Inflammation: impact on aging and disease risk, & how to identify & prevent it (AMA 59 sneak peek)

View show notes here: bit.ly/44Gd5oa
Become a member to receive exclusive content: peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: peterattiamd.com/newsletter/
In this “Ask Me Anything” (AMA) episode, Peter delves into the often misunderstood concept of inflammation. He first defines inflammation and differentiates between acute inflammation and chronic inflammation, the latter of which is linked to aging and a plethora of age-related diseases. Peter breaks down the intricate relationship between chronic inflammation, obesity, and metabolic health, and highlights the signs that might suggest someone may be suffering from chronic inflammation. From there, the conversation centers on actionable advice and practical steps one can take to manage and minimize chronic inflammation. He explores how diet plays a crucial role, including the potential benefits of elimination diets, and he examines the impact of lifestyle factors such as exercise, sleep, and stress management. Additionally, he discusses the relevance of food inflammatory tests and concludes by examining the potential benefits and drawbacks of drugs and supplements in managing inflammation.
In this sneak peek, we discuss:
00:00 - Intro
00:09 - Defining inflammation (and the cultural impact of Napoleon Dynamite)
06:54 - Acute vs chronic inflammation
10:27 - The connection between chronic inflammation, aging, and age-related diseases
18:53 - The impact of inflammation on metabolic health
In the full episode, we also discuss:
-Understanding and diagnosing chronic inflammation: blood tests and other approaches, and challenges with measurement;
-Factors that contribute to low-level chronic inflammation;
-Minimizing inflammation through diet;
-The important role of fiber for gut health and inflammation;
-A closer look at the impact of trans fats and saturated fats on overall health;
-Why Peter prefers dietary fiber from food sources over supplements;
-Debunking “superfoods”: emphasizing proven methods over marketing claims for reducing inflammation;
-Is there any value in over-the-counter food inflammatory tests?;
-Food elimination diets: how they work, symptoms and markers to watch, challenges and limitations;
-Identifying dietary triggers for gut-related symptoms through low-FODMAP diets like the “carnivore diet”;
-Dairy: the complex role of dairy on inflammation and individual responses
-Wheat: the complexities and conflicting evidence around wheat's inflammatory effects
-How exercise influences inflammation
-How sleep quality and duration impacts inflammation
-The potential impact of chronic psychological stressors on inflammation
-The impact of oral health on inflammation and overall well-being
-The role of medications in managing chronic inflammation
-Supplements: evaluating the efficacy of various anti-inflammatory supplements
-Parting thoughts and takeaways
-More.
--------
About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
Learn more: peterattiamd.com
Connect with Peter on:
Facebook: bit.ly/PeterAttiaMDFB
Twitter: bit.ly/PeterAttiaMDTW
Instagram: bit.ly/PeterAttiaMDIG
Subscribe to The Drive:
Apple Podcast: bit.ly/TheDriveApplePodcasts
Overcast: bit.ly/TheDriveOvercast
Spotify: bit.ly/TheDriveSpotify
Google Podcasts: bit.ly/TheDriveGoogle
Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. For a full list of our registered and unregistered trademarks, trade names, and service marks, please review our Terms of Use: peterattiamd.com/terms-of-use/

[@nickflynn621]

Vote for Pedro!

[@Siticmon]

as a 30yo guy from europe i have zero clue what napolean dynamite is but i enjoyed that segment greatly, thank you

[@radezzientertainment501]

Classic comedy movie

[@nicholasbeck2649]

It's a movie about a few weird misfits in highschool growing up in some podunk town in the middle of Idaho. It's hilarious because it's such an accurate representation of what it's like growing up in a middle-of-America small town.

[@marciamakoviecki3295]

idaho is not middle of America, fyi​@@nicholasbeck2649

[@HkFinn83]

As a 40yo guy from Europe I can tell you…it’s a movie.

