Immune Response, Toll Like Receptors (TLR) Pathway - IMGENEX

[@Guihlopez]

This video is absolutely amazing. Immunology completely makes sense after watching it. Congratulations to whoever made it.

[@matthewcurry3565]

I think someone poisoned me with literal LSD. What is happening?

[@killpy12]

Absolutely horrifying and inscrutable. I love it, thank you

[@shajahanmonusshajahanmonus320]

Ll LPGA LPGA

[@101Phase]

Believe it or not, I'm currently writing an essay on Toll-like receptor signalling for a coursework and this was the most accessible summary I've found so far. Excellent work!

[@litojonny]

this is what id imagine what studying immunology high must be like

[@melthompson9487]

litojonny that is exactly what I was attempting to do and I felt that my needs were tended to. 10/10

[@mroosie7488]

This IS what studying immunology is like... it's horrific.

[@matthewludivico1714]

While listening to techno music

[@widyawidya5752]

Medicine faculty be like

[@gregorykarimian3813]

LOL

[@yeshitellaaleme4419]

I watched this 6 years ago and I wanted to watch it again then my mom put out a KZbin video and it popped up I'm crying tears of joy!!

[@rickyroko1]

This is the greatest ANIMATION i've ever seen in immunology! lots of love

[@qingzheng7485]

me too

[@kingsleyuduehikingsleyudue1494]

I want to thank Dr ehime herbs for the help he has rendered to me by getting Rid of my (HIV). I was Diagnosed in July 2018 but after the Usage of Dr ehime herbs Herbal Medicine, I was cured from (HIV) and the virus was completely gone from my body. The Symptoms of the (HIV) Virus is completely Gone.. So anyone who is having the virus should contact Dr ehime herbs to give you the herbal medicine to cure yourself. HERPES, You can contact on Instagram @dr_ehime_cure2 or contact WhatsApp number ([phone]) or email ([e-mail]) He cures all this illness,. 1 cancer cure 2 diabetes cure 3 ringing ear 4 herpes cure 5 warts cure 6 HPV cure 7 Hiv 8 get your ex back 9 pregnancy herbal medicine 10 prostate enlargement 11 Hepatitis B 12 Dysfunction...

[@leticiacuellar6474]

Kudos to the producers for making this TLR series funky fun!

[@Hellos.5]

I can only imagine a game designer and a doctor collaborating on this 😂. It’s a wild ride.

[@Airhockeylirare]

So this is what happens when microbiologists take LSD...

[@joeshellhammer]

I thought the very same thing when I first watched it, even though I really liked it. But, wow, what an imagination! Pretty impressive. I thought it would have been appropriate to have this video set to "Lucy in the Sky with Diamonds".

[@prasadbotheju5682]

I'm researching relieving sarcoidosis condition naturally and found a great website at Remission Crusher Tactic (google it if you are interested)

[@innate-videos]

hahahahahahahahah

[@rittenbrake1613]

Nina Borodinskaja 😂😂😂😂😂😂👍🏻

[@giannis101]

Hahaha

[@ita14]

B7 molecules are B7.1 (CD80) and B7.2 (CD86). They both bind CD28 to sustain T cell activation.

[@juliaskripka-serry2537]

Welllll peeing my pants laughing is definitely not the outcome I was expecting when I youtubed TLR videos today

[@dr.salmanriaz1468]

what can u expect more than this?... lovely...thousands of heart loving kisses to the one who created

[@rashaessam9426]

Dr.Butterscotch certainly great effort

[@kingsleyuduehikingsleyudue1494]

I want to thank Dr ehime herbs for the help he has rendered to me by getting Rid of my (HIV). I was Diagnosed in July 2018 but after the Usage of Dr ehime herbs Herbal Medicine, I was cured from (HIV) and the virus was completely gone from my body. The Symptoms of the (HIV) Virus is completely Gone.. So anyone who is having the virus should contact Dr ehime herbs to give you the herbal medicine to cure yourself. HERPES, You can contact on Instagram @dr_ehime_cure2 or contact WhatsApp number ([phone]) or email ([e-mail]) He cures all this illness,. 1 cancer cure 2 diabetes cure 3 ringing ear 4 herpes cure 5 warts cure 6 HPV cure 7 Hiv 8 get your ex back 9 pregnancy herbal medicine 10 prostate enlargement 11 Hepatitis B 12 Dysfunction...

