Everything you NEED to Know about Rexulti (Brexpiprazole)

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🎥 This video was edited by:
Rahul Kanchi / rahulkanchi24
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References:
Rexulti (2023) FDA Label. Retrieved from www.accessdata.fda.gov/drugsa...
Stahl, S. M., Grady, M. M., & Muntner, N. (2021). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications. Cambridge University Press.
Stahl,S. (2021). Stahl’s Essential Psychopharmacology: Prescriber’s Guide, 7th Ed. Cambridge University Press.
Whitaker R. (2023). How the FDA approved an antipsychotic that failed to show a meaningful benefit but raised the risk of death. BMJ (Clinical research ed.), 382, 1801. doi.org/10.1136/bmj.p1801
Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.

[@TheJenrichichi]

Rexulti has been my lifesaver after years of treatment resistant depression. Felt like a huge black cloud was lifted.

[@LevelheadedMind]

I'm glad to hear you found a treatment that works well for you.

[@ThePeacePlant]

Amazing! I am glad. I am trying it tomorrow

[@ThePeacePlant]

Did you get a shot? The one I heard was a shot

[@bekisakura]

Did you get any side effects? Any weight gain? My doc put me on it

[@TheJenrichichi]

A few lbs weight gain, which I can't stand but it beats feeling like I am walking around feeling horrible. Good luck with it!@@bekisakura

[@suanneleepool]

I’m 54 and diagnosed a year ago with early onset dementia. I have had bipolar 1 majority of my life. I will be trying this starting tomorrow. At this point I’m really praying for as few side effects as possible. I’ve been having such a hard time with this. Thank you for the video!

[@LevelheadedMind]

Thanks for watching! I wish you well on your mental health journey 🙏

[@joechlystun7979]

hows it going? i'd like to try Rexulti for my mother with dementia and was wondering if its working for you?

[@Barbara-jq2se]

Re:comment: 👆Oh my dear! I’m so so sorry for your awful situation with such a rough/hard situation or experience that’s on your plate rt now. I don’t know you, but after reading your words my heart breaks/hurts for you. 🙏Please Jesus Christ watch over your daughter. You know precisely what & why she’s going through this horrible situation. Would you please surround her with a strength that she’s unaware of in order to deal with this awful circumstance that she’s having to endure with now. Please in whichever way you see possible for her to comprehend that she’ll get your attention that she’ll reconsider taking this particular kind of drug. It’s really between you Almighty God, Jesus Christ & Holy Spirit as to what you do & if she responds correctly. BLESSINGS to YOU!

[@ancabostinariu6550]

Your presentations are great.

[@jessm7902]

So informative thank you so much

[@LevelheadedMind]

You're welcome 😊

[@nerdbamarich2063]

Thank you for the fantastic info

[@LevelheadedMind]

Thank you for always watching and commenting! I really appreciate it 🙏

[@nerdbamarich2063]

@@LevelheadedMind you're more than welcome 🙏🏾

[@abelwright8229]

I'm taking this for treatment resistant depression and ptsd. I have a higher risk for side effects like sedation and twitching so I'm on 0.25 mg to start. I'm on testosterone as well so I already have a lot of concerns for cholesterol and things. Not many doctors have experience working with trans people so I'm worried that I might be at risk for some of these metabolic issues.

[@khimbhandari7901]

Can you make a video on oxcarbazepine?

[@maluballer23]

The recommended doses in agitation is actually 2mg. Per the clinical trials

[@michaelw6277]

I’m bipolar 1 and SSRIs send me to the moon. Before it was clear that I was BP1 I was treated for major depressive, and after reporting aggression on SSRIs, I was given Effexor and Lamictal. I felt less depressed for a while and there was no aggression, but the depression came back. After failing a trial with Vraylar I was given Rexulti and the depression morphed into severe anhedonia. Against the advice of my nurse practitioner I’ve started titrating off of the Effexor because even though it’s an SNRI, I wonder if it’s giving me a purely negative effect as an SSRI would but I can’t see it because of the Lamictal. Question: should I still see the anti depression benefit of Rexulti without an SSRI/SNRI? I feel like my mood is lifting and a straight jacket is being removed as I reduce the Effexor. Is this a case of… even if this is counterintuitive, if it works it’s the right thing to do?

