How is BREXPIPRAZOLE different from ARIPIPRAZOLE? | Mechanism of action of REXULTI | Dr Rege

Brexpiprazole [7-{4-[4-(1-benzothiophen-4-yl) piperazin-1-yl]butoxy}quinolin-2(1H)-one] is a novel atypical antipsychotic that is structurally similar to the atypical antipsychotic, aripiprazole.
#brexpiprazole #rexulti #antipsychotics
The video is about Brexpiprazole Mechanism of Action but it also covers:
-Mechanism of action of brexpiprazole compared with aripiprazole
-Brexpiprazole Side effects compared to Aripiprazole side effects
Brexpiprazole is a :
•Partial agonist of dopamine D2 receptors that is at a lower level of intrinsic activity than aripiprazole.
•Partial agonist at serotonin 5-HT1A that is at a stronger level of activity than aripiprazole.
•Potent antagonist of serotonin 5-HT2A receptors.
•Potent antagonist of noradrenaline alpha1B/2C receptors.
•Moderate affinity for histamine H1 receptors
Brexpiprazole has a lower incidence of akathisia than aripiprazole.
It has a long half-life of 86-91 hours.
It has minimal impact on prolactin levels.
It is metabolised by CYP2D6 and CYP3A4 enzymes.
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