How to read the genome and build a human being | Riccardo Sabatini

Secrets, disease and beauty are all written in the human genome, the complete set of genetic instructions needed to build a human being. Now, as scientist and entrepreneur Riccardo Sabatini shows us, we have the power to read this complex code, predicting things like height, eye color, age and even facial structure - all from a vial of blood. And soon, Sabatini says, our new understanding of the genome will allow us to personalize treatments for diseases like cancer. We have the power to change life as we know it. How will we use it?
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[@JLone55]

How is this NOT the #1 Ted talk? Breathtaking in the subject matter, expertly delivered and perfectly relevant to everyone

[@martincrown8616]

for real man

[@tarazed84]

Now THAT was a proper TED talk. Thanks!

[@dualsense8193]

100th like, woohoo!!!

[@ngailai1763]

He acknowledged Rosalind Franklin and not the other 2 guys - it's long due.

[@neharai4927]

He was being factually correct. She took the picture u know. The picture encoded in XRD data. She collected the data. The other two interpreted the data with her help to correctly predict the helical nature

[@XMysticHerox]

"the other 2 guys" do deserve recognition. They did do most of the interpretation. I don´t think he was specifically doing it to acknowledge Rosalind Franklin either. Also "it´s long due"? Everyone knows about her. But don´t take it out on Watson and Crick. Watson actually advocated for her getting a nobel prize posthumously at the time long before most people knew anything about this story or cared much about feminism.

[@XMysticHerox]

@@neharai4927 Well she didn´t actually take the picture either. What she did do and why she deserves recognition is proving the double helix structure of DNA that had been suspected from models earlier which was then used by Watson and Crick to construct their model for DNA as the building block of life.

[@novusvoss]

Ah finally a well spoken TED talk. This is how it looks, sounds and feels like when someone has no stage fear whatsoever and is completely immersed inside the topic. And what a topic it is! All I want is to hear more..

[@dsaguilardenis]

What a well-explained video! It reminds me what an ancient book of wisdom accurately states: “Your eyes even saw me as an embryo; all its parts were written in your book regarding the days when they were formed, before any of them existed.”-Psalm 139:16.

[@nathaliejohn3614]

The Bible, the word of God, the good news , you meant. Jesus Christ is the greatest designer, architect. We can never be wiser than Jesus Christ.

[@TheAnianite]

Haha I just quoted the same! :D

[@dsaguilardenis]

@@nathaliejohn3614 🙂👍 "Thus saith Jehovah, the Holy One of Israel, and his Maker . . . I have made the earth, and created man upon it."-Isaiah 45:11, 12 ASV

[@ashwinchakravarthy5603]

Hahaha his Italian accent and what he's explain are both brilliant

[@robo3644]

i'm italian

[@tyrbaldur5317]

I'm Italian and, I find it appalling.

[@Drforeverok]

U racist dipper

[@srikanthtupurani6316]

Most remarkable thing is people are able to find the structure of dna. It is not easy. Millions of combinations of a,c,t,g. It is mind-blowing.

[@user-nz5bn8iw7f]

I can't explain how mind boggling this this. We only discovered the human genome in a matter of decades ago so imagine being able to properly read it and properly manipulate it. Give it a few hundred years and we'll be able to control absolutely everything to do with the human body; from reversing diseases to *maybe* even stopping death.

[@selgut464]

It is starting to being manipulated by the va x And if u are able to control the human body, you will not be completely human anymore but part of an AI.

[@vipul6304]

This was very fascinating and especially the way he presented all the information. One of the best ted talks.

[@VolodymyrMelnyk]

There've been so many amazing talks lately and this one is so thought provoking, especially what he says at the end. So balanced and farseeing.

[@TheDrunkardHu]

Brilliant presentation.

