Immunology - Adaptive Immunity (B cell Activation, Hypermutation and Class Switching Overview)

[@haleykatz932]

I'm studying for my graduate immunology course and your videos have been a life line. Please realize how much these videos help students learn and understand material instead of just memorization.

[@Mclovin-ct6kw]

The precision of your drawing and lack of mistakes amazes me. Also, the pace and information choice is perfect. Best online lecturer for any subject I've ever seen.

[@Biman_Goswami]

Hello. I have seen a few of your videos and it helps me understand some thing better than other videos. I just want to take this time to thank you and let you know that I appreciate it. God bless

[@Jstar001]

The clear and concise nature of this video is supreme. Thank you1

[@ebuilient]

once again, your tutorials have saved my undergrad life thank you!

[@awildelife]

Thank you for not being as general as the other tutorials on here! You are my saviour.

[@sifatullahanwary343]

Spreading knowledge is virtue you are doing it

[@thebestpker1000]

It's my first year on medical school, and I have my finals in microscopic anatomy on next friday! I have sacrificed so much to learn everything. Its new year in 3 days, but I have cancelled all my plans.. None of my friends understand why I study so hard, and I don't blame them. Only medical students understand the struggle. I can't wait to see what the future will bring! Thanks for the video!

[@shreenprince]

Thank you so much!! Been following since my UG and now in my PG, you have saved me from failing this subject!

[@graciafeliasenoskorompis5421]

I just want to thank you for the videos, they really helped me preparing my exam. Thank you..

[@oy98]

special shoutout to this guy! i learn best with pictures! thank you!

[@BEEEKAYJAY]

I wish I'd found your video's sooner! But still great help for last minute overviews before my exam tomorrow! Will be using your other video's when my GAMSAT test comes around! Thanks xx

[@kevinmoll-llobell5151]

I'm a french medecine student, and I just want to say thank you and I hope you will continue to make this video on subject like physiology/anatomy ..!

[@Deadly_virus]

you must be a doctor by now, lucky you

[@armandohasudungan]

Hey, You have to save the image. Then you have to print it in a A3 paper at least. if the image fills a A3 paper, the image will be more visible. Try it Cheers armando

[@magdamalliari8059]

This saved my exam cheers!!!!

[@mekamalika]

armando.....your explanations are great.... they make thing so clear so easily... thnks

[@maegeluy2284]

He said he will take a closer look at the hypermutation and isotype switching but he literally just repeated exactly what he said on the overview. the mechanisms should be better explained in another more focused video, including enzymes and signaling or what not :/ still a great video! thank you so much

[@frida5288]

I was wondering the same :/ but I cannot find those videos. Did you find the video in the end ?

[@OasisTropicale-m3m]

Merci Mr bruscella pour cette excellente vidéo. Grâce à ça je suis sur d'avoir 20/20 au DS.

[@jkmchen1]

The pause button is op, so use it, I paused this video a lot, and loved it !

[@arthurcapdeville158]

super intérressent, merci beaucoups pour le temps passer à la réallisation.

[@rencesperez2772]

Immunology is a challenging course. thank you so much for providing this wonderful video. It really helps me to understand the material.

[@tendainjovu721]

I love this man I don’t think he knows ♥️♥️😭😭😭

[@charlescumberland6887]

Thankyou so much Armando, this really allows me to visualise the concepts. Cheers from Australia :) -- Keep up the great work!

[@gwenllianroberts5857]

You are honestly a lifesaver!!!

[@katvlogsyeah]

your explanations are amazing! you make everything so clear!

[@robertcavanagh4404]

Really good video, nothing is this good!!!

[@lindaleith9588]

Thank you so much! Very clear and easy to understand

[@loolylooly81]

Great video, thank you so much. I wish 8 years ago there was better audio recording equipment. :)

[@SaifulIslam-wm9kq]

It helps me make my concept clear.Thanks!

[@MrLolo096]

This is pure gold! Thanks a lot!

[@Olivia74940]

Thanks for your video Armando !! This is really really helpful !!

[@brunakreuz5212]

your channel is just amazing!! Thanks for sharing so much information!!!