[@HassanKhan-sx1nt]

content like this derived people's on youtube to clear concept such videos make study very easy so there is no excuse for no learning

[@wellyd44]

Yes CD80 and CD86 are B7 molecules expressed by the APC upon TLR activation. CD80 is B7.1 and CD86 is B7.2. The B7 nomenclature is old whereas the CD nomenclature is more modern.

[@mindimpulse47]

it would have been bestt if there was commentary too .. for explaining the video

[@sardarali2025]

exactly

[@nancyab9862]

Exactly👌🏻👌🏻👌🏻

[@jeherulislam6903]

This video seems to be targeted to one who already knows the whole process but feels jumbled and would like animated description. Last time I watched i didn't get a things but now I can see why i didn't. So proper description is better to target larger audience

[@rakshith1994]

Read in textbook and come back and watch. This is a good video to a clear picture. PS: I read Veterinary Immunology by Ian Tizard 10th Ed before watching this. And it gave a super good clarity. You can choose your own books too.

[@caslandry2847]

This is kinds how it feels when I study for my immunology final after a few too many edibles, and maybe some acid.

[@kingsleyuduehikingsleyudue1494]

I want to thank Dr ehime herbs for the help he has rendered to me by getting Rid of my (HIV). I was Diagnosed in July 2018 but after the Usage of Dr ehime herbs Herbal Medicine, I was cured from (HIV) and the virus was completely gone from my body. The Symptoms of the (HIV) Virus is completely Gone.. So anyone who is having the virus should contact Dr ehime herbs to give you the herbal medicine to cure yourself. HERPES, You can contact on Instagram @dr_ehime_cure2 or contact WhatsApp number ([phone]) or email ([e-mail]) He cures all this illness,. 1 cancer cure 2 diabetes cure 3 ringing ear 4 herpes cure 5 warts cure 6 HPV cure 7 Hiv 8 get your ex back 9 pregnancy herbal medicine 10 prostate enlargement 11 Hepatitis B 12 Dysfunction...

[@MrTimothy250]

Well, in fact, there is two types of B7 proteins. B7-1, which is CD80, and B7-2, also nammed CD86. Both can fix CD28 or CTLA-4, respectively stimulating or inhibiting the lymphocyte T CD4+ cell.

[@russelmiller7311]

vivid explanation on the topic. Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.

[@neerajpatil3735]

Hey! You have uploaded a really nice video. But changes should be made in the names of all component cells and proteins. One can not see properly the names in lower resolutions.

[@sophiabang7868]

When you leave no room in your budget for sound lol. Honestly though great video for visualizing TLR system and MHC II antigen presentation. Makes things make more sense as you read.

[@Saul_GC]

there are soooo many things other than what appears here that i must learn, may god have mercy on my soul, and on your souls if you are/will be in this situation

[@rtpcr3969]

imagine being a molecule

[@nechamarakow3922]

the best way to study! its really a difficult war going inside our bodies.

[@z5612y73]

PERFECT video ! I like this! But...uhhhh....I think most important cytikine for inhibition are IL-10 and TGF-beta in Treg. IL-2 is a cytokine for activation (IL-2 is so called T cell growth factor). the function of IFN-gamma is that maintain cellular immunity, and clear intracellular pathogen. It is most important Th1 cytokine. there are some people indicate that IL-10 is Th2 cytokine. too. If I've made any mistake, I'm sorry.

[@areanaangel8964]

the music was nice tho. i was dancing in my room. lol

[@Mai0211]

love the animation! makes it much more fun to watch, especially for someone with a short attention span like me who's trying to study. But you should have someone explaining each process instead of music, that would be much better :D someone with a good cartoon voice.

[@username7445]

The cast is very well chosen! Congratulations😂

[@Peter7beardmaster]

this is exactly how Kuby's describes the process..you just won a like and subscription, thanks a lot

[@malikzahid6848]

Excellent sir but name of component and cells are not clear.