[@ClockworkRBLX]

What did the librarian say to the student? *Read more*

[@thestompartist9733]

🤣got me

[@benjaminpjatkevich3641]

Truely inspiring. Every time I come across a talk like this it gives me chills because it's like geting to the future not in a dream but reality. The things that used to be fiction are now becoming ordinary. I love living nowadays.

[@cupcakearmy]

THIS are the TEDs a signed up for. Awesome, thanks for sharing

[@Von-dee]

this is the best talk I have ever watched. I was completely absorbed I forgot all surrounding noises for 16 mins.

[@harvirsingh6046]

I don't know why but this talk gave me goosebumps . Loved it !

[@mvinayagar]

A grand salute for the passion the speaker holds.

[@8203105208088]

I have watched it several times and still and still mind blowing.

[@rohanpandey2037]

AMAZING TED TALK- both presentation and content

[@dayanithi1947]

Thank you so much - what a revelation of information about human body which we have taken for granted and this gives me the incredible sensation of how complex our human body building exercise is all about yet simple.

[@nibinkarayi]

Excellent ted talk!! Riccardo is a brillant communicator!!

[@athensf]

As an outsider, I am trying to understand the significance of genomics for mankind today. This is an amazing resource to motivate the topic.

[@pratapnaik6168]

wow! to think that we are able to do this and still call it scratching the surface..what will we be able to achieve when we understand it completely. Exciting! Great work and beautifully presented!

[@mariagabrielafreitasdasilv5189]

Simplesmente fantástico está palestra!!!!

[@VexedFilms]

Fantastic talk.

[@Dimitris-uf7zx]

What an amazing speaker.

[@nothajzl]

This is one of the most interesting TED talks and it has only 290K views?? That’s sad

[@danielhicks]

this means everything to everything we can think or dream of

[@JonathanHartwig]

This + CRISPR = wow.

[@changchoonkit]

+Jonathan Hartwig exactly what came to my mind while watching this video

[@MyChihuahua]

Horrifying what they will attempt...

[@Gippo50]

Really Interesting talk, very well presented too

[@barleben48]

Excellent presentation. The use of that book collection provides a down to earth appreciation of the complexity of the subject. I wonder if this facial prediction method would work on children?

[@ebonyn8901]

wow this is amazing and he presented it so well

[@Ristro44]

Good point about personalized medicine. Will be interesting to see if/ when it translates into that field.

[@Faisal-tx9ii]

One of the best speech I heard in my life.

[@sourabhhaldar8181]

Extraordinary work

[@PraveenMax]

The most meaningful TED talk 🙂👏👏👏

[@SweetBunny706]

Thank you so much!

[@kalindaly]

Amazing talk!

[@haleIrwinG]

if there's anyone who ever think that this won't go wrong, you seriously need to think again

[@msamadyasimbarashe6646]

Psalm 139:13-16 13 For you formed my inward parts; you knitted me together in my mother’s womb. 14 I praise you, for I am fearfully and wonderfully made. Wonderful are your works; my soul knows it very well. 15 My frame was not hidden from you, when I was being made in secret, intricately woven in the depths of the earth. 16 Your eyes saw my unformed substance; in your book were written, every one of them, the days that were formed for me, when as yet there was none of them.

[@sarahverbeke3]

This excites me so much, I so badly want to learn about machine learning !!

[@hiamjanusz7354]

fascinating

[@strauss7151]

Great talk, Mr. Mario.

[@sindhuramrutha]

A Masterpiece. Period

[@karinaorozcog]

Una exposición asombrosa

[@ekeetley123]

Mind boggling...love it :o

[@TGILCLOVERSG]

This video should become the most watched video on KZbin. 👏🏼👏🏼

[@alicaptainny]

Very well done develop work.

[@cherylangel1714]

God is an awesome creator to have created us all so unique, while using such similar coding.

[@omaroprado]

This seems fascinating to me !

[@kateapples1411]

TED is wonderful when it isn't acting as a social justice and/or feminist platform for factless or out of context BS. This is definitely a talk that's high up on the list of favorites.

