How One Disease Changed What We Know About Medicine - Twice

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Searching for a cure for rickets led to the discovery of vitamin D. Fortifying foods with vitamin D led to another disease, and a whole new way to view genetic disease in general.
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Thumbnail Image Credit: Clint Budd
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[@SciShow]

Visit brilliant.org/scishow/ to get started learning STEM for free. The first 200 people will get 20% off their annual premium subscription and a 30-day free trial.

[@alto7183]

Buen video, los bebés a futuro a pesar de tener más facilidades para sobrevivir mejor, requerirán cuidados, además de que con las IA y más herramientas los pediatras tendrán más fácil su trabajo para que se desarrollen al máximo, se va requerir estarlos cuidando bastante.

[@ronr8001]

😊😅😅😅😅😅😊😅

[@esecallum]

THIS VIDEO SPONSORED BY BIGPHARMA TO SCARE YOU AND KEEP YOU SICK SO THEY LEECH MORE MONEY OF YOU. HOW MANY KILLED D3 . ZERO. HOW MANY BY BIGHARMA DRUGS? MILLIONS

[@petrai7077]

@@alto7183 o

[@sonder2164]

This video should be used as a comparison to the fluoride they are putting in everything. People are being Overdosed on fluoride daily. You cant monitor the intake because it's in everything, we even bathe in it.

[@Fayanora]

Junk DNA is the nature equivalent of those times when there's like, a random tomato behind a wall in a video game that you can noclip into the wall to find sometimes, and you're like "Why is there a tomato here?" and the devs are just like "we don't know how it got there, but the game breaks if we take it out."

[@Wiimeiser]

Like the Pineapple in TF2, except that's not actually true and it seems to just be an unfinished icon texture or something.

[@jadeasereht4638]

A perfect representation

[@wren_.]

@@Wiimeiseri thought it was a coconut

[@LetsTakeWalk]

Load bearing tomato

[@Unmannedair]

​@@LetsTakeWalk don't tell Integza... He'll bring the whole game down😂

[@thejuanderful]

I'm a bit disappointed the link between excess vitamin D and vitamin K2 deficiency wasn't mentioned. Vitamin K2 helps the body use the calcium properly after it's been created by vitamin D. So if you're deficient in vitamin K then supplementing vitamin D by itself will make the issue worse. The two work in balance.

[@justin-tyme]

I suspect the channel is funded by pharma in some way or another. They don't want people to realise the benefits of vitamin D so they skew the facts.

[@aussie405]

Similarly, iron and folate. You can be anaemic with too much iron, if you have insufficient folic acid.

[@1LY4x8s96r]

That's right

[@IKSRotarran]

Well, I guess I'm out of luck. I'm supposed to be taking vitamin D supplements, but I'm also supposed to avoid vitamin K. Vitamin K messes with regulation of warfarin dosage.

[@IKSRotarran]

@@OnlyKaerius Eel and natto? Nihonjin de wa arimasen.

[@EmilyJelassi]

This was very interesting. I recently found out that I’m missing 2 proteins in my DNA. My oncologist explained it and I’m basically working with half of my immune system, which explains why I get sick so easily. I keep hoping that new discoveries and research (like CRISPR) will one day allow doctors to replace the missing proteins. 🙏🙏🙏

[@bcd2233]

Hey, just saw a video that Deep Mind (a google ai company) just mapped 200,000 proteins and gave the results to science. I believe this happened recently. Hopefully your help will be sooner than later. Best

[@JamEngulfer]

Do you know any more specifics? I get sick way more often than most people and it might be worth looking into if that’s the issue I have (even if there’s only a tiny chance).

[@jaxblonk5127]

As an immune deficienct individual I feel ya. XLA or x-linked agammaglobulinemia for ya medical nerds.

[@bcd2233]

@@JamEngulfer If you search Deepmind Protein Folding you will see lots of hits that might point you towards something. Sorry I’m not more helpful. I’m not that scientific!

[@newfreenayshaun6651]

@@JamEngulfer dude, I have to jump in and say work on your energy. As healthy as we can all be exercise and diet-wise, it's not the end-all-be-all of good health. Qigong, exercise, gratitude, life force. In this Collective universe you have created your own. If everything is energy, you determine your Healthy Future by willing it. That also includes focusing hard on everything that you can possibly throw at it. Good luck, do. Keep in mind, you're made whole from day one, whenever you determine technically when that was and all, lol.

[@teripage3314]

The problem is that people think just because a little is good they think a lot is better. And if it's natural it won't hurt you, not true. Arsenic is natural too. Arsenic is deadly, but is used to heal in tiny amounts in both homeopathic medicine and in some chemo but more is definitely not better!

[@alexander-mauricemillamlae4567]

so youre saying I should stop taking my arsenic pills? My mum said because it cured her leukemia that it will prevent me from getting leukemia! /s (fr tho arsenic trioxide does still have a medical use as chemotherapy for two specific types of leukemia)

[@drakean8]

Also cyanide

[@justenough215]

Too much Hydrogen Dioxide will kill you and people drink it like it's water

[@conlon4332]

There are two types of vitamins. Fat-soluble vitamins, which are dangerous to get too much of because your body can't get rid of them easily, and water-soluble vitamins, which your body can get rid of easily so are generally harmless even in large doses. A quick Google tells me that vitamins A, D, E, and K are fat-soluble, while the B vitamins (folate, thiamine, riboflavin, niacin, pantothenic acid, biotin, vitamin B6, and vitamin B12) and vitamin C are water-soluble.

