How GLP-1 Agonists Are Changing Obesity Care with Dr. Spencer Nadolsky

GLP-1 agonist medications have been a popular topic of discussion recently. While this weight loss drug was designed for obesity, GLP-1 agonists like Ozempic have made their way into Hollywood. This has people questioning their safety and possible health risks, especially in the long run. Are GLP-1 agonists a quick fix for weight loss or a lifetime prescription? Who should be prescribed this medication, and what are the possible side effects?
This Longevity by Design episode features an interview with Dr. Spencer Nadolsky-An obesity and lipid specialist physician. Dr. Nadolsky explains how GLP-1 medications cause weight loss, answers questions about safety concerns, and discusses interesting patient stories about how people react to this medication. Dr. Nadolsky has extensive patient experience with GLP-1 agonist drugs and is very knowledgeable about their current use and future potential.
Why Dr. Nadolsky became a physician: (2:00-4:13)
What is cardiometabolic medicine?: (4:13-5:17)
What is a “healthy” metabolism?: (5:17-7:37)
How does diet impact glucose regulation: (7:37-10:20)
Why has insulin resistance increased in the past decade?: (10:20-11:45)
Ethnicity impacts BMI cutoffs: (11:45-12:57)
Is obesity a choice?: (12:57-17:40)
How socioeconomic status impacts obesity: (17:40-21:30)
What's better: A BMI score or a DEXA scan?: (21:30-25:33)
How strength training improves healthspan: (25:33-32:32)
What a fasting insulin blood test tells you: (32:32-36:58)
Health risks of insulin resistance: (35:15-38:08)
How insulin resistance can increase ApoB: (38:08-39:25)
How does ApoB predict heart disease risk?: (39:25-42:50)
Why isn't ApoB included in typical lipid panels?: (42:50-44:25)
Behavioral science and clinical practice: (44:25-50:06)
How do GLP-1 agonists cause weight loss? (50:06-56:03)
Negative side effects of GLP-1 medications: (56:03-57:36)
Price of GLP-1s: (57:36-58:53)
GLP-1: A short term quick fix or a lifetime prescription?: (58:53-1:02:19)
Biggest health myths on social media: (1:02:19-1:08:45)
Top tip for healthspan: (1:08:45-end)
Longevity by Design is produced by InsideTracker, your data-driven wellness guide for optimizing your healthspan. For a limited time, visit hubs.li/Q021Z4gp0 for 20% off any InsideTracker plan.
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[@BrownEyedGal77]

Very informative. Thank you.

[@jeffchastain2977]

Dr. Nadolsky, I wish that one of you online doctors would address the issue of the GLP1 agonist shortage and how Diabetics who depend on these drugs to control their A1c and to help them lose weight, CANT GET these drugs because everyone is taking them to look better in swimwear at the beach this summer. I can't fill my Trulicity prescription this month because NOBODY has it. Insurance needs to hold to their guns and not pay for these unless you are Diabetic and/or morbidly obese. Id like to hear your view on this issue.

[@ColettaDesign]

I love this man!

[@johnkelly1704]

Good video

[@InsideTracker2]

Glad you found it valuable!

[@advertiserfriendlyusername5362]

Yes. Have a competent doctor explain the risks and benefits of the medication(s) available to you. Then, make a decision together.

[@rufisdodd4318]

One big downside of GLP-1 is the fat/lean mass loss, studies are showing as much as 2/3 lean mass loss to 1/3 fat. As you mentioned, muscles are a huge sink for excess glucose, having less muscle is not a good thing. Also I think it's a little disingenuous to say you haven't received any money from pharma, when the main reason that WW acquired your company for 132Mil was to get access to GLP-1 agonists. WW saw the writing on the wall and knew they needed to have a way to get these drugs to it's members.

[@rocket2558]

No studies are showing a ratio of fat/lean mass loss. They only report weight loss. Unless you can provide a link to a study that also measured lean body mass pre and post?

[@rufisdodd4318]

www.ncbi.nlm.nih.gov/pmc/articles/PMC8089287/@@rocket2558

[@jinxigrl]

I have been on tirzepatide for 8 months and did dexa scans before and after losing over 30 lbs. My lean body mass and muscle mass are essentially unchanged. However I made an effort to eat a high protein diet and incorporate heavy resistance training.

[@rocket2558]

@@jinxigrl thats very surprising considering fat mass has a lean component to it. Everything I've seen on weightloss says losing lean mass is expected but you can maintain muscle mass or even gain some depending on training status.

[@chickensandw1tch]

Amphetamine does the same🗣️😍