[@flensdude]

Eww, is that an opinion? How gross! Why would you ever post that?

[@justdev8965]

+flensdude | pTarian did you have a stroke? Ytoy didn't make any sense at all in your comment. It was rather hot today so don't wory maybe tomorrow you won't have another stroke and blabber rubbish

[@b8m8wuts46]

I avoid all feminazi ted videos

[@flensdude]

devis ago Nah, I am not that good. I wouldn't have been able to write proper sentences if I was having a stroke, but I am sure some can.

[@B33Ys]

stay ignorant! good citizen!

[@NepalSadikshya]

that's majestic

[@jessebalderas6406]

it's a shame that only the most ignorant people in our human race leave comments and people that are actually making a difference are working so hard they don't have enough time to chime in it's embarrassing thank you for moving Humanity forward

[@user-db2ur3sh4b]

Wow ! it's awesome!

[@laelleduff8021]

Amazing

[@funnysundayfunnys8537]

this video is going to blow up in about 5 years when the news pick up the new trend

[@RGPankO]

What an era to be alive in!

[@archisachrekaryoutub]

probably the best ever...

[@sabiyamir2653]

Loved it

[@Drforeverok]

Excellent

[@fabiansanhueza278]

Great!

[@MayurPanghaal]

wow !!! that face modelling based on your genome was mind blowing. Judge dredd is a reality

[@bombytetoo]

This is the only TED Talk that didn't put me to sleep

[@arash4712]

A tiny window to peep inside, to see outside here and now, and what may be over our horizon.

[@aparice1]

I wanna see a prediction of Steve Hawkings to see how would he look if he didn't have ALS.

[@JediNiyte]

Me too! I'm guessing Eddie Redmayne? :D

[@KyuuubI92]

or we could try to cure him ?

[@chicnflopper6460]

+SystemizationHD Nah he likes his chair

[@h1nkle]

Daniel Aparicio he’s dead now :(

[@leec2724]

He would not have gone through what he did if he had not sold himself out to the devil...and therefore his disabilities would not have appeared.

[@shrutigupta5118]

Loveee it.

[@kd1s]

Actually I did a 14 month gig helping to package sequences genomic data. A full gene scan takes about 1 Terabyte of storage. Exomes take significantly less.

[@dimitrismitsopoulos4265]

