This video is a full explanation about the x inactivation, the formation of the barr body, and the heterochromatin and euchromatin structure of the DNA.
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@Nisha-hg9tc7 жыл бұрын
I never comment on anything but I had to sign in to do this. Thank you so much. This is so helpful and exactly what I was looking for! Plus it was uploaded on my birthday so I think it was just meant to be. Thanks again!
@biomedicalandbiologicalsci49897 жыл бұрын
HAHAHA thank you for your comment, I appreciate that ... Ya, maybe it was meant to be a secret gift for your birthday .. stay tuned :D
@JorgeBrown4 жыл бұрын
This response was activated by NISHA protein...haha@@biomedicalandbiologicalsci4989 This
@ciao_abhi6 жыл бұрын
Amazing as always. I cant get enough of your videos. SO helpful
@arianabusca12915 жыл бұрын
this was such a great video! i never understood this topic until now, the way you explained with the cats made it instantly click in my brain so thank you so much! and dont mind all the comments of people complaining about your english, those people just cant deal with hearing something a little different, your english gets the point across which is all that matters!
@swetakk66512 жыл бұрын
Pretty helpful. Enjoyed the session!
@pallabdutta10115 жыл бұрын
Thank you for this, the video was really awesome
@sushmithaj63438 ай бұрын
Thank you so very much! I've been struggling to grasp this concept and had a hard tie visualizing it. This video helped me comprehend the process thoroughly. It was detailed and explained in a simplified manner, making it easy to follow. The organization, emphasis and the pace of teaching was perfect. :)
@souvikghosh58253 жыл бұрын
P0, P1, P2 are promoters not primers. You didn't mention the role of Tsix amd its interaction with Xist.
@Guzmicu Жыл бұрын
Well spotted. Tsix does indeed play a role which complicates things. It should also perhaps be mentioned that the "blocking factor" is a postulated mechanism but hasn't been proven to Xist, I mean exist.
@mikeladeluka57573 жыл бұрын
Thank you so much!!! You saved me and totally helped me to understand this theme
@saidlouzi6413 Жыл бұрын
This topic was vague to me but things are starting to become clear. thanks a lot for this video .
@milavukovic87056 жыл бұрын
Thank you very much! I totally understood everything! I absolutely love the way you organize and bring your thoughts to us. I have to agree with you that nobody explained this better than you on youtube *bow for that confession* haha :)) Keep up the awesome work!:)
@biomedicalandbiologicalsci49896 жыл бұрын
HAHA .. thank you .. so you read the comments as well ... keep tuned many interesting videos are coming up, and tell me if you are interested in a certain topic :)
@mobinamohebi57563 жыл бұрын
Thank you very much! you explained very well.
@chayanikabaruah73503 жыл бұрын
Thank you so much...your explanation and presentation of the topic was very helpful..it was lucid,clear and unambiguous
@shining75276 ай бұрын
you just saved a soul. God bless u
@samuelmingo50903 жыл бұрын
This was awesome! Thank you! I had a hard time visualizing the material, and my textbook did not offer any graphics. I have to visualize things to understand how they work. Again, thank you so much! -student taking Graduate Biological Anthropology
@alexissanchez77237 жыл бұрын
Wow! This video is excellent. thank u
@biomedicalandbiologicalsci49897 жыл бұрын
Thank you .. stay tuned :)
@davidfierro73994 жыл бұрын
My professor taught this in a way that would've probably confused every scientist on the face of the planet including Steven Hawking. But you have managed to make me understand this without crying. My most sincere gratitude to you, hopefully one day my name will have the MD next to it because of you and only you.
@mo_ahmed184 жыл бұрын
David Fierro hola el bebe, what a surprise to see you here
@burakkucuk92347 жыл бұрын
Thank you so much! Your video is clearly understandable and it helped me to do my homework. :)
@biomedicalandbiologicalsci49897 жыл бұрын
Thank you .. glad to hear that :)
@adamwells53963 жыл бұрын
Thank you so much! This is really helpful in preparation for my exam coming up!
