back, and also a wonderful movie about high school debaters called Rocket Science). Please make more of these!

Another great one Milo!

[@bramstedt8997]

14:46 I haven’t seen all of the literature on the subject, but my understanding is that the racial disparity in disease survival rates has more to do with environmental factors on different continents. Europeans have some of the best immune systems due to all of the selection pressure from medieval plagues. Same with China. It’s the same reason Native Americans were affected much more by European diseases in the early 1600s; their gene pool had no prior exposure because their culture was more isolated and farmed less (less opportunity for animal to human transfer of disease). It’s also why Africans are more resilient to malaria and some other tropical diseases but may be more susceptible to some many Eurasian diseases

[@anthonykleist5144]

I did find the systemic race argument weak, as 1) The study doesn't explain that, only a racial disparity. This can be explained by like you said, other genetic aspects in selection due to a history of overwhelming diseases. 2) cultural differences, different cultures interact with themselves differently, and that aspect was most definitely NOT included in the study to a sufficient degree. Laurits just outright stating an assumption like that as if it were fact; stating it is environment, but stating also that the only environmental factor for COVID is racism, is intellectually dishonest.

[@TenOrbital]

Laurits and Stefan are a charismatic pair!

[@TrishCanyon8]

Always great content.❤❤❤

[@Masaru_kun]

stefan youre the only youtuber i know who has researchers making absurd jokes about butts by the end of your interviews, you're doing god's work

[@gentrymiller3170]

Came to watch but then realized I should wait for my fiancée because she loved your videos when I introduced her to them

[@andyrenshaw9148]

YAY more Stefan :)

[@nikanna75]

This was a great watch

[@100dessins]

Great subject! I really enjoyed this.

[@Zapperlicious]

Lost it when you phased to Gerard Depardieu 😂😂

[@lakrids-pibe]

Good lord! I didn't recognise that as Gerard Depardieu.

[@pianotte2011]

Hi Stefan! I remember Robert Sapolsky in one of his lectures saying that the FOXP2 gene in humans made vocalisations more complex. Birds and other animals also share this gene. So it could make sense if the neanderthals had a less structured communication? Great video!

[@LoisoPondohva]

As a geneticist by education, I am 99% sure (after just spending 30 mins on additional academic search to check) that we don't know that Neanderthals didn't have that gene. We have surprisingly good Neanderthal genome reconstructions, but the best are far from complete.

[@Geeserunner]

So awesome to see someone mention my favorite science bro! Love Sapolsky. Fun fact he has a lecture series on the Stanford KZbin channel if you haven't seen it yet.

[@85jacob85]

Nice vid as always

[@smileyzed3843]

Loved this Stefan Thankyou

[@terriblefez]

For 15:30, Id say since the info came out it's been a hypothesis that they were better at fighting plant toxins. There were many genes which let some of us pick up only a fragment. They could uptake, process, and let down those sorts of things quickly which is great until one of their human relatives only has the genes for one of those functions. It becomes frailty.

[@merry0ldsoul716]

Hands down, best prostate on YT! I don't care what the haters say

[@erinyes3943]

.?!

[@MatthewCaunsfield]

Nothing like a good deep dive! 😊

[@Sunmonks]

Yeaaaah New Stefan Milo vid is always a good omen.

[@Where_is_Waldo]

With the FOXP2 gene, Laurits seems to imply that the modern family with notable variation in this gene was able to understand language and use words but just struggled to form sentences so, with Neanderthals having such a similar gene to us and with what we know about the way they lived, I think they must have had language even if their language was perhaps vastly different from our own.

[@evasartorius9528]

Animals can communicate amazing things without baffle gab. Words may complicate things some but have you ever seen a bunch of wolves, or big cats heading out to hunt?

[@Where_is_Waldo]

@@evasartorius9528 Fully agree but I still strongly suspect some vocal language capacity among Neanderthals, especially considering what is known about their hyoid structure.

[@ivarbrouwer197]

Is difference in language type not amore cultural thing? I mean, I think we can ultimately learn all languages spoken but cannot speak them as a given: we also need to learn the language of our ‘tribe’. It’s not plug and play.

[@Where_is_Waldo]

@@ivarbrouwer197 I was referring more to the implications of modern variations in the FOXP2 gene on the ability to form sentences. It is my understanding that most, if not all modern languages use sentences.

[@ivarbrouwer197]

@@Where_is_Waldo well, I think genes aren’t very specific on how you string words together, as long as you do. I think it’s more context based and maybe originated already with the use of tools: referencing an object in combination with a tool… (let’s throw some shrimps on the Barbecue) if so, I would say language started with tool usage

[@Bazilli]

Rarely do I ever laugh at a thumbnail.

[@paul6925]

I definitely lol’d at that 🦭

[@Orcrez]

Love these videos! What’s a good DNA test that is not crazy expensive?

[@rowanwhite3520]

Fascinating video, thank you!