Tον αυγουστο του 2019 και ενω βρισκομουν εκτος διαδικτυακης χρησης μερικους μηνες,μιας και ειχα διακοψει την συνδεση,στο σπιτι που κατοικω μεχρι σημερα.Ομαδα ερευνητων αποτελουμενη απο γυναικες,σε συνδυασμο με ομαδα αντρων που παρισταναν του κουτσους,και σχηματιζαν γκριματσες στο προσωπο τους καθε φορα που εμφανιζοταν μπροστα μου,αρχισαν να με παρενοχλουν καθημερινα στις κοινωνικες μου συναναστροφες,ειτε βρισκουμαν για λογους ψυχαγωγιας ειτε για λογους οικονομικων και εμπορικων συνναλαγων.Πολυ γρηγορα καταλαβα οτι σχετιζοντουσαν με τα minds control programmes του artificial inelligence.Oι λογοι που με οδηγησαν στο παραπανω συμπερασμα ηταν οτι χρησιμοποιουσαν λογια που αφορουσαν τις προσωπικες μου μυστικες σκεψεις,και αναφεροντουσαν σε προσωπικες μου μνημες απο την παιδικη μου ηλικια μεχρι τη ηλικια των 49 του σημερα.Καταλαβα συχρονως οτι βρισκομουν και σε παρακολουθηση απο την αστυνομια,και τις μυστικες υπηρεσιες,ετσι πριν ακομα ξανασυνδεθω με τον διαδυκτιακο τοπο στη κατοικια μου,κατι που εγινε τον γεναρη του 2020,με συνδεση μου στην cosmote,αρχισα να αναλυω με εναν προσωπικο μονολογο,φωναχτα μιας και ηξερα οτι κατεγραφε η αστυνομια οτι ελεγα στην κατοικια μου,την σχεση της ομαδας των ερευνητριων με τα mind control programmes ,και την αναμειξη των ερευνητικων ομαδων στις πολιτικες διαδικασιες στις αναρχικες και κουμουνιστικες ομαδες,σε συνδυασμο με τη χρηση προηγμενης τεχνολογιας.Αυτο οδηγησε τις ιδιες τις ερευνητικες ομαδςς σε ενα μπαραζ αποκαλυψεων μπροστα στα ματια μου,μιας η μια ερευνητικη ομαδα ξεσκεπαζε την αλλη εμφανιζοντας μπροστα μου σχεδον ολους τους πολιτικους αρχηγους των πολιτικων κομματων της ελλαδος.Με την ακολουθη σειρα εμφανιστηκαν μπροστα μου ο κυριος μιχαλολιακος την ιδια ημερα με τον κυριο τσιπρα,στη συνεχαια εμφανιστηκε η κυρια παπαρηγα,και στη συνεχεια ο κυριος βαρουφακης.Αυτωματος συνειδητοποιησα οτι τα mind control programmes του artificial intelligence διαχειριζονται απο τις ερευνητικες ομαδες που συνδεονται μεσω του Ο.Η.Ε με τις ερευνητικες ομαδες των ηγεσιων των πολιτικων κομματων της ελλαδος,και συχρονως δραστηριοποιουνται και στις αναρχικες πολιτικες διαδικασιες παντα με τη χρηση προηγμενης τεχνολογιας,του ελεγχου σκεψης,και αλλων προηγμενων μεθοδων που χρησιμοποιουνται ανορθοδοξα και με επικυνδυνες μεθοδους απεναντι στην ασφαλεια καθε ανυποψιαστου πολιτη,και συμμετεχοντα στις πολιτικες διαδικασιεςΜιας και η συνεργασια των ερευνητικων ομαδων επεκτεινεται και στους κατασκοπικους και πρακτορικους κυκλους της ελληνικης πολιτικης κοινωνικης συνθεσης.Οι παραπανω αποκαλυψεις απο μερους μου γινανε μεσα απο την κατοικια μου χρησιμοποιωντας την ιδια την παρακολουθηση της αστυνομιας σαν μαρτυρα της βασανιστικης καθημερινοτητας που ζουσα.Επακολουθα οι ερευνητικες και κατασκοπικες μοναδες τις ελληνικης κοινωνιας εξαγριωθηκαν με αποτελεσμα να δεχθω εκατονταδες απειλες απο τους πιο σκληρους ελληνες,στον δρομο,μιας με τη χρηση της πρηγμενης τεχνολογιας,οι κατασκοποι και οι ερευνητριες με παρουσιαζαν να απειλω και να εξυβριζω,πρακτορες,αστυνομικους,παρανομους και αλλους σκληροτραχιλους ανθρωπους του στρατου και της αστυνομιας που εργαζονταν για τον ελληνικο εθνικο διοικητικο κορμο στο συνολο του.Εχω γλυτωσει τη ζωη μου ως εκ θαυματος και παρακαλω για τη βοηθεια σας...

[@geobla6600]

It's amazing to see the the genome in a printed state. It's truly mind boggling to see the massive amount of pages needed to print this out in an exact specific order . And to think that this is accurately multiplied over 3,000,000,000,000 times in every cell in a human body. And how a small mutation of the omission of just 2 letters can cause serious illness. It's also amazing that a specific group or groups of these letters can be read and reproduced to create the billions of specific cells that makeup all life , Whats even more fascinating is that there's plants , insects and other animals that have 50 times larger genomes then humans with the same very specific order that's required in the human genome. It's truly amazing that evolution was capable of testing the quadrillions of quadrillions of wrong combinations to come up with just one right one and do this trillions of individual times,

[@bretolroyd2952]

Your lost!