@sunaynasharma25314 жыл бұрын
This is very very much helpful to me. Thank you very much
@amandineclaus82503 жыл бұрын
First I don't wanted to watch your video because it is in English but I could understand it very good, you spooked very clearly
@chemiaaadil62807 жыл бұрын
Fantastic...I have research about Barr body just now I will understand. So thank for you..
@JorgeBrown4 жыл бұрын
Dear BBS presenter, I've been interested in Epigenetic for about a year. During this time I was able to watch a number of presentations none was so clarifying as this one. Thanks a lot for your enlightening presentation. I did subscribe and will follow you from now on. Success in your endeavour and be happy!
@mehmoonabutt8653 Жыл бұрын
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@mehmoonabutt8653 Жыл бұрын
Check this channel for epigenetics
@gloriamastria74592 жыл бұрын
magnificent videoooo!
@muhammedal-samarrai94985 жыл бұрын
Your are the best..thank you so much.
@shilpa.bchotu33246 жыл бұрын
Thank you...well explained.
@jingluo33856 жыл бұрын
a very helpful video! thank you
@biomedicalandbiologicalsci49896 жыл бұрын
You are welcome :)
@nishahemandharkumar90825 жыл бұрын
the video is excellent...thanks....i would like you to explain about dosage compensation
@amelmostari41503 жыл бұрын
Thank you so much. the video is worth watching 😍😍
@muratbas99663 ай бұрын
Thanks a lot. i didnt find these lessons who teach better than you.
@ursulagwozdz19553 жыл бұрын
Very well explained.
@tshetensherpa30047 жыл бұрын
Thank You!!!
@nimishatripathi78455 жыл бұрын
It is exactly what i m looking for...thnx mama
@aritramondal18253 жыл бұрын
You are too good .... lecturer....love from India...❤️❤️❤️👍❤️👍👍
@saranga76764 жыл бұрын
Very good detail explanation....thank you🤗
@subhi79454 жыл бұрын
WOW thanks that was so clear
@marianradvansky63042 жыл бұрын
Brilliant ♥
@shrabonishee59424 жыл бұрын
Very nice.. Thank you
@ishaaggarwal34273 жыл бұрын
You Actually explained the topic x inactivation in female mammals from chapter linkage, book-person a global edition Thanks a lot for such a simple simplification for such a complex topic. I was really struggling there And I really appreciate your efforts 👍👍👍😃
@aaishashaikh11885 ай бұрын
Tomorrow is my exam This helped me sooooo much I was not able to understand from many videos or google but here I've understood everything very well 😄
@yannamkrishnarjunarao99962 жыл бұрын
I am lecturer in botany I am so happy to watch your class hear. Thankyou
@inhwajeong4891 Жыл бұрын
Thank you so much for your lecture. I had to go through the basics to understand the diagnostic method to detect X chromosome skewing in case of X-linked CGD
@user-he2tk8hz9z2 жыл бұрын
very very very helpful thanks
@peggycarter64604 жыл бұрын
thanksssssss appreciate the help!
@bhaskarjyotibarman49892 жыл бұрын
Nicely presented. Its very helpful
@adrijasaha14653 жыл бұрын
The video is very helpful Thank you
@lab-technologist1232 жыл бұрын
Thank you soo much❤❤❤
@LifeistheBubbles5 жыл бұрын
I love this video!! Where is the blocking factor transcribed from? The material or paternal X chromosome?
@user-qx6nh6sj2s4 жыл бұрын
Thank you so much very helpful video
@ching24435 жыл бұрын
thnx a lot.. it's just so easy for me now
@jabalrahmat16547 жыл бұрын
thank you , Now I'm understand XIST
@biomedicalandbiologicalsci49897 жыл бұрын
you are welcome ;)
@chrysanthiiliadi77295 жыл бұрын
Thank you! Could you please upload the script of the video too?
@mahwishadnan6465 жыл бұрын
your video helped me a lot in understanding the topic easily...can u please talk explain about DNA rearrangement and allelic exclusion
@kaziwahid46463 жыл бұрын
Thank you😊
@ahamadaoukachioukachi72694 жыл бұрын
You're awesome thank you so much
@shaimaaeidibraheem1746 жыл бұрын
EXCELLENT VIDEO
@biomedicalandbiologicalsci49896 жыл бұрын
Thank you :D
@tanyushka6719905 жыл бұрын
Thank you very much! Can you please upload a video about Prader-Willi syndrome? Exactly how the syndrome occurs and what exactly happen in the cells?