[@GamingManiacMan]

So is ricin

[@gdragonlord749]

I had a problem with abysmal vitamin D in my adult years. Thought it was anemia but instead, my vitamin D levels were single digit. I was immediately given 50k supplements to be taken once per week. Was nice not having to fight for 30min just to wake up and not constantly be hungry, depressed, and weak. Edit: spelling

[@brendaoluwalana186]

Amen! Me too.

[@alien9279]

Sounds like need to dose up on D 😂

[@katarh]

@@alien9279 You might need to! I went into a yearly screening exam thinking I might have depression, but the nurse practioner was like, "have you checked your vitamin D levels?" Sure enough, they were on the floor. A few months of 50K IU once a week and I did much better. Now I also take 5K IU every day.

[@hansisbrucker813]

Same problem 😟

[@gdragonlord749]

@@katarh Wow this is more common than I thought. Granted, if I am ghost white and got it, probably not uncommon.

[@cathpalug1221]

I remember our professor drilled that too much is twice as dangerous as too little and I eternally grateful for that

[@joseywales6168]

Yes, for every thing: it is always better to do too little and need to do more, than it is to do too much and not be able to reverse the process

[@overcraft1441]

You need to also have vitamin K2 to move blood calcium into bone. If not you get calcified arteries and kidney stones.

[@Snowshowslow]

Ahhh so that's why we give D and K to babies. It seemed a little random to me.

[@momkatmax]

In other words, it is a balance. Some medications do seem to hinder the absorption of certain vitamins along with certain surgeries. Take, for example, bariactric surgery. You change the length of the gut and hinder the absorption of vitamin B. So you have to take it via shots, large oral caps, or sublingual.

[@TheresaTV1]

@@Snowshowslow no, Vitamin K helps with clotting, so newborns are given an injection of it at birth to prevent possible hemorrhage from vit K deficiency. It has nothing to do with vit D in this setting. Source: I’m a pediatrician.

[@meganofsherwood3665]

​@@momkatmax Yep! B12 specifically. In order to absorb B12, you need a protein called Intrinsic Factor, which is produced by the stomach and (iirc) is acid-activated. That's why people on long-term antacids or proton-pump inhibitors also need their B12 levels checked periodically, because the decrease in acid (which preventa heartburn, esophageal cancer, ulcers) also means that Intrinsic Factor doesn't work as well as it should

[@SovietReunionYT]

​@@Snowshowslow The vit K injection to babies is actually to stop random bleeding. The main function of the K vitamins is to make the clotting agents work properly, so without them it's like having hemophilia. And practically all babies are K-deficient because vit K is absolutely terrible at getting into the placenta and into breast milk, regardless of how much the mother has in her bloodstream.

[@Brian-L]

That voice in my head reminding me “hyper-, meaning high and -emia, meaning presence in blood. High presence in blood.”

[@salmaislam3415]

Chubbyemu

[@arielsalinger-kraft6197]

That's neat. Etymology can be fun, can't it?

[@GIMPmanipulated]

Presenting to the emergency room with....

[@mikemondano3624]

Absent one most important fact: There has never been even one case of hypercalcemia or any other problem associated with Vitamin D₃ (cholecalciferol, the form produced by sunlight). It is harmless even in massive doses of millions of units. The problems arose with Vitamin D₂ (ergocalciferol) which is found rarely in the modern world.

[@katarh]

Good point. I've never seen vitamin D2 sold anywhere.

[@aussie405]

Skin cancer on the other hand...

[@petef1273]

The comment with the URL in was removed, you will have to look up: Marins TA, Galvão Tde F, Korkes F, Malerbi DA, Ganc AJ, Korn D, Wagner J, Guerra JC, Borges Filho WM, Ferracini FT, Korkes H. Vitamin D intoxication: case report. Einstein (Sao Paulo). 2014 Apr;12(2):242-4. doi: 10.1590/s1679-45082014rc2860. PMID: 25003934; PMCID: PMC4891171. You cannot overdose from sunlight because the amount made in the skin each day is self limiting, this is not true of supplements.

[@mikemondano3624]

@@aussie405 Cholecalciferol comes in pill form.

[@GrumpyOldFart2]

@@petef1273 Yes, I’ve noticed that also. Anytime I write a comment with a link in it, KZbin drops my comment. Yet I notice others can put links in their comments. It’s annoying. Btw, thanks for the research paper title. Looks interesting.

[@christopherg2347]

It turns out the Header and End Bits _do_ mater as much in DNA as in File and Network Packet formats!

[@sshuggi]

Vitamin K is often used in tandem with Vitamin D because it helps shuttle calcium into to bone and not the rest of the body.