[@gnomevoyeur]

2% sounds small but it’s actually enormous. You have 64 great-great-great grandparents(subject to cousin marriage or closer inbreeding). They were all born 100-150 years before you and each contribute less than 2%. Archeological evidence suggests there haven’t been full blooded Neanderthals for 10s of thousands of years. 2% suggests a much larger amount of interbreeding back in the day than is comfortably imaginable.

[@terriblefez]

I want to bet there was an advantage for accommodating the enlarged modern head. The neanderthal already had huge skulls as adults but there is also a chance both species were way more similar as young people.

[@chillin5703]

It might, but not necessarily. If we had a small population (say, a few thousand) Sapiens who left Africa and they interacted with smaller populations of Neanderthals in different instances, then theoretically after only a few interbreeding events we might have a decent amount of Neanderthal DNA within every single individual in a population just because it spreads out, and by that point you don't need to inbreed to maintain the Neanderthal DNA, because no matter who you interact with they have it. Remember, this doesn't represent one or two Neanderthals who are common ancestors to all the Neanderthal DNA in us modern humans it might represent hundreds or thousands of Neanderthals giving tiny contributions each.

[@greengorillah]

Very interesting! Just it would be more precise to refer to "Neanderthal variants" here, not "Neanderthal genes", we all have these genes, just different variants of them. Btw I remember there was a family in my country with young brothers (under age 35) that had very severe Covid19, it was found a genetic variant they both carried was the reason for this, I don't know if this was a Neanderthal variant or not.

[@thelivetoad]

Fascinating. Great vid

[@LizStewart1442]

Learned alot. Thanks!

[@skytan4394]

Very cool video 👍

[@nettlarry]

How do you know? Did you watch it 3x speed?

[@skytan4394]

@@nettlarryIdk I just thought the concept of the video was cool

[@Misses-Hippy]

Great vid. Subscribed!

[@rubin8352]

stefan, you never miss. banger after banger

[@NigelIncubatorJones]

Does the gene 'reduce your risk' as you said, or is it more correct to say the gene is correlated with a lower risk?

[@Krunch2020]

I’m afraid you’re right. This is epidemiology. There’s no way of knowing whether a person will have a correlated trait or disease.

[@PeterOConnell-pq6io]

Didn't catch your genetics presentor's name, but congrats to both of you for an entertaining and informative presentation. Two things your presentor (perhaps wisely) side-stepped : 1) the ~21,000 human gene number issue is far, far, far beyond complicated, as any eukaryote's 'single' gene is comprised of numerous coding 'exons', which, depending on mRNA processing, provide a mechanism for 'one' gene to encode multiple protien products (of different functions?) from the same DNA template due to a process called 'alternative' mRNA splicing. mRNA-reassociation kinetics studies suggest the human genome can actually produce as many as 250,000 different protein products. 2) 98% of both genomes are non-coding, and the vast majority of base-pair differences between the sibling (opinion: hate to use that word, we're way closer than that) species reside in those regions of unknown (presumably regulatory) function. Interspecies DNA sequence alterations affect the actual peptide sequence of

[@Zumbs]

The name is Laurits Skov. It is also written in the title of the video 🙂

[@voodooranger1]

There is growing evidence that it was migration to Africa from greater Europe.

[@randomsandwichian]

This is why I love what science brings to light, we all may not have the best chances genetically, but where we are born in makes such significant changes to how we live.

[@USDAselect]

Thank you for this video which added to my meagre knowledge of ancient genomics Mr Top Notch Prostate.

[@DracoRubor]

Great video, Stefan. You know, speaking about neanderthals, I was thinking that a breakdown of the film "Quest for fire" (1981) would be super interesting. There are very few movies depicting human prehistory, and I rather like this one, but is also super wierd and I don't know how accurate it is. I'm sure you would have interesting stuff to say about it. Kudos and keep up the good job.

[@Where_is_Waldo]

Haven't seen it (though I've heard of it) and I'm only as knowledgeable as you can expect a non expert with a personal interest in this subject to be but, being made in 1981, this is guaranteed to be rife with inaccuracies. I would definitely love to see Stefan pick it apart... although anyone who has been a long time fan of Stefan Milo and/or North02 and/or Gutsick Gibbon would surely be able to pick out many points of inaccuracy on their own.

[@Madferreiro]

My teacher had me watching that movie as a kid. Never forgot.

[@JustInTimeWorlds]

It’s based on a Belgium book written in 1911 in French. It’s an interesting read (I spoke about it on my channel), but I wouldn’t call it accurate 😂

[@erynlasgalen1949]

Not completely accurate. The movie bills itself as Science Fantasy. I saw it in a theater when it was first released, and I have a digital copy of it.

[@anthonyp3113]

This channel hasn't been the same since the loss of the spoon mic. Really, that's the only major change to the channel but it's not the same nonetheless!

[@-xirx-]

R.I.P *_SpoonMic™_*

[@KarlaJTanner]

Award winning thumb nail. ☝️ Love ye man!!

[@carolnorton2551]

Stefan, Congratulations on your Neanderthal prostate, and many happy returns !

[@_robustus_]

Ron Perlman has a LOT more than 2%.