@mdsana32833 жыл бұрын
🤝 thank you...😊
@mucsat6 жыл бұрын
Perfect lecture
@triptiverma32084 жыл бұрын
Maam your way of explanation is awesome. Please make video on blood group inheritance also.
@nusratjahan49222 жыл бұрын
Thank you so much .....you r explained very well like my zoology dept. Professor 😍😍😍😍
@Priyanka-dh7wu5 жыл бұрын
Thanks a lot..... Luv ur way of explanation.... Superb.... Plzzz make more vedios on genetics.... It would b really helpful..... plzzzzzzz
@walidrehawi4133Ай бұрын
Thank youuuuu❤
@sabanorouzifar88054 жыл бұрын
Thank you soooooooooo much ❤️❤️❤️❤️
@laharithrilok1427 Жыл бұрын
Can I get the article from which this information was taken??
@user-ti8pw9mt1o5 жыл бұрын
U r perfect and very wonderful. I understood you. Really to be frank and honest I love your voice very much :$
@drchaitanyagottapu66985 жыл бұрын
tq sooo much......pls prepare more for...desimminate the knowledge
@meylingloo76315 жыл бұрын
gracias por explicar lo que el profe quiso decir en una hora y media de clase
@souravdalapati.62707 жыл бұрын
This is really helpful.Thank you.
@biomedicalandbiologicalsci49897 жыл бұрын
Thank you ... Stay around many videos are coming up ;)
@competitionwallah47633 жыл бұрын
Hey, I have a query. How X inactivation occurs in somatic cell inspite of germinal cell that is sperm and egg cell participate in fertilization and leads to the baby
@Poopyduckling9999 Жыл бұрын
Hellow ma'am, how's it possible for a rna transcript to have hydrogen bonding with a ds dna? Is hoogsteen base pairing occurs there??
@CHIAMAKAMARYANN-hh4rc5 ай бұрын
Very informative video. I think the P regions should be the promoter regions not the primer regions
@abhyarthanabehera48023 жыл бұрын
Where does the blocking factor come from?
@khalidbashir40332 жыл бұрын
Superb
@Dineshkumar-cv9pd4 жыл бұрын
but why blocking factor does not bind to the another x chromosome and what the role of Tsix...?
@ulukbekzhumaliev25883 жыл бұрын
Turkish accent; good explanation!
@jamesdoleyofficialmisingso53224 жыл бұрын
Thank you very much Mam.
@medicaleducation89782 жыл бұрын
Methylation and deacetylation take place for every normal DNA when they become condense in metaphase or methylation and deacetylation occurs only in Inactive X chromosome ???
@joselyncolumbusponce35522 жыл бұрын
What it is the diferentes of this and codominance?
@divijakg91764 жыл бұрын
Hello, thanks for the video, is the x inactivation mechanism only in Calico cat or in general or in humans??
@nirvana1526 жыл бұрын
Can you please tell me how the blocking factor is produced ?? Thank you son much, and great vidéo by thé way ;)
@biomedicalandbiologicalsci49896 жыл бұрын
Oh thank you, the blocking factor is produced like any other protein in the cell, it has a coding gene called the blocking factor gene, and it will be transcribed and then translated into the blocking factor protein ... is that what you meant?
@larademiney79146 жыл бұрын
Would you mind explaining the correlation between the unstable RNA transcript and the production of the blocking factor. Also, at the pre-8 cell stage would there be more blocking factor produced to be sufficient for both X-chromosomes. LOVED the video! thank you so much
@hintofjay5 жыл бұрын
:) thank you !
@sushreeacharya5510 Жыл бұрын
Can u please explain.. Which histone modifications will activate and deactivate the transcription. Like methylation, phosphorylation..... But i want to know about ubiquitylation and somoylation....
@anagiovannaart4 жыл бұрын
I have a question, what are the genes that are affected for this inactivation?