[@shieh.4743]

K2, not K

[@agnelomascarenhas8990]

3 pieces in the puzzle. Vitamins A, D3, K2. Vit D3 helps Calcium absorption from diet. Vit K2 (Menoquinones) gets Calcium to the target - bone. Vit A has a role in extraction of Calcium from bone. That's my understanding.

[@petersimmons3654]

Not often used, but essential!

[@samwill7259]

Disease when humans think we're in control of our own history: "I'm about to mess up this man's whole life"

[@Richdragon4]

Diseases do that. There is always the one who has to ruin something.

[@cerberaodollam]

In my language, rickets is called "English disease". IDK how that happened.

[@Xnkta]

LOL what language is this???

[@lianneye5061]

Maybe since the industrial revolution started in England, bringing conditions that prompted rickets to develop in babies born there, thus for a period of time, there were a lot of English people with rickets and people in your country started identifying the disease as English?

[@DucatiDave904]

@@XnktaIts German

[@seanpoore2428]

This is a fairly common leftover from the old days where all our neighbors were enemies 😅 the Spanish called syphilis the French disease, the French called it the Spanish disease, and the ottomans called it the christian disease, etc etc lol

[@xWood4000]

@@seanpoore2428 I mean there's also the Spanish flu in the English language, that definitely wasn't only Spanish

[@teambeining]

I, apparently, can’t get enough Vit D. When I was at my lowest, I felt like I was dying. Now I’m on 5KIU a day just to keep it up. My body definitely doesn’t make it.

[@fuzzynippleman]

I was tested in August when I had a tan and spent hours in the sun everyday and my vit d was undetectable. 5k unit pills a day and now I feel normal. It's weird because it's normally a naturally occurring thing that you get from even a little sun exposure.

[@glenngriffon8032]

Quite a pain when your dna has the biological equivalent of "read error, data may be corrupted" Especially odd to me since i have a fair number of mutations cause my grandfather was exposed to plutonium at Hanford and yet i have no problems with making Vit D.

[@ParadoxalDream]

I take 40K IU of Vitamin D3 daily, with vitamin K2, for autoimmune diseases.

[@conlon4332]

@@glenngriffon8032 I'm sure it's entirely random what mutates and what doesn't.

[@glenngriffon8032]

@@conlon4332 Oh no, i totally understand that. It's just kind of funny to me that there's people out there who likely have nothing else wrong but this little mutation that means that they can't make Vitamin D and here i am born small and tiny like i was premature even though I was born on time, born with a dsformity in my heart, bad eyes, bad spine, and yet i have no problem with making Vitamin D. I can't help but see myself like a car that comes out of a demolition derby and the driver is like "at least the cup holder is fine".

[@asterlofts1565]

That is why there is a saying that goes: Extremes are always bad, even for good things. But it is a relief to know that they knew how to solve these diseases better.

[@helenamcginty4920]

A student at my late dad's school had naturally too much calcium. He was hot all the time. Mid winter only needed a sweater to stay warm. No idea how he was medically treated. This was years ago.

[@MichaelKingsfordGray]

Possibly had a vitamin K deficiency that was causing the malady.

[@thattassiewargamer]

Darker skinned people living in further northern and southern latitudes will also be at risk of lower vitamin D levels due to the melanin reducing synthesis.

[@snazzypazzy]

Yes, and people who cover there skin, like people who veil for religious reasons. Here in the Netherlands it's recommended that PoC and people who cover take vitamin D life long, as well as people who are unable to be outside in the sun frequently (like people living in nursing homes).

[@petersimmons3654]

But ... all those 'BAME' doctors and nurses who died of Covid were down to racism surely? That's what ignorant race baiters claimed. Since half the NHS staff are BAME it beggars belief, unless the virus was racist!

[@katarh]

There's been some debate in the scientific community regarding whether the 400 IU recommendation is based on bad math - literally off by a factor of ten for some adults I personally take a 5,000 IU daily as an adult but I was diagnosed with very low vitamin D about 10 years ago. I'm so pale that once equinox has passed I can't get any sunshine without a layer of serious sun block on (already got burned once this year because I forgot about my neck.) My vitamin D levels once dropped as low as 12 ng/dl, when the recommendation is a minimum of 30 ng/dl. 5K IU daily is my magic number for keeping it at normal levels. This is also partly a consequence of having genes that were meant to be a few latitude parallels above where I actually live. I'm sure the ancestors that lived in the snowy frozen north and ate salmon every day had no problems maintaining vitamin D. But again, I'm an adult, not an infant. 400-600 is probably plenty for a small human!

[@petef1273]

The references to the two publications in peer reviewed journals are (J Prev Med Public Health. 2017 Jul; 50(4): 278-281. Published online 2017 May 10. doi: 10.3961/jpmph.16.111 PMCID: PMC5541280 PMID: 28768407 The Big Vitamin D Mistake Dimitrios T. Papadimitriou) (Paul Veugelers, John Ekwaru. A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D. Nutrients, 2014; 6 (10): 4472 DOI: 10.3390/nu6104472).