[@MyChihuahua]

Out of all that you get 'evolution'?? *eyeroll*

[@annab8312]

Code cannot arise by random chance.

[@seamus9305]

Amazing, I was expecting to be disappointed with such a title.

[@adarshtiwari5473]

Amassing 👌👌

[@keerthijakart9211]

brilliant

[@silencesanchez5894]

Revelation 20:11-12 Then I saw a great WHITE throne and Him who sat on it, from whose face the earth and the heaven fled away; and there was found no place for them. And I saw the dead, small and great, stand before God; and the books were opened: and another book was opened, which is the book of life: and the dead were judged out of those things which were written in the books, according to their works. This man testified that our genome, our DNA is actually our BOOKS which we will be judged by on judgement day. Remember we are made in "God's own likeness and image". Notice that it said a great WHITE throne. Did you know that DNA is only found in WHITE blood cells? Also, sadly, do you think it's coincidence that this Cov!d shot will alter the genome of a person? Stay blessed and get ready.

[@jimwilliams1536]

a longer useful life span is paramount in the quest for a better world. With age comes wisdom.

[@kianheus2487]

With age also comes a higher population and a faster rate of global warming, increasing the chance that we won't overcome it and die to extreme climate change

[@spongebobspongebob24]

Politicians don't listen to wise people today, why do you think they would in the future. Actually, I think that the majority of people who will ever get to afford and want to use this tech so they could add more years into their life are the greedy, powerful, rich moguls/politicians who bring devastation to our planet. Wise people, on the other hand, doesn't need to live forever to help mankind. Leaving their knowledge on books, internet, videos, etc. are enough.

[@jimwilliams1536]

I'll remember to read the pamflet of your life..

[@spongebobspongebob24]

Oh. I thought I'd get a proper discussion. I was wrong. Bye.

[@jimwilliams1536]

With a name like spongebobspongebob24 you should expect no one to take you seriously. I bet you think immortality is unnatural too..

[@chavanavinash502]

Awesome

[@dragony3931]

what a lecture

[@KriegerT]

this dude is so funny :D also interesting talk!

[@brittbrann5797]

Anyone else wondering about practical applications for this device? Like possibly creating photo profiles based on crime scene evidence? No, it's not an exact match, but it could give general descriptions, particularly when there are no witnesses or witness stories don't match.

[@AbhishekVerma-iz2hl]

Current update please! It must have been upgraded enormously by now (after 6 years).

[@nesrineemira6381]

"think about that again when we think that we are different THIS IS THE AMOUNTTHAT WE SHARE "

[@zohrafatimah4033]

He's just great , how effortlessly he taught us everything ✨✨✨

[@moseseqiovula7288]

Nice

[@SamyHacker]

i got shivers from this talk. i know people will try to play god and they will suffer harsh consequences from it mark my words.

[@mohammaddarawsheh8498]

I am supposed to study for my test tommorow!

[@SirNightmareFuel]

Neat.

[@rufusmackenzie2020]

What about in forensics? Surely this could be used find out what criminals look like?

[@ledi_vits]

очень классное произношение, даже не смотря на то что я вообще не очень в английском половина слов мне поняты

[@markslovik4115]

Does anyone know where could I get a handle of the books in digital? It would be very interesting to investigate them

[@csiobainbeddow6115]

A lot to think about here.

[@darwinm906]

reading the wisdom in the comments everyone thinks To have eventhough they know nothing about genetics is so stressfull

[@Garium87]

Almost as stressful as reading your "I am so smart!" comments.

[@antonvelmozhnyi7401]

Gattaca?

[@NEOL1NK]

My thought exactly

[@solidrevo9008]

The topic is amazing, he sound a bit like the "renzi" but I think that renzi can't think like him. He can't pronounce gn like in England but I would thank him for showing to the world the problems and how they started solve some of them. 4 sure politicians can't solve certain problems...

