Inside the Brain: Unraveling the Mystery of Alzheimer's Disease [HQ]

[@westfield90]

It’s been 10 years since this video and we are still nowhere close to curing this condition. The more we discover the more we realize how little we know.

[@leukota]

Bullshit, Alzheimer’s is mainly caused by aluminum ingestion, aspartame, and LACK OF SLEEP. Prevention is the best cure.

[@JaneCandy_50_94]

Now it’s been 13 years

[@LizChern]

Great video that covers everything essential! Well presented!! DESERVES A "LIKE"

[@jatinmachhi8098]

Amazing animation showing Alzheimer's pathophysiology. Tau and amyloid formation is excellently described..

[@masterchief4868]

My grandma got Alzheimers recenty, she confuses my name with my cousin's. It is really sad. I hope this disease can be cured some day.

[@nickrod32]

My Grandmother has final stafe Alzheimer's, It's very upsetting when I visit her.

[@myusername3689]

May she rest easy now

[@jeskai3ai3e]

@stacyjann This is a great video. I'm in medical school and I was actually looking for a video that showed a tour through some of the "confusing" structures of the brain. Specifically the ventricular system and the structures in relation to where the ventricular system lies (thalamus, massa intermedia, internal capsule, lalala). Instead I found an awesome tour of the process of Alzheimers! Thank you. With your video talent design, I bet you could make an awesome video of what I was lking fr

[@terryex2]

I am a yr2 pharmacy student studying drug like AChEI for treatment of Alzheimer's disease and this video really helps me a lot to understand the pathophysiology of Alzheimer.Thank you so much for producing this video!!!!

[@k3vin151993]

how did it go are you a pharmacist now ?

[@terryex2]

@@k3vin151993 Yes I am, working in a hospital now. Thx for asking after ten yrs since I posted my comment 😂 👍

[@jmw9904]

I'm glad they chose this type of music instead of the techno sound. As I've gotten older, I've started noticing that this disease and cancer seems to be more common or it could be that I'm paying attention more.

[@elbuenome]

I am more than thankful, with the developers of this great article, because you helped me quite a lot, with my final school score!!!!! EXCELLENT WORK!!!!

[@esmeraldaelhamzawy9114]

great job, that was really helpful!!! Thank youuu

[@drdani111]

Yes...KZbin is great to scrue your exam preparation, in fact me too very often get stuck in here rather than studying, so good luck for the exam dude....!

[@AlzheimerUniversal]

Hi Stacy @stacyjann, is a big pleasure and honor be your friend. Thanks for ur work, and sorry for my poor english. I love your job "Inside the Braing: Unraveling the Mystery of Alzheimer's Disease", really fantastic ! :)

[@atushalipuria]

its the best explanation given for the disease...!!so clearly illustrated,all doubts cleared in 4 mins......!! keep up d good work......!!

[@AhsetofAtum]

I feel hopeful based on this evidence which shows it's a communication/retrieval problem. This means that there is no reason to believe that the persons' memories and personalities are not still in there...they just have trouble being expressed/retrieved. This may explain why there is death bed clarity in Alzheimer/dementia patients (called Terminal Lucidity) where they suddenly are able to express/think clearly and say goodbye to loved ones,etc. Life is so mysterious!

[@dragoonsunite]

+K Aldaya The problem is the actual neurons are dying, and its the inter-connectivity between these neurons, and the actual neuron pathways which form much of human memory. There is a common misconception in neuro-anatomy, where people assume that the brain is a physical storage device for 'memories' which are stored via electrical impulses. This is inaccurate. The brain structure itself is what stores and processes memories and all your actions ideas and behaviors, the electrical impulses are merely the means by which neurons decide how to connect, disconnect, and reconnect to form different structures within the brain. The reason people 'die' when electrical activity ceases in the brain is because neurons have a sort of auto-destruct mechanism when they are prevented from discharging. There is a baseline discharge rate for neurons, which if not made results in neural death. What this means is the way Alzheimers effects patients is very real loss of mental function, acuity, and memory. It's not limited to sections of the brain though, so the mildly good thing is that the loss of function is sporadic, and represents 'general' degradation. Thus if it could be reversed, the brain has a remarkable plasticity and ability to 'fill in' the gaps of information where neurons were lost. This means after a time a person who was cured of Alzheimers could once again behave normally, and reconstruct past memories with the help of friends and families. However, that's the extent of the good news.

[@noahwilliams8996]

What are you talking about? This would absolutely Destroy everything the patient is over time.

[@rosenewell6984]

Charlotte i totally agree to what you have written as this is exactly the problem I am finding with my husband.

[@christophernazario4982]

They should look more into the research linking heavy metal toxicity and oxidative stress and alzheimers.

[@thusharikandamby4436]

Thank you for helping to get a better idea about Alzheimer disease

[@likeakittie]

This is so informative. Thank you very much for the knowledge!

