Farese and Walther (HSPH) 3: Physiology of Lipid Droplet Formation

[@dirkschafer8713]

Hi Robert & Tobias, Congratulation to all of your 3 presentations om lipid droplets! what a pity that only quite recently I detected your youtube lecture... A fascinating clear and inspiring insight into the lipid metabolism of cells. I absolutely agree with the conclusions and summaries you made - based on our own research on inflammatory diseases in humans: lipid droplets (lipid bodies) are more central involved than currently noticed... 'will track your future research... best regards ds

[@spkm4tube]

You briefly described Mycobacterium. There is no ER in Mycobacterium. But LD making it has a strong connection with persistence. Looks like they break LD outside, take the fatty acid in the bacterial inner membrane and then bud out in Bact. cytoplasm. Can you please comment on it?

[@louisebuijs3221]

I would like to know how the lipid droplets remain continuous with the ER and not bud off (10:16) Can you really say it is still continuous with one of the ER membranes at that point? To me it looks like there is an equal possibility that some kind of protein might thether the two... Btw very interesting series. I also read your Nature paper from 2013 on this subject and I was wondering wether there were any new advances. Thank you!

[@quimlast7180]

Could FRET be used to test for conformational change upon change in environment from the ER to the lipid droplet?

[@InquilineKea]

so THIS is the reason why eating too many MUFAs is nowhere as bad as eating too much carbs