[@vexivero]

This is insane

[@silencesanchez5894]

Terrifying

[@carlose4314]

That is a feat.

[@chromanin]

I think it's funny that he points out the result of missing two letters in the whole code is cystic fibrosis, then proceeds to downplay differentiation by pointing out the half-book we don't share. Obviously small alterations lead to big differences. Otherwise, very enlightening.

[@DWZBT]

I think the point of the latter is to give a visual comparison between how much we differ and how much we are similar

[@Aleziss]

I feel I am born in the wrong era... half my life just passed in a flash and all the best discoveries, medical breakthrough and techonologies are coming or will be available in the near future, just when I will be on my death bed... I wish I could have benifit from all these new discoveries...

[@jacksonyu7257]

From your comment, it sounds like you are going through an existential crisis where you are scared of death and that you think this research is able to increase longetivity, perhaps give immortality. The reason why i think you are thinking this, is that I too am also thinking about this.

[@jacklynyeh4893]

we all think we're born in the wrong era! everyone behind us wishes they could be a part of being able to mass communicate, and to experience that for the first time, and everyone ahead of us wishes they were born in time for space exploration, and those ahead time travel. we're all just longing for the future. good luck in figuring it out though

[@SpaceHawk13]

Relax, we are in the future now, craziest stuff ever is going to happen over the next 10 years, we have just entered into the new medical revolution, and like everything it starts off slow, kind of like a light breeze but soon its going to turn into a hurricane, better hold onto something so you don't get blown away.

[@Aleziss]

I wish you were right... I see TONS of incradible breakthrough in medical and engineering but where is this stuff ? all those incradible discoveries are soooo slow to release yet, life passes like a flash...

[@Aleziss]

I don't think I'm scared of death but rather from suffering or becoming mentally hill like my 82 year old mom is starting to get mentally hill, uncurable... In 40 years from now, these horrible degenerative illness or cancer will probably be a thing from the past or be controlled way better than how they are handled right now... I won't be part of it... Another thing is that I do enjoy technology a lot... I saw how technology grew from when I was I yong kid, having the chance to play with an Apple IIe with a green monochrome monitor and a tape recorder to keep your program or an IBM PC junior having 128k of memory running an Intel 8088 processor with a 16 color monitor... Now my mobile phone has a AMOLED display with millions of colors, a processor 100X faster than a 8088 and it's holding 128GB of data in the palm of my hand... I saw and listen to an 8 track tape up to high end DSD digital music files being playable in the palm of your hand for hours... This all happened in a little more than 40 years... A tiny micro SD card can hold billions of bit of information that fit on the tip of your finger... probably the entire human genome that we see in all the big books could fit on a micro sd card... My dad used to install phones for Bell back in 1950, and his dad who also worked for Bell was also installing phones that you had to crank, talk to a live operator to patch the call... When my dad sees my mobile phone, if finds that pretty amazing... Imagine what will be the technology in another 40 years from now in science or health care ? and I (with all the other in my age) won't be part of it... just so close though, this is what makes me sad... I think that in the last 100 years, advencement has never gone soooo fast and exponential... this is where you realize that you are alive for a microscopic period in the whole timeline of evolotion and incradible discoveries... time goes fast... way fast...

[@HanadiH]

DOES HE REALISE THIS TECHNOLOGY CAN BE USED FOR CRIMINAL IDENTIFICATION??!!

[@StephenRoseDuo]

Where's the publication for this?

[@Thisguysgoinplaces]

watching this in 0.5 speed is absolutely worth your time lol

[@onsinasri9775]

3 letters for cystic fibrosis not 2 letters . 3 letters that code for the Aminoacid phenylalanine. Otherwise , good presentation !

[@MrChessmaster53]

Someone needs to show this to Edward and Alphonse