[@myusername3689]

This disease is so deadly and uncurable but so common, why? This should be extremely rare like other uncurable diseases except death.

[@paulparcon7860]

A very excellent review of the basic events in Alzheimer's disease!

[@hin19922002]

I will have examination about the disease tomorrow. the animation is so clear that I understand more about it thx:)

[@sunny4lady]

Great video - gave me a good illustration of the tangles and plaques. Thank you!!! :)

[@Dominic-yf8gm]

there has to be a link between alpha secretase deficiency creating the bodys use of beta secretase, and the disolving protein structures from the abundance of tau in the second clip. It would make sense that there would be a connection of the abnormal beta secretase and the problems occuring on the microtubules

[@mrhiphopem]

Animation is excellent and this will help me on my Finals.

[@nikjosafatow4167]

What ya doing now

[@nicolesaint-john4347]

Great animation! Thank you.

[@LilasLotus]

@stacyjann Hi Stacy, I liked your video. It was accurate and comprehensive. The improvement I could suggest is to also explain that the pathophysiological processes involved in AD are so complex and many other cellular components are suggested to be involved. I'm a researcher in the field of AD. Good luck with future works

[@harrywbfmv]

thanks for upload, very clear and useful

[@jenningspony]

Aluminium causes amyloid plaques and by consuming silica you can avoid and reverse some of this devastating illness.

[@elietawk4975]

informative video! keep going guys! we r all looking forward to know new ideas about Alzheimer's Disease

[@SuperObenn]

thank you for helping me with my assignment! I already downloaded it ;)

[@ZekelFoundation]

Great Work

[@vanaik]

Great video. "Researchers move ever closer to treat this disease". Almost 10 years now and yet no cure in sight. It's sad.

[@Mikolaj_u]

Great, thanks for upload!

[@carissawilkins3881]

Amazing video! Thank you very much.

[@BarryAi]

Visually informative, thank you!

[@Staruha91]

I saved it to my “Pocket” about 8 years ago. And only now got round to watch it.

[@elijahnkambule5539]

its excellent explaination of the disease process,well presented thank you

[@raquellopes880]

Incrível este vídeo obrigado principalmente à prof não Paiva pelo vídeo

[@imegatrone]

Nice Video That You Share , So Very Nice Thanks You This 4-minute captioned video shows the intricate mechanisms involved in the progression of Alzheimer's disease in the brain.

[@terryex2]

I'm studying neurodegenerative drugs and this video is very helpful!!

[@ryandavis7593]

It’s a good video overall but could loose the static music.

[@laoying20]

thanks friend...keep it up...

[@marginacocozza7740]

very good work, but the captions need a little more work...

[@victofranco]

@stacyjann once again, great video!

[@cwsun08]

Great animations!!

[@CLEANDrumCovers]

Splendid video.

[@Leapinghorse-zt8wt]

This is just Us People,We have to Fight day in,day out!! Just be Active👍

[@Elaine1933]

Thank you so much!

[@misbahkachchi2236]

Best video. It's like Harrison on the screen.

[@shadoonrha]

i am interested in downloading this for a presentation is it available somewhere?

[@Lone_wolf_31]

wonderful depiction !

[@scragglewaggle4109]

i love my brain

[@celonman]

this really helped me !!!

[@jonphillips6727]

cool video really liked it

[@laurahollitt3088]

Do you have the exact link and citations for this video? It has helped on an assignment and the correct details would be very much appreciated. Thanks!

[@TheFranchfry]

Can you please provide links to the research articles where this information was published?

[@Sherirose1]

Thank you so much

[@murdemo]

@stacyjann this video is great, just a comment, the direction of the signal is not always propagating down an axon to the cell body and dendrites of the next cell? i mean, basing in the video i think you make the opposite (sorry for my english)

[@DjTechortiz]

what program do you use to create this kinds of videos?

[@EUROPAMusicOfficialChannel]

That's terrifying.

[@SemiCollin]

I know, id rather lose my life than to have to suffer through losing myself

[@victofranco]

@stacyjann great vido, good description!

[@mediavision2000]

i am interested in downloading this for a documentary. How could we get it?

[@sisiempreaprendoyo6663]

Gracias!.... podran subtitularlo al español por favor!

[@TheJerusalemite]

What software was used here to create these animations?

[@nadiasantosuosso812]

Hi, I was wondering if it would be possible for me to use a short clip of this video in a video I am making for a school project? Thank you very much.

[@abhis568]

Nadia Santosuosso 😁😁hi

[@lima1234ize]

easy thank you

[@tankstudios]

incredible

[@AlzheimerUniversal]

@shadoonrha Hi Shadoonrha, you can load this in your hard disk using Firefox & the plugin "DownloadHelper"

[@nimraiqbal9832]

Nice

[@John94098]

Go for gold!!

[@opendoora6]

Why did the microtubules in the neuron disolve or got destroyed in the progressiveness of Alzeimers disease?