[@mek.carvalho]

This anhedonia may be caused by the type of the antidepressive you're taking, it may be too serotoninergic for you (this happened to me when I was taking fluvoxamine - I felt like a robot). Then my doctor changed it to one that goes for that dopamine and norepinephrine area, bupoprione. Besides lamotrigine may not be enough for treating bipolar disorder, but it depends on your organism. I'm bipolar type 2, and started with lithium, lamotrigine and bup. My aunt only took lamotrigine, but it took her 6 months to get better. Psychiatrist disorders are not easy to find the medicine that fits very well dor each paciente. But keep trying, it's worth it. Ps; if you take lithium, don't forget to dose it's blood level because there is a range that is therapeutic, otherwise it may be toxic.

[@buttercup2305]

Thanks so much this was so helpful, i'm about to start 2.0 Rexulti

[@LevelheadedMind]

You're welcome! I wish you the best of luck.

[@ThePeacePlant]

Please let me know your experience

[@lkjyuiop1987]

I’m on that it’s hard to tell what it does but it is night and day for depression

[@user-gs3ci8zy4f]

Rexulti gave me bad side effects I couldn't stop moving felt restless nausea allergic reaction and spaced out

[@Ireallydontcaredoyou]

Jezel , what are your thoughts about its off label use for Borderline symptoms/behaviors (i.e. emotional dysregulation) ?

[@199martin1]

After trying almost all atypical antipsychogic including low dose clozapine without success or very low results or sometimes worse outcome than the original state, I started 2mg Rexulti 18days ago. So far it works better than previous ones but I don't know if the dosage is ok. I liked Abilify but it stopped working and side effects was horrible. I hope Rexulti will work for my disorganised shizophrenia with therapy resistant negative symtomps. I already feel something positive.

[@LevelheadedMind]

I hope it works out for you, thanks for sharing your experience 🙏

[@Barbara-jq2se]

Re:comment: 👆Just be very careful with anything you take into your beautiful body. A long time ago I was on Abilify & my mood was definitely much better than ever but I wasn’t hypomanic just enjoyed being alive. Felt like a happier human being. But unfortunately & unexpectedly I found I was gaining weight & started looking heavy! I had gained 20 Ibs of water! I really had to get off Abilify quickly. With Rexulti I’ve heard enough about the horrific side effects that I personally wouldn’t want it around me 1 bit! May Jesus Christ & The Holy Spirit surround you personally with His Divine power & intervene where you need it. 🙏Blessings being sent to you!

[@fatimazehra2928]

How did it work for u @199martin1

[@A_Walk_In_Their_Shoes]

Could this medication make a panic disorder worse? I had similar experiences with Wellbutrin and Effexor..

[@marymarsillette6551]

I had the same with Effexor!! Id also be interested to know. I hope it doesnt becus im being put on this for panic/anxiety on top of an antidepressant. What i read online was that if it does just contact your doctor right away.

[@rishikhan7180]

Which medicine for feeling bieng trapped anxiety anywhere there you cant find exit

[@LevelheadedMind]

Try therapy.

[@jatinsharma5024]

In your opinion , Which medicines are best for tourette tics? If they are mild .

[@LevelheadedMind]

Have you tried clonidine?

[@jatinsharma5024]

@@LevelheadedMind No effect.

[@jatinsharma5024]

@@LevelheadedMind I have mixture of Tics ( Mild ) and OCD

[@kriskakumani5620]

Please make a video on clomipramine. Thanks

[@wsp7794]

Luvox 100mg + .5mg rexulti for depression. Anyone? Any comments?

[@irecover]

I started Abilify and the noise in my head (racing thoughts & negative thoughts) completely silenced. But I stayed constipated 5 days, heart burn stuffy nose and weight gain maybe due to being constipated also my tongue felt like I was having to talk funny like it felt thick . Now I am on Rexalti I am scared bc I am border line diabetic high cholesterol and taken HTN meds. Giving it a chance. Nose still stuffy.