[@ronenen]

I suggest you take vitamin K2 as well, it makes sure that the calcium will go to your bones, and thus will not cause calcification in tissues where it's problematic.

[@katarh]

@@petef1273 Thank you very much for citing for me, I wasn't in a place where I could easily search that yesterday. I appreciate you!

[@YouTube_4u]

Wow you never stop to find new interesting things to tell us, nice job and thank you SciShow

[@mikemondano3624]

It's all the stuff that they leave out that makes some presentations misleading.

[@Arthera0]

@@mikemondano3624 thats the problem with shorter videos. You have to sacrifice some stuff. Also to the general public you sometimes have to make things easier to understand.

[@GameTimeWhy]

​@@mikemondano3624 is it misleading or is it 101 level learning that makes it understandable for layman but is not all that useful for experts?

[@mikemondano3624]

@@GameTimeWhy I guess it's true that you need to start somewhere.

[@GameTimeWhy]

@@mikemondano3624 yeah it's important to remember that a layperson doesn't need to know what an expert does and it would probably be incredibly boring content meaning most people would be learning zero on the subject. Science communication is about getting people interested in a complex topic and good science communication is doing that with the least amount of "clickbait".

[@Beryllahawk]

Kind of appreciated the visuals on this one, esp showing the calcium deposit in blood vessels. This also happens to anybody whose kidneys have quit working - without proper kidney function your body doesn't filter out ANYTHING (or well, okay, the liver can take up some of the slack). Main thing here is, vitamins - like D among others - when we take, say, a multivitamin pill, those always have more than we "need" in there, to make sure that enough of the various vitamins survive being digested, etc etc etc. And in normal bodies, the excess just gets filtered out by the kidneys. (And that's why you might have really intense color to the urine if you're taking lots of B complex.) BUT. Without that filtering, all of those vitamins just hang out, and everything goes wonky, even more so than it was already from just not having kidney function. Calcium and phosphorous normally "cancel each other out," but without the vitamin D you can't actually make enough mineralized calcium to do that, leading to too much phosphorous compounds; but if you try to make up for that by (for instance) drinking more milk, then you have a good chance of going the OTHER way and having too much calcium! Calcium deposits in blood vessels can mean a stroke, and too much phosphorous can make your heart stop. It's TERRIFYING when you're first trying to learn and navigate the incredibly specialized diet needed to stay mostly healthy while on dialysis.

[@FuzzyElf]

Trying to live with no functioning kidney is challenging -- and then, quickly, just impossible. Trying to live with dialysis is hard as hell, but possible!

[@helenamcginty4920]

When I was a kid in the 1950s it wasnt uncommon in my northern England home town to see old folk with short bowed legs. My mum told us about rickets when we asked about them. And as the eggs from which we all grow are created when our mothers are conceived the health if our grandmothers directly affects our own health. So many if these diseases caused by our environments take at least a couple of generations to die out? Someone with more knowledge on this than I will be able to correct or add to this

[@oldernu1250]

Epigenetics is in its infancy. Food ingested by parents, grandparents, etc. does impact descendants---but we haven't figured out the how or why yet. Crops grown in soils with--or without--minerals could also impact descendants. The distance between eating organic veggies because they're good for you and oops, hundreds of your ancestral generations ate millet which damaged brain tissues is a place science does not have guts to go. And this doesn't even start the bacteria biomes discussions.

[@ronenen]

What about vitamin K2 as a prevention of hypercalcemia?

[@goldtimerockandroll]

Am I the only one who was bracing themselves to hear about tuberculosis?

[@sophiedowney1077]

I'm guessing you've been following John Green's new obsession.

[@emilysmith2965]

>o) CORRECT!

[@ma.angelikaninaarmada-tong5372]

@@sophiedowney1077 wait what?

[@sophiedowney1077]

@@ma.angelikaninaarmada-tong5372 John green has been posting a lot of videos talking about tuberculosis. I wouldn't be surprised if he was planning on writing a book about it.

[@joangordon3376]

I am a 70 year old Brit and was brought up on that milk, cod liver oil and a malt extract - Virol and i thank God and the NHS for that.

[@TacComControl]

"It's possible to have too much Vitamin D." Oregonians: "Doubtable."

[@FreedomIII]

Yeeeeeah 😢

[@Cricket2731]

Too much Vit D will make you vomit--frequently.

[@TacComControl]

@@Cricket2731 Too much vitamin D can calcify you in bad ways, but also everyone in Oregon is vitamin D deficient because of the climate. Which is changing rapidly, so on the plus side, less D deficiency, downside, more cancer and more deaths due to heat because almost no one has central HVAC, especially in apartments.

[@ckq]

I've been deficient in vitamin d for like 4 years now when I stopped having food with fortified vitamin D (cereal, bread, and milk)

[@conlon4332]

Oof, can't you take pills?

[@jeannewallace8967]

Sunshine? Is natural and free

[@nickim6571]

@@jeannewallace8967 Also causes skin damage and sunscreen blocks the vitamin D absorption.

[@emilyauld8622]

Hyper, meaning high. Calci, referring to calcium and emia meaning presence in blood. So, high calcium, presence in blood.

