Whole Genome Sequencing and You

This video is about whole genome sequencing. What is a genome? What are the basics of how whole genome sequencing works? What can you find out about yourself from getting your genome sequenced? And what are the potential benefits and risks? You might be considering getting your genome sequenced for clinical, research or personal reasons. Or you might just be curious and want to learn a bit more about this technology. This video was developed to help you understand a bit more about what whole genome sequencing is, and what it could mean for you. It was developed by researchers at Mount Sinai's Department of Genetics and Genomic Sciences and Department of Emergency Medicine with funding from the Charles Bronfman Institute for Personalized Medicine, with valuable input from several community consultants, patients and others from around the Mount Sinai community.
• Visit the Department of Genetics and Genomic Sciences: ow.ly/f8saW
• Visit the Department of Emergency Medicine: ow.ly/f8sfq
• Visit the Charles Bronfman Institute for Personalized Medicine: ow.ly/f8sjU

[@neerajkulkarni]

Very informative and extremely well presented. I just loved how neatly and beautifully the information was represented and more so the way it transitions from one piece to the next!

[@madhankumar8463]

This video is still awesome after nearly a decade...wow !

[@TilakRajKapoor]

Excellent. A simplistic approach to explain a complex subject. Love the efforts put in.

[@nibeditaroynitu226]

Terribly well presented. Super kudos to you all! 🙏❤️

[@rachelsturm3312]

I enjoyed the video very much. It was well done in all areas. I had my DNA tested at 23andMe last year in the Spring and still get excited about it! Thank you!

[@Ghadir.Hollywood]

This is very informative and well presented. Thank you.

[@raresiesruleolliersdisease8107]

Very interesting, very well presented. My Genome is off, I have a mutation, that is for sure. I have a very rare bone disease; multiple enchondromatosis. Research using Genome sequencing would truly help understand this rare disease much more.

[@khloudmoh1030]

This is absolutely useful! thanks very much

[@user-qk8rb7tf6g]

incredibly informative and well presented, thank you!

[@amitaryan67]

Its too informative and easy to learn..bcoz of ur teaching style.. ! Thank for This Dear..! #INDIA

[@FmTrini]

Very interesting lol I’m an IT undergrad and this video is part of my curriculum. What I interpreted from it however, is that the whole genome sequencing is similar to one opening Pandora’s box symbolically or not so much based on its inaccuracies 👌🏾

[@SRIMAN2021]

Very good information thank you

[@juneribaldi7093]

EXCELLENT EDUCATIONAL VIDEO. Thank you Icahn School of Medicine.

[@aryaram8192]

Well presented informative video thanks❤✨

[@AR-oi8ks]

very informative and awesome vedio!

[@sandhyasarpotdar7340]

.madam youhave given a very good i information about genom sequencing tha ks a lot.

[@bananaplease5262]

Seriously, the sound effects had me damn near in panic mode.

[@raanoooshh9296]

Sameeeee

[@luisbetancourt8213]

I looked around more than once

[@aashmagyawali6331]

Seriously i felt the same

[@harshitashrivastava8877]

What a video!

[@memfromsomerville]

This was well done. The only aspect I thought was missing was the implication of your sequence data on your relatives. I think people need to consider that.

[@teacher36870]

Why would it have any consequence for your relatives unless you choose to share it with them? It wouldn't change anything, one way or the other. "It is what it is" basically. Personally, I am very curious about my whole genome or as much as I can find out. I was in the group that 23andMe did that included health related information from which I learned that I have an increased risk of developing Alzheimer's. It did not scare me one bit but has led me to participate in a clinical trial that it focused on the plaques formed in the brain by a protein called amyloid. It is interesting for sure and may be helpful for others in the future and for me unless I am receiving placebo.

[@no-won]

@@teacher36870 Because when the government uses it against you they can use it ag your whole family.

[@no-won]

I agree with the op. Anyone in the family take a 23and me or dna test and it affects the whole family.

[@Anime_cooks]

Nice keep it up

[@sumeyye_1243]

Well presented and explained clearly! You vanished Mount Sinai

[@ivoryowl]

Where would one nowadays to get a genome sequencing? I'm kind of curious to know what kind of genetic conditions I have (or might develop)... I live on Portugal though, so my options might be a tad more limited...

[@rhyothemisprinceps1617]

5:27 Huntington's Disease is cause by a repeat expansion. Does whole genome sequencing now routinely include detection of repeat expansions?