[@gloriareszler4196]

Me too! No idea what they are talking about. Better co.munication would be to explain!!👏

[@Jeph629]

SO much talk. "The Anti-Inflammation Zone" by Barry Sears (2005, Harper-Collins) is still the best and thorough discussion of inflammation and diet out there. Also, it contains no irrelevant reference to the moronic, pop culture motion picture mentioned here, though fans will be excited/beside themselves to know it was written the same year the movie was released.

[@peggyon1]

I'm an RN and one major reason I would never work in an operating room is that the surgeon's determine which 'music' will be listened to while the rest of the staff have no voice. Sometimes the 'music' is too loud, too Metal, too loud Rock, etc. Also, I don't think it is responsible to take one's eyes off the patient to look at clips of your favorite show. The focus should be on the patient and not the surgeon. I wouldn't advertise what really goes on in operating rooms.

[@nancyhonea1935]

He said it was a CD, not a DVD, so hopefully, they were only listening to the movie excerpts. ALL of he men I know completely stop everything they are doing and go into a hypnotic state when there are actual moving pictures. So I hope it wasn't a DVD in the operating room... 😮

[@peggyon1]

@@nancyhonea1935 You are clearly not in the medical field.

[@miaash3870]

You need to explain to the viewers/audience what Napoleon Dynamite is.

[@stillholding4975]

Dude, you're clearly enjoying yourself here. I know I feel cool when I prattle on about my knowledge of construction and engineering. But when I'm trying to deliver a clear point to a client or employee, I try to simplify the verbiage and get to the GD point. You should try it.

[@agontop1]

Completely agree. You’re channel is a general audience KZbin channel, using medical jargon which makes no sense to the everyday person, loses my sub. That and everything being a paywall!

[@starstern1077]

Oh wow. He has a sense of humor! Love to know this.

[@GreenLit3]

I bet I could throw this here football over that mountain. Crazy uncles are the THE BEST

[@saurabhav4202]

It's like 2 scientists talking in an airplane and I'm just stuck in the middle. You guys could have simplified the discussion just a little bit for us mortals to understand.

[@agontop1]

You’re right, has nothing to do with mortals tho. He is no smarter than you or I except in his trade. I wonder who is audience is he’s trying to cater to.

[@vs-yy5cx]

i liked the first 4 mins of nap dyn, but it was a little weird that they didn't even crack a smile thru it!

[@EvaiAten]

I am surprised how this video ended without fulfilling what was promised in the title of the video.

[@elizabethmcgregor4062]

I havent seen the end yet...but what you said is usually the case

[@BorneoAgent]

The title is for the full episode. This is a sneak peak of the full episode, so just a snippet. Full episode covers it.

[@nashscan]

@@BorneoAgentwhere is the full one?

[@ananavarrete7218]

Yes never listened the preventative part 😢

[@lynnerousseau9676]

I think these are TEASERS to get you to 💰/Subscribe to “The Drive”… if you 💰/Subscribe then you get access to full episodes of AMA {Ask Me Anything}☹️😖🫣

[@Michael_Komansky2679]

Napoleon Dynamite. Essential viewing for medical practitioners 😊

[@boomgag]

I have chronic inflammation from an auto-immune condition and I absolutely cannot live without the Protein inhibitor-like drugs mentioned in the video. If you find the right one that blocks a certain channel (in my case interleukin-17), it can remove inflammation almost entirely.

[@lukenukem1207]

Inflammation is why Uncle Rico can no longer throw a pigskin over dem mountains

[@reforesters]

But, the medical establishment identifies an Hba1c of 5.7 as prediabetic, no matter the fasting glucose level. Any idea why that's the case? Also, Hba1c increases with age. Any idea why?

[@natew4489]

I am noting there wasn’t discussion of icing, cold therapy for injury or the cold plunge stuff.

[@brian3185]

The opening bit about Napoleon Dynamite was hilarious 😂. The interviewer is fine btw. Thank you for all your work.

[@kman777FW]

I might have to revisit Napoleon Dynamite

[@jugeebean]

Vote for Pedro

[@bwspringer217]

The Napoleon intro was too funny… one my best friends from pharmacy school was from Preston, ID where the movie was filmed. Many of our late night study sessions ended with some quotes from the movie. He knew many of the local characters who showed up in the film. He was probably the smartest student in our class but just funny and unassuming. Peter thanks for the info on the podcasts. I get more from them than most CE classes. I’ll have to pay you with change.