[@MailleGrace]

Presenting (Finger raised in emphasis)

[@compulsoryevacuationdevice]

Good video. I accidentally gave myself a little "calcification" from too much vitamin D. I got a tiny pinhead sized lump and thought it was cancer. Doctor said it was fine. I stopped taking 5000+ iu of vitamin d.

[@petersimmons3654]

Start taking it again, perhaps 4,000IUs this time, but take K2 as well, also a cheap supplement we can't get enough of from diet.

[@Tromador]

To sufferers from sarcoidosis (a rare orphan disease) like myself, vitamin D can be extremely dangerous.

[@esecallum]

TOTAL RUBBISH

[@Tromador]

@@esecallum We have to avoid vitamin D as it is produced in excess by sarcoid granuloma. Taking vitamin D is therefore generally not recommended as it can lead to hypercalcemia. You can write shouty text in all caps if it makes you happy, but if you wish to convince me (and, I would imagine anyone reading this thread) that you know more about the disease I have lived with for the past decade or so, you'll have to do better by presentation of evidence. However, I think you will find that a cursory web search for sarcoid and vitamin D will show that I know what I am talking about.

[@BillionairesArentYourFriends]

@esecallum dude said he's got a condition and it's BS how?

[@RealDealy]

Vitamin D should always be taken with Magnesium rich foods to avoid the accumulation of calcium I like hemp seeds or peanuts, just a handful eaten right before I take my Vitamin D pills or I just drink the milk versions

[@sarahrosen4985]

And vit K2 which is what will keep the calcium in your bones.

[@markdemma]

Both hemp seeds and peanuts will leech nutrients

[@RealDealy]

@@markdemma it what way? All you're eating is a handful amount

[@ShawnForno]

Every time I think I understand DNA I learn one more thing and I’m reminded I know nothing.

[@teddybearroosevelt1847]

Now the next step in you learning DNA is learning how and when to use the dot key on your keyboard. Each sentence has a main verb and it ends with a period, unless it has words like and or while or which in it. Then after that you can start a new sentence with a new main verb. You’re welcome.

[@seth7745]

Another paradox many geneticists have trouble reckoning with is that even though inbreeding results in expression of genetic defects. In the long run this expression can result in purging of those defects through natural selection. This is how cockroaches have evolved to be completely immune to inbreeding depression.

[@mptyalln]

​grammar police 👹

[@ParadoxalDream]

High doses of Vitamin D are only a problem if you're deficient in Vitamin K2. K2 takes the calcium out of the blood and brings it to the bones.

[@jasongibbs5357]

Perfectly worded, it is sad a science show doesn't know what they are talking about. Almost every person with any sense or knows anything about calcium problems know K2 is lacking.

[@zealman79]

Exactly. They should stick to dinosaurs and black holes.

[@FuzzyElf]

​@@jasongibbs5357 It is not perfectly worded, because it is always going to be possible for a large enough amount of vitamin D to exist that will cause problems. It's *possible*. Is it likely anyone will ingest that much? Well, look at human behavior, and think you will have your answer.

[@The_Cyber_System]

I had a chronic deficiency last year and got prescribed 1000IU tablets per day for 4 weeks and then 1 tablet per week for 3 months after that. It sounds like a lot but you gotta make sure it's appropriate to your circumstance

[@justin-tyme]

I've taken about 4000-8000 daily for years. I'm fine and have never been ill.

[@shieh.4743]

1000IUI isn't alot.

[@tabby73]

1000 IU a day is the amount you should normally have to stay healthy.

[@MsPeabody1231]

​@@shieh.4743Nope I take 2000IU daily after being severely deficient 15 years ago.

[@markparker5585]

It’s perhaps worth mentioning that the daily recommendations by most Governmental health authorities is still based around what is needed to prevent rickets in children, not what is required for an optimum immune system for a child, or certainty for an adult . It’s such an important Vitamin (it actually functions as a hormone), for the entire body’s physical and mental well-being, that it shouldn’t be dismissed, or ignored because “I eat a healthy diet”. Personally, I’d recommend people get their levels checked before any supplementation, if they can, as that provides a baseline to work from. Doing a test over the Winter will be the most useful, as that’s when D levels in the blood will be lowest. There are home tests available, if you can’t get it done by your Doctor. In the UK, a blood prick home test costs about £30, so not expensive, and results are usually back within two weeks. However, if that’s not possible, there are many videos available which go through Vitamin D levels of deficient, insufficient, sufficient, optimum and toxic, and suggest levels of supplementation based on various criteria, such as age, ethnicity, geographical location etc, as well as what should be taken with the D to safely optimise its use when higher levels of D are taken.

[@petersimmons3654]

Agreed. Except for 'toxic' so far there's not been any data to indicate toxicity, but there have been some scare stories which can often last way past when the facts are revealed. Professor Holick determined the mechanism for how vitamin D is synthesized in the skin, demonstrated the effects of aging, obesity, latitude, seasonal change, sunscreen use, skin pigmentation, and clothing on this vital cutaneous process. In the north we are fully clothed, many use sunscreen because of fear of skin cancer, and much of our lives are spent indoors. Our ancestors were naked hunter gatherers on the African plains.