[@LoveistheSea]

Yep, this seems to be one of the easier things to determine. I don't think WGS is even needed for this - there are micro arrays and other techniques available for targeted DNA sequencing

[@LoveistheSea]

Sorry, not targeted DNA sequencing in this case, but to simply determine the number of repeats in that region

[@britoronto6628]

There are many important oversimplifications here--starting with really basic ones: (1) the video states that genes encode proteins...but this isn't always the case as many genes encode functional RNAs that can affect the expression of other genes or function on their own (nobody lives without ribosomal RNA!). (2) The concept of DNA variants isn't well explained--for instance, defining a variant (SNP) vs a rare variant is relative to the population. (3) The concept of "disease causing" variants is a lot less clear than the video claims (and there's no mention of epigenetics!!!--the 1000 genomes project showed that most asymptomatic healthy people carry disease causing mutations--so context clearly matters and multi-gene and epistatic interactions are very difficult to scope out in non-model organisms. (4) Interpreting a person's genome isn't just complex, it's currently pretty much guesswork. What we know is a small fraction of what we don't. (5) Most "whole genome sequencing" is in fact SNP typing, which is NOT in fact sequencing the whole genome (which costs much much more).

[@robcasey4096]

The goal was to provide a simple presentation so that non scientists can understand. Mission accomplished...Thanks.

[@johnvandenberg8883]

Difference is 0.1% (not 1%) or ~3m letters.

[@thanojssurendran7454]

kollam ,good

[@Malak-xp2xb]

i like daaatttttt

[@gettingpaid82]

Just like a computer 10010101110 Lol and yeah I would like the full results..Why don't they do this for free at birth!!!

[@mimiwill5618]

Good thing your brought that up! 😃😃❤❤. I'm using my stimulus money to have whole genome sequencing done at sequencing.com and have been doing a lot of reading. We, as a society, are getting closer to having this done at birth, at least in Asia. Dont fall for sequencing through 23 and me for $100 or $200 though! They only uncover a PORTION of your DNA...like literally 1%. It isn't the real deal. Its only a mini portion of genome sequencing. Expect to pay about $400 to $600 here in America...this complete 100% genome sequencing like this video talks about.

[@pauldodd2120]

1. It would be a privacy violation as you could not give informed consent. 2. The cost might be better spent on other items. 3. General health improvement regardless of your genome may make better sense. 4. Could prevent you getting medical insurance. 5. The environment is more responsible for health in general than your genome.

[@jasonhunter6125]

why don't the government obtain full genome from every citizen? What is the price for it?

[@michakozicki8923]

Jason Hunter 1000USD at its lowest.

[@starkeclipse]

Not to mention that would have a large number of ethical concerns. Say your genome shows that you will assuredly end up with an incurable, fatal disease that will require $100,000s in care costs beforehand. Would you really want the government (or, heck, even your insurance company knowing that)?

[@jasonhunter6125]

@@starkeclipse sure, no problem as long as you make a law that prevents any company operating in the nation from treating you differently. Also here in Norway most health Care is a right, which it should be everywhere

[@pauldodd2120]

The government could then track everyone using any trace of DNA.

[@2bannedaccountscountingblo99]

The CDC says this is how they're detecting the delta covid-19 variant. Let that sink in.

[@pauldodd2120]

Nothing to do with whole genome sequencing.

[@2bannedaccountscountingblo99]

@@pauldodd2120 The covid pandemic was scam. Normies & leftards got played. It's the reason the establishment uses the dem party as a spear point. They let them think they're smart tell everyone they have Dunning Kruger syndrome while they get used & abused. It was an amazing experience to see how Hitler, Mao, Stalin, Pol Pot etc did what they did. Now I know.

[@LITO_FREDO]

Our genomes spread out looks like a female?! 🤣 jk

[@abh2248]

Mount Sinai should know better as human skin DOESN'T come in COLORS, after all humans are not crayons. Human skin only comes in different tones of the same color--yellow--so, the only thing genes can reveal is skin's lightness or darkness. Additionally, the "INTERPRETATION" of a "variance" that gives a "likelihood" of where your ancestors lived is, today, liken by scientist to a best guess as much is still unknown. Moreover, the standardized "reference" populations from different parts of the world to which ones DNA is compared are actually very remote or small, and that's why what results from whole genome sequencing is a best guess as to the likelihood of where ones ancestors lived. To be sure, so far, whole genome sequencing is not very useful as a predictor of disease and the likelihood of the location on the planet of ones ancestors. Therefore, the only ones who gain from this kind of marketing are businesses set up to take money from those who don't know better.

[@michaelstone761]

Minus your last sentence there, I believe this video is intended for the general public, not scientists. It is for people most likely already sick and looking for an alternative to current standardized tests. So, really it is tailored to the audience and one must "know your audience" when judging a speech (or video's) merit.

[@LITO_FREDO]

Our genomes spread out looks like a female?! 🤣 jk