[@raymonddowns6064]

Ok so the first 3:30 of this video has revealed to me that I have been living under a rock…

[@lesliedaily7951]

Does LDN help with inflammation?

[@Rose-nb6su]

I will go read Barry Sears. Waste of time to listen here for a sales calll. Wish we warned in beginning.

[@philiproesel7885]

Peter, thank you for all of your work. Maybe someone will see and reach out. If I take a round of dexamethasone, joint pain is reduced 90%. Resting hr will drop from low 40’s to high 30’s. Otherwise, I’m one of the healthiest 65 yr olds out there. I am on a very restricted diet.

[@chazwyman]

skip first 5:20 mins if you want to know about inflammation.

[@annettesoss2114]

Thanks

[@ownerdirector]

How much dairy is considered a moderate amount?

[@VeganStrong]

funny this popped up. i just started omega 3 epa about a week ago to reduce inflammation, and i also hear magnesium glycinate helps

[@samstone32]

Peter, I am a big fan, have the book watched lots of KZbin, but this one was a total waste of time. Consider redoing this KZbin so that the average citizen can understand what you are saying.

[@karenhikesalot]

Napoleon Dynamite is the greatest movie of our lifetime, hands down. It beats out The Goonies

[@radiant2012]

This is the typical word salad I get from my cardiologist.. inflammation is what the subject is. There is a drug out there that (IN THE PAST 6 MO) was approved by the FDA specifically for inflammation in patients with active Cardiovascular Disease. My cardiologist will not RX for me/ he rather put me back on the table. It is clear there are people out there who do not want to stop it at the source and practice proactive health care. Sad.

[@robynhope219]

Would like to know if the venison jerky you eat is homemade. Is beef jerky ok? I need a lot of protein...thanks!

[@justinklenk]

Brilliant appreciation piece on the genius of Napoleon Dynamite... Fuck all that I clicked on this for. Also, I finally spotted it/pieced it together: Peter Attia is the Jordan Schlansky of wellness science. 👍

[@vladimirbellevueinnovation4835]

Huge Napoleon Dynamite fan.

[@stantheman7908]

I still have a talking Napoleon Dynamite doll. Push a button, and you get 16 different Napoleon quotes

[@BillyBoy66]

Hey Dr. Attia, do you have any plans to comment on the Lean Mass Hyper Responder study done by Feldman and Norwitz? Would love to hear your opinion, as always.

[@epicentering]

Inflammation is an underappreciated component of depression. ❤

[@JDevlin90]

Most inflammation can be fixed with diet. Take out inflammatory foods and food sensitivities by going to the allergy doctor.

[@C8zzzD]

Inflammation is a resource strain, so i would lean towards that, but haven't found any research on it nor am I an expert.

[@epicentering]

@@JDevlin90 I agree. I also wonder if an individual's background viral load, and perhaps early life trauma could contribute.

[@epicentering]

@@C8zzzD good point.

[@nancyhonea1935]

I have heard that an increased cortisol load can be caused childhood related traumas. So, yes, I would agree that the inflammatory process is well established in these individuals before some of them even reach their pubescent years.

[@MandalaBunnyhome]

AMA question for Peter Attia- have you ever laughed or are you always in doctor mode

[@aa-xn5hc]

why is it not on the website yet, after days from the YT preview?

[@harveyjones1]

I think Peter should do a podcast about crystals

[@imaginationland474]

peter being a napoleon dynamite fan is a very unexpected yet welcome attribute of his personality. lmao

[@kathrynpoppywagner]

When women bloat monthly (or menopausal-aged women are chronically bloated), is this a “qualifying inflammatory response” as defined by this podcast? Even if C reactive protein is not elevated?

[@annettesoss2114]

I might have to watch this movie😊

[@stevespringer8385]

Does the chronic inflammatory disease, eczema, have an adverse effect on metabolic health and aging?