[@adielleluv]

your drawings are amazing

[@varshameena9742]

Best explanation ❤️

[@whencanigraduate]

Very clear explaination

[@pavasahuja5859]

Very informative and simplified!

[@abrehamephrem1302]

One minor correction: Follicular dendritic cells do not possess MHC but rater presents antigen tightly bound on its membrane, if the centrocye can extract this antigen with high affinity and present it to T helper follicular cells via their MHCII, it will get selected.

[@demkomusic]

If I pass this midterm, I'm going to find you and kiss you on the mouth. Or donate money to your channel, whichever ends up being easier.

[@ingridlam125]

did you pass that midterm 3 years ago?

[@demkomusic]

I did! And have since entered a career HIV research!

[@ingridlam125]

ladies and gentlemen, here is another successful person :D Proud of you even though i dont know you hehehe

[@wassimabdou7649]

did you kiss him or donated money to his channel ?

[@haroonsarwarful]

@@wassimabdou7649 He did both

[@poojapatwal6525]

Thank you so much . You are a saviour

[@LELOKIMOTO]

This is a very good basic introduction and follows along with my textbook, including the afferent pathway sentence. This should be a good review for your basic intro to immunology course.

[@yuvasaikumar.p2543]

Excellent sir!!

[@MrPatschen]

Your videos are amazing

[@TrickyDicky89]

Armando slight mistake here. T-helper cells do not present antigens to the centrocytes. They do not process MHC2. They do activate b-cells but this is through them recognising antigen on the APC and then releasing the appropriate cytokines to trigger class switching and differentiation.

[@dr.shadmbbsdphmasco]

Yes

[@mariad707]

Thank you for the great video ! 🎉

[@abdulwehabsefa2696]

hey Armando its awosome u make things easy would please keep on.

[@hananqaqish4272]

This is an awesome video, thank you so much!! Also I love your icon bracelet! I have a similar one :)

[@MsMissy314]

Thank you for posting these videos!!!

[@rimeln6443]

absolutely amazing like all of your other videos!! finally makes sense :)

[@kier2985]

Cells enter lymph node primarily through high endothelial venules (HEV) by L-selectin mediated rolling. Only about 10% of TCells actually come in through the afferent lymphatics. HEV's are in the paracortex and that is why the paracortex is filled with mostly T cells.

[@TanTan-ch3vq]

I agree with you

[@TanTan-ch3vq]

I think both T and B cells

[@whatsnew955]

damn this is supreme! thankyou sm for your work

[@adrianlau7727]

If you set the speed to 0.5x, he sounds like a really smart really drunk lecturer.

[@sillystorm28]

I snorfled in the middle of the library from this, thank you xD

[@00ShiNoda]

just like rick. lol

[@yuvincent6833]

Thanks for your video !! This is really really helpful !!

[@HD_Alm]

Thank you, Armando!!

[@samaelberashy8091]

it's amazing armando.....thank you

[@vmjable]

dude u are awesome! love this video....really cleared some things up for me.

[@bunneenee5867]

Those are the cutest B cells ever :3

[@ihsiung8]

Thank you for the great immunology lesson!!!

[@yeeshao9233]

thank you, thank you, thank you

[@gomerpyle6113]

Very helpful. Thank you

[@onetwoBias]

Great job on this one man! Really helpful :)

[@mehraanaa]

You are amazing . Thanks a lot

[@Mendoch]

the purpose of the class switching is mainly to promote the union of the specific cell tipe that are professionals eliminating the infection for eg, eosinofilos have Rc. for IgE so when a TCD4 Th2 activates a B cell it will induce a class change to Ig E and not G that that would call macrofages and not eosinofilos to bind with the pathogen

[@philomenebui-xuan2940]

Thanks a lot for you overview !!!

[@armandohasudungan]

Hey, I will do that, ill try to do it next week:)

[@ruhitghosh5511]

thank you so much for this one.

[@kasraakbari229]

Thank you so much again, fantastic!

[@RabidREDGirl]

@Shrimpcrackr Class swiping is important because they do different things. For example IgM can activate complement, but it's short lived and doesn't neutralize well. IgE and IgA a better at opsinization. IgE binds to mast cells.