@naziahussain55055 жыл бұрын
enjoyed a alot
@athulsankarc65913 жыл бұрын
Thanks
@shaheenmajeedwani19695 жыл бұрын
X inactivation is necessary for dosage compensation. In Marsupials, most monotreams and humans, one of the X chromosome of the female is inactivated in order to compensate the dosage. In case of Drosophilla no inactivation occurs but the single X chromosome of male is hyperactivated inorder to compensate the two X chromosomes of the female.
@nishanthgm5185 жыл бұрын
Good lecture
@abdulrahimalomran19126 жыл бұрын
Thank u so much , very helpful vid I bet that u meant there is H3K4 (hypomthylation) rather than saying methylation :)
@rjbhatia3 жыл бұрын
Really very well explained ❣️. Plz make a video course on csir net life sciences syllabus. Many of us really need your help. Thank u ❣️❣️❣️❣️❣️❣️❣️
@honeyfarms19822 жыл бұрын
Hi nice video...got a doubt ..if one x is inactivated...how does recessive and heterozygous dominant find it's expression in sex linked disorder...
@parthadutta34953 жыл бұрын
excellent maam
@sarahamdy10414 жыл бұрын
Thank you What are References please?
@benitaariaslara84857 жыл бұрын
At 17:31 you talk about the H3K4me being present as well as H3 deacetylation, is this happening at the same time or is the deacetylation happen after the fact that H3k4me is present. My understanding is that H3k4me is associated with gene activation and euchromatin while deacetylation is associated with heterochromatin and silenced genes. thank you!
@AmeyRedkar76956 жыл бұрын
As far as I understand, h3k4 site is modified as in 4th amino acid(which is lysine) is modified to be methylated there are other sites as well like k9 and k27. As for deacytlation sites are different.
@shaheenmajeedwani19695 жыл бұрын
Actually the X-Inactivation occurs randomly after the cytodifferentiation of embryo according to the Lyon's hypothesis.
@caleigh75755 жыл бұрын
shaheen majeed only in eutherian mammals
@azifahahmed44624 жыл бұрын
Hello, how does X inactivation leads to haploinsufficiency of SHOX gene?
@sudiptajana18543 жыл бұрын
At first what a great video this is...👍 I have question..I have read that methylation of K4 in H3 cause the chromosome not to condense..that is it is active..then why in 8th cell stage u have shown H3K4.. showing chromosome condensation...?please clear this doubt..thank u.
@shwetapatel-bq4st5 жыл бұрын
I have one confusion. At 17:18 you mentioned H3 K4 methylation after xist transcription. But H3 K4 methylation is associated with chromatin activation and not condensation. Can you please clear this doubt...?
@giantbob79795 жыл бұрын
Methylation of Lysine makes the chromatin more condense, which is opposite of chromatin activation. However if the Lysine was acetylated the chromatin structure would loosen up.
@hraqhraq5 жыл бұрын
You should say "Xq13" Xq one Three, not Xq thirteen; it is the band and sub-band nomenclature.
@sudiptajana18543 жыл бұрын
Ook.aslo is it right that methylation of H3K4 for chromosome compaction/condensation..?as mentioned in this video.. I have read that H3K9 methylation is for condensation...what u say??
@hraqhraq3 жыл бұрын
@@sudiptajana1854 H3K4me3-promoters H3K9me3 = Tri-methylated Lysine number 9 from N-terminal causes heterochromatin (condensation), but there might be more to condensation than just one location, even recent discoveries suggest mechanisms of action of methylation and acetylation are different than just blocking mechanisms to enzymes
@sudiptajana18543 жыл бұрын
@@hraqhraq so both H3:(K4met and (K9met, acetylation)) are responsible for heterochromatin structure??
@hraqhraq3 жыл бұрын
@@sudiptajana1854 No just K9
@sudiptajana18543 жыл бұрын
@@hraqhraq ok..then is this video giving wrong information...the 8th cell stage..have u noted that??
@shaheenmajeedwani19695 жыл бұрын
In case of human females, due to the inactivation of one of the X chromosomes, the inactivated X chromosome becomes darkly stained and condensed and remains transcriptionally inactive. This darkly stained body is known as Barr body. Every human female is having a single Barr body.