Howard Chang (Stanford, HHMI) 2: LncRNA Function at the RNA Level: Xist

[@ecesari8775]

One of the best quality lessons i've seen on youtube. I enjoyed, thank you! ^-^

[@greghampikian5515]

I have assigned this to my graduate class, Viral/Human Coevolution. Thank you!

[@mmartin5816]

Fascinating advances in imaging accessible DNA!

[@DG-xg8vg]

The female cell treats the male chromosome like a bunch of viral genes to inactivate the promoters. That's fascinating.

[@r.guerreiro140]

Understanding the roots of it all

[@salvadorhirth1641]

Thanks Dr. Howard Chang. I need to watch your video sometimes until I can understand all of it. I'd like to comment on my hypothesys for the cause of Huntington's disease: I believe that stop codons are formed when the carbon '5 in cytosines from CAG triplets are methilated and a subsequent deamination transforms C into T, creating the stop codon TAG. If my hypothesis is correct, I wonder if an existing drug like Decitabine could retard or prevent the onset of Huntington's. Perhaps stop codons are the cause of other neurodegenerative diseases, like the transformation of CGA codons into TGA codons in Parkingsons. Also, if you have time let me know if a restriction enzyme specific for the palindromic region of +ss RNA viruses, like the Coronavirus, could cleave the viral RNA inside cells, provided its possible to get the restiction enzymes molecules inside the cytoplasm. Thanks again for your consideration! Salvador

[@TheDarim]

I wonder if these data on the mechanism of silencing of viral genes by human cells could somehow explain the individual differences (or maybe even sex-related differences) in human susceptibility to viral diseases....

[@aysehaleguckr3557]

Thanks Dr. Howard Chang. This is very helpful video. I would like to ask you that is it possible for any drug not to target any lncrna? I am writing a project about targeting lncRNAs with drug for cancer cells. However I couldn't convince referees about targeting lncRNAs. Could you please give me some advice.

[@joeschmoe5583]

PLZ MORE EPIGENETICS!! MY APPETITE CANNOT BE SATIATED!!!

[@y68pan94]

impressive

[@numericalcode]

This essentially a very complex chemical computation

[@johachinjoel2076]

Hopefully, you won't get bash by the Trans agenda for saying that men and women are biologically different. Thanks for the video.

[@owoeyepaul8995]

That doesn't make it a lie that God made the woman different from the man. Of course, there has to be a mechanism for bringing about the difference in creatures meant to be equal in worth and usefulness, but complementary(not similar) in works(physiologically, psychologically, and such like) and form(anatomically). To create is Divine. Why is the gorilla not as wise as man? God made some things inactive by one mechanism or the other in them, but made it active in man. We humans are to search out if we have the time. The glory of God is to conceal a matter, but the honour of Kings is to reveal it, so the Bible says. NO DOUBT, THERE'S NO WISE HUMAN; WE ALL LEARN ONLY A LITTLE OF THE MIGHTY WISDOM OF CREATION. SO WHY BE PROUD? GOD'S WORDS WE MUST OBEY.