[@LevelheadedMind]

I hope you have better luck with Rexulti. Make sure to monitor your labs every 3 months if your concerned about the metabolic syndrome. It doesn't happen to everyone, but beign that you are diabetic you are a higher risk for it.

[@ooakRAREGEM]

Hello, how is it working for you?

[@melysam.9049]

Thanks so much for doing Rexulti. Should we use as a monotherapy in agitation?

[@LevelheadedMind]

It is approved for monotherapy use for those with Alzheimer's dementia and agitation. It is also used off label as monotherapy for agitation in other populations.

[@melysam.9049]

Thanks again! I appreciate you covering this topic

[@bethhansen]

Can you please do a video on the preferred anti-depressants & anti-anxiety meds for people with pre-existing bruxism? Is Wellbutrin + buspirone a good combo?

[@ThePeacePlant]

It does work. It's more of a mood booster. I hate to say but I used to snort them to get a sort of amphetamine high. I was not using it right but it definitely worked for that. In short it did lift my mood

[@kamiwellman8056]

​@@ThePeacePlantwhat was that?

[@richwilson5969]

I take wellbutrin and buspar. I think they work well together. If I don’t take wellbutrin I cry easy. If I don’t take buspar every day several times a day I end up with having lot of anxiety. I’m looking for a good anti depressant right now. Which brought me to this.

[@cpru957]

Can you make a video about Buspar/Buspirone?

[@LevelheadedMind]

Here it is: kzbin.info/www/bejne/lYbKlnhmqMqJr8ksi=AVS-EJMTq75AjZHj

[@anantpandey8672]

Ma'am please make a video on etizolam.

[@LevelheadedMind]

I am not familiar with this medication, but will look into it. Thanks.

[@Swart781]

Rexulti was beyond psychotic, after a half hour of taking it I would have flashes of orange and yellow and my eyesight, after a couple months of use it gave me the feeling of cancer in my bones sluggish to walk.

[@timcepin3386]

How are you doing now?

[@Swart781]

@@timcepin3386 it almost ended my marriage..... The doctor took me off it and it turns out no medication is better

[@Ireallydontcaredoyou]

Ironic that it did that since it’s an antipsychotic medication used for schizophrenia but I guess it induced almost immediate visual hallucinations for you , and within a half hour as well after starting it which I guess means you have one of the most rare genetic profiles in terms of how you metabolize medications because it takes at least a week generally for it or any antipsychotic to have actual psychopharmacological action in the brain.

[@pygmy_leopard]

I've had horrible Insomnia from Rexulti 2mg onwards and Now I'm looking to switch. I was unable to find my goldilocks zone.

[@LevelheadedMind]

I'm sorry to hear that I hope you find something that works for you.

[@timcepin3386]

How’s your sleep now? I’m generally able to sleep every other night!

[@matthewrousseau2982]

So it's better than abilify for akathasia but worse for weightgain

[@LevelheadedMind]

I wouldn't say worse, but about the same.

[@user-uj8gz1lr6j]

How does Rexulti improve cognitve disfunction?

[@Barbara-jq2se]

Re:comment: 👆Please think 2x or more before taking this drug! You’d better pray 🙏 before taking this drug into your body. There are many good reason to reconsider it! There’s really too many seriously bad/horrible side effects that could trigger inside your body anytime. I cringe thinking about how all these poisonous chemicals/drugs can affect your body from head to toe. Re: your head that involves your brain 🧠! It’s called: Head quarters! It’s a quarter of your body. But that’s where your personal computer is located! The wrong drug can easily cause havoc on/in it. Guess you’re gonna do what you’re gonna do.

[@ivaniscool99]

Please make a video on Geodon (Ziprasidone)

[@LevelheadedMind]

Thanks for the video idea, I will consider it.

[@ivaniscool99]

@@LevelheadedMind Thank you for considering it

[@ThePeacePlant]

I am on it. It works

[@cpnstbn1266]

I tried ability and it worked for my mood and sleep but caused me intense akathesia ( restlessness). Now I’m trying Rexulti, hoping it works but we’ll see

[@fatimazehra2928]

How is your experience with it ?