[@dianapennepacker6854]

Just get blood work ups if you can in general. Its good to know and changes constantly! I have hepatorenal syndrome and so my kidneys and liver are defunct. Need a transplant and it is a pain in my freaken arse trying to balance everything. The key thing is that I've learned? Everyone is different so what you and I need and absorb or use are drastically different. If I followed the standard medical advice my potassium would be dangerously low constantly for instance. My phosphorous on the other hand is getting very high. Double what it should so I am taking calcium binders but now my calcium is getting high too. Now if you guys are healthy you might not need as much checking but it is useful. Micronutrients imbalances cause a load of issues!

[@slomo4672]

In US big lab chain Quest Diagnostics offers vitamin d test for $75

[@dinomanalo8817]

I have very low levels of Vit D but whenever I take the Vit D that my doctor prescribes I always feel like there is a chemical imbalance in my body because I am often agitated for whatever reason so I instead of taking vit D everyday I take it every 3 days. I even told my doctor about this but she says that she hasn't heard anything like it.

[@Ikajo]

Be in the sun more ☺ it helps

[@sarahrosen4985]

Try changing the brand of vit D3 and make sure it comes with vit K2. The number of illnesses and conditions you are at increased risk for with low vit D is not a joke.

[@shieh.4743]

Magnesium might help with feeling agitated.

[@timjonkhout]

The vitamin d takes around 3 months to build up, so even taking relative high dosages could only get rid of deficiencies after weeks after the dosage "could" be lowered to maintain. (From the knowlage i collected)

[@LauraRealLife]

Do what you can to take your supplement at the same time you are consuming a naturally fatty food (such as milk, yogurt, salmon, nuts, eggs, avocado, etc., - not fried foods). Vitamin D is a fat soluble vitamin. Taking the supplement at the same time you consume a naturally fatty foods helps your body process the vitamin D *much, much* more efficiently - and it will reduce if not eliminate the "spikes" you are getting.

[@Sean_Piper]

Wesley Crusher vibes with that sweater. Here for it

[@SureshKumar-gc8rl]

This is applicable to elders too with over consumption of supplements specially fat soluble vitamins that gets stored in the body. Anything in excess is,........

[@newfreenayshaun6651]

I sunbathe my mushrooms after I cut them for a meal for about 10 to 15 minutes. Being that we are cousins, sunlight helps mushrooms also produce vitamin D.

[@paulmaxwell8851]

Yes, a little known fact!

[@grammasgardenofideas5081]

04:09. "... but if the error is something else ....well ... meh." lol

[@joshylord]

I wish I started Vitamin D supplementation earlier. I fractured my finger from Touch Rugby back in highschool and was definitely malnourished. (Through a fault of my own, no one else's)

[@solentbum]

National Dried Milk was a favourite of mine as a small child, sprinkled on rice pudding. I wonder how I made it until now! But I never had Rickets.

[@AlthenaLuna]

Seeing this right after finding out that I have a vitamin D *deficiency* is funny timing.

[@MikeSheehan727]

More than 50% of the population does.. turns out it doesn’t even matter if you get enough sunlight because you can be “resistant” to vitamin d and many people are

[@dees3179]

If you take a supplement for it do your research and take the compliment mk72 to prevent the resultant calcium going to the wrong place. It is important and not publicised widely enough.

[@mike7546]

Well, yknow its always like this in medicine and there still are a lot of "idiopathic diseases" or "we dont really know how this came to be a disease" because many illnesses are multifactorial and involves several genes

[@exosproudmamabear558]

I want to talk about a very important thing vit d suplemantations does not do same effect as producing due to mechanism that produce vitd in the skin modulate certain nuerotransmitters and vit d storage, synthesis and usage. Basically just one dosage of uvb makes vitd synthesised in the liver peaking in 7-10 days released only when needed so it does not cause hypercalsemia nor reduce vitd absorbtion while only %50 of the vitd suplemantation gets into liver remaining parts goes around in the body actively cause calsifications in organs and vessels(take k vit if you use antibiotic or probiotics to make your guts produce vir k. So the calcium goes into bone rather than other organs or calsify vessels) plus hypercalsinosis Unfortunately it causes skin cancer but this can be mediated with carrot oil plus 15 spf since vitd threshold is lower than skin damage therefore this will actually increase vitd absorbtion since you wont get tanned and your skin wont damaged.

[@ste6004]

My dad keeps his powdered wood glue in the same milk tin that's in the thumb nail ,it looks just like powdered milk as well 😂😂😂

[@crybebebunny]

Thank you Brilliant❣️

[@hijeffhere]

That hypercalcemia instantly registered to my brain as: Hyper - meaning high Calc - meaning calcium Emai - meaning presence in blood I may be watching too much Chubbyemu 😂

[@bearstarpresents2264]

There is never too much -emia!😜

[@bananadane]

k2 is super important with vitamin D, especially for adults where it will reduce any tendency to deposit calcium where you don't want it, like arteries

[@Articulate99]

Always interesting, thank you.