[@margomoore4527]

What about Andre the Giant?

[@That-Native-Guy]

I am Emberá Native American and my results came in at 3.1% even though I am also mixed blood so it’s not as high as full-bloods at 4-5% but not as low as Spaniards at 1-2%, so yea it’s pretty high for the average

[@johntomasini3916]

On the edge of my seat again Stefan, learned a bit more about my genetic past, think I'm good for prostate, the doctor confirmed that one. As for the nether regions, b@lls not so good. Thanks mate.

[@pseudopetrus]

This was so good, I had a good laugh!

[@malcolmcurran6248]

What is truly overwhelming for those of us still around who go back to the paleolithic of computer punch cards and endless perforated yellow tape, is the absolutely mind blowing advance in computing power without which modern genetics especially would still only be a few steps from Mendel's garden of wrinkled peas. It's incredible how we now take it as a normal, natural and essential part of everyday life. And to think that most of that potential capacity was contained and then expressed in possibly a single gene for language is simply mind boggling. And now computers are taking on a life of their own perhaps way beyond our capacity to comprehend and control! We may become, if it hasn't happened already, to them as neanderthals were once scornfully considered by us.

[@Ass_of_Amalek]

thumbnail shows one sapiens chin and one neanderthaliensis chin

[@bdempster44]

Absolute legend of a thumbnail photo.

[@ericharris5299]

Man I love your videos.

[@joshuabauman3209]

Smash that like button for our beautiful boy Stefan Milo!!!

[@eyetrollin710]

I have shovel teeth, this comes from My Father's Side, I've actually asked my mom if I could feel her teeth and that is what normal Sapient teeth are like,, I highly doubt that I've never had a broken bone and that I have shovel teeth because of a meager 2%,, some of us have a lot more. And in regards to never having a broken bone I have done things that doctors are questioning why I'm alive and yet no broken bones no hematoma and I heal from things that should kill normal people,, I buggered up my knee they wanted to do surgery I said no, here I am a few years later with a perfectly healed knee. Yeah I might be a little bit Ginger and I'm very very passionate but I don't think those are bad things at all😊

[@tcuisix]

Your videos are excellent

[@ParameterGrenze]

Milo… you are a wonderful human being.

[@Reticulating-Splines]

The covid thing is interesting, something funky is going on in my family genetics in that area. Me, my mom, and my brother are all still either covid-free or asymptomatic at most. My dad and my sister both had typical covid experiences, all while we were living with them. My brother and I were even working in hospitals w/covid patients at the beginning of the panny, still nothing. By now pretty much all the rest of our family and friends have had it. We're all black, btw.

[@bramstedt8997]

Could just be that you’re all pretty healthy and among the large group of people who aren’t really affected by it. Aside from that, Africa as a continent has more (excluding Neanderthal and Denisovan contributions) genetic diversity than the rest of the world combined, so you may have just won the lottery as far as which African variants you have of certain genes. Or if that’s not the reason, perhaps there’s a distant Eurasian ancestor somewhere in your family tree

[@WujiErTaiji]

There are plenty of people that didn't have covid yet or had it really late and as you wrote you could just have been asymptomatic. My wife works in a psychiatric ward where they have covid outbreaks all the time and she just had (symptomatic) covid for the first time a month ago. She also thought she has been somewhat immune as she also lived with me when I had covid or she has been with friends that had it before they knew.

[@Exquailibur]

Its very likely that human Neanderthal hybrids were like some fish hybrids, some fish hybridize and for example only the females between species A and species B are fertile but only when species B is the male and Species A is the female while all other combos fail to be fertile.

[@LimeyLassen]

The "Neanderthal deserts" thing does suggest that hybrids had reduced fitness. I think that justifies calling them different species even when they can interbreed.

[@Exquailibur]

@@LimeyLassen Well a species is a pretty arbitrary classification overall, there is no point at which two populations become different species but instead its a gradient as shown by how impossibly hard classification of species gets in insects and fish. What It probably was is that Hybrids in human settlements would presumably need to live by human rules and therefore if the genes in these deserts harm their ability to socialize smoothly or otherwise function by human rules than they will be selected against. If the hybrid is too neanderthal it may get bullied, become an outcast, or otherwise be disadvantaged by the social atmosphere.

[@simonward-horner7605]

Fascinating! Thank'ee!

[@crowvii]

Hahaha the thumbnail. Great video as always!!

[@almusquotch9872]

1980: "I bet there'll be flying cars in the future." 2023: Double chin clikbait to smuggle in lessons on Neanderthal genes.

[@MrClarkisgod]

That thumbnail kills me. Lookin like a hairy thumb of ancient knowledge.

[@billsmith5166]

Very interesting episode.

[@studytuning3549]

When you first mentioned "genes" I thought you said "jeans" 😅 listening to the video while replacing "genes" by "jeans" provides a different experience 😂 great video as alsways 😊 thank you so much!!

[@margomoore4527]

Me, too. I instantly imagined leather jeans with the fur forming the lining….