How the immune system works and why it seems to allow cancer to proliferate

  Рет қаралды 13,231

Peter Attia MD

Peter Attia MD

Күн бұрын

Пікірлер: 43
@lindencalloway5
@lindencalloway5 4 күн бұрын
The concept of health in "The 23 Former Doctor Truths" book completely explains this. I wish I read it sooner
@civilgoody
@civilgoody 4 күн бұрын
Summary 😇 - The immune system works by detecting proteins or molecules that are not part of the normal self of the body, with lymphocytes (B cells and T cells) recognizing and responding to foreign antigens. 02:06. - An antigen is a molecule that is not normally expressed in the body by tissues, typically proteins or carbohydrates, and is recognized by T-lymphocytes or B lymphocytes. 02:42. - Cancer cells have acquired mutations that produce proteins or molecules that can be recognized by the immune system, but the immune reaction is often too small or not vigorous enough to overcome the growth of the tumor. 06:37. - Tumor cells can develop properties that suppress the local immune reaction, such as producing molecules like transforming growth factor beta (TGF beta) or cytokines like interleukin 10. 07:12. - The balance between aggressive immune reactions and inhibitory molecules is crucial, and treatments like checkpoint modulators (e.g., aaluma or PD1 inhibitors) aim to stimulate the immune reaction by inhibiting these inhibitory factors. 08:37.
@MattUFL
@MattUFL 5 күн бұрын
This is tricky if you haven’t had an immunology class, but he is essentially saying that although the immune system recognizes cancerous cells, it is not effective at removing those cells, because: (1) the rapid growth of tumors is too much for the immune system to fight; and (2) the tumors release factors that inhibit/suppress the immune system. The latter is likely the more critical. I say that because, as an analogy, the immune system can attack entire transplanted organs, but those transplanted organs survive if the patient receives immunosuppressive therapy.
@MitigateOurRuin
@MitigateOurRuin 5 күн бұрын
That's a great analogy.
@btudrus
@btudrus 4 күн бұрын
"the rapid growth of tumors is too much for the immune system to fight" This is how eating sugar (fructose/sucrose) causes cancer because it activates the Warburg effect and allows it to outgrew what the immune system is capable of dealing with. Also eating sugar makes the immune system less effective...
@thinktwice888-p4d
@thinktwice888-p4d 4 күн бұрын
@@btudrusI’m eating sugary cheesecake at the moment - I hope I don’t get cancer… 😅
@mikaelajasonnn3
@mikaelajasonnn3 Күн бұрын
Incredible insights! It reminds me of what I learned in Health and Beauty Mastery by Dr. Julian Bannett. That book reveals hidden truths about the industry that completely reshaped how I think about health and wellness.
@meditim2032
@meditim2032 Күн бұрын
i heard about that book before i might buy it now
@kaylacurtis111
@kaylacurtis111 Күн бұрын
yes
@robertsmyk4102
@robertsmyk4102 5 күн бұрын
Obviously this answer is incomplete because cancer is less likely in a youngster, it doesn't account for aging where more older people develop tumors compared to youths. It is more likely that cancer arises because the immune system becomes tired and less vigorous than when youthful and it seems that the solution is to invigorate the immune system as we get older to avoid cancer growth.
@thiagobartolo
@thiagobartolo 4 күн бұрын
Mutations leading to cancer are more likely to manifest as age increases, chromosomes telomeres become degraded and cell reproduction becomes increasingly imperfect
@LTPottenger
@LTPottenger 2 күн бұрын
it's mainly mitochondrial in origin
@btudrus
@btudrus 4 күн бұрын
Cancer is NOT caused by RANDOM somatic mutations. Cancer is a response to evolutionary pressure (e.g. toxic environment)!
@danielfiori
@danielfiori 5 күн бұрын
you should interview Steve Rosenberg again
@whatthefunction9140
@whatthefunction9140 5 күн бұрын
Cancer is not a random mutation it's a metabolic and genetic metamorphosis.
@MitigateOurRuin
@MitigateOurRuin 5 күн бұрын
All three and a litany of other paths to cancer exist. Some cause others. For example, metabolic issues generating large amounts of free radicals can lead to random mutations that inevitably develop into cancer. Or random mutations cause the buildup of some problematic thing going in the opposite direction. Cancer is very complex.
@btudrus
@btudrus 4 күн бұрын
almost correct
@whatthefunction9140
@whatthefunction9140 4 күн бұрын
@btudrus enlighten me
@btudrus
@btudrus 4 күн бұрын
@@whatthefunction9140 1) cancer is a response to growth signals, i.e. dietary sugar (fructose/sucrose) 2) cancer is a response to evolutionary pressure, such as a toxic environment. (Cells "trying" to survive develop into cancerous cells)
@whatthefunction9140
@whatthefunction9140 4 күн бұрын
@btudrus yeah I thinknwe are on the same wavelength. It's anything but random
@Easy_Living1
@Easy_Living1 5 күн бұрын
swoosh, right over my head. 😂 But, thank you! Happy Thanksgiving 2024. 🦃
@officespaceredstapler2287
@officespaceredstapler2287 2 күн бұрын
Cancer does get "squashed out" by the immune system. All of us have some level of cancer cells in us at all times that a healthy immune system deals with. Runaway cancer results from a broken immune/gut bacteria system. Cancer is not unlike AIDS (broken immune system) and most who succumb to the consequences of AIDS die of cancer. The focus should be on the immune system and not the cancer cell for long term survival. This also requires diet/lifestyle changes as part of the solution.
@angelarose1738
@angelarose1738 5 күн бұрын
Fascinating...
@officespaceredstapler2287
@officespaceredstapler2287 2 күн бұрын
Yes - fascinating ignorance.............
@tkorte101
@tkorte101 3 күн бұрын
What about doing a periodic course of Iver mectin to clean up any damaged cells and prevent cancer from developing.
@whatthefunction9140
@whatthefunction9140 5 күн бұрын
Seems like metabolites in our blood from food would be triggering the immune system all the time.
@btudrus
@btudrus 4 күн бұрын
Yes, eating plants is making you sick!
@nhtathinfbntb2746
@nhtathinfbntb2746 5 күн бұрын
Ok so when is a cure or a better treatment than chemo coming?
@btudrus
@btudrus 4 күн бұрын
The carnivore diet is already there...
@officespaceredstapler2287
@officespaceredstapler2287 2 күн бұрын
@@btudrus which over stimulates IGF-1 and the mtor pathway and will accelerate cancer formation.
@LynnFishmanNurse
@LynnFishmanNurse Күн бұрын
Doubtful anytime soon when talking conventional therapy.
@robynhope219
@robynhope219 Күн бұрын
The thing i wanna know is WHY children get cancer.
@Karl88-cb6dk
@Karl88-cb6dk 9 сағат бұрын
Sounds obvious but it's exposure to carcinogens, either from diet or the environment, including what the mother is exposed to whilst pregnant. Impossible to pin point exactly what caused the cancer but it will be one or a combination of those factors.
@robynhope219
@robynhope219 Сағат бұрын
@Karl88-cb6dk not obvious, since cancer is a disease of aging.
@DavidJonesImages
@DavidJonesImages 5 күн бұрын
In plane English please
@WILLSIMM7
@WILLSIMM7 5 күн бұрын
✈️ English or plain English?
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