[@3800S1]

I've had it up to here with these rickets!

[@AriaHarmony]

Please make a video on the DNA stuff you didn't mention in this video, it's very fascinating!

[@FuzzyElf]

ALL of it?

[@AdumbroDeus]

This is making me think of other research in the negatives of too much vitamin D. One of my friends specializes in HIV research and published a paper about how too much vitamin D can lead to worse health outcomes from people who suffer from HIV. The mechanism was a bit different and dealing with that vitamin D is fat soluble, but this is definitely fascinating stuff.

[@Earwaxfire909]

Can people with the cyp24a1 mutation take mk7 to side-step the kidney disorder? Or is the only hope to keep the Vitamin D3 lower?

[@TheOnyxFlame]

I love the mid-century modern shirt!

[@Limrasson]

So...we are just software running on code that was directly pushed to prod without testing. That explains a lot.

[@fbbWaddell]

I just rode my bike out to the beach to get my first big dose of vitamin D for the year. Nice to come home to this video afterward.

[@douglasboyle6544]

Several years ago at an annual physical my doctor told me my vitamin D was low and I said "Am I going to get Rickets?" She didn't think that was as funny as I did.

[@peronik349]

In the 1950s in France, all school children (from 5 to 17 years old) had to swallow a tablespoon of cod liver oil every day, given by the school. the reason was that this oil is full of vitamins and other trace elements deemed to be very beneficial to the development of children. the problem is that there was also a problem of excessive dose, but also, and above all, a problem of taste! ! in addition to being an oil (and a rather thick one), the qualifiers given for its flavor are VERY VERY far from positive. the children's ordeal ceased when they realized that it could have harmful effects far superior to the beneficial ones

[@OlgaAndreyeva]

wow learned some new stuff from this, cool stuff. thanks for sharing

[@Frenchaboo]

What a nice thumbnail to see after I just took 2 vit D tablets 😅

[@nadiehtje10]

As my mum always says “anything with too in front of it is bad, “too much” “too little” etc.

[@magenty_m_axol]

Good to hear the mystery of the D explained.

[@rhosllwyd2863]

Thank you. Well explained!

[@Goldenheart_345]

Wish I had too much vitamin D, instead I need to get bloodwork every few months

[@OT_Tips]

Great info!

[@davidbass296]

I know there are charts and studies to tell us when an overdose is dangerous. But are they based on how much is ingested in a short space of time or by now much is consumed over the entire day? And does the difference matter enough to be worth keeping in mind?

[@markupton3482]

You didn't explain how mis-folded mRNA could make proteins get bent up as well... Fascinating topic!!!

[@JLocke0113]

Great video

[@rosaliethurkins1359]

Is it tuberculosis?

[@singingsiren82]

My first thought 😅

[@TLguitar]

​@@singingsiren82 Before watching and deducting from the thumbnail, it's rickets.

[@TLguitar]

2 seconds later, yup.

[@almostanengineer]

I would have said rickets, just based on the thumbnail

[@oldvlognewtricks]

It’s never tuberculosis… …wait, that’s lupus

[@Weirdoid]

Catching Rickets is bad while catching crickets is fun.

[@helenamcginty4920]

But catching at cricket can hurt your hands. (UK here)

[@bbbenj]

Thanks

[@ParallelPenguins]

Anyone else getting Wesley Crusher vibes from Stephan’s shirt?

[@fabrisseterbrugghe8567]

There are kids in Britain today with scurvy. How did we get back to scurvy?

[@tabby73]

Isn't that from vitamin c deficiency? Maybe people have no money to buy citrus fruits or vit c supplements 🤷🏻‍♀️ Idk

[@terrencetrussell7625]

Generalizations are dangerous because they can lead to sloppy thinking and erroneous conclusions. This report is good in that it encourages careful consideration in supplementation. At the same time, vitamin D deficiency is also real. I am maintaining a blood level of about 70 to fight my cancer- this requires an intake of about 10,000 IU of supplemental D3 daily. I would NOT recommend this for a child! Use common sense, and MONITOR! And D2 is NOT a wise choice.

[@TheReaverOfDarkness]