[@kakhangchungpanmei8205]

So helpful. wasnt sure about PPR an TLR, now i know , ur website is really helpfull. kip up the good work.

[@aishabhat2358]

This is toooo cute,never seen anything so interesting and creative related to my studies. Thank you so much for this animation❤

[@Prettyspeck]

Wish everything could be explained in this way. zthis is Amazing

[@edwardhaughney9665]

Rather stunning presentation. Pictures are more powerful than words. Keep up the good work. Don't usually care for music accompaniment but this seems to work.

[@DrMcGunner]

Great video! I am a visual learner so it really helped me to put faces with all these things.

[@MrPawan05]

Holy shit! We should have nanoscopic cams installed in our body. That would make great reality show of all time.

[@stemked]

Very nice. I'm going to use this video in my Immunology class.

[@zeeto_k]

this video is more helpful more than my prof.

[@kruger5962]

B7-1 = CD80, B7-2 = CD86, they both link with CD28.

[@habibehk]

Saved it, and sent the link to my kids- Cool, fun and creative animation! If you can, please share the link(s) to your other work(s) in the reply to comment section.

[@marvahkhalid5060]

wow this is soo amazing!! thankyou for your efforts in creating this

[@capriccioso35]

@gerbilinatube CD 80 is another name for B7 and yes it links with CD28 as a costimulator for T cell ( in this case, CD4 , helper T cells) activation

[@brooklyn5466]

So if you give the body the right foods it's able to have the stuff needed to do it job.

[@leonstellander8602]

I will never forget this

[@walidsong2255]

Please explain the work of the enzyme 5 alpha reductase in changing the male hormone, and where it is produced. Thank you.

[@fenotipobombay]

what is the function of cd80/cd86? and why the microbe is destroyed once he gets (endocytosis?) inside the cell? what is the mechanism that lead to the production of the antigens linked to mhc II?

[@vaidyakannadiga1005]

Kindly give background lecture ,that might helpful for exact and detailed understanding

[@kandrew5v5]

Also check out Imgenex's new apoptosis detection tool called pSIVA

[@drsomto007]

I thought it's supposed to be CD4 on the T cell, please explain

[@dezafeatle]

Very helpful video. Helped me understand my immuno-biology class a lot better.

[@britneythao]

Very nice and well made animation. However, there are some parts I don't understand. For example, I don't know why the dude CD80/CD86 at 2:31 got stuck at the cell membrane. LOL. This might be for higher level in immunology. It would be nicer if there is explanation going along with the video.

[@hgsnk333]

Please (and thank you) make one for CLRs, RLRs and NLRs!!!

[@sxyngel]

whats an ikb???? would help alot if you list the full names of all the abbreviations

[@kotosqoposrly]

I gotta give it to you that such a complex subject being presented in this childish way, with horrible sound effects, does work because I understood what was going on here.

[@investigacaopsicologiaavan8256]

Hi IMGENEX, can I download your video for my self? Thank you

[@marcleblanc3602]

Those monsters dont really exist, what chemical reactions drive them?

[@infovitindia]

Hi guys....Don't u think the quality, look n feel and overall composition is -sorry to say- is quite low in comparison with the earlier ones ??...it could hv been better.......

[@jkegan6037]

+Biswa bhanu As a graphic designer, this is a little painful to watch. But if it helps people learn, then it has my approval.

[@esse318]

the presentation is clear and fun but it's a little complicated for me to understand the codes of molecules

[@SimonCU]

I think the letters needs to be larger in font because its difficult to see clearly. Or someone needs to add voice into it.

[@mesentsev]

It is hard to read whatever was in this video. The font is too small

[@kandrew5v5]

@Mjhond Thanks, I appreciate it! We are working on more videos as we speak.

[@NLNikoleta]

i am using anti-TNF inhibitors and i like your video so much!

[@brazilian777able]

This is a very creative ingenious video. Excellent!!! I love the end with the showing of the cast. LOL

[@marekfutryna3804]

I do not know what stuff was taken by the author but i want it too

[@karleffertz]

Great video!! when are 2 and 3 coming out??