[@MaddenScience]

Railing against superfoods yet advising/investing in AG1?

[@rufisdodd4318]

HA good point. Also when he says "There is no evidence..." He needs to clarify is this because there was not highly funded studies, or has there been lots of studies and no advantages have been found. Like in the case of super foods.

[@peggyquinlan2364]

He’s hilarious in a very low key manner.

[@michellem434]

Great movie lol

[@Pablocajiga3093]

Brilliant, Opening, middle, and ending. !!

[@jodie3339]

Eat your ham, Tina!

[@robynhope219]

Just finished reading No Time To Die in the NYer. Never heard of you before then...agreed with all you said about aging. You say that with each decade after 30 we lose a meaningful amount of muscle mass and cardo fitness. This certainly happened to me since my chronic fatigue diagnosis...so depressing. I'm already in my 70s, so cant expect a lot of change at this point. Pleased to know i'm doing a lot of things right. I carry heavy bags of groceries in both hands despite my hip surgery that left one of my legs a bit shorter. I am definitely on an anti aging journey. Cheers!

[@annettesoss2114]

70s? Never to late!

[@allyjhughes]

Is this a repost?

[@hay_w1re645]

If you watch napoleon dynamite once, you’ll hate it. I imagine it’s the same with the soundtrack hahaha.

[@tomsamek2936]

New levels of sarcasm have been achieved here (first five minutes)

[@QuintinHowell]

My respect for Dr PA has just gone up 1000%. Napoleon Dynamite... 😂😂 I just want to say, your mom goes to college

[@briand5379]

Napoleon Dynamite is no doubt a good movie, but if I had to listen to the soundtrack every day for at least a month, I'd probably never watch the movie again.

[@qualqualie1518]

❤

[@JS2k514]

While you are at it, give me advice on hair loss prevention.

[@mbmurphy777]

This had literally no information in it related to the title.

[@frankconte]

What a waste of my time!

[@immortalityIMT]

How did Elon Musk's Neuralink brain chip get approval for a human trial or is it a case of do not go there?

[@Joy80JJ]

Never was interested in that movie...

[@lindamagness1167]

Watched a bit of Napoleon Dynamite. What a pathetic ,ordinary movie. What the hell do you think is so remarkable?

[@jugeebean]

First time it's stoopid....but the second time you get it.....and then watching people watch it for the first time while they aren't "getting it," is even more entettaining.

[@peterkizer6163]

"Napoleon dynamite"??? WTF.

[@cdtimmin]

One more video from this doc that doesn’t have the solution!!

[@spnyce4414]

WTF!?!?!! really???

[@Smitch-hw1bv]

Once again, peter this seems like version 2.0 that you play this little clip and then say spend $20 a month on being a member … I appreciate your hard work, but perhaps five or six dollars would be reasonable since you talk about people not having the money and yet you make this content exclusive… seems ironic…

[@josh_wags]

😂

[@DoctorDerp6969]

lol

[@brendanwilliamson4590]

Wtf bait and switch!

[@ALT-vz3jn]

This was mostly useless.

[@emmaluciaev1938]

True

[@oceanside66]

Very disappointing content.

[@mzoesp]

Useless.

[@robertbowen4533]

Pete loss the nice guy doing the interveiw style show iit reflects poorly on you and is somewhat insulting to the viewer. Not saying your pal is not smart. He can make on his own and you will do better by yourself

[@GABAG00L]

Congrats on one of the stupidest comments in this year

[@ghostcat2465]

It's like i'm reading a chatgpt 2.0 generated comment.

[@lotfibouhedjeur]

I so agree with you. I just don't get the interviewer, and he does reflect badly on Peter. I just wanna listen to Peter. He's on point, he knows what he's talking about, and he has that voice. Really, there's no need for that other guy.

[@joebartles3986]

Can you translate into English please?

[@robertbowen4533]

Thank you😊​@@lotfibouhedjeur

[@cuervos69]

Misleading title

[@mzoesp]

Useless.