It is useful to understand how vitamin D affects calcium levels in the body. I have lived my life generally at mild risk of hypocalcemia--evidence for this is that I get muscle cramps rather easily (especially if I need to boost my electrolytes), and a mildly-calcium-depleting saline solution administered into my body to replace a blood donation can send me into a hypocalcemia attack if I have not pre-emptively raised my blood calcium level prior to the blood draw. I also recently passed a couple of calcium oxalate kidney stones, which my urologist told me are formed as a result of not having enough calcium in your bloodstream to balance out any oxalate contained in your food. I don't eat a particularly high amount of oxalate-rich foods, and I never have. So, clearly I need to study calcium in the body more, in order to understand and better manage my condition. I never thought of myself as having any sort of vitamin D deficiency and my doctors in the past have never said that there was anything particularly notable about my bone health. I've always eaten fortified foods and, while I enjoy a lot less sunlight than most people, my very pale (melanin-lacking) skin is said to make it easier for my body to process the first phase of Vitamin D (from the food) into the second phase (photosynthetic product). I do not experience the winter depression which most people feel after going with reduced sunlight exposure for several weeks, so I had always just assumed that I must not be craving sunlight because my Vitamin D levels must be fine. I have had some sort of undiagnosed musculoskeletal condition which has made me have a posture mismatch from everyone else which I can't fix, and my performance in various physical stretches is often highly different from most others. For example, I cannot get anywhere near to being able to touch my toes without bending my knees (I scored WAY below the 0 mark in a physical exam at school once), but I can quite easily and comfortably press my thumb against my wrist which I have only occasionally seen anyone else be able to do at all. I had never considered a link between this condition and my vitamin D levels until recently, but my doctor ordered me a nutritional blood panel and it came back saying that I was a bit vitamin-D deficient. I still don't know if I was just low on the day I came in, or if I have an actual deficiency, but the latter is seeming increasingly likely with deeper analysis. My doctor ordered me to increase my dietary intake of vitamin D which I am trying to do, but I suspect I'm actually going to need more sunlight. 😝 We'll see if I can make that happen. 🖥 ⌨🖱

[@TheReaverOfDarkness]

@Nicky L Are there people on this planet who don't have health issues? I donate for the health of others. =)

[@justayoutuber1906]

This is why 2000% of your daily recommended allowance for vitamins is a bad idea, GNC.

[@candycemonroe7345]

Water soluble vitamins it's okay to have an excess; you will pee out the extra. However fat soluble like D isn't one you want to have in a great percent.

[@rogerszmodis]

I’ve had it up to here with these damn rickets

[@mindoffliv5976]

Can you do a video on Ehlers Danlos Syndrome

[@khushijain3325]

Could you please make a video on charcot-marie-tooth disease

[@petef1273]

If you take 10,000 IU of vitamin D a day from birth until you are 80 years old then at the end of that period you will have consumed about 1.5 teaspoons of vitamin d. 10,000IU is 250 micrograms.

[@Xeldur]

The "thanks, I guess?" got me :D

[@ryanblystone5153]

Thank you

[@LaineyBug2020]

Can you do a video on the MTHF-R gene mutation and the diet needed to great it? Would love to have more info than Google gave me on the history, all the ways this mutation can express itself, maybe what causes it and the statistics of it...

[@shy-watcher]

So protein-coding DNA is the C code that gets compiled into executable instructions and junk DNA is the makefiles? Of course it's super important and gets impossibly bloated, the project has been in development for eons!

[@alixena9340]

And in the future humans will realise that a lot of what we thought was fact at this moment in time will also turn out to be incorrect.

[@mikkelnatas]

Rockin' that Wesley Crusher shirt! NICE!

[@ChrispyNut]

But also props and thanks to those annoying asshats who keep asking "but, why though", with that desire to understand driving further investigation and greater discovery.

[@oldvlognewtricks]

This is a fairly good working definition for ‘Scientist’

[@ChrispyNut]

@@oldvlognewtricks and engineering, can also make for great administrators, mathematicians and many other disciplines. Knowledge, understanding and experience are important attributes for wisdom.

[@Pluggit1953]

I was born in 1953 in the UK and remember those large blue and white National Dried Milk tins.

[@amandaking6554]

I don't know what the name of it is exactly, but about a decade ago, I was told that I have a genetic condition which, among other things, inhibits my body from processing vitamin d correctly. As a result, even though I had a relatively normal diet as a child, I developed a mild case of rickets, which resulted in a lot of expensive dental work as an adult. Once the drs were able to track down the problem I was prescribed a weekly dose of 50,000ius of vitamin D (which, I understand is much higher than the usual reccomended dose) and since I've started the regimen I've had much fewer problems with my teeth.

[@vaibhavanandsharma900]

Love from India.

[@General12th]

Hi Stefan!

[@stopno2507]

you guys should make more merch for example a hat i would def buy!

[@up-uw4op]

This explains why my grandma thinks a baby will be bow legged if they walk too early. Its not a concern these days with proper nutrition.

[@lavellnutrition]

Why didn't they just tell them to take K2 within a few hours since they share the same receptor?

[@TheSuzberry]

I remember thinking that ‘junk’ was just the scientists version of ‘I don’t know’.

[@sciencenerd7639]

fascinating

[@jeffreyhill4705]

We have created a world safe from skin cancer with uv glass everywhere. Skin color differences in humans indicate that vitamin D is incredibly important. How much vitamin D3 supplement is required is unknown until we include the effective amount of processed D3 is in each person via standard blood tests. K2 is also important to vitamin D3. In short the war against skin cancer and our indoor lifestyle has created a vitamin D3 crisis.

[@Christian-jz3xt]

Never even knew about this

[@SteveFrench_420]

400 iu may be fine for children but study after study has shown its its not enough for adults. Studies have shown that 80% or more US citizens are Vit D deficient. Some scientists claim there is no cold and flu season but a vitamin D deficiency season (you have to be in the latitude of Northern Georgia USA or lower to get enough sun year round for Vit D production. I've been taking 2000 iu from around the fall equinox to spring for 5 yrs now and my blood work is great