[@daWonkinator]

Lol. At 5:15 he went "now let's look at (...) in a bit more detail" after which he just explained the exact same thing again. Don't get me wrong; I like the video. Probs and thanks to Armando Hasudungan for making it and all. I just found this detail a bit odd :-)

[@princesskairi001]

Thank you for this! Amazing.

[@Bite999]

Armando! Great vids! Would like to ask of you if you could insert bookmarks that indicate when you start talking about for example "somatic hypermutation" or "class switch combination" so it would become easier to navigate :)

[@RSwarve]

Amazing guy! Thank you.

[@sidwakeup8039]

thank you .... thank you so much

[@amitsaklani1207]

Very informative video. But you didn't talk about the role of bcl-6.

[@mistywink]

very helpful. a little bit fast for me when i first watch the video but it made sense when I watched it again. thanks.

[@aj-uo3uh]

Very good. But I thought a germinal center is in a follicle which is in turn in the cortex. So not in the medulla.

[@nicoleluvdogs]

Soso helpful! Thank you!

[@phuthuy14101996]

wondering whether the drawer and lecturer is the same of different individuals? :s Awesome video thank you!

[@aliceroxcullen98]

It is the same person.

[@gigimatz9222]

thank you so much! You have helped me alot.

[@ahmedhassan3009]

thank you so much

[@buttcrackboy]

I have a question about the CD4+ cells. At about the 3:30 mark you say that the Helper T cell presents the antigen to the mature B cell in the first place. I don't understand how this mechanism works considering Helper T cells don't express MHC II, but instead REACT to it. So if Helper T cells don't express MHC II how are they able to present an antigen? I thought all antigen presenting cells express MHC II. Any clarification would be great ty

[@johng6962]

apparently nobody knows.

[@yzchan0905]

I reckon that TH2 do not present an antigen, instead they react to the CD40 surface protein on a mature B cell (in which TH2 expresses CD40L when antigen-presenting cell presents antigen to TH2).

[@BigioBio]

B-cell will present the antigen to T-helper cells (they act as APCs). When B-cells bind an antigen, their BRC will be internalized, the antigen will be processed (exogenous presentation) and presented on MHC class II molecules.Then a CD4+ T-helper (specific for that processed antigen) can bind the MHC-peptide complex and through CD40L expression can stimulate the B cell (which expressed CD40).

[@camilalara1545]

BRILLIANT

[@chiedzanago6168]

hello i love your videos, could you please do some on gene technology,biotechnology,crop plants, inherited change and regulation and control

[@seungminyeom5451]

awesome... It was great..!!

[@aya_Bou]

thaaaaaaank youuu sooo much

[@drmanojbansode9678]

thank u very much..........i liked this vedeio....

[@Leenylulu95]

I love your videos! But do you mind linking the videos you mention at the end onto the video, because I find them hard to find. Thank you :)

[@plencykr3213]

I was thinking why the textbook we have don't explain like this?? :'( especially medical not at all clear...

[@Sweetieheart99]

its really helpful thx for all your effort 5||5||2022

[@AnnuAparajita]

So the antibodies keep getting produced even after the B cell has matured?

[@deborahkarega9541]

thank you !

[@arabstaff1]

great video， But a little complicated

[@MonicaSariDevy]

You guys awesomeeee!!!!!

[@Singh2007bhupendra]

A good video....

[@fangirl00x]

thank you

[@eleonoramaria6300]

Where is the link quoted in the last minute of the video in which I should find the further information about the somatic hypermutation and class switching in a lot more detail? I can't find it... Thanks in advance

[@adrinashafiqah1759]

Thank youu!!!

[@500Krish005]

love ur videos man... can u pls show T cell activation pathway with either MHC1 or MHC2...

[@ainafarra5432]

Thanks a lot 🤗

[@HussainAli-xn8nr]

please can give me a summary about production of B lymphocyte please quickly

[@carlete300]

at the end of the video isnt it missing the APPC as another effector mechanism of humoral immune reponse?