[@esra11102010]

This is amazing. Keep up with the good work, I like them all

[@anujapatil2902]

very thoughtful, thanks, guys for uploading this video!

interesting animations you got there. Keep up the good work!

[@bangtanbeau2131]

VERY GOOD ANIMATION. Thankyou! It helped me a lot!

[@imegatrone]

Nice Video That You Share , So Very Nice Thanks You . In invertebrates it is the sole mechanism of defense against pathogens but in higher vertebrates constitutes the first line of defense

[@tropicantei5550]

WAAAAW THANK YOU. YOU JUST SAVED MY FINALS x))))

[@fenotipobombay]

one more question.. TLR know every kind of microbic antigen or just some of them?

[@MadrassaDzOubahMed]

Hi ...thank you very much for your videos .. could you tell me please the name of the program that can make that animation style ... thanks again

[@Salma_Mulla]

this video is better 10x than my teacher explanation

[@theBUBBAMANcan]

This is exactly the way it went down. I know, I was there.

[@Electroblade360]

Why Did The Pathogen Killed Itself This Means The Pathogen Hates Itself

[@knucklescapricorn31]

Oh my gosh, this is great! Why the hell does this vid only have around 2000 views while other sh!t ones have like over 100,000???

[@oinker1695]

1:03 dont look at me with those bedroom eyes yo-

[@raspberry996]

When I first read the title I thought it said 'Troll Like Receptors'

[@savi263]

Superb animation to understand the TLR biology! Thanks

[@kandrew5v5]

@gutrp Thats Great! If I only I had videos like this through school, it would have made immunology a lot easier to digest!

[@pfeliciano4062]

These creatures look creepy but after after reading the section this makes it stick

[@MeganWhamGMfan]

Germs think were their home But cells said no

[@kandrew5v5]

@PastelitaVelys Do you mean our TLR book? Or another resource? Thanks!

[@kandrew5v5]

@jennyEvansmd Thanks for the comments, we are working on 2 additional videos that expand on this presentation. The new videos should fill in some of the gaps ins the sequence that is currently shown.

[@giannis101]

Go on ! You are the best ( greetings from Greece )

[@ashwinishinde64875]

Please upload more videos ..... This is so easier to understand everyone ..... I have never see like this animation 😂🤦😍😍

[@HaoSci]

Although I very much appreciate your effort into this, I don't like the molecules to be more like human. Although I would like the text to be bigger (so I can see it clearly), and also hope that the the text to stay with the whatever it labels. Thanks very much.

[@jaquelinemanuel5716]

cute, entertaining, and interesting! I hope more videos on immunology and other topics in med will come soon! Thanks!

[@rrintan9140]

W000WWW omg. thank you so much for creating this creative animation! this will definitely help me so much to pass the exam :)

[@Ozinco]

Genuinely the best signalling animation I have seen to date, bravo sir!

[@thatblindgamer726]

This looks like an HD version of Rhapsitte Street Kids Believe In Santa

[@Racheal700]

This is awesomeeee....things like this make it so much easier

[@guybrown9422]

im a bit confused, does Th1 differentiation require both IL-12 AND IFNy?

[@ileikdonuts]

i read an article and i think IL12 (more than IFNy) is needed to help stimulate the transcription factors for Th1 development if that helps haha

[@guybrown9422]

Cool thanks it did actually! and that would be STAT4. I think IFNy must just be the effector cytokine

[@kandrew5v5]

@bundawartini We tried to show as much information as we could. There are still many areas in which this video does not cover. We are releasing a 2-3 part series following up on these areas.

[@sagan20]

Yes B7.1 is CD80 and B7.2 is CD86

[@azeemnaeem6720]

Lovely inspiration for immunology

[@_SankalpaBhusal]

It was like a complete review for me!!! Great job...🙌✌🙌

[@vionagunawan5938]

Wow this is so cool, and I can understand it immediately

[@ekimzaga]

hell yeah, a video that is speaking in my terms!! house music, animation, and not dumbed down! =)

[@RabiesTheBeagle]

Posted 10 years ago?

[@ashithak6268]

Excellent. The video says it all....