[@cpnstbn1266]

@@fatimazehra2928my akathesia continued with the Rexulti so I had to stop taking it.

[@imhidingasecret]

Can this be used for OCD?

[@ThePeacePlant]

Try with your doctor and if it doesn't work then you can stop

[@LevelheadedMind]

With caution as it can cause issues with impulse control as I discussed in the video.

[@Rebecca-zr3lu]

I pray for healing from all medications’ side effects and EPS symptoms in Jesus name Amen Yesterday, today and tomorrow. For eternity. 😊

[@gregoryalbert6020]

Anyone take this for anxiety? I was just prescribed this alongside my SSRIs but I haven’t seen much talk about anxiety.

[@LevelheadedMind]

There really aren't studies on its efficacy for anxiety. Depending on the type of anxiety you have, it may benefit.

[@dell1032]

I thought 5HT-2A was serotonin. I might be wrong.

[@LevelheadedMind]

Yes, it's a serotonin 2A receptor. 5HT refers to serotonin and the numbers ans letters are specific receptor sites.

[@garysimone4977]

God what a dangerous med !!!!

[@LevelheadedMind]

Yes, medications aren't for everyone and you must always weigh the risk vs benefits.

[@usmanwisa3386]

Talk about the new drug Gemiperone

[@LevelheadedMind]

I'm not sure about this one, is thar the correct spelling? Do you mean Geodon?

[@usmanwisa3386]

@@LevelheadedMind sorry I mean Gepirone

[@wsp7794]

I cant take rexulti, too many side effects

[@timcepin3386]

Such as? I mean did you take it?

[@capsule2326]

Taking it as an add-on to anti depression med. Got started at .25mg every other day. After 3 weeks of that, was moved to .25mg every day. After just over a week of the every day, I noticed I had gained about 7 -8lbs. Was first given Abilify which hit me with terrible side-effects almost right away. I haven't noticed any change what so ever being on this stuff and certainly don't see anything positive that would counteract the negative self-image I have with the continuing weight gain.

[@LevelheadedMind]

That is unfortunate! I hope you are working with a provider who can help you get to the root cause of your depression so you can get off these medications and feel good again!

[@zrtknl]

I'm on day 21 of 1 mg rexulti and 5 mg prozac for depression. No results yet. which is disappointing since it is so easy to use. It gives me absolutely zero side effects.

[@LevelheadedMind]

That's a very low dose of Prozac, perhaps discuss that with your provider.

[@coreyboren3476]

I’m on the same thing but higher Prozac and it does help me

[@zrtknl]

I made a mistake. I was on 10mg Prozac (not 5) but I think Prozac is my problem. I don't think it works anymore. Will be looking at new SSRIs to pair with Abilify or Rexulti. @coreyboren3476 @@coreyboren3476

[@xgengx7530]

5mg of prozac is a very low dose

[@user-dv4qp5ll5q]

This is a dangerous drugs for seniors should not be used

[@anthonybenedetto9315]

Your videos are great but the little sound effects drive me absolutely mad. The snapping of fingers, clicking and popping sounds are extremely irritating. Perhaps this might be part of MY mental issues. 🤷‍♂️

[@lkjyuiop1987]

So that’s where the running nose comes from

[@user-dv4qp5ll5q]

Reckless decision

[@darcylamourea6666]

Rexulti makes me feel like I took Adderall

[@ascgazz]

Avoid anything that begins with “Brex”. 😂

[@user-zy7zo2je1m]

Avoid meds begins with Z

[@ascgazz]

@@user-zy7zo2je1m avoid unsolicited medical advice from strangers on social media. 👍🏻

[@jasondrobick2363]

What abou panic attacks?

[@blacKKKjesus]

PSYC MEDS DO NOT WORK 🤦🏽‍♂️

[@ThePeacePlant]

They do

[@GoogleUser-kl7qu]

Rexulti works great for depression added to antidepressants. What else it works great for, I couldn’t tell you.

[@michaelw6277]

They do work. The difficulty is finding the right combination that works for you.