[@roshithvr4913]

Is that, the thing which is reason behind starting point of this disease, what is that actually? sorry if i wrong in English.

[@AlzheimerUniversal]

@mediavision2000 Stacy says: go to this website: nia.nih.gov/Alzheimers/Publications/Unraveling/

[@ImaSkeptic1]

Sorry. I didn't know you were a KZbin troll. Carry on.

[@kaigabac3275]

informative

[@redouaneortiz4917]

Crazy how this video is 12 years old yet no cure nor effective treatment for this horrible disease...

[@callimjanda830]

i would hate to have this disease

[@blinxcat]

my grandma died from it 2 years ago and its related to mad cow Aka BSE

[@Marcodiazgrey]

its horrible........its painful to watch and even more painful to feel the person's distress.....i wish there was a way to repair the cells. but if the person seals a part of themselves it causes severe neural disconnection. Then the system crashes. Errors in the script of memory storage, memory retrieval. memory categorisation. its worse then death. sigh.......i hope we find a cure soon. Have we tried Stem-cell to Neural interfacing and memory reintegration by use of Collaborated psycho restore

[@DreamsOfFinland]

I discovered CBD oil restored much function within minutes, no side effects. Cheap. Non toxic. It seemed to me ALZ has been treated like the engine in your car blew up, and science has been looking for way to repair it, but really you just ran out of gas. Fuel. Not one person I sent info to wanted to deal with it. Is it because it is inexpensive and safe? Need something costs millions to make and has toxic side effects and you can't afford it anyway? I have declined but every morning I can do a lot more by taking drops sublingual. Improved finction withing minutes. Totally gave me my life back. I could hardly walk 6 years ago, I walk 2 miles a day and swim now.

[@ponguia]

I'm sad for the poor kinesin

[@mustafasamiahmed3772]

nice

[@ImaSkeptic1]

Aren't we also speaking of mis-folding of proteins in the brain? Do you drink artificially fluoridated water? [see link] life-enhancement[DOT]com/magazine/article/2247-fluoridation-and-mis-folding "Fluoridation and Mis-Folding" "...exposure to fluoride can inhibit protein synthesis,... proteins fail to fold properly (or become misfolded), and endoplasmic reticulum stress response genes are induced that together comprise the unfolded protein response.

[@solapowsj25]

Looking at illness in an integrated manner, rather than from a single point for diagnosis and treatment, would help develop preventive measures. A baby with Apgar 8 or above does well through infancy and childhood. But damage to the brain either in the womb or during infancy is often neglected. I've had atypical polio, raised ICT due to aseptic meningitis, and was DOR in an unresponsive state at age 7 mo. I took cetrizine to help prevent lancing pain following certain foods which my autistic wife 👰refuses to stop serving. The response is good. Soon after the first dose, I felt better and after a period of seeing shooting stars all over the fields for a minute, my vision improved. I had a lovely day, free from the lance that shreds me up daily. Praise to our Lord, Jesus. But, everyday isn't a Sunday. I must start again from here without drugs 💊💉or anticholinestarase agents 🕵.

[@dimitrijekrstic4701]

I love the animation! However maybe the proposed toxicity-mechanism is not correct! See why here: A potential cause leading to failures in finding a drug for Alzheimer`s disease

[@crackmaster88]

damn it, it's scary :/ awesome video

[@lizichell2]

this is some scary shit

[@SemiCollin]

I know, alzheimers is scary

[@ismaelvoltaire8743]

what causes the tau to seperate?

[@heling5137]

Phosphorylation of tau

[@JonathanR1994]

I wish I had watched KZbin animations instead of giving myself a mental breakdown from my medical Biochemistry course slides

[@ishaqishaq1667]

U A⁰

[@ishaqishaq1667]

07

[@noahwilliams8996]

But how can we stop the proteins from sticking to each other?

[@AyakaruJuuhachi]

DNAJB6b

[@debralittle1341]

We lost our father to Alzheimer's

[@sonyaNBA]

@Ibringthetruth1 the by-product that results from the cleavage of APP by alpha secretase is harmless - when cleaved by beta secretase, the product is more "sticky" and attracts lipids and cholesterol which results in the plaques

[@ChaoticTeen16]

The funny thing about Alzheimers is that it doesn't just happen once. And I'll tell you that again later, if I can remember.

[@katUnMause]

What is food?

[@dilawarrana5999]

Glucose

[@roshithvr4913]

Alzheimer Universal, what are those BLUE things coming merging Tau Protein, and forcing them to fall apart.

[@حمدولله-ل8ي]

الترجمة بالعربية

[@nimraaslam7715]

Explicit!

[@Spoons123]

Calling someone a nerd on the KZbin, INTERNET FIGHT!

[@VladyslavKL]

🕊

[@hoopdydoable]

Join the Forget Me Not group on Facebook

[@nooreldenayman8032]

انا ايه اللي دخلني طب عين شمس

[@pako5586]

my mother has this